ライフサイエンスコーパス: acyl carrier protein

1 yield an extended beta-ketoacyl chain (ACP = acyl carrier protein).

2 dehydratase, a decarboxylase and a dedicated acyl carrier protein.

3 inds exclusive of the native substrate, acyl-acyl carrier protein.

4 re identified as proteolytic products of the acyl carrier protein.

5 ranes via the synthesis of [(14)C]linolenoyl-acyl carrier protein.

6 very tight, albeit noncovalent, complex with acyl carrier protein.

7 fect of fatty acid length on the dynamics of acyl carrier protein.

8 other PKS domains, the ketoreductase and the acyl carrier protein.

9 on but did induce the deacylation of butyryl-acyl carrier protein.

10 ntermediate domain functions similarly to an acyl carrier protein.

11 ned with favourable dynamic properties of an acyl carrier protein.

12 cillatus for formation of the methoxymalonyl-acyl carrier protein.

13 ms through Claisen condensation with malonyl-acyl carrier protein.

14 pantetheine group of either coenzyme A or an acyl-carrier protein.

15 -phosphopantetheine moiety of coenzyme A and acyl-carrier protein.

16 ultimately being incorporated into essential acyl carrier proteins.

17 coli FabZ dehydratase subunits with six AcpP acyl carrier proteins.

18 heine (Ppt) from coenzyme A (CoA) to diverse acyl carrier proteins.

19 exes along with a reduction in mitochondrial acyl carrier proteins.

20 and 2e(-) dependent desaturation of stearoyl-acyl carrier protein (18:0-ACP) to yield oleoyl-ACP (18:

21 Gly, H-Asn-Phe-Gly-Ala-Ile-Leu-Gly-NH2) and acyl carrier protein (65-74) fragment (H-Val-Gln-Ala-Ala

22 ave constructed a conditional null mutant of acyl carrier protein, a central component of the FAS II

23 e NADPH-dependent reduction of beta-ketoacyl-acyl carrier protein (AcAc-ACP) to generate (3S)-beta-hy

24 d protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.

25 Every polyketide synthase module has an acyl carrier protein (ACP) and a ketosynthase (KS) domai

26 A interference (RNAi) or genomic deletion of acyl carrier protein (ACP) and beta-ketoacyl-ACP synthas

27 es coelicolor consists of three proteins: an acyl carrier protein (ACP) and two beta-ketoacyl ACP syn

28 mologues that utilize acetyl- or propionyl-S-acyl carrier protein (ACP) as a substrate.

29 at both PKSs are able to use dimethylmalonyl acyl carrier protein (ACP) as an extender unit.

30 ructures of acyl chain loaded species of the acyl carrier protein (ACP) as used in fatty acid biosynt

31 es are in the wall of the assembly facing an acyl carrier protein (ACP) bound to the ketoacyl synthas

32 ls with small interfering RNAs targeting the acyl carrier protein (ACP) component reduced ACP mRNA an

33 with TE1 for the acyl chain attached to the acyl carrier protein (ACP) domain of FASN is unknown.

34 d as an acyl-adenylate and ligation onto the acyl carrier protein (ACP) domain of MbtB to form covale

35 Mutation of the acyl carrier protein (ACP) domain of the upstream module

36 eates a reaction chamber for the intramodule acyl carrier protein (ACP) domain that carries building

37 id or macrolactone products from an adjacent acyl carrier protein (ACP) domain.

38 ntermediates, respectively, each bound to an acyl carrier protein (ACP) domain.

39 Acyl carrier protein (ACP) domains act as interaction hu

40 ntetheinylation of polyketide synthase (PKS) acyl carrier protein (ACP) domains in polyketide product

41 Acyl carrier protein (ACP) domains shuttle acyl intermed

42 -bundle, which forms extensive contacts with acyl carrier protein (ACP) during catalysis.

43 esizes DSF by dehydration of a 3-hydroxyacyl-acyl carrier protein (ACP) fatty acid synthetic intermed

44 The acyl carrier protein (ACP) from fatty acid synthases seq

45 onsible for the C2-methylation of 3-ketoacyl-acyl carrier protein (ACP) intermediates to give the cor

46 Acyl carrier protein (ACP) is a cofactor in a variety of

47 Acyl carrier protein (ACP) is a highly conserved cofacto

48 Acyl carrier protein (ACP) is a key component of the fat

49 s atypical primer is transformed to pimeloyl-acyl carrier protein (ACP) methyl ester by two cycles of

50 in is cleavage of the ester bond of pimeloyl-acyl carrier protein (ACP) methyl ester.

51 In this study, we expressed the acyl carrier protein (ACP) of FUM1 and in vitro loaded a

52 required the presence of an unsaturated acyl-acyl carrier protein (ACP) or acyl-CoA and was antagoniz

53 g fatty acids in thioester linkage to either acyl carrier protein (ACP) or CoA as acyl donors.

54 dicates that LuxI homologs prefer fatty acid-acyl carrier protein (ACP) over fatty acyl-CoA as the ac

55 thase (FASII) cycle for the beta-hydroxyacyl-acyl carrier protein (ACP) pathway intermediates.

56 Acyl carrier protein (ACP) plays an essential role in fa

57 tained a candidate gene encoding a beta-keto acyl carrier protein (ACP) reductase (BKR) putatively as

58 Enoyl-acyl carrier protein (ACP) reductase catalyzes the last

59 Enoyl-acyl carrier protein (ACP) reductase catalyzes the last

60 on its similarity to FabG, the beta-ketoacyl-acyl carrier protein (ACP) reductase of type II fatty ac

61 Enoyl-acyl carrier protein (ACP) reductase, FabI, is a key enz

62 r of many complex biosynthetic pathways, the acyl carrier protein (ACP) shuttles substrates to approp

63 these assembly lines, the extender unit and acyl carrier protein (ACP) specificity of keto synthase

64 atalyze the reduction of 2-methyl-3-ketoacyl acyl carrier protein (ACP) substrates and in certain cas

65 catalytic (NFS1), LYRM protein (ISD11), and acyl carrier protein (ACP) subunits.

66 Acyl carrier protein (ACP) synthase (AcpS) catalyzes the

67 ted via esterification by the bacterial acyl-acyl carrier protein (ACP) synthase AasC but inhibitors

68 st the KASIII domain of the beta-acetoacetyl-acyl carrier protein (ACP) synthase FabH.

69 beta-Ketoacyl-acyl carrier protein (ACP) synthase II (KASII) elongates

70 16:0 due to decreased activity of 3-ketoacyl-acyl carrier protein (ACP) synthase II.

71 The beta-ketoacyl-acyl carrier protein (ACP) synthase III encoded by mtfab

72 in which BioZ proteins catalyze a 3-ketoacyl-acyl carrier protein (ACP) synthase III-like reaction to

73 d and polyketide biosynthesis, beta-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this

74 0 microm cerulenin, an inhibitor of ketoacyl-acyl carrier protein (ACP) synthetase I/II.

75 he separate domains of the bifunctional acyl-acyl carrier protein (ACP) synthetase/2-acylglycerolphos

76 Acyl-CoA and acyl-acyl carrier protein (ACP) synthetases activate exogenou

77 ytic efficiency with substrates linked to an acyl carrier protein (ACP) than with the corresponding C

78 rom a fatty acid synthetic intermediate, the acyl carrier protein (ACP) thioester of 3-hydroxydodecan

79 lasmid for the Umbellularia californica acyl-acyl carrier protein (ACP) thioesterase was shown to hav

80 ds are not efficiently converted to the acyl-acyl carrier protein (ACP) thioesters required by the pa

81 alyzes decarboxylation of 3-methylglutaconyl-acyl carrier protein (ACP) to 3-methylcrotonyl-ACP, the

82 by a specialized acyl-transferase that uses acyl carrier protein (ACP) to covalently link fatty acid

83 acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the FAS primer beta-a

84 ransfer of an R-3-hydroxyacyl chain from its acyl carrier protein (ACP) to the 3-OH group of UDP-GlcN

85 We reveal that subunit B22 anchors an acyl carrier protein (ACP) to the complex, replicating t

86 e R-3-hydroxyacyl chain from R-3-hydroxyacyl acyl carrier protein (ACP) to the glucosamine 3-OH group

87 Acyl carrier protein (ACP) transports the growing fatty

88 the ATP-dependent acylation of the thiol of acyl carrier protein (ACP) with fatty acids with chain l

89 dule is comprised of a ketosynthase (KS), an acyl carrier protein (ACP), a malonyl-CoA:ACP transacyla

90 s a type I PKS module minimally contains AT, acyl carrier protein (ACP), and ketosynthase (KS) domain

91 transferases, a decarboxylase, an additional acyl carrier protein (ACP), and several oxygenases.

92 of the PKS and NRPS modules mediated by the acyl carrier protein (ACP), condensation (C) and ketored

93 based on a thioesterase specific for butyryl-acyl carrier protein (ACP), which allows native fatty ac

94 study, we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role

95 S-adenosyl-l-methionine and either cellular acyl carrier protein (ACP)-coupled fatty acids or CoA-ar

96 ally, both acyltransferases catalyze an acyl-acyl carrier protein (ACP)-dependent transfer of a fatty

97 ituted extender units switches largely to an acyl carrier protein (ACP)-independent mode.

98 t are coupled via a phosphopantetheine to an acyl carrier protein (ACP).

99 thioester bond to either coenzyme A (CoA) or acyl carrier protein (ACP).

100 ly, AftD is non-covalently complexed with an acyl carrier protein (ACP).

101 re thioesterified to either coenzyme A or an acyl carrier protein (ACP).

102 tive for UDP-GlcNAc and R-3-hydroxymyristoyl-acyl carrier protein (ACP).

103 g., malonyl-CoA or methylmalonyl-CoA) and an acyl carrier protein (ACP).

104 panthetheine and the serine-36 side chain of acyl carrier protein (ACP).

105 yl-CoA, ethylmalonyl-CoA, and methoxymalonyl-acyl carrier protein (ACP).

106 tion of FAS-I-derived acyl-CoAs with malonyl-acyl carrier protein (ACP).

107 in a single enzymatic step to an orthogonal acyl carrier protein (ACP).

108 tic subunit (NFS1), LYR protein (ISD11), and acyl carrier protein (ACP).

109 ADPH), a polyene was detected in the tryptic acyl carrier protein (ACP).

110 PlsX is an acyl-acyl carrier protein (ACP):phosphate transacylase that i

111 rgets two essential proteins, beta-ketoacyl-[acyl carrier protein (ACP)] synthase II (FabF) and III (

112 se (KS)-acyl transferase (AT) didomains with acyl-carrier protein (ACP) and KR domains from different

113 n-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketid

114 yl-CoA:ACP transferase (MAT) didomain and an acyl-carrier protein (ACP) domain, whereas the second ap

115 inhibits the essential NADH-dependent enoyl-acyl-carrier protein (ACP) reductase, InhA.

116 hiolase superfamily, including beta-ketoacyl-acyl-carrier protein (ACP) synthases, polyketide synthas

117 in disclosed a region similar to malonyl-CoA:acyl-carrier protein (ACP) transacylases (MATs).

118 ine desulfurase (NFS1), LYR protein (ISD11), acyl-carrier protein (ACP), and the iron-sulfur cluster

119 urbation likely required an interaction with acyl-carrier protein (ACP), as judged by the failure of

120 sis hinges on improving our understanding of acyl-carrier protein (ACP)-protein interactions.

121 of 18:1 free fatty acid, 18:1-CoA, and 18:1-acyl-carrier protein (ACP).

122 gh the selective targeting of beta-ketoacyl-(acyl-carrier-protein (ACP)) synthase I/II (FabF/B) in th

123 plsX (acyl-acyl carrier protein [ACP]:phosphate acyltransferase), p

124 global transcriptional regulator Fis and the acyl carrier protein AcpP, were identified in P. aerugin

125 for 4'-phosphopantetheine attachment to the acyl carrier protein (AcpP) of fatty acid synthesis.

126 e developed to target acpP, which encodes an acyl carrier protein (AcpP) that is thought to be essent

127 rase selects from the bacterial pool of acyl-acyl carrier proteins (ACPs) an acyl chain of a specific

128 Acyl carrier proteins (ACPs) are essential to both fatty

129 Acyl carrier proteins (ACPs) are essential to the produc

130 Acyl carrier proteins (ACPs) are the scaffolds for fatty

131 Acyl carrier proteins (ACPs) are universal and highly co

132 laboratory has developed methods to prepare acyl carrier proteins (ACPs) loaded with substrate mimet

133 Prior work showed that expression of acyl carrier proteins (ACPs) of a diverse set of bacteri

134 The acyl carrier proteins (ACPs) of fatty acid synthesis are

135 Acyl carrier proteins (ACPs) play a central role in acet

136 HMGS is highly selective for two specialized acyl carrier proteins (ACPs) that deliver the donor and

137 sferase (AT), which loads monomer units onto acyl carrier proteins (ACPs), small, flexible proteins t

138 ion lies a gene that encodes the specialized acyl carrier protein AcpXL, on which the VLCFA is built.

139 mimetics are positioned on the actinorhodin acyl carrier protein (actACP) to probe the underpinnings

140 It makes acylphosphate from acyl-acyl carrier protein (acyl-ACP) and is also involved in

141 Cyanobacteria possess two enzymes, acyl-acyl carrier protein (acyl-ACP) reductase (AAR) and alde

142 Long-chain acyl-acyl carrier proteins (acyl-ACP) are established biochem

143 ay in the plastid, glycerol-3-phosphate acyl-acyl carrier protein acyltransferase, is thought to be e

144 und that RNAi depletion of the mitochondrial acyl carrier protein, an important component of the fatt

145 in blocking crosslinking of Escherichia coli acyl carrier protein and FabA, a direct mimic of the bio

146 tering (SAXS), the positions of the flanking acyl carrier protein and ketosynthase domains have been

147 dependent tailoring enzymes, a free-standing acyl carrier protein and two hypothetical proteins in oo

148 synthesis of fatty acyl-phosphate from acyl-acyl carrier protein, and then PlsY transfers the fatty

149 e have cloned all three genes, expressed the acyl carrier proteins, and characterized each as a subst

150 rate specificities and can employ acyl-CoAs, acyl carrier proteins, and galactolipids as acyl donors.

151 a thioesterase that hydrolyzes beta-ketoacyl acyl-carrier protein, and ShMKS1 is a decarboxylase that

152 iments identified four stable complexes: the acyl-carrier proteins ApeE and ApeF bound to the thioest

153 thases cannot be functional unless their apo-acyl carrier proteins (apo-ACPs) are post-translationall

154 of the reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual rea

155 ing radiolabeled lipid A substrates and acyl-acyl carrier protein as the fatty acyl donor, we were ab

156 been observed in X-ray and NMR structures of acyl carrier proteins attached to different fatty acids.

157 ee carboxyl of either malonyl-CoA or malonyl-acyl carrier protein based on the ability of O-methylate

158 e (TtmT), five proteins for methoxymalonyl-S-acyl carrier protein biosynthesis (Ttm-ABCDE), eight pro

159 Acyl carrier proteins, both free-standing and as embedde

160 nse inhibition of synthesis of the family of acyl carrier proteins can be attributed to a single gene

161 sion, as an altered distribution of acylated acyl carrier proteins correlated with the SpoT-dependent

162 nthesis of either FabZ (3-R-hydroxymyristoyl acyl carrier protein dehydratase), slrA (novel RpoE-regu

163 l hadABC genes encoding the (3R)-hydroxyacyl-acyl carrier protein dehydratases resulted in more than

164 s such as methane monooxygenase and stearoyl acyl carrier protein Delta(9)-desaturase.

165 s of soluble methane monooxygenase, stearoyl acyl carrier protein Delta9 desaturase, and variants of

166 lian ribonucleotide reductases, and stearoyl acyl carrier protein Delta9-desaturase from plants, sugg

167 3 FATTY ACID DESATURASE3 (FAD3) and STEAROYL-ACYL CARRIER PROTEIN Delta9-DESATURASE6 (SAD6).

168 atty acids into its phospholipids by an acyl-acyl carrier protein-dependent pathway.

169 etailed biochemical studies with this unique acyl carrier protein-dependent, nonribosomal peptide syn

170 Stearoyl-acyl carrier protein desaturase (Delta9D) catalyzes the

171 Stearoyl-acyl carrier protein desaturase (SACPD) activity is esse

172 les formed on plants mutated in the stearoyl-acyl carrier protein desaturase (sacpd-c) gene, which we

173 Stearoyl-acyl carrier protein desaturase (SACPD-C) has been repor

174 nt of the castor (Ricinus communis) stearoyl-Acyl Carrier Protein desaturase (T117R/G188L/D280K) that

175 ganization of the soluble castor Delta9-18:0-acyl carrier protein desaturase, specifically, the hypot

176 Stearoyl-acyl carrier protein desaturase-mediated conversion of s

177 ely determined by the action of the stearoyl-acyl-carrier-protein desaturase (SAD) homolog SAD5.

178 2 mutant, which encodes a defective stearoyl-acyl carrier protein-desaturase (S-ACP-DES) and conseque

179 via a mutation in the SSI2-encoded stearoyl-acyl carrier protein-desaturase, or by exogenous applica

180 ative trait loci to a region containing ACYL-ACYL CARRIER PROTEIN DESATURASE1 (AAD1) and AAD3 We foun

181 However, soluble plant acyl-ACP (acyl carrier protein) desaturases have been studied in f

182 of an invariant arginine at the hypothesized acyl carrier protein docking site in the context of the

183 transfer from acetyl-CoA to load an adjacent acyl carrier protein domain (ACP(L)).

184 revealed that (i) the PKSs contain a central acyl carrier protein domain and C-terminal phosphopantet

185 tion is governed by interactions between the acyl carrier protein domain and the ketosynthase domain

186 fully extended phosphopantetheine arm of the acyl carrier protein domain from module 5.

187 domain, transfer of the acetyl group to the acyl carrier protein domain is suppressed.

188 ransfers the polyketide chain from the final acyl carrier protein domain of the synthase to a separat

189 disc-shaped structure capable of caging the acyl carrier protein domain proximal to each active site

190 ediates that are ready for transfer from its acyl carrier protein domain to its ketosynthase domain a

191 the malonyl group can be transferred to the acyl carrier protein domain, transfer of the acetyl grou

192 of the condensation domain to recognize the acyl carrier protein domain.

193 lyketide assembly are covalently tethered to acyl carrier protein domains of the synthase.

194 version of extracellular fatty acids to acyl-acyl carrier protein, elongation, and incorporation into

195 tructures of three forms of Escherichia coli acyl carrier protein engaging LpxD, which represent stal

196 active centers of malonyl-CoA and malonyl- S-acyl carrier protein, essential to fatty acid, polyketid

197 the biosynthesis of the unusual aminomalonyl-acyl carrier protein extender unit and the signature car

198 ons at the interface that optimally position acyl carrier protein for acyl delivery and that directly

199 pantetheine modification of Escherichia coli acyl carrier protein for visualization and functional st

200 metabolism using inhibitors to prevent acyl-acyl carrier protein formation or glycerol-phosphate acy

201 e the preferred acyl donors, while acyl-ACP (acyl carrier protein), free fatty acids, or galactolipid

202 and the inherent conformational mobility of acyl carrier protein have stymied previous attempts to v

203 is then loaded onto phosphopantetheinylated acyl carrier protein (holo-MbtL) to form covalently acyl

204 ent activation of apo-ACPP to generate holo-(acyl carrier protein) (holo-ACPP) in an early step of fa

205 lytic chamber shows an unprecedented role of acyl carrier protein in product release.

206 biosynthetic intermediates tethered to their acyl carrier proteins interact with multiple active site

207 hMKS2, are required to convert beta-ketoacyl acyl-carrier protein intermediates of the fatty acid bio

208 uce epimerized (2S)-2-methyl-3-ketoacyl-ACP (acyl carrier protein) intermediates.

209 -deformylating oxygenase (ADO) converts acyl-Acyl Carrier Proteins into corresponding n-1 alkanes via

210 Acyl carrier proteins involved in fatty acid biosynthesi

211 For example, acyl carrier protein is central to the biosynthesis of t

212 ia monocytogenes encode two functional enoyl-acyl carrier protein isoforms based on their ability to

213 Interestingly, acyl carrier protein knockout also leads to defects in a

214 dated Cryptosporidium ACS (and related acyl-[acyl-carrier-protein]-ligases) as pharmacological target

215 holoenzyme contains four subunits, having an acyl-carrier protein (MdcC subunit) with a distinct pros

216 pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein) metabolism in Yarrowia lipolytica

217 ylation and thus activation of mitochondrial acyl carrier protein (mtACP) of mitochondrial fatty acid

218 sence of an unsaturated thioester (of either acyl carrier protein or CoA) in order to bind the fabA a

219 get-specific deletions of ketosynthase (KS), acyl carrier protein, or ketoreductase.

220 ters have been used as mimics of the natural acyl carrier protein pathway intermediates to assay FASI

221 train PAO1, which is annotated as a probable acyl carrier protein phosphodiesterase (acpD), has been

222 The Escherichia coli AcpH acyl carrier protein phosphodiesterase (also called ACP

223 cts as a thioesterase hydrolyzing 3-ketoacyl-acyl carrier proteins (plastid-localized intermediates o

224 Acyl carrier proteins play a central role in metabolism

225 Conformational differences among the stalled acyl carrier proteins provide the molecular basis for th

226 rase (MT) is fused with an N-terminal pseudo-acyl carrier protein (psiACP), in which the apo state of

227 d A biosynthesis, the (R)-3-hydroxymyristoyl-acyl carrier protein ( R-3-OHC14-ACP)-dependent N-acylat

228 InhA, the enoyl acyl carrier protein reductase (ENR) from M. tuberculosi

229 Enoyl-acyl carrier protein reductase (FabI) catalyzes a rate-c

230 mical tool to specifically inhibit the enoyl-acyl carrier protein reductase (FabI) of C. trachomatis

231 the bacterial target of 6-OH-BDE-47 as enoyl-acyl carrier protein reductase (FabI), an essential and

232 2-pyridone compound that inhibits the enoyl-acyl carrier protein reductase (FabI), has recently been

233 Staphylococcus aureus that targets the enoyl-acyl carrier protein reductase (FabI).

234 Mycobacterial enoyl acyl carrier protein reductase (InhA) is a clinically va

235 cobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA).

236 Beta-ketoacyl-acyl carrier protein reductase (KACPR) catalyzes the NAD

237 malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR).

238 The pathway consists of an acyl-acyl carrier protein reductase and an aldehyde decarbony

239 A cyanobacterial pathway consisting of acyl-Acyl Carrier Protein reductase and an aldehyde-deformyla

240 Enoyl-acyl carrier protein reductase catalyzes the last step i

241 The enoyl-acyl carrier protein reductase enzyme FabI is essential

242 -1452, namely potent inhibition of the enoyl-acyl carrier protein reductase FabI, as validated by in

243 results show that FabI is the primary enoyl-acyl carrier protein reductase of type II bacterial fatt

244 nzyme Mycobacterium tuberculosis InhA (enoyl-acyl carrier protein reductase) due to formation of an i

245 ts Arabidopsis (Arabidopsis thaliana) enoyl (acyl carrier protein) reductase (ENR).

246 Human enoyl-acyl carrier protein-reductase (hER) is one of the FAS c

247 Acyl carrier protein represents one of the most highly c

248 fact a FAAL that transfers fatty acids to an acyl carrier protein (Rv0100).

249 Notably, type II acyl carrier proteins serve as a crucial interaction hub

250 During lipid A synthesis (Raetz pathway), acyl carrier protein shuttles acyl intermediates linked

251 that saFabI is NADPH-dependent, and prefers acyl carrier protein substrates carrying fatty acids wit

252 the ALT proteins used endogenous fatty acyl-acyl carrier protein substrates to generate fatty acids

253 of fatty acyl-coenzyme A (CoA) or fatty acyl-acyl carrier protein substrates to primary fatty alcohol

254 he peptide competes with both nucleotide and acyl carrier protein substrates.

255 caused concomitant loss of the mitochondrial acyl carrier protein subunit ACPM1 from the enzyme compl

256 transit peptide from the apicoplast-resident acyl carrier protein supports this idea.

257 of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase (ACP) II mtKasB, a mycobac

258 omyces, is an inhibitor of the beta-ketoacyl-acyl carrier protein synthase (KAS) enzymes in the bacte

259 luding the elongation enzymes, beta-ketoacyl acyl carrier protein synthase I/II (FabF/B).

260 cid dehydrogenase complex and beta-keto acyl-acyl carrier protein synthase III from Bacillus subtilis

261 ation of the kasIII gene encoding 3-ketoacyl acyl carrier protein synthase III into tobacco plastids.

262 tochondrial fatty acid synthesis by ketoacyl-acyl carrier protein synthase is not vital for protein l

263 yl chains provided by mitochondrial ketoacyl-acyl carrier protein synthase to meet the high lipoate r

264 The Escherichia coli holo-(acyl carrier protein) synthase (ACPS) catalyzes the coen

265 one biosynthetic pathway, the beta-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme Pq

266 oduct that inhibits bacterial beta-ketoacyl-(acyl-carrier-protein) synthase (FabF), is described.

267 losis genes encoding distinct beta-ketoacyl- acyl carrier protein synthases involved in mycolic acid

268 te genes (putatively encoding beta-ketoacyl-(acyl-carrier-protein) synthases, peroxisomal acyl-activa

269 ellular fatty acids are activated by an acyl-acyl carrier protein synthetase (AasN) and validate type

270 The gene encoding the unique soluble acyl-acyl carrier protein synthetase (AasS) of the biolumines

271 bacteria harbor an enzyme known as the acyl-acyl carrier protein synthetase (AasS), which allows the

272 t in the only cytoplasmic Synechocystis acyl-acyl carrier protein synthetase (SynAas) were highly res

273 oumarin inhibitors directly inhibit the acyl-acyl carrier protein synthetase activity of FadD32.

274 asS::kan strains retained low levels of acyl-acyl carrier protein synthetase consistent with prior in

275 lus, than to that of the membrane-bound acyl-acyl carrier protein synthetase of E. coli, an enzyme th

276 LplT for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of

277 acylated cardiolipin by acyltransferase/acyl-acyl carrier protein synthetase, demonstrating the first

278 r general elongase activity, one to ketoacyl acyl-carrier protein synthetase, and two each to fatty a

279 ne in the biosynthetic operon for NOS, as an acyl carrier protein that delivers 3-methylindolic acid

280 ty acid omega-6 desaturase 2 (FAD2) and acyl-acyl carrier protein thioesterase 2 (FATB) to improve ol

281 Starting with introducing an acyl-acyl carrier protein thioesterase gene, we made six succ

282 dramatic up-regulation of a specialized acyl-acyl carrier protein thioesterase paralog and the concer

283 s by heterologous over-expression of an acyl-acyl carrier protein thioesterase, or by suppression of

284 id desaturase and either desaturase or fatty acyl-carrier protein thioesterase.

285 sion with cDNAs for various Cuphea FatB acyl-acyl carrier protein thioesterases (FatB) that produce a

286 previous attempts to visualize structurally acyl carrier protein tied to an overall catalytic cycle.

287 biosynthesis involves the conversion of acyl-acyl carrier protein to acylphosphate by PlsX and the tr

288 ting transfer of a dodecanoyl chain from one acyl carrier protein to another en route to the key bios

289 ain reorganization appears necessary for the acyl carrier protein to interact successively with both

290 condenses with either malonyl-CoA or malonyl-acyl carrier protein to produce 3-(2-aminophenyl)-3-oxop

291 e enzyme LpxL transfers laurate from lauroyl-acyl carrier protein to the 2'- R-3-hydroxymyristate moi

292 he transfer of R-3-hydroxymyristic acid from acyl carrier protein to the 3'-hydroxyl group of UDP-Glc

293 e R-3-hydroxyacyl chain from R-3-hydroxyacyl acyl carrier protein to the glucosamine 3-OH group of UD

294 ransfer of the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the E2 sub

295 us mutation p.L81R and pR212W in malonyl CoA-acyl carrier protein transacylase (MCAT), a mitochondria

296 acterial proteasome substrates, malonyl Co-A acyl carrier protein transacylase and ketopantoate hydro

297 the expression of mitochondrial malonyl CoA-acyl carrier protein transacylase, a key enzyme in the p

298 up, as well as decarboxylase (MdcD-MdcE) and acyl-carrier protein transferase (MdcA) catalytic activi

299 tic methodology in vitro to reversibly label acyl carrier protein variants and apply these tools to N

300 malonyl-CoA as the methyl acceptor, malonyl-acyl carrier protein was a far better acceptor of methyl

301 f an adaptor domain, the GNAT domain, and an acyl carrier protein, was assessed biochemically, reveal