ライフサイエンスコーパス: acyl-CoA synthetase

1 the enzyme is a broad substrate specificity acyl-CoA synthetase.

2 was to use triacsin C to inhibit long-chain acyl-CoA synthetase.

3 d by an inhibitor (triacsin C) of long chain acyl-CoA synthetase.

4 imilarity to the Escherichia coli long chain acyl-CoA synthetase.

5 it encodes LACS2, a member of the long-chain acyl-CoA synthetases.

6 wo highly conserved motifs characteristic of acyl-CoA synthetases.

7 ptide synthetases, luciferase, and aryl- and acyl-CoA synthetases.

8 the defective gene had sequence homology to acyl-CoA synthetases.

9 and murine homologs comprise a new family of acyl-CoA synthetases.

10 ultigene family of very long chain (C20-C26) acyl-CoA synthetases.

11 Firefly luciferase is homologous to fatty acyl-CoA synthetases.

12 for RpPat, all of which are also AMP-forming acyl-CoA synthetases.

13 SrtN) regulate the activities of AMP-forming acyl-CoA synthetases.

14 ing Peri A and HSL but stably overexpressing acyl-CoA synthetase 1 (ACS1) and fatty acid transport pr

15 hearts with a temporally induced knockout of acyl-CoA synthetase 1 (Acsl1(T-/-)) are virtually unable

16 he potential relationship between long-chain acyl-CoA synthetase 1 (ACSL1) and lipid metabolism in re

17 The enzyme acyl-CoA synthetase 1 (ACSL1) is induced by peroxisome p

18 Long-chain acyl-CoA synthetase 1 (ACSL1) plays a key role in fatty

19 ates with increased expression of long-chain acyl-CoA synthetase 1 (ACSL1), an enzyme that catalyzes

20 lated with early induction of the long-chain acyl-CoA synthetase 1 (ACSL1).

21 genous perilipins and HSL but overexpressing acyl-CoA synthetase 1 and fatty acid transporter 1.

22 ipotoxicity overexpressing ACSL1 (long-chain acyl-CoA synthetase 1) in cardiomyocytes, we show that m

23 ACSL1 (acyl-CoA synthetase 1), the major acyl-CoA synthetase of

24 We also increased the levels of acyl-CoA synthetase-1 (ACS1) and ACS2 proteins to determ

25 that requires activation by very long-chain acyl-CoA synthetase-1 (ACSVL1) to modulate both targets,

26 sters GLUT4 in fat cells contains long chain acyl-CoA synthetase-1 and its product fatty acyl-CoA, sh

27 ectrometry of a p75 protein band, long chain acyl-CoA synthetase-1, specifically present in immunoads

28 y increased the beta-cell mRNA expression of acyl CoA synthetase-2 and peroxisomal acyl CoA oxidase i

29 Here, we show that long chain acyl-CoA synthetase 3 (ACSL3) plays a crucial role in se

30 transfected with control siRNA, knockdown of acyl-CoA synthetase 3 (ACSL3) significantly decreased re

31 A comparative analysis demonstrates that the acyl-CoA synthetase 3 is recruited early to the assembly

32 ember 4, fatty acid synthase, and long-chain acyl-CoA synthetase (3), and glucose transport genes (gl

33 rial HMG-CoA synthase and increases in fatty acyl-CoA synthetase (3-8-fold) and carnitine palmitoyl-C

34 Long-chain acyl-CoA synthetase 4 (ACSL4) catalyzes the covalent add

35 cancer, we found selective overexpression of acyl-CoA synthetase 4 (ACSL4) in TNBC, which is primaril

36 g-chain fatty acid 5 (ELOVL5) and long-chain acyl-CoA synthetase 4 (ACSL4).

37 Here we show that long-chain acyl-CoA synthetase 4a (Acsl4a), an LC-PUFA activating e

38 KEY POINTS: Long-chain acyl-CoA synthetase 6 (ACSL6) mRNA is present in human a

39 Long-chain acyl-CoA synthetase 6 (ACSL6) mRNA is present in human a

40 th basal and Wy-14,643-induced expression of acyl-CoA synthetase, a well characterized PPARalpha targ

41 s were generated in two domains conserved in acyl-CoA synthetases: a 6- amino acid substitution into

42 The NDP-forming acyl-CoA synthetases (ACDs) catalyze the conversion of v

43 We show that the acyl-CoA synthetase ACS-7, which localizes to lysosome-r

44 enzymes and provide direct evidence that the acyl-CoA synthetase ACS-7, which was previously implicat

45 CoA toxicity in mycobacteria by inactivating acyl CoA synthetase (ACS).

46 uggested that FATP1 exhibits very long chain acyl-CoA synthetase (ACS) activity and that such activit

47 Long chain acyl-CoA synthetase (ACS) and diacylglycerol acyltransfe

48 Acyl-CoA synthetase (ACS) enhances the uptake of FAs by

49 tify multiple mutations in the P. falciparum acyl-CoA synthetase (ACS) genes PfACS10 (PF3D7_0525100,

50 Inhibition studies have suggested that acyl-CoA synthetase (ACS, EC ) isoforms might regulate t

51 omes and FA synthesis in the cytosol, namely acyl-CoA synthetase (acs-1 and acs-2), acyl-CoA oxidase

52 stence of inhibitor-sensitive and -resistant acyl-CoA synthetases (ACS, EC ) that are linked to speci

53 A cDNA encoding a novel isoform of acyl-CoA synthetase (ACS6) was isolated from embryos of

54 uction in 20:4n-6-CoA mass and in microsomal acyl-CoA synthetase (Acsl) activity toward 20:4n-6.

55 contained not only CPT1a but also long chain acyl-CoA synthetase (ACSL) and the voltage-dependent ani

56 Long chain acyl-CoA synthetase (ACSL) catalyzes the initial step in

57 ACSL3 is a member of the long chain acyl-CoA synthetase (ACSL) family that plays key roles i

58 s directly inhibiting recombinant long-chain acyl-CoA synthetase (ACSL)-4 activity.

59 ng myelin, requires activation by long-chain acyl-CoA synthetase (ACSL).

60 tal muscle-specific deficiency of long-chain acyl-CoA synthetase (ACSL)1.

61 ABSTRACT: Long-chain acyl-CoA synthetases (ACSL 1 to 6) are key enzymes regul

62 Long-chain acyl-CoA synthetases (ACSL 1 to 6) are key enzymes regul

63 Long chain acyl-CoA synthetases (ACSL) activate fatty acids (FA) an

64 Long chain acyl-CoA synthetases (ACSL) and fatty acid transport pro

65 TMEM120A interacts with the ER-localized acyl-CoA synthetase ACSL1 and ACSL3 to promote long-chai

66 acs-13 encodes a homolog of the human acyl-CoA synthetase ACSL1, and localizes to the mitochon

67 Long-chain acyl-CoA synthetases (ACSLs) are key host-cell enzymes t

68 Long-chain fatty acyl-CoA synthetases (ACSLs), a group of rate-limiting e

69 In mammals, a family of five acyl-CoA synthetases (ACSLs), each the product of a sepa

70 is the conversion to acyl-CoA by long chain acyl-CoA synthetases (Acsls).

71 he first crystal structure of a medium-chain acyl-CoA synthetase ACSM2A, in a series of substrate/pro

72 A large family of acyl-CoA synthetases (ACSs) regulates FA metabolism by e

73 ly of proteins that includes very long-chain acyl-CoA synthetases (ACSVL) consists of six members.

74 (ACSL) and very long chain acyl-coenzyme A (acyl-CoA) synthetases [(ACSVL)/fatty acid transport prot

75 Expression of the fatty acyl-CoA synthetase ACSVL3 was found to be markedly elev

76 -chain fatty acids, and have very long-chain acyl CoA synthetase activities that were 40% wild-type.

77 The depression in very long-chain acyl CoA synthetase activities were not apparent in cell

78 ls at 24 h after infection had 2-fold higher acyl-CoA synthetase activities and 30% higher rates of f

79 al, exhibiting both fatty acid transport and acyl-CoA synthetase activities that work in concert to m

80 tty acid transport and very long-chain fatty acyl-CoA synthetase activities were distinguishable.

81 tty acid accumulation, very long-chain fatty acyl-CoA synthetase activities, and the fatty acid profi

82 on of mmFATP5 did not substantially increase acyl-CoA synthetases activities using the substrates tes

83 ximal levels of fatty-acid import and has an acyl CoA synthetase activity specific for very-long-chai

84 chain fatty acids and has reduced long-chain acyl-CoA synthetase activity (fat1Delta faa1Delta).

85 tal muscle (Acsl1(M) (-/-)) severely reduces acyl-CoA synthetase activity and fatty acid oxidation.

86 Acyl-CoA synthetase activity detected in GLUT4-enriched

87 the cytoplasm of transfected cells displayed acyl-CoA synthetase activity for long chain fatty acid s

88 FATP4 protein and acyl-CoA synthetase activity localized to multiple organ

89 The very long chain acyl-CoA synthetase activity of the two enzymes was comp

90 n either wild-type or nearly wild-type fatty acyl-CoA synthetase activity profiles; 2) those that had

91 lls revealed that most of the hsBG-dependent acyl-CoA synthetase activity was soluble and not membran

92 rmal LCAD activity but reduced mitochondrial acyl-CoA synthetase activity with C(12).

93 s, COS-1 cells expressing hsBG had increased acyl-CoA synthetase activity with either long-chain fatt

94 ACSL3 knockdown decreased total acyl-CoA synthetase activity without substantially alter

95 odulation of endoplasmic reticulum-localized acyl-CoA synthetase activity, although mutant forms of a

96 However, despite decreased acyl-CoA synthetase activity, initial rates of fatty aci

97 howed that VLCS activity, but not long-chain acyl-CoA synthetase activity, was reduced to about 40% o

98 tional in fatty acid import, only FATP2a had acyl-CoA synthetase activity, with an apparent preferenc

99 dominant negative effect against long-chain acyl-CoA synthetase activity.

100 tic Acsl1 mRNA and protein levels as well as acyl-CoA synthetase activity.

101 ntributes the majority of cardiac long-chain acyl-CoA synthetase activity.

102 converted to 5HD-CoA by mitochondrial fatty acyl CoA synthetase and acted as a weak substrate or inh

103 ssociated with genes encoding for a putative acyl-CoA synthetase and a MeaB-like chaperone.

104 esis of TAGs and CEs by targeting long-chain acyl-CoA synthetase and acyl-CoA:cholesterol acyltransfe

105 n this paper, we present evidence that FATP1/acyl-CoA synthetase and DGAT2/diacylglycerol acyltransfe

106 In contrast, adipocyte acyl-CoA synthetase and diacylglycerol acyltransferase a

107 fic activities of the key enzymes long chain acyl-CoA synthetase and diacylglycerol acyltransferase,

108 lsugar accumulation due to trichome specific acyl-CoA synthetase and enoyl-CoA hydratase genes.

109 equent genetic analysis identified ACS-4, an acyl-CoA synthetase and its FA-CoA product, as key germl

110 reactions are known reactions, catalyzed by acyl-CoA synthetase and peptidylglycine alpha-amidating

111 lts indicate that FATP1 is a very long chain acyl-CoA synthetase and suggest that a potential mechani

112 AAE15 has sequence similarity to long-chain acyl-CoA synthetases and a predicted N-terminal plastidi

113 s a tumor-promoting function of medium chain acyl-CoA synthetases and positions ACSM1 and ACSM3 as ke

114 ed fatty acids are esterified to acyl-CoA by acyl-CoA synthetases and transferred to lysophospholipid

115 Triacsin C, an inhibitor of fatty acyl-CoA synthetase, and troglitazone, an enhancer of FF

116 whether adipocyte lipogenic proteins (CD36, acyl-CoA synthetases, and diacylglycerol acyltransferase

117 Because CPT-I and long-chain acyl-CoA synthetase appear to be associated with both in

118 vation in these cells, indicating that other acyl-CoA synthetases are necessary for very long-chain f

119 results show that many different AMP-forming acyl-CoA synthetases are regulated by N-lysine acetylati

120 The AMP-forming acyl coenzyme A (acyl-CoA) synthetases are a large class of enzymes found

121 n a conformation similar to those adopted by acyl-CoA synthetases as they convert acyl adenylates int

122 t did not acetylate the wild-type long-chain acyl-CoA synthetase B (RpLcsB; formerly Rpa2714) enzyme

123 Acyl-CoA synthetases belong to the superfamily of adenyl

124 The acyl:CoA synthetase blocker, triacsin C, inhibited ester

125 as palustris (RpPat) inactivates AMP-forming acyl-CoA synthetases by acetylating the epsilon-amino gr

126 M. aquaeolei VT8, to search for WS/DGAT and acyl-CoA synthetase candidate genes.

127 rence confirmed that endogenous ACSVL3 is an acyl-CoA synthetase capable of activating both long-chai

128 Short- and medium-chain acyl coenzyme A (acyl-CoA) synthetases catalyze the formation of acyl-CoA

129 Here we show that the Drosophila fatty acyl-CoA synthetase CG6178, which cannot use d-luciferin

130 onserved amino acid residues in the 12 fatty acyl-CoA synthetases compared.

131 Acyl-CoA synthetases comprise numerous proteins with div

132 lar trafficking were also found in the fatty acyl-CoA synthetase-deficient strains.

133 that PMNs and their plasma membranes use an acyl:CoA synthetase-dependent route to esterify 5-HETE a

134 This enzyme, a medium-chain acyl-CoA synthetase designated Macs(Ma), utilizes 2-meth

135 ein 2 (FATP2) (also known as very long-chain acyl-CoA synthetase) directly interacts with CerS2 in mo

136 on of an FATP4 variant with mutations in the acyl-CoA synthetase domain did not provide any degree of

137 lude that expression of FATP4 with an intact acyl-CoA synthetase domain in suprabasal keratinocytes i

138 acylglycerol O-acyltransferase or long-chain acyl-CoA synthetase, effectively disrupted TAF functiona

139 CP) synthase AasC but inhibitors of the host acyl-CoA synthetase enymes ACSL also impaired growth of

140 eudomonas palustris, at least 10 AMP-forming acyl-CoA synthetase enzymes are acetylated by the Pat ho

141 nt lysine residue in a number of FadD (fatty acyl CoA synthetase) enzymes is acetylated by KATmt in a

142 olar morphology through the long-chain fatty acyl-CoA synthetase Faa1, independently of the RNA methy

143 l for fatty acid export in cells lacking the acyl-CoA synthetases Faa1 and Faa4.

144 bolic utilization proceeds through the fatty acyl-CoA synthetases Faa1p and Faa4p.

145 These data support the hypothesis that fatty acyl-CoA synthetase (Faa1p or Faa4p) functions as a comp

146 mes acyl-CoA oxidase (POX1) and medium-chain acyl-CoA synthetase (FAA2).

147 xa2p complex functionally interacts with the acyl-CoA synthetases Faa2p and/or Fat1p on the inner sur

148 In Saccharomyces cerevisiae Fat1p and fatty acyl-CoA synthetase (FACS) are hypothesized to couple im

149 Fatty acyl-CoA synthetase (FACS, fatty acid:CoA ligase, AMP-fo

150 oA hydrolase (HIBCH, p = 8.42 x 10(-89)) and acyl-CoA synthetase family member 3 (ACSF3, p = 3.48 x 1

151 e nonsynonymous variants in the gene for the acyl-CoA synthetase family member(2-4) PfACS8 on chromos

152 mutations in a gene encoding a member of the acyl-CoA synthetase family, a diverse group of evolution

153 ese proteins were members of the AMP-forming acyl-CoA synthetase family.

154 fatty acid transport protein/very long chain acyl-CoA synthetase (FATP/Acsvl) family are emerging as

155 ulin affects the subcellular localization of acyl-CoA synthetase FATP1.

156 and murine cells, we further identified the acyl-CoA synthetase, FATP4 (ACSVL4), as a mitochondrial

157 in fatty acids are converted to acyl-CoAs by acyl-CoA synthetase (fatty acid CoA ligase: AMP forming,

158 Fatty acyl-CoA synthetase (fatty acid:CoA ligase, AMP-forming;

159 Saccharomyces cerevisiae contains four known acyl-CoA synthetases (fatty acid activation proteins, Fa

160 ly of AMP-forming enzymes that also includes acyl-CoA synthetases, firefly luciferase, and nonribosom

161 WLHTGDIGXWXPXGXLKIIDRKK, common to all fatty acyl-CoA synthetases for which sequence information is a

162 This region of fatty acyl-CoA synthetase from E. coli, 431NGWLHTGDIAVMDEEGFLR

163 repressing ATP citrate lyase and short-chain acyl-CoA synthetase gene expression.

164 quence information from putative WS/DGAT and acyl-CoA synthetase genes identified in this strain was

165 identified gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) was cloned and characteriz

166 The E. coli fatty acyl-CoA synthetase has remarkable amino acid similariti

167 Enzymes catalyzing activation, acyl-CoA synthetases, have been classified by their chai

168 Fatty acid transport protein 1 (FATP1) is an acyl-CoA synthetase highly expressed in skeletal muscle

169 te synthase homology (CSH) module flanked by acyl-CoA synthetase homology (ASH) domains, with ATP and

170 A human homolog of very long-chain acyl-CoA synthetase, hVLCS-H2, has two requisite propert

171 RpPat acetylated all nine of the acyl-CoA synthetases identified by this work, and RpLdaA

172 enic mouse lines that overexpress long-chain acyl-CoA synthetase in the heart (MHC-ACS).

173 hen bred to transgenic mice that overexpress acyl-CoA synthetase in the heart, a strain that exhibits

174 hus appears to function as a very long-chain acyl-CoA synthetase in wax metabolism.

175 insulin stimulation and after knocking down acyl-CoA synthetases in adipocytes.

176 While many structures exist of acyl-CoA synthetases in both conformations, to date only

177 ymatic mechanism of FadK is similar to other acyl-CoA synthetases in that it forms an acyl-AMP interm

178 ns a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, co

179 ily of both prokaryotic and eukaryotic fatty acyl-CoA synthetases, indicating a common ancestry.

180 The long-chain acyl-CoA synthetase inhibitor triacsin C completely reve

181 Moreover, mLD formation was blocked by the acyl-CoA synthetase inhibitor triacsin C, implicating th

182 2 cell lysates with (2E)-hexadecenal and the acyl-CoA synthetase inhibitor triacsin C.

183 pression was completely blocked by the fatty acyl-CoA synthetase inhibitor, triacsin C, evidence of i

184 Triacsins are notable as potent acyl-CoA synthetase inhibitors in lipid metabolism, yet

185 nation of a branched chain fatty acid and an acyl-CoA synthetase is required for critical cellular pr

186 acids to their CoA derivatives, catalyzed by acyl-CoA synthetases, is involved in AMPK activation by

187 Thus, long-chain acyl-CoA synthetase isoform 1 (ACSL1) deficiency in the

188 Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal

189 Long-chain acyl coenzyme A (acyl-CoA) synthetase isoform 1 (ACSL1) catalyzes the syn

190 Moreover, FATP1 and Acsl1, the 2 major acyl-CoA synthetase isoforms in adipocytes, are essentia

191 ation of fatty acids by one of 13 long-chain acyl-CoA synthetase isoforms.

192 ynthesis, as an inhibitor of host long-chain acyl CoA synthetases, key enzymes for glycerolipid biosy

193 Long-chain acyl-CoA synthetase (LACS) activities are encoded by a f

194 CS6 and LACS7, encode peroxisomal long-chain acyl-CoA synthetase (LACS) isozymes.

195 Long-chain acyl-CoA synthetases (LACS) play diverse and fundamental

196 C transporter and the peroxisomal long chain acyl-CoA synthetases (LACS)6 and -7.

197 utin pathway genes, which encodes long-chain acyl-CoA synthetase LACS2, is likely to be directly targ

198 e palmitoyltransferase-I (CPT-I), long-chain acyl-CoA synthetase (LCAS), and voltage-dependent anion

199 tment increased the activities of long chain acyl-CoA synthetases (LCASs), including oleoyl-CoA synth

200 dy revealed a central role of the long-chain acyl-CoA synthetase LCS2 in the production of triacylgly

201 y CDCP1's interaction with and inhibition of acyl CoA-synthetase ligase (ACSL) activity.

202 letion of codons 350-353 in a 528-codon-long acyl-CoA synthetase-like gene (ACS).

203 ion into TAG, with long lasting increases in acyl-CoA synthetase long 1 (ACSL1) and diacylglycerol ac

204 rnitine O-palmitoyltransferase 1 (Cpt1a) and acyl-CoA synthetase long chain family member 1 (Acsl1),

205 The screen revealed two genes, acyl-CoA synthetase long chain family member 4 (ACSL4) a

206 plex consisting of TIP30, endophilin B1, and acyl-CoA synthetase long chain family member 4 (ACSL4) t

207 l glutathione peroxidase 4 overexpression or acyl-CoA synthetase long chain family member 4 depletion

208 A28:g.23380074_23483377del, containing genes Acyl-CoA Synthetase Long Chain Family Member 5 (ACSL5) a

209 Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) l

210 (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1),

211 s inserted within an intron of the autosomal acyl-CoA synthetase long-chain family member 3 (Acsl3) g

212 Acyl-CoA synthetase long-chain family member 4 (ACSL4) i

213 However, the ferroptosis regulator acyl-CoA synthetase long-chain family member 4 (ACSL4) w

214 in parallel with increased expression of the acyl-CoA synthetase long-chain family member 4 (ACSL4),

215 increased expression of 15-lipoxygenase and acyl-CoA synthetase long-chain family member 4 (enzyme t

216 ferentiation, and that overexpression of rat acyl-CoA synthetase long-chain family member 6 (Acsl6, f

217 pression of the proferroptotic protein ACSL (acyl-CoA synthetase long-chain family member) 4 on PAH w

218 aESA-triggered death is mediated by acyl-CoA synthetase long-chain isoform 1, which promotes

219 ependent steroid dehydrogenase-like protein, acyl-CoA synthetase, long chain family member (ACSL) 1,

220 These results suggest that although acyl-CoA synthetases may have the ability to utilize a b

221 Here, we identified acyl-CoA synthetase medium chain family members 1 and 3

222 osphate acyltransferase mRNA fell by 57% and acyl-CoA synthetase mRNA by 67% (brain isoform) and 38%

223 reported that hBG1, the human homolog of the acyl-CoA synthetase mutated in the Drosophila mutant "bu

224 allowed us to delineate a new superfamily of acyl-CoA synthetases (nucleoside diphosphate-forming) an

225 ACSL1 (acyl-CoA synthetase 1), the major acyl-CoA synthetase of adipocytes, has been proposed to

226 was significantly more similar to that of an acyl-CoA synthetase of the distantly related bacterium,

227 echanism and crystal structure evidence, the acyl-CoA synthetases, one of three subgroups of a superf

228 ACSBG1, an acyl-CoA synthetase originally identified in the fruit f

229 factor-TU, methylglutaryl coenzyme A (CoA), acyl CoA synthetase, oxoacyl CoA thiolase, and ubiquitin

230 Acyl-CoA synthetases play a pivotal role in fatty acid m

231 atty acid-CoA ligase (also called fatty acid acyl-CoA synthetase) plays an essential role in lipid bi

232 enzyme A (acyl-CoA) dehydrogenase (pltE), an acyl-CoA synthetase (pltF), a thioesterase (pltG), and t

233 ACYL-COA SYNTHETASE, POLYKETIDE SYNTHASE A (PKSA) and PK

234 rases are thought to have evolved from fatty acyl-CoA synthetases present in all insects.

235 Triacsin C, an inhibitor of fatty acyl-CoA synthetase, prevented the increase in PFK activ

236 hibition of either acetyl-CoA carboxylase or acyl-CoA synthetase reduced mineralization of CVCs, wher

237 owledge, these mutant proteins are the first acyl-CoA synthetases reported that are defective in aden

238 conserved motifs from all known families of acyl-CoA synthetases revealed that hsBG along with the D

239 tion, activation of the carboxylate anion by acyl-CoA synthetase(s), and re-esterification to the sn-

240 cluding multiple AMP-forming CoA ligases and acyl-CoA synthetases seem to be present as ways to form

241 tors, a crotonyl-CoA-producing enzyme ACSS2 (acyl-CoA synthetase short chain family member 2) is foun

242 o acetyl-CoA by ATP-citrate lyase (ACLY) and acyl-CoA synthetase short-chain 2 (ACSS2), respectively.

243 Identify acyl-CoA synthetase short-chain family 2 (ACSS2) as a di

244 dney dysfunction on chromosome 20 target the acyl-CoA synthetase short-chain family 2 (ACSS2).

245 Acyl-CoA synthetase short-chain family member 2 (ACSS2)

246 athway for acetyl-CoA production mediated by acyl-CoA synthetase short-chain family member 2 (ACSS2).

247 al cholesterol ester hydrolase 1 (NCEH1) and acyl-CoA synthetase short-chain family member 2 (ACSS2).

248 pose that this sequence represents the fatty acyl-CoA synthetase signature motif (FACS signature moti

249 e ATP/AMP binding domain and the 25-aa fatty acyl-CoA synthetase signature motif, but displays low ov

250 een site-directed mutations within the fatty acyl-CoA synthetase structural gene (fadD) corresponding

251 Evidence for homologous acyl-CoA synthetases supports a domain alternation catal

252 D cells by using triacsin C, an inhibitor of acyl-CoA synthetase that blocks the reincorporation of h

253 We report that FadK is as an acyl-CoA synthetase that has a preference for short chai

254 Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeabi

255 acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very l

256 As such, LACS1 defines a functionally novel acyl-CoA synthetase that preferentially modifies both VL

257 5 and triacsin C, an inhibitor of long chain acyl-CoA synthetase that reduces LC-CoA levels, did not

258 rthermore, purified MbcS is an ATP-dependent acyl-CoA synthetase that selectively catalyzes the activ

259 Acyl-CoA synthetases that activate fatty acids to their

260 rresponding sequences from other AMP-forming acyl-CoA synthetases that were known RpPat substrates.

261 eversed by triacsin C, an inhibitor of fatty acyl-CoA synthetase, the enzyme that generates LC-CoA.

262 To determine whether FATP4 is an acyl-CoA synthetase, the murine protein was engineered t

263 The adenylate-forming enzymes, including acyl-CoA synthetases, the adenylation domains of non-rib

264 studies have focused on the structure of the acyl-CoA synthetases, their post-translational modificat

265 R8/LACS1, one of nine Arabidopsis long-chain acyl-CoA synthetases thought to activate acyl chains.

266 on of Triacsin-C, an inhibitor of long-chain acyl-CoA synthetase, to AdCMV-GlpK-treated INS-1 cells d

267 e palmitoyl-CoA transferase, very long chain acyl-CoA synthetase, very long chain acyl-CoA dehydrogen

268 n crossed with animals expressing long-chain acyl-CoA synthetase via the MHC promoter (MHC-ACS), whic

269 port proteins (FATP) and the very long-chain acyl-CoA synthetases (VLACS).

270 , which each have very long-chain fatty acid acyl-CoA synthetase (VLCFA-ACS) activity, as negative re

271 d with decreased peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity and decreased peroxi

272 ta-oxidation and peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity.

273 previously that homolog 2 of very long-chain acyl-CoA synthetase (VLCS) can activate cholate.

274 odystrophy, are activated by very long-chain acyl-CoA synthetase (VLCS) normally found in peroxisomes

275 unction of peroxisomal very long chain fatty acyl-CoA synthetase (VLCS) that leads to severe and prog

276 tly identified family is the very long-chain acyl-CoA synthetases (VLCS).

277 Five non-acyl-CoA synthetases were identified as possibly acetyla

278 Other long- and very long-chain acyl-CoA synthetases were incapable of activating cholat

279 y (C16:0), characteristic of very long chain acyl-CoA synthetases, whereas both mutant M1 and M2 were

280 When acyl-CoA synthetase, which catalyzes the conversion of f

281 membrane-bound fatty acid transporters or as acyl-CoA synthetases, which activate long-chain fatty ac

282 ture motif) common to long- and medium-chain acyl-CoA synthetases, which appears to contribute to the

283 ed, expressed, and characterized as a 65-kDa acyl-CoA synthetase with extremely high specificity for

284 wn crystal structures of the T. thermophilus acyl-CoA synthetase with remarkably high levels of conse

285 dings indicate that inhibition of long-chain acyl-CoA synthetases with triacsin C, a fatty acid analo

286 The ydiQRSTD operon encodes a putative acyl-CoA synthetase, ydiD (renamed fadK), as well as put