ライフサイエンスコーパス: adaptor

1 n motors assembled with dynactin and a cargo adaptor.

2 eedforward and feedback representation of an adaptor.

3 a ternary complex with dynactin and a cargo adaptor.

4 is mediated by ClpA/P protease and the ClpS adaptor.

5 d rather than the retinal orientation of the adaptor.

6 otor complexes bound to cargoes via specific adaptors.

7 could regulate the activity of other kinesin adaptors.

8 hagic targets and recruit multiple autophagy adaptors.

9 rified, end-repaired and ligated to Y-shaped adaptors.

10 nteractions with the MAL and MyD88 signaling adaptors.

11 functional autophagy machinery and mitophagy adaptors.

12 rgo remodeling as a novel function of dynein adaptors.

13 activation of related PRRs and engagement of adaptors.

14 phorylation of itself and production of anti-adaptors.

15 equires the myosin motor Myo1C and signaling adaptor 14-3-3beta.

16 The bicaudal D cargo adaptor 2 (BICD2) gene encodes a conserved cargo adaptor

17 r transport) and LEM2, a transmembrane ESCRT adaptor(2-4).

18 Finally, like constitutively ubiquitinated adaptors, a Ubp2 deficiency increased both the adaptor a

19 inate IL-17 signaling by phosphorylating the adaptor ACT1 leading to the release of the essential ubi

20 by cell type-specific deletion of IL-17R and adaptor Act1, we demonstrated that IL-17R/Act1 exerts a

21 Ubiquitination-dependent adaptor activation required a ubiquitin-binding surface

22 aptors, a Ubp2 deficiency increased both the adaptor activity and the ability to compete for Rsp5.

23 including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms

24 nvolving the multifunctional PPxY-containing adaptor Amot, which regulates both the Hippo pathway and

25 x relies on the interaction of an N-terminal adaptor and pseudoenzyme domain of CDTa with six subunit

26 motility is activated and regulated by cargo adaptors and accessory proteins.

27 chanism whereby ubiquitination activates the adaptors and how this process is regulated remain unclea

28 How DnaA, its adaptors and the helicase form a complex at the origin i

29 cSMAC localization varied between the adaptors and was diminished upon blockade of the costimu

30 ers, the dynactin complex and an 'activating adaptor', and they show faster velocity when two dynein

31 eview, we discuss the roles of the CCV core, adaptors, and accessory components in plant defense sign

32 r-containing, ARF-binding protein), clathrin adaptors, and clathrin.

33 e response is driven by the clathrin-sorting adaptor AP-1B, which mediates the polarized sorting of T

34 odeficiency virus (SIV) engages the clathrin adaptor AP-2 to downregulate tetherin via its DIWK motif

35 t of 1) endocytosis mediated by the clathrin adaptor AP2; 2) Tf, which was suggested to facilitate Tf

36 tudies indicate that the activities of these adaptors are elevated when they undergo ubiquitination,

37 a support a model whereby ubiquitinated Rsp5 adaptors are more active when "locked" onto Rsp5 via its

38 s indicate that peptidoglycan regulators and adaptors are part of PG biosynthetic multi-enzyme comple

39 rapid translocation of the ubiquitin ligase adaptor Art1 to the PM and dephosphorylation of Art1 at

40 Ubiquitylation of the Vac17 adaptor at the bud cortex provides spatial regulation of

41 The polarity adaptor Bem1p also regulated the fMAPK pathway.

42 e through its spectrin repeats, acting as an adaptor between nesprin-1alpha and Pcnt or AKAP9.

43 rameric phosphoprotein P serves as a crucial adaptor between the ribonucleoprotein template and the L

44 t with Nesprin-2 through the dynein/kinesin "adaptor" BicD2, both in neurons and in non-mitotic fibro

45 ns representing three families of activating adaptors-BicD2, Hook3 and Ninl-all show enhanced motile

46 M not only functions as a quadruplex binding adaptor but also promotes the remodeling of RNA duplex a

47 myeloid differentiation primary response 88 adaptors, but not toll/interleukin-1 receptor/resistance

48 g L. pneumophila failed to recruit autophagy adaptors by a process that was independent of RavZ funct

49 These observations reveal how an adaptor can simultaneously modulate the catalytic activi

50 -box) motif that allows binding with two APC adaptors, CDC20-homologue 1 (CDH1) and cell division cyc

51 expression experiments revealed that several adaptors compete for Rsp5 in vivo.

52 was distinct from labeling for the endocytic adaptor complex AP-2.

53 t the PM-anchored Rsp5/Rcr1 ubiquitin ligase-adaptor complex can provide an acute response to degrade

54 The COPII-cargo adaptor complex Lst1-Sec23 selectively sorts proteins in

55 ance of AAGAB, AP2 subunits fail to form the adaptor complex, leading to their degradation.

56 mbling the motile dynein-dynactin-activating adaptor complex.

57 regulated assembly and disassembly of motor-adaptor complexes ensures that cargoes are loaded at the

58 ome core component, or components of exosome adaptor complexes, we identify ~2900 transcription start

59 The ClpS adaptor delivers N-degron substrates to ClpAP but inhibi

60 a critical role for SNARE proteins and their adaptors during early stages of CCP nucleation and stabi

61 through interactions of proteasomes with the adaptor Ecm29 and the axon initial segment (AIS) scaffol

62 The Cullin 5 (CUL5) Ring E3 ligase uses adaptors Elongins B and C (ELOB/C) to bind different SOC

63 laboratory identified EHD1 (Eps15 [endocytic adaptor epidermal growth factor receptor substrate 15] h

64 Arabidopsis (Arabidopsis thaliana) clathrin adaptor EPSIN1 (EPS1) is implicated in clathrin-coated v

65 e CRKL (CRK-like proto-oncogene, cytoplasmic adaptor) expression.

66 drome, whereas mutations in caspase-8 or its adaptor FADD-which mediate cell death downstream of FAS

67 etween dynein and structurally diverse cargo adaptor families that is critical for dynein function in

68 endent endocytosis, mediated by two distinct adaptors, Flot-1 in noncaveolar lipid rafts and the AP2A

69 containing protein 1 (ACAP1) functions as an adaptor for a clathrin coat complex that has a function

70 e zipper-like transcription regulator 1), an adaptor for CUL3 (CULLIN3) ubiquitin ligase complex.

71 Kelch-like 15 (KLHL15) is a substrate adaptor for cullin3-containing E3 ubiquitin ligases, and

72 lathrin with Rab11, implicates Flot-1 as the adaptor for faster recycling and AP2A1/2 as the adaptor

73 is unlikely that 14-3-3beta acts as a cargo adaptor for Myo1c-powered transport; rather, we propose

74 B cell adaptor for phosphoinositide 3-kinase (PI3K) (BCAP) is a

75 ptor for faster recycling and AP2A1/2 as the adaptor for slower IGF1R recycling.

76 Active Syk mediated linker adaptor for T cell protein phosphorylation and membrane

77 complexes to the signaling region and linker adaptor for T cell signalosome formation in this region

78 roach identified insomniac (inc), a putative adaptor for the Cullin-3 (Cul3) ubiquitin ligase complex

79 interaction with Bem4p, the pathway-specific adaptor for the fMAPK pathway.

80 ry, our results suggest a role of Msp1 as an adaptor for the proteasome that drives the extraction of

81 alpha-arrestin family protein Art2/Ecm21, an adaptor for the ubiquitin ligase Rsp5, and its induction

82 finding shows that TASL is an innate immune adaptor for TLR7, TLR8 and TLR9 signalling, revealing a

83 Loss of NE adaptors for ESCRT-III exacerbates ER invasion and nucle

84 that explains how ubiquitination stimulates adaptor function and how this process can be regulated b

85 th in a GTPase-independent manner through an adaptor function.

86 h serves as a docking site for proteins with adaptor functions (c-Cbl, CIN85, CRKL), connecting CD5 t

87 artner-binding' mechanism for carrying out P adaptor functions.

88 es that contained the RAB7-binding Kinesin-1 adaptor FYCO1, and depletion of RAB7, FYCO1, or Protrudi

89 reased the association of EGFR with the MAPK adaptor Grb2 and decreased that with p85.

90 erins, including importin beta and its cargo adaptors, have been shown to co-precipitate with the C9o

91 how that the protein kinase Akt acts as a co-adaptor in this complex, and is needed in conjunction wi

92 ique and sequential functions for Rho GTPase adaptors in regulating MAPK pathways.

93 evious work implicated clathrin and clathrin adaptors in the polarized trafficking of fast recycling

94 oic acid-inducible-I-like receptors (RLR) or adaptor, indicating that RLR signaling also contributed

95 cases, this coupling involves organelle- or adaptor-induced activation of the microtubule motors by

96 rleukin-1 receptor (IL-1R) domain-containing adaptor-inducing beta interferon (TRIF) for signaling, b

97 receptor/resistance [TIR] domain-containing adaptor-inducing IFN-beta (TRIF), in the control of NiV

98 representing three subfamilies of unrelated adaptors, interact with the same amphipathic helix of th

99 inducible protein, which we refer to as 'TLR adaptor interacting with SLC15A4 on the lysosome' (TASL)

100 We propose that a tunable LIC1-adaptor interaction modulates dynein's motility in a car

101 We show that clathrin adaptor interaction sites on clathrin heavy chain (CHC)

102 specific and robust inhibition via the anti-adaptor interaction.

103 a show that ESCRT-I is not merely a bridging adaptor; it has an essential scaffolding and mechanical

104 ff substrates in vitro require intracellular adaptor Kindlin3 but not microglial integrins.

105 itical importance of the E3 ubiquitin ligase adaptor KLHL15 in proteostasis of neuronal microtubule-a

106 1 was largely mediated through the lysosomal adaptor LAMTOR1.

107 , we identified the late endosomal/lysosomal adaptor MAPK and mTOR activator (LAMTOR) complex as an i

108 , from the dsRNA sensors RIG-I and MDA5, the adaptor MAVS, transcription factors IRF3, IRF7, and STAT

109 onic defect in mice lacking FADD, the shared adaptor mediating apoptosis.

110 is regulated by biochemical signaling, cargo adaptors, microtubule-associated proteins, and mechanica

111 is factor alpha, and ionized calcium binding adaptor molecule 1 (Iba1) expression levels in at least

112 Furthermore, ionized calcium-binding adaptor molecule 1 staining revealed reduced damage patt

113 c protein (GFAP) and ionized calcium binding adaptor molecule 1(IBA1) immunostaining indicated morpho

114 he adaptor protein STAM1 (signal-transducing adaptor molecule 1) because disruption of the interactio

115 Here, we investigated the role of Arl8B, an adaptor molecule between lysosomes and kinesins.

116 atural killer (NK) receptor NKG2D and the NK adaptor molecule DAP12, which promoted cytotoxicity agai

117 stimulating signaling pathways that coax the adaptor molecule ezrin (EZR) to tether rPhe508del-Na(+)/

118 We achieved this by expressing the adaptor molecule Protrudin which is normally found at lo

119 nducing interferon-beta (TRIF), TRIF-related adaptor molecule, interferon regulatory factor 3 (IRF-3)

120 Early studies indicated that the adaptor molecule, MyD88, might be important for this cha

121 Mice deficient in an adaptor molecule, STAT1(-/-), for interferon signaling h

122 crophage activation (Ionized calcium binding adaptor molecule-1 [Iba-1]) and interleukin-6 [IL-6]) an

123 endosomes, we identified signal-transducing adaptor molecule-binding protein (STAMBP) and ubiquitin-

124 the cytoplasm where they serve as essential adaptor molecules in translation.

125 om the cytokine IL-34 and Toll-like receptor adaptor MyD88, and occurs in coordination with neutrophi

126 g IRAK4 and TRAF6 but not the IL-1R/TLR-IRAK adaptor MyD88.

127 proinflammatory cytokines via the signaling adaptor MyD88.

128 tcome, activating mutations in the signaling adaptors MYD88 and CD79B, and immune evasion through mut

129 nophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic ca

130 s requires the Rsp5 ubiquitin ligase and ART adaptor network.

131 ing the association of EDS1 with the Cullin3 adaptors NPR3 and NPR4.

132 POZ) protein (SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial ro

133 ization domain 5 (KCTD5) protein, a putative adaptor of cullin3 E3 ubiquitin ligase, as a novel TRPM4

134 ease due to gain-of-function in STING, a key adaptor of IFN signaling.

135 ined the three core components and two F-box adaptors of a cullin-RING ligase complex that promotes t

136 B/POZ-MATH) proteins, which act as substrate adaptors of CUL3-based E3 ubiquitin ligases.

137 Since other multimeric trafficking adaptors operate in an analogous manner to AP2 adaptor,

138 One such adaptor, p47, forms a complex with p97 to direct lipid m

139 experimental data of the kinase Csk and the adaptor PAG in primary human T cell immunological synaps

140 Conditional mutants of the substrate-adaptor (PfClpS) demonstrated its essential function in

141 r unexplainable by their involvement in AP-2 adaptor phosphorylation and endocytosis.

142 n is controversial and the mechanism of anti-adaptors preventing RssB-sigma(S) interaction remains el

143 s involved in TGN transport, three different adaptor protein (AP) complexes promote vesicle generatio

144 The epithelial cell-specific clathrin adaptor protein (AP)-1B has a well-established role in p

145 The B cell adaptor protein (BCAP) is a multimodular regulator of in

146 B-cell adaptor protein (BCAP) is a multimodular, multifunctiona

147 arrangement and cell mobility, including Nck adaptor protein (Nck), p120-Ras GTPase-activating protei

148 mmetric SctD inner membrane ring (IR) via an adaptor protein (SctK).

149 SHC adaptor protein (SHCA) and lipoma-preferred partner (LPP

150 eta-dependent role for Src homology/collagen adaptor protein (SHCA) in the initiation of dynamic adhe

151 oll-Interleukin 1 Receptor Domain-Containing Adaptor Protein (Tirap(-/-)), attenuated inflammation an

152 or Toll-IL1 receptor (TIR) domain-containing adaptor protein (TIRAP).

153 The T cell-specific adaptor protein (TSAd), encoded by the SH2D2A gene, is a

154 CDR1, which directly interacted with adaptor protein 1 (AP1) complex subunits and coatomer pr

155 This led to the identification of adaptor protein 2 (AP-2) as a protein that recognizes th

156 e phosphorylated active form of the clathrin adaptor protein 2 (AP2) at clathrin-coated pits.

157 It is well known that adaptor protein 2 (AP2) complexes trigger clathrin assem

158 morphine-induced MOR endocytosis through an adaptor protein 2 (AP2)/clathrin-dependent mechanism, at

159 the heterozygous depletion of the autophagy adaptor protein Alfy/Wdfy3 has no consequence in control

160 lution structure of Cdc48 in complex with an adaptor protein and a native substrate.

161 mature RPMs through activation of the MyD88 adaptor protein and ERK1/2 kinases downstream of the IL-

162 onstrate that mPRbeta signaling requires the adaptor protein APPL1 and the kinase Akt2.

163 it is known to function as a scaffolding or adaptor protein at cell-cell junctions and in the cytoso

164 affold adaptor protein SH2 domain-containing adaptor protein B (Shb) is essential for EphB2 functiona

165 The multifaceted adaptor protein beta-arr1 (beta-arrestin1) promotes acti

166 d by forming a complex with dynactin and the adaptor protein BicD2.

167 ron microscopy shows that the essential CbbO adaptor protein binds to the conserved, concave side of

168 The stability of Cullin3 substrate adaptor protein BPM1 is regulated by multiple environmen

169 Neuroligin-2 alters the conformation of the adaptor protein Collybistin-2 and thereby controls Colly

170 AP2M1 encodes the mu-subunit of the adaptor protein complex 2 (AP-2), which is involved in c

171 the cell surface by hijacking clathrin- and adaptor protein complex 2 (AP2)-dependent endocytosis.

172 The heterotetrameric adaptor protein complex 4 (AP-4) is a component of a pro

173 ariants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical ye

174 Deficiency of the adaptor protein complex 4 (AP-4) leads to childhood-onse

175 The TPLATE complex (TPC) is a key endocytic adaptor protein complex in plants.

176 We have previously shown the adaptor protein complex, AP-4, and small G protein ADP-r

177 These proteins included members of adaptor protein complex-2 (AP-2) involved in vesicular e

178 In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) sorts plasma membrane (

179 Null mutants of numb or the alpha-subunit of Adaptor Protein complex-2 enhance dominantly this phenot

180 regulated receptor dimerization dynamics and adaptor protein concentrations play critical roles in EG

181 hatase SHP-1 but more phosphorylation of the adaptor protein Crk than did triggering of high-abundanc

182 complex between CDK12-cyclin K and the CUL4 adaptor protein DDB1, bypassing the requirement for a su

183 ng was shown previously to involve the F-box adaptor protein Dia2 and an endosomal effector protein,

184 dentify the OM lipoprotein NlpI as a general adaptor protein for PG hydrolases.

185 Spn-F, Ik2, dynein light chain, and Hook, an adaptor protein in early endosome transport.

186 To investigate profilin's role as an adaptor protein in formin-mediated elongation, we engine

187 ted kinase 1 binding protein 2 (TAB2), a key adaptor protein in IFN-gamma production by NK cells.

188 longing to a human protein ALIX, a versatile adaptor protein involved in essential cellular processes

189 We found that the anti-adaptor protein IraD has higher affinity than sigma(S) t

190 that fusion is abrogated when binding of an adaptor protein is prevented and that direct coupling of

191 F1 cells: small leading-edge clusters of the adaptor protein lamellipodin (Lpd) that subsequently rec

192 spatial separation of the key transmembrane adaptor protein LAT from the TCR.

193 biquitin chain to cause filamentation of the adaptor protein MAVS and activation of the downstream tr

194 We previously discovered that the mammalian adaptor protein melanophilin of the actin-associated myo

195 out cells and patient cells lacking the Drp1 adaptor protein MiD49 fail to undergo injury-triggered m

196 similar regulatory mechanism operates for an adaptor protein named SKIP (also known as PLEKHM2).

197 or MYC3, but not with the repressor complex adaptor protein NINJA.

198 lization to bind and signal through the MAVS adaptor protein on intracellular membranes, thus directi

199 Adaptor protein p66Shc is overexpressed in smooth muscle

200 cause of the mutation leading to the lack of adaptor protein PSTPIP2, these animals suffer from autoi

201 tor 2 (BICD2) gene encodes a conserved cargo adaptor protein required for dynein-mediated transport.

202 pase-1-dependent cleavage of the trafficking adaptor protein RILP.

203 The adaptor protein Sel1L (Suppressor/Enhancer of Lin-12-lik

204 cell segregation, we found that the scaffold adaptor protein SH2 domain-containing adaptor protein B

205 Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflamm

206 3 ubiquitin ligases HOIP and HOIL-1L and the adaptor protein SHARPIN.

207 of beta-arr1 requires the assistance of the adaptor protein STAM1 (signal-transducing adaptor molecu

208 The adaptor protein Ste50 activates Ste11p, the MAP3K of all

209 hed microdomains 1 (PAG1) is a transmembrane adaptor protein that affects immune receptor signaling i

210 in FcRgamma (FcRgamma(-)), an intracellular adaptor protein that associates with CD16.

211 CARD11 encodes an adaptor protein that expresses dominant-negative and gai

212 Grb2 is an adaptor protein that recruits Ras-specific guanine nucle

213 (Amot) is a multifunctional PPxY-containing adaptor protein that regulates angiogenesis, actin dynam

214 Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet ag

215 Vinculin is a universal adaptor protein that transiently reinforces the mechanic

216 It is well known that TLR3 uses the adaptor protein Toll/interleukin-1 receptor (IL-1R) doma

217 identify a 28-amino-acid sequence in the TJ adaptor protein ZO-1, which is responsible for actin bin

218 tion between NOS1AP (nitric oxide synthase 1 adaptor protein) and neuronal nitric oxide synthase (nNO

219 Here we identify TRADD(4-6), an adaptor protein, as a direct regulator of both cellular

220 many diseases by reacting with thiols on the adaptor protein, Keap1.

221 We show that the adaptor protein, SKAP2, is required for protection again

222 r of the sheddase, ADAM17, and the antiviral adaptor protein, stimulator of IFN genes.

223 lasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intracel

224 saccharide (LPS)-containing phagosomes in an adaptor protein-3 (AP-3)-dependent manner, and both PI4K

225 n increased interaction with the 14-3-3theta adaptor protein.

226 the vacuole via Vac17, the vacuole-specific adaptor protein.

227 cluding phospholipase D 1 (PLD1), and kinase adaptor proteins AKAP9 (AKAP450) and AKAP13 (AKAP-Lbc).

228 betaarrs are known to act as adaptor proteins binding receptors and various effectors

229 d function of two novel desmosome-associated adaptor proteins enriched in the desmosome proteome, Crk

230 Herein, we demonstrate a role for the Nck adaptor proteins in disturbed flow-induced endothelial a

231 Adaptor proteins modulate substrate selection by AAA+ pr

232 necrosome activation is mediated through the adaptor proteins MyD88 and TRIF, and this is inhibited b

233 activity by depleting a core protein or the adaptor proteins of the catalytic domain, and hence inte

234 he nucleus, including nuclear pore proteins, adaptor proteins such as FAK and Akap8, chromatin-modify

235 ) and Ser(511) mediate recruitment of 14-3-3 adaptor proteins that hold CaMKK2 in the inactivated sta

236 5 directly and instead rely on PY-containing adaptor proteins that interact with Rsp5.

237 domain as a crucial site for recruitment of adaptor proteins that mediate membrane translocation, di

238 The arrestins are ubiquitously expressed adaptor proteins that orchestrate transmembrane signalin

239 d by components of the coat complex known as adaptor proteins(1-3).

240 between cell adhesion proteins, scaffold and adaptor proteins, and gamma-aminobutyric acid (GABA) or

241 d by specialized adhesive membrane proteins, adaptor proteins, and the actin cytoskeleton.

242 volves downregulation of two major autophagy adaptor proteins, sequestosome 1 (p62/SQSTM1) and optine

243 al phosphorylation of kinases, phosphatases, adaptor proteins, transcription factors such as nuclear

244 P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cel

245 re Rsp5 to interact with PY-motif containing adaptor proteins.

246 motors, a process that is often mediated by adaptor proteins.

247 phosphorylation in a manner dependent on the adaptor Rad9.

248 ion of these loci requires the mTORC1 kinase adaptor, Raptor, but not Xbp1.

249 show that two paralogous transmembrane Rsp5 adaptors, Rcr1 and Rcr2, are sorted to distinct cellular

250 Enhanced adaptor recruitment to the vacuole was observed by using

251 The mechanism by which these adaptors regulate dynein transport is poorly understood.

252 Here, we find that the dynein adaptor RILP is essential for retrograde transport of ne

253 P machinery for degradation dependent on the adaptor RssB.

254 dence that GPCRs interact with 14-3-3 signal adaptor/scaffold proteins and that this interaction regu

255 cyclase domain fused to a nucleotide-binding adaptor shared by apoptotic protease-activating factor-1

256 suggesting the complementarity of these two adaptor-specific pathways.

257 onstitutes the main interaction site for the adaptors Spindly (SPDL1), bicaudal D homolog 2 (BICD2),

258 blockage, siRNA depletion of Mincle and its adaptor spleen tyrosine kinase (Syk), and Syk pharmacolo

259 s cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMULATOR OF INTERFERON GENES (STING), activati

260 rmal activation of the cytosolic DNA sensing adaptor STING (stimulator of interferon genes) play a cr

261 bsequent activation of cytosolic DNA sensing adaptor STING signaling represent a key mechanism in aor

262 ng a clear mechanistic analogy with the IRF3 adaptors STING, MAVS and TRIF(10,11).

263 One of the adaptor strands is responsible for high selectivity of t

264 pears to prime CDTa for translocation as the adaptor subdomain enters the lumen of the preinsertion s

265 r of the interaction is conserved, the three adaptor subfamilies use different folds (coiled-coil, EF

266 tiple substrate-binding specificities of its adaptor subunit.

267 ity in the BRCC36 DUB family, with different adaptor subunits conferring diversified targeting and re

268 SMAD3 and its adaptors, such as beta2SP, are important mediators of TG

269 undergoes endocytosis and switches signaling adaptor; surface TLR4 engagement predominantly induces p

270 egrins and depend on these integrins and the adaptor Talin for their retention in blood-exposed regio

271 regulated through interactions with protein adaptors targeting it to specific cellular tasks.

272 ; this function of TBK1 relies on a specific adaptor-TBK-binding protein 1 (TBKBP1).

273 sitide 3-kinase (PI3K) (BCAP) is a signaling adaptor that activates the PI3K pathway downstream of B

274 l an unexpected function of a cellular motor adaptor that coordinates virus membrane penetration and

275 response regulator and the only known ClpXP adaptor that is inhibited by multiple but dissimilar ant

276 cterial ligands, while NLRC4 is a downstream adaptor that multimerizes with NAIPs to form an inflamma

277 nelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) mot

278 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel targets

279 on the TCR; these motifs recruit kinases and adaptors that lead to the activation of alphaLbeta2.

280 y depend on a group of so-called "activating adaptors" that link dynein to its general cofactor, dyna

281 aptors operate in an analogous manner to AP2 adaptor, their assembly likely involves a similar regula

282 acts as a redox-activated pexophagy receptor/adaptor, thereby identifying a previously unknown functi

283 lgi-associated BICD2 and BICDR1 dynein motor adaptors; this juxtaposition enables the adaptors to dir

284 lic RNA sensors that signal through the MAVS adaptor to activate IFN responses against viruses.

285 p32 functioned as an adaptor to recruit phosphorylated PKC-delta and Cap to t

286 We found that the ability of the adaptors to compete effectively was enhanced by their ub

287 tor adaptors; this juxtaposition enables the adaptors to directly bind to and disassemble SV40 upon a

288 G proteins and beta-arrestins, which act as adaptors to regulate AT1R internalization and mitogen-ac

289 ar mechanisms are likely to be used by other adaptors to regulate substrate choice and the catalytic

290 mechanism prevents the binding of autophagy adaptors to the ubiquitin-decorated surface of the L. pn

291 conducive to the binding of the TLR sorting adaptor Toll-IL1 receptor (TIR) domain-containing adapto

292 re, we investigate the role of the endosomal adaptor Tollip during the mitochondrial stress response

293 This work uncovers a novel role of clathrin adaptor-type interactions to stabilize nonkinetochore fi

294 itochondrial pool of the transmembrane Cdc48 adaptor, Ubx2, are implicated in their degradation.

295 acuole protein sorting (HOPS), that serve as adaptors which tether cargo vesicles to target membranes

296 CIN85 required the SH3 and PR regions of the adaptor, which associated with the phosphatase suppresso

297 the vacuolar cargo requires the GGA clathrin adaptors, which arrive during the early-to-late Golgi tr

298 tion in tumor cells by linking growth factor adaptors with hypoxia signaling.

299 redicted for other RHIM-containing signaling adaptors, Z-nucleic acid-binding protein 1 (ZBP1) (also

300 uitin ligase (CRL), containing the substrate adaptor ZSWIM8, that mediates TDMD.