ライフサイエンスコーパス: adaptor protein

1 l-interacting protein of 85 kDa) is one such adaptor protein.

2 of Steppke and Stepping stone, an implicated adaptor protein.

3 ique mechanism that involves a discrete PilZ adaptor protein.

4 via the appropriate receptors and the MyD88 adaptor protein.

5 terleukin-1 receptor (TIR) domain-containing adaptor protein.

6 f an enzyme target indirectly through a PilZ adaptor protein.

7 by the PDZ-protease Prc bound to its cognate adaptor protein.

8 es recruiting syntenin-1, a CD63-interacting adaptor protein.

9 the vacuole via Vac17, the vacuole-specific adaptor protein.

10 n increased interaction with the 14-3-3theta adaptor protein.

11 T cell receptor (TCR) that are organized by adaptor proteins.

12 cturally conserved between COPI and clathrin/adaptor proteins.

13 motifs could be a common mechanism for PilZ adaptor proteins.

14 s, cGAS, and IFI16 as well as their proximal adaptor proteins.

15 re Rsp5 to interact with PY-motif containing adaptor proteins.

16 motors, a process that is often mediated by adaptor proteins.

17 ncoding the beta subunit of heterotetrameric adaptor protein 1 (AP-1) complexes, which mediate endome

18 CDR1, which directly interacted with adaptor protein 1 (AP1) complex subunits and coatomer pr

19 ical for interaction with the mu1 subunit of adaptor protein 1 and the major histocompatibility compl

20 d by components of the coat complex known as adaptor proteins(1-3).

21 lasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intracel

22 the viral UL25 protein to SH3 domains of NCK Adaptor Protein-1.

23 tions create potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold p

24 Interaction of T-bet with the adaptor protein 14-3-3z in the cytosol of CD8(+) T cells

25 This led to the identification of adaptor protein 2 (AP-2) as a protein that recognizes th

26 Two of these proteins, a homolog of the adaptor protein 2 (AP-2) complex subunit alpha-1 and a h

27 pid down-regulation of CD4 via the endocytic adaptor protein 2 (AP-2) complex, a process linked to en

28 e phosphorylated active form of the clathrin adaptor protein 2 (AP2) at clathrin-coated pits.

29 It is well known that adaptor protein 2 (AP2) complexes trigger clathrin assem

30 Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathr

31 morphine-induced MOR endocytosis through an adaptor protein 2 (AP2)/clathrin-dependent mechanism, at

32 requires palmitoylation for interacting with adaptor protein-2 (AP-2) and AP-3, respectively, for tra

33 al cord slices and that it is carried out by adaptor protein-2 (AP-2) via clathrin-mediated endocytos

34 saccharide (LPS)-containing phagosomes in an adaptor protein-3 (AP-3)-dependent manner, and both PI4K

35 HgIA also required the adaptor protein-3 complex, which transports TLRs from th

36 When anchorage is disrupted, both the adaptor Protein 4.1B and the cytoskeleton protein betaII

37 Many different adaptor proteins activate the processivity of dynein-dyn

38 cluding phospholipase D 1 (PLD1), and kinase adaptor proteins AKAP9 (AKAP450) and AKAP13 (AKAP-Lbc).

39 ally inhibited activation of the prosurvival adaptor protein Akt.

40 the heterozygous depletion of the autophagy adaptor protein Alfy/Wdfy3 has no consequence in control

41 lution structure of Cdc48 in complex with an adaptor protein and a native substrate.

42 r-binding protein 10 (GRB10) is a well-known adaptor protein and a recently identified substrate of t

43 F receptor-associated factor 6 (TRAF6) is an adaptor protein and an E3 ubiquitin ligase that mediates

44 sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulate

45 mature RPMs through activation of the MyD88 adaptor protein and ERK1/2 kinases downstream of the IL-

46 transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of an

47 They bind to the STING adaptor protein and trigger expression of cytokines via

48 f the canonical and noncanonical cascades to adaptor protein and ubiquitination-related enzymes.

49 ey regulator of the clathrin-associated host adaptor proteins and regulates the intracellular traffic

50 tion between NOS1AP (nitric oxide synthase 1 adaptor protein) and neuronal nitric oxide synthase (nNO

51 between cell adhesion proteins, scaffold and adaptor proteins, and gamma-aminobutyric acid (GABA) or

52 ed process that involves actin cytoskeleton, adaptor proteins, and integrin receptors.

53 ification of IAP antagonists, unique caspase adaptor proteins, and mutually exclusive subcellular dom

54 molecular interactions among RNA molecules, adaptor proteins, and scaffold proteins.

55 d by specialized adhesive membrane proteins, adaptor proteins, and the actin cytoskeleton.

56 Here we show that loss of the cytoskeletal adaptor protein anillin (ANLN) from oligodendrocytes dis

57 ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in

58 ine but not glutamate vesicles depend on the adaptor protein AP-3, revealing an unrecognized linkage

59 AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in protein

60 ly unappreciated functional motifs including adaptor protein (AP) complex interaction site and a C-he

61 s involved in TGN transport, three different adaptor protein (AP) complexes promote vesicle generatio

62 The epithelial cell-specific clathrin adaptor protein (AP)-1B has a well-established role in p

63 Silencing of clathrin adaptor proteins (AP) AP-1A, AP-1B, or both caused redis

64 AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatiti

65 rotein 3 (NLRP3) inflammasome to recruit the adaptor protein apoptosis-associated speck-like protein

66 onstrate that mPRbeta signaling requires the adaptor protein APPL1 and the kinase Akt2.

67 Adaptor proteins are a class of cytoplasmic proteins tha

68 CD2AP in inflamed vessels, identifying this adaptor protein as a potential therapeutic target.

69 Here we identify TRADD(4-6), an adaptor protein, as a direct regulator of both cellular

70 ulation of caspase-1 activation requires the adaptor protein ASC (apoptosis-associated speck-like pro

71 ed cell-to-cell transfer of the inflammasome adaptor protein ASC in exosomes.

72 es and forms inflammasome complexes with the adaptor proteins Asc and caspase-1 to promote the matura

73 it is known to function as a scaffolding or adaptor protein at cell-cell junctions and in the cytoso

74 affold adaptor protein SH2 domain-containing adaptor protein B (Shb) is essential for EphB2 functiona

75 The B cell adaptor protein (BCAP) is a multimodular regulator of in

76 B-cell adaptor protein (BCAP) is a multimodular, multifunctiona

77 The multifaceted adaptor protein beta-arr1 (beta-arrestin1) promotes acti

78 ces for binding other regulators, either the adaptor protein Bicaudal-D2 (BicD2) or the multifunction

79 d by forming a complex with dynactin and the adaptor protein BicD2.

80 During CME, endocytic adaptor proteins bind cargoes at the cell surface and li

81 Second, fusion kinase inhibition shifted adaptor protein binding from the fusion oncoprotein to E

82 betaarrs are known to act as adaptor proteins binding receptors and various effectors

83 ron microscopy shows that the essential CbbO adaptor protein binds to the conserved, concave side of

84 The stability of Cullin3 substrate adaptor protein BPM1 is regulated by multiple environmen

85 cts constitutive phosphorylation of BCAP, an adaptor protein bridging PI3K and TLR pathways.

86 riers by interaction of sorting signals with adaptor proteins, but proteins in the other domain exit

87 Here the authors show that unique caspase adaptor proteins can regulate caspase activity within mu

88 ing through these receptors converged on the adaptor protein CARD9, a component of the CARD9-Bcl10-MA

89 The adaptor protein CIN85 is a partner of Cbl that augments

90 The EGFR adaptor protein, CIN85, has been shown to promote breast

91 iated with phosphorylation of the checkpoint adaptor protein Claspin and activation of the Chk1 effec

92 Neuroligin-2 alters the conformation of the adaptor protein Collybistin-2 and thereby controls Colly

93 AP2M1 encodes the mu-subunit of the adaptor protein complex 2 (AP-2), which is involved in c

94 the cell surface by hijacking clathrin- and adaptor protein complex 2 (AP2)-dependent endocytosis.

95 The heterotetrameric adaptor protein complex 4 (AP-4) is a component of a pro

96 ariants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical ye

97 Deficiency of the adaptor protein complex 4 (AP-4) leads to childhood-onse

98 The TPLATE complex (TPC) is a key endocytic adaptor protein complex in plants.

99 We have previously shown the adaptor protein complex, AP-4, and small G protein ADP-r

100 we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippo

101 embrane trafficking mediated by the clathrin adaptor protein complex-1 (AP-1) is important for the pr

102 These proteins included members of adaptor protein complex-2 (AP-2) involved in vesicular e

103 In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) sorts plasma membrane (

104 Null mutants of numb or the alpha-subunit of Adaptor Protein complex-2 enhance dominantly this phenot

105 These findings show that 14-3-3 adaptor protein complexes are druggable targets and iden

106 regulated receptor dimerization dynamics and adaptor protein concentrations play critical roles in EG

107 owed by recruitment of SH2 domain-containing adaptor proteins constitutes a central mechanism of intr

108 hatase SHP-1 but more phosphorylation of the adaptor protein Crk than did triggering of high-abundanc

109 l regulators of cell motility, including the adaptor protein CrkII.

110 rotein 2 (GRB2) and CRK-like proto-oncogene, adaptor protein (CRKL).

111 Unexpectedly, the periplasmic adaptor protein CusB is a key metal-sensing element that

112 Loss of the adaptor protein cyclin-dependent kinase regulatory subun

113 complex between CDK12-cyclin K and the CUL4 adaptor protein DDB1, bypassing the requirement for a su

114 moving processively towards minus ends in an adaptor protein-dependent manner.

115 ng was shown previously to involve the F-box adaptor protein Dia2 and an endosomal effector protein,

116 this network in Drosophila We find that the adaptor protein Disabled stimulates Abl kinase activity.

117 d function of two novel desmosome-associated adaptor proteins enriched in the desmosome proteome, Crk

118 e endocytosed in signal-sending cells by the adaptor protein Epsin.

119 C4 and its H443P mutant are dependent on the adaptor protein FADD.

120 termine how the capsid engages the kinesin-1 adaptor protein FEZ1.

121 Thus, CD28 functions as a novel adaptor protein for CSK, and CSK regulates signaling dow

122 We propose that Pet309 acts as an adaptor protein for Mss116 action on the COX1 mRNA 5-UTR

123 dentify the OM lipoprotein NlpI as a general adaptor protein for PG hydrolases.

124 rial antiviral-signaling protein (MAVS), the adaptor protein for RIG-I like receptor in regulating ho

125 rial antiviral signaling protein (MAVS), the adaptor protein for RIG-I-like receptor in regulating ho

126 HO-2 was also found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and the

127 eractions are often indirect and mediated by adaptor proteins, for example, Rab GTPases.

128 pproach identified the SH2 domain-containing adaptor protein GADS as the dominant interaction partner

129 ains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycli

130 receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to sti

131 rt the high-resolution structure of the tail adaptor protein gp7 from phage Sf6.

132 Proproliferatve function of adaptor protein GRB10 in prostate carcinoma.

133 nce that Drk, the Drosophila ortholog of the adaptor protein Grb2, is essential for ARM within adult

134 Themis2 constitutively bound the adaptor protein Grb2, src-kinase Lyn and signal transduc

135 CABIT domain of Themis and indirectly to the adaptor protein Grb2, with the latter interaction enabli

136 h factor receptor (EGFR) and the cytoplasmic adaptor protein growth factor receptor-bound protein 2 (

137 Here, we show that the phagocytic adaptor protein Gulp1 regulates EphB/ephrinB trogocytosi

138 Imd is a receptor-proximal adaptor protein homologous to mammalian RIP1 that is reg

139 is negatively regulated by an actin-binding adaptor protein, i.e., CD2AP, to allow a balanced and sp

140 PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-kappaB

141 s, including CRKLCRKL encodes a src-homology adaptor protein implicated in mediating tyrosine kinase

142 Spn-F, Ik2, dynein light chain, and Hook, an adaptor protein in early endosome transport.

143 To investigate profilin's role as an adaptor protein in formin-mediated elongation, we engine

144 ted kinase 1 binding protein 2 (TAB2), a key adaptor protein in IFN-gamma production by NK cells.

145 ide insight into the mechanistic role of the adaptor protein in mediating the sequential assembly of

146 CARD9 is an immune adaptor protein in myeloid cells that is involved in C-t

147 Herein, we demonstrate a role for the Nck adaptor proteins in disturbed flow-induced endothelial a

148 n of T cells (LAT) leading to recruitment of adaptor proteins, including Grb2, is one prototypical ex

149 formation is triggered beyond a threshold of adaptor protein, integrin, or extracellular ligand densi

150 longing to a human protein ALIX, a versatile adaptor protein involved in essential cellular processes

151 MINT2/APBA2 is a synaptic adaptor protein involved in excitatory synaptic transmis

152 tein is the most polymorphic of the four key adaptor proteins involved in TLR signaling.

153 We found that the anti-adaptor protein IraD has higher affinity than sigma(S) t

154 that fusion is abrogated when binding of an adaptor protein is prevented and that direct coupling of

155 NAs as colocalized clusters of integrins and adaptor proteins is developed.

156 However, since CusB is an adaptor protein, its role in operating this system is si

157 many diseases by reacting with thiols on the adaptor protein, Keap1.

158 r cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEA

159 nterfering with a putative synaptic tag, the adaptor protein KIBRA, which protects the atypical PKM f

160 orms in a previously undefined domain of the adaptor protein KIBRA.

161 is required, the kidney and brain expressed adaptor protein (KIBRA) is also required.

162 The integrin-activating adaptor protein kindlin-2 plays a central role for cell

163 F1 cells: small leading-edge clusters of the adaptor protein lamellipodin (Lpd) that subsequently rec

164 spatial separation of the key transmembrane adaptor protein LAT from the TCR.

165 ssical" MAPK cascade that is mediated by the adaptor protein LAT, it also stimulates an "alternative"

166 ically manipulated the localization of three adaptor proteins, LAT, SLP-76, and Grb2.

167 k-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenan

168 nals in the cytosolic tails of the cargos by adaptor proteins, leading to cargo packaging into coated

169 erate intracellular signals, the immune cell adaptor protein linker for the activation of T cells (LA

170 aryotic cells which involves clathrin and/or adaptor proteins, lipid kinases, phosphatases and the ac

171 egulate JAK2 stability and signaling via the adaptor protein LNK/SH2B3.

172 Here, we present the structure of the PilZ adaptor protein MapZ cocrystallized in complex with c-di

173 biquitin chain to cause filamentation of the adaptor protein MAVS and activation of the downstream tr

174 The GIPC family adaptor proteins mediate endocytosis by tethering cargo

175 This adaptor protein-mediated dynamic pump assembly allows th

176 ), a 4.1R-ezrin-radixin-moesin (FERM) domain adaptor protein, mediates numerous cellular responses, i

177 gy, causing abnormal accumulation of p62, an adaptor protein mediating NF-kappaB activation.

178 We previously discovered that the mammalian adaptor protein melanophilin of the actin-associated myo

179 out cells and patient cells lacking the Drp1 adaptor protein MiD49 fail to undergo injury-triggered m

180 These sensors then interact with the adaptor protein mitochondrial antiviral signaling protei

181 RIG-I, as well as the adaptor protein mitochondrial antiviral signaling protei

182 ly promotes Drp1 binding to the MOM resident adaptor protein mitochondrial fission factor (Mff).

183 Adaptor proteins modulate substrate selection by AAA+ pr

184 Signaling through the adaptor proteins MyD88 and TRIF resulted in activation o

185 necrosome activation is mediated through the adaptor proteins MyD88 and TRIF, and this is inhibited b

186 oll-interleukin 1 receptor domain containing adaptor protein)-MyD88-IRAK (interleukin-1 receptor-asso

187 mplexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and

188 similar regulatory mechanism operates for an adaptor protein named SKIP (also known as PLEKHM2).

189 arrangement and cell mobility, including Nck adaptor protein (Nck), p120-Ras GTPase-activating protei

190 nositide 3-kinase (PI3K) p85 subunit and NCK adaptor protein (NCK), together with previously unknown

191 or MYC3, but not with the repressor complex adaptor protein NINJA.

192 One autophagic adaptor protein not previously identified in sIBM was FY

193 c homology 2 (SH2) and SH3 domain-containing adaptor proteins, notably growth factor receptor-bound p

194 Here, we have found that the endocytic adaptor proteins NUMB and NUMBL were required for downre

195 activity by depleting a core protein or the adaptor proteins of the catalytic domain, and hence inte

196 lization to bind and signal through the MAVS adaptor protein on intracellular membranes, thus directi

197 ed for its interaction with a Golgi-resident adaptor protein or a specific lipid environment that lik

198 the regulatory dominance of the melanophilin adaptor protein over its associated motor and offer an u

199 It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of E

200 tigated whether epigenetic regulation of the adaptor protein p66(Shc), a key driver of mitochondrial

201 Adaptor protein p66Shc is overexpressed in smooth muscle

202 via its receptor roundabout4 (Robo4) and the adaptor protein, Paxillin were involved in reducing BBB

203 MYO6 is present on peripheral adaptor protein, phosphotyrosine interacting with PH dom

204 ouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysf

205 The adaptor proteins Polychaetoid and Canoe are enriched at

206 gnized innate protective function of SAP, an adaptor protein primarily reported in T cells, NK cells,

207 LITAF acts as an adaptor protein promoting NEDD4-1-mediated ubiquitinatio

208 cause of the mutation leading to the lack of adaptor protein PSTPIP2, these animals suffer from autoi

209 ssays showed that suppression of AP2M1 (AP-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting

210 ranches of the pathway, in that mTORC1 (with adaptor protein Raptor) is the main complex mediating th

211 -prenylated Rac1 has a high affinity for the adaptor protein Ras GTPase-activating-like protein 1 (Iq

212 Spata2 (spermatogenesis-associated 2) is an adaptor protein recruited into the TNF-RSC to modulate t

213 The 14-3-3 family of adaptor proteins regulate diverse cellular functions inc

214 lar targets other than TIR domain-containing adaptor protein remain unclear.

215 tor 2 (BICD2) gene encodes a conserved cargo adaptor protein required for dynein-mediated transport.

216 and function of islets, whereas mTORC2 (with adaptor protein Rictor) impacts islet mass and architect

217 pase-1-dependent cleavage of the trafficking adaptor protein RILP.

218 The adaptor protein Schnurri-3 (SHN3) is a promising therape

219 mmetric SctD inner membrane ring (IR) via an adaptor protein (SctK).

220 The adaptor protein Sel1L (Suppressor/Enhancer of Lin-12-lik

221 through the downregulation of the autophagy adaptor protein sequestosome (p62/SQSTM1) and of the mit

222 volves downregulation of two major autophagy adaptor proteins, sequestosome 1 (p62/SQSTM1) and optine

223 a1 fostered an interaction with a checkpoint adaptor protein, Sgs1, and contributed to checkpoint kin

224 cell segregation, we found that the scaffold adaptor protein SH2 domain-containing adaptor protein B

225 Disruption of the adaptor protein SH2B1 (SH2-B, PSM) is associated with se

226 Deficiency of the LUBAC adaptor protein Sharpin results in a multi-organ inflamm

227 3 ubiquitin ligases HOIP and HOIL-1L and the adaptor protein SHARPIN.

228 ted the possibility that the phosphotyrosine adaptor protein ShcA regulates nephrin turnover.

229 SHC adaptor protein (SHCA) and lipoma-preferred partner (LPP

230 eta-dependent role for Src homology/collagen adaptor protein (SHCA) in the initiation of dynamic adhe

231 mily protein, is generally believed to be an adaptor protein similar to BAK and BAX, regulating the m

232 While the immune cell adaptor protein SKAP1 mediates LFA-1 activation induced

233 We show that the adaptor protein, SKAP2, is required for protection again

234 els by (1) severing the bonds between the PM adaptor proteins Sla2 and Ent1 and the actin cytoskeleto

235 The adaptor protein SLP-76 is recruited to the phosphorylate

236 l the molecular basis for how dynein and its adaptor protein Spindly are recruited to the ROD-Zw10-Zw

237 The adaptor protein Src homology 2 domain-containing leukocy

238 of beta-arr1 requires the assistance of the adaptor protein STAM1 (signal-transducing adaptor molecu

239 The adaptor protein Ste50 activates Ste11p, the MAP3K of all

240 r of the sheddase, ADAM17, and the antiviral adaptor protein, stimulator of IFN genes.

241 econd messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs

242 oduces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases

243 he nucleus, including nuclear pore proteins, adaptor proteins such as FAK and Akap8, chromatin-modify

244 Adaptor proteins such as receptor-interacting serine/thr

245 Upon ligand binding, TLRs and IL-1Rs recruit adaptor proteins, such as myeloid differentiation primar

246 Binding of the cytoskeletal adaptor protein talin to the beta-integrin cytoplasmic d

247 Here, we show that the adaptor protein TAX1BP1 functions as a negative regulato

248 hed microdomains 1 (PAG1) is a transmembrane adaptor protein that affects immune receptor signaling i

249 in FcRgamma (FcRgamma(-)), an intracellular adaptor protein that associates with CD16.

250 lex virus 1 (HSV-1) interacts with CIN85, an adaptor protein that augments Cbl functions.

251 of multiple proteins, among which is a tail adaptor protein that connects the portal protein to the

252 CusB is an adaptor protein that connects the two membrane proteins

253 LNK is an essential adaptor protein that constrains HSC expansion through da

254 n receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 recep

255 p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS pr

256 CARD11 encodes an adaptor protein that expresses dominant-negative and gai

257 f wild-type two-pronged binding of the UBXD1 adaptor protein that is impaired in disease; this underl

258 ur results support that GpsB functions as an adaptor protein that mediates the interaction between me

259 ation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and in

260 iated factor 2 (TRAF2) is a second messenger adaptor protein that plays an essential role in propagat

261 Grb2 is an adaptor protein that recruits Ras-specific guanine nucle

262 (Amot) is a multifunctional PPxY-containing adaptor protein that regulates angiogenesis, actin dynam

263 Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet ag

264 VE-PTP serves as an adaptor protein that through binding and inhibiting the

265 Vinculin is a universal adaptor protein that transiently reinforces the mechanic

266 bility of RpoS is regulated by multiple anti-adaptor proteins that are also synthesized in response t

267 Syntrophins are a family of modular adaptor proteins that are part of the dystrophin protein

268 llular proteins are dimeric, multifunctional adaptor proteins that bind to and regulate the activitie

269 llin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskeletal rearrangem

270 ) and Ser(511) mediate recruitment of 14-3-3 adaptor proteins that hold CaMKK2 in the inactivated sta

271 5 directly and instead rely on PY-containing adaptor proteins that interact with Rsp5.

272 domain as a crucial site for recruitment of adaptor proteins that mediate membrane translocation, di

273 The arrestins are ubiquitously expressed adaptor proteins that orchestrate transmembrane signalin

274 d, A55 may also sequester Cul3 from cellular adaptor proteins, thereby protecting substrates of these

275 ubiquitination and degradation of the TLR2/4 adaptor protein TIRAP and TLR2 in macrophages and microg

276 hat CLIP170 interacts with the TLR2 and TLR4 adaptor protein TIRAP.

277 oll-Interleukin 1 Receptor Domain-Containing Adaptor Protein (Tirap(-/-)), attenuated inflammation an

278 TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling cascade

279 or Toll-IL1 receptor (TIR) domain-containing adaptor protein (TIRAP).

280 The adaptor protein TNF receptor associated factor (TRAF) 3

281 r the tail nozzle only after the assembly of adaptor protein to the portal.

282 methylation could facilitate recruitment of adaptor proteins to FLT3 in a phospho-tyrosine (Y) resid

283 ytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of

284 facilitating the recruitment of cytoskeleton adaptor proteins to mediate pathogen uptake.

285 n 2) and the isolated PTB domain of Shc (SHC adaptor protein) to the EGF receptor.

286 It is well known that TLR3 uses the adaptor protein Toll/interleukin-1 receptor (IL-1R) doma

287 The adaptor protein TRAF6 has a central function in Toll-lik

288 al phosphorylation of kinases, phosphatases, adaptor proteins, transcription factors such as nuclear

289 Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-domain-containing adapter-indu

290 screenings, we report that the mitochondrial adaptor protein tripartite motif (TRIM)14 provides a doc

291 The T cell-specific adaptor protein (TSAd), encoded by the SH2D2A gene, is a

292 -like protein necroptotic signaling with the adaptor protein tumor necrosis factor receptor-associate

293 ion and phagocytosis through coupling to the adaptor protein TYRO protein-tyrosine kinase-binding pro

294 Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions.

295 riasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that coup

296 ce of an association of native neuronal AP-2 adaptor proteins with Slack channels, facilitated by a d

297 P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cel

298 rs that regulate the number of integrins and adaptor proteins within NAs through a mechanosensitive c

299 We found that the adaptor protein YjbH activates cspA expression.

300 identify a 28-amino-acid sequence in the TJ adaptor protein ZO-1, which is responsible for actin bin