ライフサイエンスコーパス: adaptor protein complex

1 plex with AP-2, the plasma membrane clathrin adaptor protein complex.

2 1b but not other CD1 isoforms bound the AP-3 adaptor protein complex.

3 for communicating conformational changes to adaptor protein complexes.

4 through E3-mediated ubiquitination of Smad4/adaptor protein complexes.

5 unctional homologies with the beta-chains of adaptor protein complexes.

6 Although adaptor protein complex 1 (AP-1) and Golgi-localized, ga

7 Here we show that adaptor protein complex 1 (AP-1) controls the terminatio

8 Adaptor protein complex 1 (AP-1) is an evolutionary cons

9 Disruption of the clathrin adaptor protein complex 1 (AP-1) restores Chs3p transpor

10 Disruption of the clathrin adaptor protein complex 1 (AP-1) restores Fus1p localiza

11 Association of the Golgi-specific adaptor protein complex 1 (AP-1) with the membrane is a

12 ay rapid movement, colocalize with clathrin, adaptor protein complex 1 (AP-1), and TGN46, but not the

13 toward the subendothelial matrix, using the adaptor protein complex 1 (AP-1), where it may provide t

14 plasmic domains and the core of the clathrin adaptor protein complex 1 (AP1).

15 thrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1).

16 oat proteins such as coat protein complex I, adaptor protein complex 1 and GGA3 and altered the morph

17 ea, whereas the localization of the clathrin adaptor protein complex 1 in the trans-Golgi network rem

18 etween Nef, MHC-I, and the hijacked clathrin adaptor protein complex 1, we have developed a fluoresce

19 identified an essential requirement for both adaptor protein complexes 1 and 3 in this process by emp

20 Thus, adaptor protein complexes 1 and 3 play an essential dual

21 strain background (lacking a dynamin and an adaptor-protein complex 1 subunit).

22 ous biomedically important cargoes depend on adaptor protein complex-1 (AP-1) for their localization.

23 embrane trafficking mediated by the clathrin adaptor protein complex-1 (AP-1) is important for the pr

24 Here, we find that the adaptor protein complex-1 (AP-1) mediates trafficking of

25 The adaptor protein complex-1 (AP-1) sorts and packages memb

26 ir roles in membrane traffic mediated by the adaptor protein complex-1 (AP1).

27 autoinhibition and increased binding to the adaptor protein complex-1 gamma-appendage.

28 ail via their VHS domains, as well as to the adaptor protein complex-1 via their hinge domains.

29 internalization is mediated by the clathrin adaptor protein complex 2 (AP-2) and epsin-1, rather tha

30 LR9 requires UNC93B1-mediated recruitment of adaptor protein complex 2 (AP-2) for delivery to endolys

31 m HIV-1 and to the medium chain (mu2) of the adaptor protein complex 2 (AP-2) in vitro and in vivo.

32 and a receptor containing a mutated putative adaptor protein complex 2 (AP-2) interaction motif, we d

33 AP2M1 encodes the mu-subunit of the adaptor protein complex 2 (AP-2), which is involved in c

34 oding Picalm, clathrin, or components of the adaptor protein complex 2 (AP2) have been previously des

35 the cell surface by hijacking clathrin- and adaptor protein complex 2 (AP2)-dependent endocytosis.

36 kes place through Nef hijacking the clathrin adaptor protein complex 2 (AP2)-dependent endocytosis.

37 eract with agonist-occupied 7TMRs as well as adaptor protein complex 2 and clathrin.

38 ha), a kinase devoid of a clathrin-dependent adaptor protein complex 2 binding site, caused a delay i

39 via clathrin-coated pits, where clathrin and adaptor protein complex 2 nucleate and polymerize upon e

40 the plasma membrane preceding recruitment of adaptor protein complex 2, clathrin, and dynamin-related

41 nds on the capacity of CD63 to interact with adaptor protein complexes 2 and 3.

42 These proteins included members of adaptor protein complex-2 (AP-2) involved in vesicular e

43 lar loop of PAR4 and found that the clathrin adaptor protein complex-2 (AP-2) is important for intern

44 In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) is required for the for

45 In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) sorts plasma membrane (

46 unactivated PAR1 is mediated by the clathrin adaptor protein complex-2 (AP-2), where the mu2-adaptin

47 stitutive internalization is mediated by the adaptor protein complex-2 (AP-2), whereas AP-2 and epsin

48 unactivated PAR1 is mediated by the clathrin adaptor protein complex-2 (AP-2), which binds to a dista

49 Null mutants of numb or the alpha-subunit of Adaptor Protein complex-2 enhance dominantly this phenot

50 The clathrin adaptor AP2 (adaptor protein complex-2) is critical for constitutive

51 lysosomal membrane proteins coexist with the adaptor protein complex 3 (AP-3) in neuronal cells.

52 Adaptor protein complex 3 (AP-3) is a heterotetramer tha

53 Here we show that the adaptor protein complex 3 (AP-3) is required for the eff

54 complex 1 (BLOC-1), which interacts with the adaptor protein complex 3 (AP-3), mediating a common end

55 zygous mutation of the gene encoding the dog adaptor protein complex 3 (AP3) beta-subunit, directing

56 E-) found in its cytoplasmic tail to recruit adaptor protein complex 3 for export from the trans-Golg

57 The yeast AP-3 (Adaptor Protein Complex 3) coat and the class C Vps/HOPS

58 Examples of common components are the adaptor protein complex-3 (AP-3) and biogenesis of lysos

59 Adaptor protein complex-3 (AP-3) mediates cargo sorting

60 We now report that the adaptor protein complex-3 (AP-3) regulates PAR1 ubiquiti

61 TG9A vesicles through the recruitment of the adaptor protein complex-3 (AP-3).

62 es mutated in the Hermansky-Pudlak syndrome, adaptor protein complex-3 and biogenesis of lysosome-rel

63 The heterotetrameric adaptor protein complex 4 (AP-4) is a component of a pro

64 ariants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical ye

65 Deficiency of the adaptor protein complex 4 (AP-4) leads to childhood-onse

66 P4S1 gene, encoding the sigma subunit of the adaptor protein complex 4 (AP-4).

67 one mutation in each of three genes encoding adaptor protein complex 4 (AP4) subunits: a nonsense mut

68 d functioning as an accessory protein of the adaptor protein complex 4 (AP4).

69 Adaptor protein complex 5 (AP-5) and its partners, SPG11

70 teract both with the mu2 subunit of the AP-2 adaptor protein complex and with ALG-2-interacting prote

71 res both a functional AP-3 (heterotetrameric adaptor protein complex) and HOPS (homotypic fusion and

72 The endosomal clathrin adaptor protein complex AP-1 is a key cellular cofactor

73 We identified multiple subunits of the adaptor protein complex AP-2 (CLAP), an essential compon

74 ions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internal

75 with beta-adaptin, a subunit of the clathrin adaptor protein complex AP-2.

76 llular partner of the GYxxtheta motif is the adaptor protein complex AP-2.

77 The heterotetrameric adaptor protein complex AP-3 has been shown to function

78 The adaptor protein complex AP-4 mediates anterograde axonal

79 medium subunit mu4 of the recently described adaptor protein complex AP-4.

80 Using RNAi, we found that clathrin adaptor protein complexes AP-1 and AP-3, as well as seve

81 s, whose sorting is mediated by the clathrin adaptor protein complex (AP) AP-1B.

82 oblasts from mocha mice that lack functional adaptor protein complex (AP)-3, small interfering RNA-me

83 Clathrin and the adaptor protein complex (AP-2) constitute the major coat

84 own to be important for the interaction with adaptor protein complexes (AP) that mediate the endosoma

85 tive association with the endocytic clathrin adaptor protein complex, AP-2, strongly suggest that Eps

86 cytoplasmic domains by the heterotetrameric adaptor protein complex, AP-2.

87 onjugate and a fluorescently tagged clathrin adaptor protein complex, AP-2.

88 Stonin 2 also interacts indirectly with the adaptor protein complex, AP-2.

89 Here we show that the adaptor protein complex, AP-3, directly interacts with m

90 We have previously shown the adaptor protein complex, AP-4, and small G protein ADP-r

91 One of the adaptor protein complexes, AP-3, is present in two forms

92 Adaptor protein complexes (AP1-4) are ubiquitously expre

93 Specifically, the adaptor protein complex AP2 binds phosphatidylinositol-4

94 Thus, as with the classical endocytic adaptor protein complex AP2, beta-arrestin1 functions as

95 chain of the clathrin-associated coated pit adaptor protein complex AP2.

96 diates this function by interacting with the adaptor protein complex AP4 and Stargazin and possibly u

97 Adaptor protein complexes (APs) are evolutionarily conse

98 ct interactions with the clathrin-associated adaptor protein complexes (APs) in C. elegans.

99 rganelles, the coat components, clathrin and adaptor protein complexes (APs), must be released.

100 These findings show that 14-3-3 adaptor protein complexes are druggable targets and iden

101 Heterotetrameric adaptor protein complexes are important mediators of car

102 ng clathrin and the beta-subunit of the AP-2 adaptor protein complex, at discrete locations that are

103 R-mediated signals modulate a multimolecular adaptor protein complex containing Grb2, Shc, SHIP, CrkL

104 adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of

105 re of three leukemia transformation-relevant adaptor protein complexes (Grb2/Gab2/Shc1 complex, CrkI

106 IDTS and did not impede interaction with the adaptor protein complex IcmS/IcmW, which is thought to f

107 The TPLATE complex (TPC) is a key endocytic adaptor protein complex in plants.

108 A new study reveals a key role for the AP4 adaptor protein complex in the Golgi-to-endosome traffic

109 we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippo

110 Pase domain, was shown to bind both clathrin adaptor protein complexes, indicating a role in membrane

111 ntegration at the postreceptor level through adaptor protein complexes, influencing cellular dependen

112 he major coat constituents, clathrin and the adaptor protein complexes, interact with each other, wit

113 report that both the AP-3 (heterotetrameric adaptor protein complex) interaction domain and clathrin

114 t endocytic processing through disruption of adaptor protein complexes is likely to result from the A

115 stematically examined the effect of ablating adaptor protein complexes on the localization of this pr

116 r protein (KIF13A) and a clathrin-associated adaptor protein complex subunit (AP1S2) from microRNA-de

117 pp120 co-localized with alpha-adaptin in the adaptor protein complex that anchors endocytosed protein

118 ef to adaptor protein-2 (AP-2), which is the adaptor protein complex that is required for the interna

119 sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal

120 , results in the recruitment and assembly of adaptor protein complexes that function to transduce sig

121 Through genetic analyses, we uncover the adaptor protein complexes that genetically interact with

122 otif that is similar to motifs recognized by adaptor protein complexes that sort transmembrane protei

123 g., coat protein complex I, II, and clathrin/adaptor protein complex), the exomer does not form buds

124 tifs that are known to interact with various adaptor protein complexes; the other is the sequence ESS

125 ocks recruitment of BIG1 and BIG2, Arfs, and adaptor protein complexes to the endosome.

126 encodes sigma3A, a small subunit of the AP-3 adaptor protein complex, was demonstrated to bind IRS-1

127 5 protein spastizin and heterotetrameric AP5 adaptor protein complex, which includes the SPG48 protei

128 migration through regulation of Crk and CAS adaptor protein complexes, which are necessary for cell