ライフサイエンスコーパス: addictive

1 fective analgesics, but they are also highly addictive.

2 SCRAs are highly potent and addictive.

3 wly discovered genomic action to achieve its addictive action.

4 attractive enough to make rehearsing them an addictive activity.

5 ement can be generalized across the range of addictive agents.

6 remains a promising strategy to achieve non-addictive analgesia for multiple pain conditions.

7 Tobacco smoking is highly addictive and causes respiratory disease, cardiovascular

8 n) potentially could treat a wide variety of addictive and depressive disorders.

9 neuropsychiatric-related behaviors, such as addictive and depressive-like behaviors.

10 eflect the burgeoning literature focusing on addictive and feeding behaviors across multiple domains

11 ry, such as engineering junk food to make it addictive and marketing it to young children.

12 Methamphetamine (MA) is highly addictive and neurotoxic, causing cell death in humans a

13 ther subunits (alpha4beta2* nAChRs) regulate addictive and other behavioral effects of nicotine.

14 wer pharmacokinetics, which results in fewer addictive and reinforcing effects than cocaine; the effe

15 y those high in refined sugars and fats, are addictive and that some forms of obesity can usefully be

16 Opioid drugs are highly addictive and their abuse has a strong genetic load.

17 Addictive and therapeutic psychostimulants inhibit DA re

18 erally safe in a clinical setting, it can be addictive, and several of its derivatives are being inve

19 Nicotine has strong addictive as well as procognitive properties.

20 Cocaine is thought to be addictive because it elevates dopamine levels in the str

21 t overeating of palatable food is similar to addictive behavior and characterized by dysregulation of

22 mus (LH), a target region known to influence addictive behavior and mood.

23 s depressive-like effects and contributes to addictive behavior in male nonhuman primates and rodents

24 This decrease in addictive behavior is associated with a long-term reduct

25 defense functions; the partially selfish and addictive behavior of the defense systems; and coupling

26 Substantial evidence from rodent models of addictive behavior points to the involvement of the vent

27 nt dendritogenesis are also involved in such addictive behavior remains unknown.

28 et region amygdala, a key area implicated in addictive behavior, differs depending on the GATA4 genot

29 eural systems interact with sex to influence addictive behavior, emphasizing throughout that the impa

30 on tobacco use, in particular, as well as on addictive behavior, in general.

31 Do negative feelings in general trigger addictive behavior, or do specific emotions play a stron

32 ability of neuropsychiatric traits including addictive behavior, schizophrenia, and neuroticism, thus

33 e synaptic changes associated with facets of addictive behavior, supporting partial coincident neurol

34 king behavior, novelty-seeking behavior, and addictive behavior, we hypothesized alterations of the f

35 tly or indirectly-to processes of reward and addictive behavior, with a focus on psychostimulants and

36 understanding of their efficacy in reducing addictive behavior.

37 pendent remodeling that may underlie certain addictive behavior.

38 ges are entirely dissociable from changes in addictive behavior.

39 derstanding the neurobiological mechanism of addictive behavior.

40 ng is critical for movement, motivation, and addictive behavior.

41 plays a critical role in the development of addictive behavior.

42 d depression-like behavior and bHRs prone to addictive behavior.

43 Excessive sun tanning can result in addictive behavior.

44 ts for sleep disorders, eating disorders, or addictive behavior.

45 hereby causing development and expression of addictive behavior.

46 mon vertebrate model system for the study of addictive behavior.

47 ual reward-seeking behavior is a hallmark of addictive behavior.

48 -analysis, representing 643 individuals with addictive behaviors and 609 healthy control individuals.

49 a period of heightened vulnerability both to addictive behaviors and drug-induced brain damage.

50 o a negative affective state contributing to addictive behaviors and risk of relapse.

51 mesolimbic dopamine system, suggesting that addictive behaviors are encoded by changes in the reward

52 The development and persistence of addictive behaviors comes from a complex interaction of

53 d aggression, impulsivity, and proclivity to addictive behaviors compared with low-novelty reactive r

54 dopamine stimulation and might contribute to addictive behaviors in CA.

55 ibute to impulsivity, which is a hallmark of addictive behaviors that underlie compulsive drug seekin

56 t the applicability of theoretical models of addictive behaviors to the social-networks-use disorder

57 ociated memories is critical for maintaining addictive behaviors, as presentation of drug-associated

58 re central to pain control, drug reward, and addictive behaviors, but underlying circuit mechanisms h

59 Addictive behaviors, including relapse, are thought to d

60 atal dysfunction, is a key characteristic of addictive behaviors.

61 ribute to the acquisition and maintenance of addictive behaviors.

62 ion in target regions in an effort to dampen addictive behaviors.

63 entifying new therapeutic targets for opiate addictive behaviors.

64 a role in the association between stress and addictive behaviors.

65 lated reward circuits, ultimately leading to addictive behaviors.

66 ased stress reactivity and irritability) and addictive behaviors.

67 rapeutics to better understand and influence addictive behaviors.

68 xpression in neural circuits responsible for addictive behaviors.

69 amygdala, they modulate our pain, fear, and addictive behaviors.

70 ipation and/or outcome; participants showing addictive behaviors; and healthy control group.

71 ce use or gambling; participants at risk for addictive behaviors; and studies using the same patient

72 , so habit is unlikely to explain most human addictive behaviour where these conditions apply.

73 ons, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizin

74 Likewise, both obesity and addictive behaviours have similar correlations with broa

75 , that regulate motor control, motivated and addictive behaviours.

76 ses that have been well accepted to motivate addictive behaviours.

77 on phenotype can be abrogated in the cystine-addictive cells by miR-200c, which converts the mesenchy

78 a drug of abuse that is a potent and highly addictive central nervous system (CNS) stimulant.

79 s in the rate of metabolism of nicotine, the addictive chemical in tobacco, affect smoking behavior a

80 ng the neural correlates of demand for other addictive commodities.

81 ularly vulnerable to nicotine, the principal addictive component driving tobacco smoking.

82 Nicotine, the addictive component of cigarettes, accelerates cell prol

83 Nicotine, the addictive component of cigarettes, promotes lung cancer

84 Nicotine, the major addictive component of tobacco smoke, can induce prolife

85 rongly contribute to both nicotine, the main addictive component of tobacco, and alcohol use.

86 xtracellular transmitter and is a target for addictive compounds such as cocaine, amphetamine (AMPH),

87 ors (KOR) are involved in mood disorders and addictive conditions.

88 ucts are cotinine, a major metabolite of the addictive constituent nicotine, and 4-(methylnitrosamino

89 ecting ethanol withdrawal and thus the whole addictive cycle.

90 mans on basic biobehavioral functions, or on addictive diseases and mood disorders.

91 o implicated in several neuropsychiatric and addictive diseases.

92 Opioid dependence, a severe addictive disorder and major societal problem, has been

93 sification of obesity and binge eating as an addictive disorder is merited.

94 exists whether obesity can be regarded as an addictive disorder or not.

95 e-compulsive (OC) spectrum disorder or as an addictive disorder.

96 nature and therefore contains elements of an addictive disorder.

97 We review how addictive disorders (ADs) are presently diagnosed and th

98 l intermediate phenotype (endophenotype) for addictive disorders and comorbid externalizing psychopat

99 The striatum has a clear role in addictive disorders and is involved in drug-related crav

100 Addictive disorders are a major public health concern, a

101 value in this regard, because both pain and addictive disorders are characterized by impaired hedoni

102 related disorders, and substance-related and addictive disorders as well as in end-of-life care.

103 t state of knowledge of reward processing in addictive disorders from a widely used and validated tas

104 importance for the neurochemical systems of addictive disorders including gambling disorder.

105 One strategy proposed to treat addictive disorders is to extinguish the association bet

106 ward decisions, all of which are impaired in addictive disorders such as alcoholism.

107 literature on the use of neuromodulation in addictive disorders to highlight progress limitations wi

108 idual HR associated with dispensed drugs for addictive disorders was 0.48 (95% CI, 0.23-0.97), based

109 depressants, psychostimulants, drugs used in addictive disorders, and antiepileptic drugs) after pris

110 sor-related disorders, substance-related and addictive disorders, and gender dysphoria).

111 ge of the importance of genomic variation in addictive disorders, and provide an addiction CNV pool f

112 disorder, to extend these findings to other addictive disorders, and to relate variations in them to

113 allow us to probe affected brain circuits in addictive disorders, but also seem to have unique therap

114 ntribute to symptoms in eating disorders and addictive disorders, but little is known about the molec

115 ipsychotics, psychostimulants, and drugs for addictive disorders, compared with periods in which they

116 atic symptom disorder, substance-related and addictive disorders, feeding and eating disorders, schiz

117 ariation in addictions, shared mechanisms in addictive disorders, impact of changing environmental in

118 ed across a network of regions implicated in addictive disorders, including insula, superior temporal

119 otivation and have been repeatedly linked to addictive disorders, including nicotine dependence.

120 kappa-opioid receptor (KOR) abnormalities in addictive disorders, other central nervous system diseas

121 in the risk for and clinical presentation of addictive disorders, risk for addiction may be different

122 d dopamine D2 receptor (D2R) availability in addictive disorders, the role that these systems play in

123 s have been linked to impaired cognition and addictive disorders, we hypothesized that reduced GABA i

124 eness is shared across other psychiatric and addictive disorders, we predicted that as rates of smoki

125 ate phenotype vulnerable for alcohol use and addictive disorders.

126 icated in the development and maintenance of addictive disorders.

127 may provide novel therapeutic strategies for addictive disorders.

128 portant goal for the successful treatment of addictive disorders.

129 re similar to opioid addiction than to other addictive disorders.

130 ity will be vital for improving treatment of addictive disorders.

131 ted in several neuropsychiatric diseases and addictive disorders.

132 ie cognitive dysfunctions in psychiatric and addictive disorders.

133 emerged as a candidate therapeutic target in addictive disorders.

134 en stress-promoting neuropeptides and NOP in addictive disorders.

135 fying amphetamine (AMPH), cocaine, and other addictive dopamine-transporter inhibitors (DAT-Is) suppo

136 ction with a peer and then choose between an addictive drug (heroin or methamphetamine) and social in

137 amine, a potent psychostimulant, is a highly addictive drug commonly used by persons living with HIV

138 , and its oligomerization may be relevant to addictive drug effects.

139 ol.SIGNIFICANCE STATEMENT Over the course of addictive drug exposure, there is a transition in the co

140 a marker for neuroadaptive changes following addictive drug exposure.

141 Addictive drug reinforcement and stress signaling involv

142 Cocaine is an addictive drug that acts in brain reward areas.

143 nown by its genetic name Fenethylline, is an addictive drug that complicates the War on Drugs.

144 Addictive drug use causes long-lasting changes in synapt

145 Amphetamine, a highly addictive drug with therapeutic efficacy, exerts paradox

146 Although cocaine is known to be a highly addictive drug, there appears to be a select subset of i

147 002 to 0.0052; p=0.069), and the presence of addictive-drug metabolites in urine (0.103, -0.013 to 0.

148 By increasing dopamine in the striatum, addictive drugs alter the balance of dopamine and glutam

149 al tegmental area (VTA) is a major target of addictive drugs and receives multiple GABAergic projecti

150 vern activity-dependent synaptic plasticity, addictive drugs can derail the experience-driven neural

151 of the brain mechanisms they activate; most addictive drugs cause elevations in extracellular levels

152 Not everyone who tries addictive drugs develops a substance use disorder.

153 ely used to study motivational properties of addictive drugs in animals, but has rarely been used in

154 ation and consumption of HP foods as well as addictive drugs is discussed.

155 Seeking addictive drugs is regulated by synaptic plasticity in t

156 red the observation that a common feature of addictive drugs is to activate, by a double tyrosine/thr

157 It has been recently discussed that addictive drugs may hijack the learning-and-memory machi

158 a (VTA) dopamine (DA) neurons in response to addictive drugs may underlie the transition from casual

159 SIGNIFICANCE STATEMENT: It is believed that addictive drugs often render an addict's brain reward sy

160 Repeated exposure to addictive drugs or alcohol triggers glutamatergic and ga

161 ressive predominance of rewarding effects of addictive drugs over their aversive properties likely co

162 Addictive drugs such as cocaine induce synaptic plastici

163 Exposure to addictive drugs such as psychostimulants produces persis

164 tamate interaction in MSN that is usurped by addictive drugs to elicit persistent behavioural alterat

165 lecular changes induced by administration of addictive drugs to rodents.

166 Many studies support a perspective that addictive drugs usurp brain circuits used by natural rew

167 Addictive drugs usurp neural plasticity mechanisms that

168 nally address the question of whether or not addictive drugs usurp the neuronal networks recruited by

169 ediction of the three most frequently abused addictive drugs with the sensitivity and accuracy of the

170 In some cases, such as addictive drugs, aggression can be highly rewarding (app

171 ral tegmental area (VTA) are a key target of addictive drugs, and neuroplasticity in this region may

172 As a result of habitual intake of addictive drugs, dopamine receptors expressed in the bra

173 Addictive drugs, such as cocaine, induce a rapid increas

174 yle but also the immunomodulatory effects of addictive drugs, such as cocaine, may account for their

175 esolimbic dopamine-a defining feature of all addictive drugs-as a neural substrate for these drug-ada

176 mission and a target for antidepressants and addictive drugs.

177 at mediate vision, memory, and the action of addictive drugs.

178 etic mechanisms in the behavioral effects of addictive drugs.

179 m was stimulated by food, sexual arousal, or addictive drugs.

180 liking of various rewards including food and addictive drugs.

181 tural rewards converges with that engaged by addictive drugs.

182 nt role in homeostatic adaptations caused by addictive drugs.

183 ving-that are associated with chronic use of addictive drugs.

184 hyperpalatable foods associated with a quasi-addictive effect and that the prevailing European Union

185 disabling, rendering an urgent need for non-addictive, effective new therapies.

186 gnaling and that this mechanism mediates the addictive effects of AAS.

187 HD sufferers, may be more susceptible to the addictive effects of amphetamine-like drugs.

188 se data suggest a possible mechanism for the addictive effects of Delta(9)-tetrahydrocannabinol in ju

189 Neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be involved i

190 s (MORs) are necessary for the analgesic and addictive effects of opioids such as morphine, but the M

191 oid receptors mediate both the analgesic and addictive effects of opioids.

192 BNA) during smoking and thereby enhances its addictive effects.

193 l output of NAc neurons, contributing to the addictive emotional and motivational state.

194 ues become powerfully attractive in a nearly addictive fashion.

195 idence suggests that UV-seeking behavior has addictive features.

196 ion that self-efficacy and desire to quit an addictive habit are inversely related.

197 limiting adverse effects and are potentially addictive, highlighting the need for improved therapeuti

198 ambling or video-game play may be considered addictive in the absence of exogenous (i.e. drug-induced

199 Condemning food as addictive is mere polemic, ignoring the contextualised s

200 anxiety-related behavior without sedative or addictive liabilities.

201 effects of opioids that may lead to a lower addictive liability of opioids with selective low potenc

202 nsistent with these impairments, we observed addictive-like behavior in DIO-prone rats, including 1)

203 iet-induced obesity (DIO) is associated with addictive-like behavior, as well as synaptic impairments

204 nd serves to protect against cocaine-induced addictive-like behavioral abnormalities.

205 tributes to the transmission of MHFD-induced addictive-like behaviors and obesogenic phenotypes acros

206 vely little is known about the regulation of addictive-like behaviors by DNA methylation.

207 e of this posttranslational modification for addictive-like behaviors was unknown.

208 ational HFD exposure leads to more prominent addictive-like behaviors with reduced striatal dopamine

209 onfer resilience to poor decision making and addictive-like behaviors, such as excessive ethanol drin

210 zygotes reproduces obesogenic phenotypes and addictive-like behaviors, such as increased preference o

211 ities in the nucleus accumbens that underlie addictive-like behaviors.

212 allenging because it appears to be driven by addictive mechanisms.

213 is at the center of a variety of cognitive, addictive, mood, anxiety, and developmental disorders.

214 to play an important role in mediating their addictive nature.

215 ugh long-term exposure to nicotine is highly addictive, one beneficial consequence of chronic tobacco

216 Identifying non-addictive opioid medications is a high priority in medic

217 ch engages numerous components of tumor cell-addictive pathways and highlights the ability to deliver

218 One possible mechanism underlying addictive phenotypes is the ability of cocaine to block

219 hese results indicate that GRIP may modulate addictive phenotypes through its regulation of synaptic

220 and e-cigarettes contain nicotine, a highly addictive, plant-derived alkaloid that binds to nicotini

221 Both systems have an "addictive" plasmid maintenance phenotype.

222 r pipe smoking, and misperceptions about the addictive potential and potential adverse health effects

223 sed as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic.

224 V on COT, opioid misuse and awareness of the addictive potential of COT are common, yet COT monitorin

225 e may be increasing among youth, however the addictive potential of pregabalin has not been well esta

226 e of the major obstacles is the cocaine-like addictive potential of the agonists themselves.

227 ing behavior, suggesting significantly lower addictive potential than cocaine.

228 Methamphetamine (METH) is a drug with a high addictive potential that is widely abused across the wor

229 demonstrate antidepressant activity without addictive potential.

230 the mouse mesolimbic DA system to drugs with addictive potential.

231 tor, speculated to have a role in nicotine's addictive potential.

232 Ninety percent acknowledged opioids' addictive potential.

233 nical benefit is limited by side effects and addictive potential.

234 and use of nicotine, the latter of which has addictive power and untoward effects.

235 Fentanyl is an addictive prescription opioid that is over 80 times more

236 We find that the addictive process is an extreme expression of aesthetic

237 selected clusters are highly relevant to the addictive process, including regions relevant to cogniti

238 te use in humans and highlight the potential addictive properties and harmful effects of chronic nico

239 produce unrivaled pain management, but their addictive properties can lead to severe abuse.

240 The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals(1).

241 otential participation of this system in the addictive properties of cannabinoids is unknown.

242 olimbic system are involved in mediating the addictive properties of chronic alcohol use.

243 cent brain is particularly vulnerable to the addictive properties of cocaine.

244 , which may contribute to the reinforcing or addictive properties of drugs of abuse.

245 ediate some of the reinforcing, aversive and addictive properties of drugs of abuse.

246 oward a better understanding of the proposed addictive properties of food, the components and the mec

247 responsible for mediating the analgesic and addictive properties of most clinically relevant opioid

248 e on a habenula-pancreas axis that links the addictive properties of nicotine to its diabetes-promoti

249 Tobacco smoking, driven by the addictive properties of nicotine, continues to be a worl

250 VTA) plays a key role in the reinforcing and addictive properties of opioids.

251 VTA) plays a key role in the reinforcing and addictive properties of opioids.

252 vity, a mechanism that may contribute to the addictive properties of the drug.

253 thought to be primarily responsible for the addictive properties of tobacco.

254 c natural product with psychoactive and anti-addictive properties(13,14).

255 nconsistent with its therapeutic effects and addictive properties, which are thought to be reliant on

256 treatment of severe pain conditions that has addictive properties.

257 s in the brain, leading to its rewarding and addictive properties.

258 se is limited due to its psychotomimetic and addictive properties.

259 d is a major target for both therapeutic and addictive psychostimulant amphetamines.

260 Methamphetamine (METH) is a powerfully addictive psychostimulant that has a pronounced effect o

261 Amphetamine is a highly addictive psychostimulant, which is thought to generate

262 anisms underlying the effects of this highly-addictive psychostimulant.

263 products usually contain nicotine, which is addictive, raising concerns about e-cigarette use and ni

264 t increased G9a expression in NAcSh enhances addictive-related and anxiety-related behaviors, indicat

265 bens shell (NAcSh) of male rats reduces both addictive-related and anxiety-related behaviors.

266 molecular events underlying the emergence of addictive responses remain unknown.

267 This overactivity may be associated with the addictive scratching and/or neural hypersensitization.

268 s is thought to critically contribute to the addictive state.

269 have important implications for learning in addictive states marked by elevated direct pathway activ

270 nvolved in the neurobiological regulation of addictive states, and of mood.

271 racterization of peptidomic regulation by an addictive substance along two distinct projection system

272 The initial response to an addictive substance can facilitate repeated use: That is

273 be the primary target of nicotine, the main addictive substance in cigarette smoking.

274 Nicotine, the main addictive substance in tobacco, is known to play a role

275 1) increase craving, impatience, and actual addictive substance use and 2) do so through mechanisms

276 with those that influence the rate at which addictive substance use is taken up during adolescence a

277 nd the first such analysis in humans for any addictive substance.

278 ., cola, soft drinks, and energy drinks) and addictive substances (nicotine, caffeine, alcohol, canna

279 However, it is not known how addictive substances alter the glutamatergic strength of

280 s at genetic risk for both escalating use of addictive substances and poor abilities to quit may prov

281 Addictive substances are known to increase dopaminergic

282 Alcohol and other addictive substances can remold neural circuits importan

283 atent class that displayed low use of common addictive substances during adolescence (P=0.0004) and (

284 Addictive substances elicit changes in brain circuitry i

285 Addictive substances mediate positive and negative state

286 large amounts of sugar also tend to use more addictive substances, but it is unclear whether this is

287 s of drug addiction: high motivation to seek addictive substances, despite adverse consequences, and

288 lity traits, intelligence, happiness, use of addictive substances, parental separation, age, and gend

289 eterminant underlying sensitivity to diverse addictive substances.

290 common genetic modulators of sensitivity to addictive substances.

291 lar to, but less strong than, the effects of addictive substances.

292 developmental trajectories of use of common addictive substances.

293 n of individuals who repeatedly seek and use addictive substances.

294 Here I discuss examples of these addictive symbiotic relationships and how they are a lik

295 and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain workshop convened scient

296 withdrawal has been linked to allostasis in addictive types.

297 partially effective and in some cases can be addictive, underscoring the need for better therapies.

298 These 2 effects may combine to explain the addictive use of levodopa after loss of midbrain dopamin

299 reating chronic pain, but opioids are highly addictive when repeatedly used because of their strong r

300 whereby marijuana could exert rewarding and addictive/withdrawal effects.