ライフサイエンスコーパス: adenosine A(2A) receptor

1 wakefulness by antagonizing function of the adenosine A2A receptor.

2 y cytokines most likely by activation of the adenosine A2a receptor.

3 in a high-resolution structure of the human adenosine A2A receptor.

4 occurred when PKA was activated through the adenosine A2a receptor.

5 egulates the macrophage response through the adenosine A2A receptor.

6 (or Galpha(olf)) coupled to dopamine D1 and adenosine A2A receptors.

7 n response to pharmacological stimulation of adenosine A2A receptors.

8 the NTS by way of activation of presynaptic adenosine A2a receptors.

9 ion by neutrophils via occupancy of specific adenosine A2A receptors.

10 lular adenosine and activation of Gs-coupled adenosine A2A receptors.

11 al spike patterns and requires activation of adenosine A2A receptors.

12 s T cell inhibition was mediated through the adenosine A(2A) receptor.

13 ligand interaction dynamics within the human adenosine A(2A) receptor.

14 drug design approaches as antagonists of the adenosine A(2A) receptor.

15 istent with the postsynaptic localization of adenosine A(2A) receptors.

16 as largely abolished through the blockade of adenosine A(2A) receptors.

17 Exercise hyperaemia is partly mediated by adenosine A(2A)-receptors.

18 r the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B rec

19 te dose of caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; diss

20 The adenosine A(2A) receptor (A(2A) R) is a potential drug t

21 hat nerve growth factor (NGF) down-regulates adenosine A(2A) receptor (A(2A)AR) mRNA in PC12 cells.

22 Adenosine A(2A) receptor (A(2A)R) agonists synergize wit

23 (TLR) 2, 4, 7, and 9 agonists, together with adenosine A(2A) receptor (A(2A)R) agonists, switch macro

24 l CICI, we revealed robust elevations in the adenosine A(2A) receptor (A(2A)R) and its downstream eff

25 ults showing that preferentially presynaptic adenosine A(2A) receptor (A(2A)R) antagonists counteract

26 model for GPCR signaling efficacy using the adenosine A(2A) receptor (A(2A)R) as a model system, und

27 Adenosine A(2A) receptor (A(2A)R) blockade enhances inna

28 ed to delineate key functional states of the adenosine A(2A) receptor (A(2A)R) complexed with heterot

29 Inactivation of the adenosine A(2A) receptor (A(2A)R) consistently protects

30 An association between a polymorphism of the adenosine A(2A) receptor (A(2A)R) encoding gene-ADORA2A,

31 The adenosine A(2A) receptor (A(2A)R) is a G-protein-coupled

32 The adenosine A(2A) receptor (A(2A)R) is abundantly expresse

33 The human adenosine A(2A) receptor (A(2A)R) is an integral membran

34 The adenosine A(2A) receptor (A(2A)R) is increasingly recogn

35 that SCD causes a 9- and 6-fold induction of adenosine A(2A) receptor (A(2A)R) mRNA in mouse pulmonar

36 and-modulated conformational dynamics of the adenosine A(2A) receptor (A(2A)R) on nanosecond to milli

37 Pharmacological activation of adenosine A(2A) receptor (A(2A)R) or optogenetic activat

38 We previously reported that the adenosine A(2A) receptor (A(2A)R) specific agonist, ATL1

39 tes that lie along the activation pathway of adenosine A(2A) receptor (A(2A)R), a class A GPCR.

40 Herein, we focus on the human adenosine A(2A) receptor (A(2A)R), a model GPCR that for

41 Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an imp

42 Adenosine A(2A) receptor (A(2A)R)-dependent signaling in

43 ld be referred from the activating effect of adenosine A(2A) receptor (A(2A)R).

44 in the serial femtosecond crystallography of Adenosine A(2A) receptor (A(2A)R).

45 tal structures of the thermostabilized human adenosine A(2A) receptor (A(2A)R-GL31) bound to its endo

46 Deletion of adenosine A(2A) receptors (A(2A)ARs) has been reported t

47 latory coupling of dopamine D(1) (D(1)R) and adenosine A(2A) receptors (A(2A)R) to adenylyl cyclase w

48 Adenosine A(2A) receptors (A(2A)Rs) are highly enriched

49 The function of striatal adenosine A(2A) receptors (A(2A)Rs) is well recognized b

50 f adenosine or alterations in the density of adenosine A(2A) receptors (A(2A)Rs) or their degree of f

51 direct pathway neurons of the NAc expressing adenosine A(2A) receptors (A(2A)Rs) to induce SWS.

52 The adenosine A2A receptor (A(2A)R) plays a key role in tran

53 adenosine receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurod

54 The duration of action of adenosine A2A receptor (A2A) agonists is critical for th

55 ese regions also have the highest density of adenosine A2a receptors (A2a) in the brain.

56 Adenosine A(2A) receptor (A2AR) activation triggers Akt

57 Adenosine A2A receptor (A2AR) activation in cartilage vi

58 We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung is

59 Adenosine A2A receptor (A2AR) agonists are known to pote

60 Adenosine A2A receptor (A2AR) agonists reduce invariant

61 Adenosine A2A receptor (A2AR) agonists with Toll-like re

62 inoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 recept

63 ced in the mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related ki

64 ith depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as cand

65 Endogenous adenosine acting at the adenosine A2A receptor (A2AR) can modify brain injury in

66 e describe the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formati

67 this study was to examine the regulation of adenosine A2A receptor (A2AR) gene expression during hyp

68 We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show th

69 The adenosine A2A receptor (A2AR) has long been implicated i

70 nvestigated the specific requirements of the adenosine A2A receptor (A2AR) in mature adipocytes for t

71 ealed a 43-fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared

72 The adenosine A2A receptor (A2AR) is a particularly interest

73 The adenosine A2A receptor (A2AR) is a potent anti-inflammat

74 The adenosine A2A receptor (A2AR) is expressed in lymphatic

75 We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bon

76 thanol-induced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their w

77 ll molecule pharmacophore that activates the adenosine A2A receptor (A2AR) linked to antibody fragmen

78 Activation of adenosine A2A receptor (A2AR) promotes fibrosis and coll

79 Adenosine A2a receptor (A2aR) signaling acts as a barrie

80 Here, we show the necessity of adenosine A2A receptor (A2AR) signaling and the GSH/GPX4

81 Synergy between Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macroph

82 racellular adenosine resulting in diminished adenosine A2A receptor (A2AR) stimulation and altered ch

83 Adenosine A2A receptor (A2AR) stimulation promotes wound

84 umans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in t

85 e reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as re

86 sed basal synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plastic

87 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R)

88 to investigate the mechanism underlying the adenosine A2a receptor (A2aR)-mediated positive inotropi

89 sity and morphology, and upregulation of the adenosine A2A receptor (A2AR).

90 Activation of adenosine A2A receptors (A2AR) has been shown to antagon

91 Adenosine A2A receptors (A2AR) modulate dopamine and glu

92 Striatal adenosine A2A receptors (A2AR) play an essential role in

93 Although T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activ

94 lated by several modulators, among which are adenosine A(2A) receptors (A2ARs) and Wingless/Integrate

95 Cerebral adenosine A2A receptors (A2ARs) are attractive therapeut

96 Adenosine A2A receptors (A2ARs) are enriched in the stri

97 Adenosine A2A receptors (A2ARs) are highly expressed in

98 Since adenosine A2A receptors (A2ARs) control lysosome traffic

99 d reference memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic pla

100 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or

101 Indeed, pharmacological inhibition of adenosine A2A receptors (A2ARs) significantly reverses S

102 Activation of adenosine A2A receptors (A2ARs) stimulates bone formatio

103 ladenant) was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.

104 ced by lymphocyte depletion or activation of adenosine A2A receptors (A2ARs) with the selective agoni

105 We recently found that adenosine A2A receptors (A2ARs), which control synaptic

106 lzheimer's disease through the antagonism of adenosine A2A receptors (A2ARs).

107 CRs): the beta-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA2AR), and the sphingosine 1-

108 tivation/deactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A

109 h pathways were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.

110 derably in their responsiveness to selective adenosine A(2A) receptor activation, the phosphorylation

111 Instead, adenosine A2A receptor activation of G alpha(s/olf) seem

112 However, the combination of adenosine A2A receptor activation with either isoflurane

113 induced a better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditi

114 Through adenosine A2A receptor activation, MTX promotes reverse

115 volve CaMKII inhibition, but may not involve adenosine A2A receptor activation.

116 Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice

117 Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-induci

118 Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA

119 any of its effects via antagonist binding to adenosine A2a receptors (ADORA2A).

120 ntracellular cyclic AMP (cAMP) increase upon adenosine A(2A) receptor agonism by CGS21680 (CGS).

121 remia induced by intravenous infusion of the adenosine A(2A) receptor agonist ATL-146e (0.3 micro g/k

122 behavioral and neurochemical effects of the adenosine A(2A) receptor agonist CGS 21680 [2-p-(2-carbo

123 An adenosine A(2a) receptor agonist did not alter the local

124 evidence that an exogenous agent such as an adenosine A(2A) receptor agonist increases neovasculariz

125 5'-N-ethylcarboxamidoadenosine(CGS 21680; an adenosine A(2A) receptor agonist).

126 Specifically, the adenosine A(2A) receptor agonist, CGS 21680, was used to

127 carboxamido-adenosine (CGS21680), a specific adenosine A(2A) receptor agonist, modestly increases VEG

128 on in wounds, we sought to determine whether adenosine A(2A) receptor agonist-augmented wound healing

129 ffeine on the vasodilatory properties of the adenosine A(2A)-receptor agonist ATL-146e (ATL).

130 ATL is a new adenosine A(2A)-receptor agonist proposed as a vasodilat

131 agonist N6-cyclohexyladenosine (CHA) or the adenosine A2a receptor agonist 2-[(2-aminoethylamino)car

132 In contrast, the adenosine A2A receptor agonist 2-p-(2-carboxyethyl)-phen

133 Pretreatment with the adenosine A2a receptor agonist APEC, but not the adenosi

134 The selective adenosine A2A receptor agonist binodenoson results in an

135 nosine and a second study with the selective adenosine A2A receptor agonist binodenoson, using 1 of 4

136 PA (2-chloro-N6-cyclopentyladenosine) or the adenosine A2A receptor agonist CGS 21680 (2-p-(2-carboxy

137 We hypothesized that a selective adenosine A2A receptor agonist would induce coronary vas

138 in maximal vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the co

139 arboxamidoadenosine (CGS 21680), a selective adenosine A2a receptor agonist, for 5 min prior to the S

140 that involves the synergistic interaction of adenosine A(2A) receptor agonists through A(2A) receptor

141 idence indicates that topical application of adenosine A(2A) receptor agonists, unlike growth factors

142 e on pharmacologic stress using adenosine or adenosine A(2A)-receptor agonists should be evaluated in

143 e suppresses aPL Ab-mediated NETosis via the adenosine A(2A) receptor and mitigates venous thrombosis

144 acological signature consistent with that of adenosine A(2A) receptors and are expressed at similar l

145 The adenosine A2A receptor and PDE2, 3, 4, and 7 are importa

146 These effects are mediated via the adenosine A2A receptor and protein kinase A (PKA).

147 VEGF gene expression through stimulation of adenosine A2a receptor and subsequent activation of the

148 ly explained by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptor

149 a partner for the carboxyl-terminal tail of adenosine A2A receptors and showing that this interactio

150 ckade of a transactivation pathway that uses adenosine A2a receptors and src-family kinases (SFKs).

151 bbles by 70% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids ha

152 in response to adenosine (via activation of adenosine A2A receptors) and to further determine the si

153 cleus accumbens also contain high numbers of adenosine A(2A) receptors, and, for that reason, the beh

154 TrkB, adenosine A2a receptors, and SFKs associate into complex

155 re significantly attenuated by the selective adenosine A(2A) receptor antagonist 4-(2-{7-amino-2-(2-f

156 's disease (PD) pathophysiology, a selective adenosine A(2A) receptor antagonist, istradefylline, sho

157 The adenosine A2a receptor antagonist 8-(3-chlorostyryl)caff

158 kade of glutamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blo

159 present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002

160 aling downstream of CD39 using the selective adenosine A2a receptor antagonist istradefylline.

161 The novel adenosine A2A receptor antagonist KW-6002 has been exami

162 Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[

163 Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor fu

164 pentyl-1,3-dipropylxanthine), or a selective adenosine A2A receptor antagonist ZM 241385.

165 en demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited

166 te mice, C57BL/6 mice, and mice treated with adenosine A2A receptor antagonist.

167 1 receptor antagonist but not by a selective adenosine A2A receptor antagonist.

168 hibitory effects were reduced by addition of adenosine A2A receptor antagonist.

169 mine D2 receptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.

170 Adenosine A(2A) receptor antagonists are psychomotor sti

171 Adenosine A(2a) receptor antagonists reduce symptom seve

172 been demonstrated to be potent and selective adenosine A(2a) receptor antagonists with oral activity

173 esulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1

174 Adenosine A2A receptor antagonists provide a promising n

175 These results suggest that selective adenosine A2A receptor antagonists represent a new class

176 structural information for the discovery of adenosine A2A receptor antagonists that have potential t

177 Thus, accumbens adenosine A(2A) receptors appear to regulate behavioral

178 The adenosine A(2A) receptor appears required for neurotoxic

179 Results of biophysical mapping of the adenosine A(2A) receptor are presented.

180 Adenosine A(2A) receptors are colocalized with D(2) rece

181 Adenosine A(2A) receptors are predominantly expressed in

182 Adenosine A(2A) receptors are preferentially expressed i

183 ly expressed in striatonigral neurons, while adenosine A2a receptors are preferentially expressed in

184 tissue-nonspecific alkaline phosphatase, and adenosine A2a receptors are significantly increased in d

185 While it is well-known that dopamine D2 and adenosine A2a receptors bi-directionally regulate iSPN p

186 A receptor ligand, showed that the number of adenosine A2A receptor binding sites was similarly incre

187 the crystal structure of an engineered human adenosine A(2A) receptor bound to a partial agonist and

188 Activation of adenosine A(2A) receptors can broadly inactivate inflamm

189 Here we report that selective agonism of the adenosine A(2A) receptor (CGS21680) suppresses aPL Ab-me

190 We therefore examined whether adenosine A2A receptors contribute to the pathogenesis o

191 Adenosine A2A receptor-deficient and A2A receptor antago

192 leomycin-induced dermal fibrosis model using adenosine A2A receptor-deficient wild-type littermate mi

193 These results indicate that stimulating adenosine A(2A) receptors diminishes BSR without produci

194 Stimulation of accumbens adenosine A(2A) receptors disrupted performance of an in

195 Herein we describe adenosine A2A receptor distribution, signaling pathways,

196 ha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (

197 Finally, Western blot analysis of adenosine A(2A) receptor expression indicated that the s

198 ter, and adenosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.

199 protein-coupled receptors (GPCR), the human adenosine A(2A) receptor (hA(2A)AR) remains an attractiv

200 olution X-ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric

201 The adenosine A2A receptor has emerged as an attractive non-

202 agonist- and agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a

203 xperimentally enabled homology models of the adenosine A(2A) receptor, identifying a diverse range of

204 that project to the ventral pallidum showed adenosine A(2A) receptors immunoreactivity.

205 Adenosine A2A receptor immunoreactivity (A2A-LI) has bee

206 (PD), we determined whether deletion of the adenosine A(2A) receptor in knockout (KO) mice protects

207 that HIF-2alpha but not HIF-1alpha regulates adenosine A(2A) receptor in primary cultures of human lu

208 Future studies on the role of adenosine A(2A) receptors in CSR-induced GM plasticity a

209 ccurately define the spatial distribution of adenosine A(2A) receptors in fetal sheep diencephalon, w

210 tory cytokines on function and expression of adenosine A(2A) receptors in the human monocytic cell li

211 ant implications for the functional roles of adenosine A(2A) receptors in the thalamus and pineal of

212 ut not A(2A)-/- mice, confirming the role of adenosine A(2A) receptors in this pathway.

213 collagen production after stimulation of the adenosine A2A receptor in a dose-dependent fashion.

214 Blockade of the adenosine A2A receptor in striatopallidal neurons reduce

215 s- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, el

216 Adenosine A2A receptors in striatum are selectively loca

217 It was also apparent that this population of adenosine A2a receptors in the NTS desensitized within 2

218 An antagonist selective for adenosine A(2A) receptors induced feeding and locomotion

219 These results show that adenosine A2A receptor-induced protection is most likely

220 sine is an immunosuppressive nucleoside, and adenosine A(2A) receptors inhibit T-cell activation.

221 ncology despite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson d

222 on pathways by which occupancy of neutrophil adenosine A2A receptors inhibits superoxide anion genera

223 Thus, targeting the adenosine A(2A) receptor is a novel approach to promotin

224 The adenosine A2A receptor is a G-protein-coupled receptor (

225 The adenosine A2A receptor is a prototypical rhodopsin-like

226 The cerebral adenosine A2A receptor is an attractive therapeutic targ

227 VHD, and the pharmacologic activation of the adenosine A2A receptor is protective.

228 -isomer (Sp-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC

229 nosine) on wound closure and angiogenesis in adenosine A(2A) receptor knockout mice and their wild-ty

230 Wild-type (WT), A(2A)AR(-/-) (adenosine A(2A) receptor knockout), A(2B)AR(-/-) (adenos

231 de novo molecules contain known or promising adenosine A(2A) receptor ligand chemistry that is not av

232 ntially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selecti

233 Adenosine A2A receptor ligation stimulated ERK phosphory

234 We observed that the striatal adenosine A2A receptor links adenosine tone and psychomo

235 ening inflammation through signaling via the adenosine A2A receptor may limit tissue damage but may a

236 termine the signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen pr

237 cological inhibitors of signal transduction, adenosine A2A receptor-mediated stimulation of procollag

238 al-regulated kinase (erk), but surprisingly, adenosine A2A receptor-mediated stimulation of procollag

239 The adenosine A2a receptor mediates a new cyclic AMP-indepen

240 tributes to the development of OA; targeting adenosine A2A receptors might treat or prevent OA.

241 ese studies were to determine the effects of adenosine A(2A) receptor modulation in the NAc on cocain

242 Adenosine A2A receptor occupancy promoted collagen produ

243 pression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells gen

244 The adenosine A(2A) receptor pharmacologic signature of the

245 rior studies indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis b

246 These results demonstrate that adenosine A2A receptors play an active role in the patho

247 ted adenosine can trigger a cAMP response in adenosine A(2A) receptor-positive but not A(2A) receptor

248 Pharmacological blockade of adenosine A(2A) receptors precluded the alpha(1)AR-induc

249 egulates inflammation and tissue repair, and adenosine A2A receptors promote wound healing by stimula

250 We have recently reported that activation of adenosine A(2A) receptors promotes collagen synthesis by

251 affeine and more specific antagonists of the adenosine A(2A) receptor recently have been found to be

252 aspartate (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD

253 on, we demonstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that

254 The adenosine A(2A) receptor-selective agonists 2-p-(2-carbo

255 Selective agonism of the adenosine A2A receptor should result in a similar degree

256 These results indicate that adenosine A2A receptors signal for increased collagen pr

257 e physiological and behavioral correlates of adenosine A(2A) receptor signaling have been extensively

258 PKA were evaluated as potential mediators of adenosine A(2A) receptor signaling in the striatum.

259 2 (CK2) negatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.

260 tivity, reducing EAAT2 function or enhancing adenosine/A2a receptor signaling.

261 27-hydroxylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.

262 f the following PKA targets is responsive to adenosine A(2A) receptor stimulation in this tissue: Ser

263 and this modulation is primarily through the adenosine A2a receptor subtype.

264 cal GPCRs with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor an

265 latory response is mediated primarily by the adenosine A2A receptors, these side effects result from

266 he contributions of endogenous adenosine and adenosine A(2A) receptors to skin fibrosis.

267 immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in acti

268 high affinity and excellent selectivity for adenosine A(2a) receptor versus the adenosine A(1) recep

269 (1) and beta(2) adrenergic receptors and the adenosine A(2a) receptor were determined in the antagoni

270 of D(2)R (dopamine receptor D2) and A(2A)R (adenosine A(2A) receptor) were used to study the role of

271 report the discovery of an acid sensor, the adenosine A2a receptor, which can be activated solely by

272 A minority of microglia expressed the adenosine A2A receptor, which has been linked with proce

273 on of Th1 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for th

274 esent study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A