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1 ium of Neuro-2A cells or intracellularly via adenoviral 7B2 overexpression, blocked the neurocytotoxi
7 selected and cloned into nonhuman Great Ape Adenoviral and Modified Vaccinia Ankara vectors to gener
12 on, squirrel monkeys given ICV injections of adenoviral BDNF/noggin showed similar addition of striat
16 -office test can prevent the misdiagnosis of adenoviral conjunctivitis that leads to the spread of di
17 Hopkins Hospital with signs and symptoms of adenoviral conjunctivitis underwent evaluation by nurse
20 then randomized to targeted injection of an adenoviral construct (10 muL; 8x10(9) plaque forming uni
22 e present study, injections of Cre-dependent adenoviral constructs were targeted to the ventrolateral
23 v/Wv mice by either intrabursal injection of adenoviral Cre or inclusion of the MISR2-Cre transgene a
25 KRAS(G12D) in the lung by nasal delivery of adenoviral Cre recombinase (Cre), here we show that KRAS
27 ograde pancreatic ductal injection of either adenoviral-Cre or lentiviral-Cre vectors allows titratab
28 n lung cells by intratracheal infection with adenoviral-Cre particles generated hyperplasias in all r
33 Increasing nuclear abundance of p27(kip1) by adenoviral delivery decreases the proliferative response
34 ression or downregulation was achieved using adenoviral delivery of CADM1 short hairpin RNAs or isofo
35 Tumorigenesis was triggered by intravenous adenoviral delivery of Cre recombinase in transgenic mic
36 We determined as a proof-of-principle that adenoviral delivery of CRISPR/Cas9 is capable of correct
39 ortality during hyperoxia, and lung-targeted adenoviral delivery of Hsp70 effectively rescues both Hs
40 e pulmonary disease airway disease utilizing adenoviral delivery of IL-1beta to determine that adapti
41 pecific goal of the study was to evaluate if adenoviral delivery of LOXL2 is anabolic to human and mo
42 at HDACIs enhance MDA-7/IL-24 lethality, and adenoviral delivery of mda-7/IL-24 combined with tumor-s
46 sponse to VEGF, administered via intradermal adenoviral delivery or through systemic injection of rec
48 f using a KSHV LANA-targeted CRISPR-Cas9 and adenoviral delivery system to disrupt KSHV latency in in
52 ural and nonstructural proteins, can prevent adenoviral dissemination and provide a novel method to m
54 observed that endothelial cells responded to adenoviral DNA by phosphorylation of ATM and CHK2 and th
55 of DNA damage that can also be activated by adenoviral DNA, and on IRF1, a transcriptional regulator
56 s decreased in ApoER2(-/-) mice, and whereas adenoviral-driven apoE3 expression in wild-type mice has
57 efine a novel function of the antiapoptotic, adenoviral E1B 19K protein that may limit local host inn
61 r cells expressing MDA-7/IL-24, in which the adenoviral early region 1A (E1A) gene was driven by the
62 ed induced pluripotent stem cells and during adenoviral editing of mice, paving the way for in situ o
65 pharmacological inhibitor BI-D1870 or after adenoviral expression of a dominant negative RSK1 mutant
66 f ischemic skin flaps, which was reversed by adenoviral expression of ANKRD1, and delayed excisional
68 prevented in cultured human chondrocytes by adenoviral expression of catalase targeted to the mitoch
69 ion of a CF airway cell line (CF15 cells) by adenoviral expression of CFTR reduced the activation of
71 n and increased BK-beta1 expression, whereas adenoviral expression of MuRF1 in mouse coronary arterie
72 VEGF neutralization in mice, accomplished by adenoviral expression of soluble Flt1, resulted in 7-fol
73 in vivo attenuation of caspase activity via adenoviral expression of the biologic effector caspase i
78 liver 5 x 10(13) total viral particles of an Adenoviral firefly luciferase vector with a cytomegalovi
79 ng cultured neonatal rat cardiomyocytes with adenoviral gene delivery and pharmacological inhibitors,
83 ad candidates for their capacity to increase adenoviral gene expression in an orthotopic in vivo mode
84 irst time that cationic polymers can enhance adenoviral gene expression in an orthotopic model of bla
85 o determine if cationic polymers can enhance adenoviral gene expression in cells that are difficult t
86 polymer NPGDE-1,4 Bis significantly enhanced adenoviral gene expression in the orthotopic model of bl
87 ide-based polymer paromomycin-BGDE, enhanced adenoviral gene expression within the bladder without ad
88 ly, further overexpression of vasohibin-1 by adenoviral gene transfer exerts multifold beneficial eff
91 cyte canalicular expression of hAQP1 through adenoviral gene transfer promotes biliary BS output by m
94 owing heterologous expression in myocytes by adenoviral gene transfer, wild-type telethonin became bi
96 E1A expression translates into inhibition of adenoviral genome replication, infectious particle produ
100 Recent work has shown that helper-dependent adenoviral (hdAD) vector-mediated plasma CocH reduced th
102 using ROSA(mTmG);Wt1(CreER) mice showed that adenoviral hSCF treatment increased Wt1(+) lineage-deriv
104 une responses to HAdV.IMPORTANCE An emergent adenoviral human pathogen, HAdV-B76, associated with a f
105 DC chemokine receptor ccr6 both protect from adenoviral IL-1beta-induced airway adaptive T cell immun
106 e insertion of artificial aptazymes into the adenoviral immediate early gene E1A enables small-molecu
107 tivity and PCR were employed to quantify the adenoviral inactivation rates using narrow bands of irra
115 ed using its specific inhibitor AS1842856 or adenoviral infection of constitutively active FOXO1.
116 inducing reactive oxygen species (ROS) after adenoviral infection of mda-7/IL-24 leads to greater tra
118 imental murine AIH (emAIH) by a self-limited adenoviral infection with the hepatic autoantigen formim
120 /2 phosphorylation remained unchanged during adenoviral infection, suggesting specificity of JNK acti
121 ion was induced at a magnitude comparable to adenoviral infection, suggesting that AQP1 is primarily
123 es of graft failure, cytomegalovirus, and/or adenoviral infections and transplant-related mortality a
124 stream pathways mediate these Ito,f changes, adenoviral infections were used to inhibit CaMKIIdeltac,
127 siRNA; affecting FGFR3-IIIb and -IIIc) or an adenoviral kinase-dead FGFR3-IIIc construct (kdFGFR3).
130 as applied as an imaging reporter to monitor adenoviral liver transduction with both nuclear and opti
132 protected from pulmonary fibrosis induced by adenoviral-mediated expression of active TGF-beta1.
133 ty and pain in a model of cystitis caused by adenoviral-mediated expression of claudin-2 (Cldn2), a t
134 Effects of vasohibin-1 overexpression by adenoviral-mediated gene transfer on angiogenesis, fibro
135 xtent similar to isoproterenol exposure, and adenoviral-mediated knockdown of Epac1 prevented isoprot
141 e role of versican, a vitreous component, in adenoviral-mediated transgene expression was examined.
145 NF-kappaB activation involve infection of an adenoviral NF-kappaB-luciferase reporter into cell lines
151 This reduced expression was not restored by adenoviral overexpression of BiP (immunoglobulin-binding
153 d endothelial cells, metformin treatment and adenoviral overexpression of constitutively active AMPK
155 on was impaired in CREBH-deficient mice, and adenoviral overexpression of FGF21 suppressed adipose ti
157 e decreased the vascular leakage compared to adenoviral overexpression of green fluorescent protein.
159 Using therapeutic silencing of miR-33 and adenoviral overexpression of miR-33, we show that miR-33
160 gely non-amyloidogenic degradation products, adenoviral overexpression of MMP-9 in amyloid-prone isle
166 t3 ablation sensitized mice to NASH, whereas adenoviral overexpression of Sirt3 alleviated the NASH p
171 Through a series of genetic silencing and adenoviral overexpression studies, we have defined GLUT1
172 parent absence and then reemergence of human adenoviral pathogens, as well as present pathways for th
174 h the PLD product, phosphatidic acid (PA) or adenoviral PLD1 expression in Pld1(-/-) hepatocytes, con
176 er proteins, maturational proteolysis by the adenoviral protease leads to the differential release of
177 nhanced inactivation at low wavelengths with adenoviral protein damage at those wavelengths, adding f
178 define a new function of the antiapoptotic, adenoviral protein E1B 19K, which we have termed "apopto
180 This research shows UV-induced damage to adenoviral proteins across the germicidal UV spectrum at
181 is and by promoting exit from mitosis, these adenoviral proteins act to prevent the infected cell fro
185 Additionally, the presence of a critical adenoviral replication element found in HAdV genomes, in
190 and the immunity induced by the recombinant adenoviral RSV vaccine administered by use of an intramu
193 Importantly, acute hepatic knockdown by adenoviral shRNA targeting G9a abolishes Fgf21 repressio
200 t examinations should take measures to avoid adenoviral spread from contaminated handheld equipment.
202 Furthermore, overexpression of miR-133b via adenoviral system in vitro led to decreased CTGF express
204 r497/495 was reversed by micro-calpsiRNA and adenoviral transduced dominant negative protein kinase C
206 ukocytes from 112 Hispanic patients by using adenoviral transduction and 24-h culture, with quantitat
209 ression of desmin or vimentin was induced by adenoviral transduction to examine the sufficiency of in
210 We overcame this obstacle through in vivo adenoviral transduction with matrix-targeted photoactiva
213 d through transgenic overexpression of TFF2, adenoviral transfer of TFF2 or transplantation of TFF2-e
214 and prolonged following vaccination with an adenoviral vaccine encoding GP linked to Ii compared wit
217 the lymphatic network in the defected area, adenoviral vascular endothelial growth factor C (VEGF-C)
218 clones, gene correction by helper-dependent adenoviral vector (HDAdV) or Transcription Activator-Lik
219 er vaccination with a rhesus macaque-derived adenoviral vector (simian adenovirus 7 [SAdV-7]) enhance
221 rus receptor (sCAR-Fc) was expressed from an adenoviral vector and 2 short hairpin RNAs (shRdRp2.4) d
224 nfection strategies and provide insights for adenoviral vector development and structure-based design
225 thway, rats were intravenously injected with adenoviral vector encoding a decoy VEGF receptor (Ad-Flk
226 ritic cells transduced with the adjuvant, an adenoviral vector encoding a dominant negative isoform o
227 Intranodally injected adenoviral VEGF-C and adenoviral vector encoding control gene LacZ induced mac
228 neural targets of the VMHdm by injecting an adenoviral vector encoding Cre recombinase (Cre)-regulat
229 e demonstrated that intratumoral delivery of adenoviral vector encoding single-chain (sc)IL-23 (Ad.sc
230 lymphoblastoid cell lines transduced with an adenoviral vector expressing either LMP2 alone (n = 17)
231 genital administration of an IL-4-expressing adenoviral vector greatly increased in vivo ESC prolifer
233 er vaccination with a rhesus macaque-derived adenoviral vector in rhesus macaques enhances mucosal CD
234 The results showed that vaccination with an adenoviral vector indeed increases activation of mucosal
236 o/fl) and Flna (o/fl)/ LC mice with AdPCSK9 (adenoviral vector overexpressing proprotein convertase s
237 that a genetically engineered RSV-F-encoding adenoviral vector provides protective immunity against R
238 cancer cell line (HT29) transfected with an adenoviral vector that expressed Ad VP16hLXRalpha, compa
239 ght on this, we developed a helper-dependent adenoviral vector that expresses the genetically encoded
242 in preBotC astrocytes bilaterally (using an adenoviral vector to specifically express tetanus toxin
243 perfusion strategy, optimized for efficient Adenoviral vector transduction, was utilized to deliver
244 hese data implicate versican G1 in enhancing adenoviral vector transgene expression in a hyaluronic a
245 intracerebroventricular (ICV) delivery in an adenoviral vector triggers the addition of new neurons t
247 Therefore, we created a helper-dependent adenoviral vector with the mitochondria-targeting peroxi
248 often retain wild type p53, we developed an adenoviral vector, AdRGD-PG, which provides robust trans
255 ose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike pr
257 patients were vaccinated using heterologous adenoviral vectors (ChAd3-NSmut and Ad6-NSmut) encoding
260 ssed and CD63 was knocked down in mice using adenoviral vectors AdTIMP1 or AdshCD63, respectively.
261 t liver detargeting and tumor retargeting of adenoviral vectors after coating with synthetic dendrime
264 n astrocytes of mouse cortex by injection of adenoviral vectors containing a strong and astrocyte-spe
266 ly reduced by cotreatment with sorafenib and adenoviral vectors encoding hOCT1 under the control of t
267 in vitro experiments with HSCs infected with adenoviral vectors encoding LacZ, Dyn2K44A, or Dyn2WT.
268 B/c (L. monocytogenes-susceptible) mice with adenoviral vectors encoding natural L. monocytogenes-der
269 ion of XBP1 was knocked down by injection of adenoviral vectors encoding small hairpin RNAs against X
271 and why this is so, we have generated potent adenoviral vectors encoding the endogenous tumor Ags (TA
274 ERS-CoV infection by prior transduction with adenoviral vectors expressing the human host-cell recept
275 xpressing Cyclo-oxygenase-2 by 600-fold, and adenoviral vectors expressing the pro-apoptotic gene Bax
276 o overcome these hurdles in order to develop adenoviral vectors for combination of systemic oncolytic
277 antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors.
280 SK-N-DZ neuroblastoma cells transduced with adenoviral vectors in the presence of versican respond w
281 Chronic central administration of MCH and adenoviral vectors increasing MCH signaling were perform
282 nd suggest that E1B 19K-deleted, replicating adenoviral vectors might induce greater inflammatory res
283 king the kappa opioid receptor (kappaOR) and adenoviral vectors overexpressing or silencing kappaOR w
286 lymphocytic choriomeningitis virus model and adenoviral vectors to compare a vaccine expressing unmod
288 lls (HUVEC) were transduced with recombinant adenoviral vectors to express wild-type, constitutively
290 induced by the brain delivery of recombinant adenoviral vectors with neuronal-specific expression of
291 Importantly, via its compatibility with adenoviral vectors, pMAGIC uniquely enables use of dCas9
298 ii) ear angiogenic responses to intradermal adenoviral-VEGF injection, and iii) vascular flow recove
299 tivation profiles and binding affinities for adenoviral virus-associated RNA I (VA RNAI) and HIV-1 tr