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1 nt for the catalytic activity of B. subtilis adenylosuccinate lyase.
2 41 is the reaction product of 6-BDB-TAMP and adenylosuccinate lyase.
3 the substrate binding site of rabbit muscle adenylosuccinate lyase.
6 n followed by mass spectrometry, we identify adenylosuccinate lyase (ADSL) as an EglN2 hydroxylase su
8 a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated
10 alysis confirmed that fumarate, generated by adenylosuccinate lyase (ADSL) in the de novo purine synt
12 d Arg(301) are indispensable to catalysis by adenylosuccinate lyase and probably interact noncovalent
13 ate sites in adenylosuccinate synthetase and adenylosuccinate lyase and to regulatory sites of glutam
16 Both adenylosuccinate synthetase (ADSS) and adenylosuccinate lyase (ASL) have been identified as vit
20 ygous for two mutations in the gene encoding adenylosuccinate lyase (ASL), resulting in the protein m
22 studies suggest that 2-BDB-TAMP inactivates adenylosuccinate lyase by specific reaction at the subst
25 show here for the first time that wild-type adenylosuccinate lyase exhibits a protein concentration
29 re of the tetrameric assembly are similar to adenylosuccinate lyase from the thermophilic eubacterium
32 esidue Glu275 (both His141 and Glu275 are in adenylosuccinate lyase numbering), acts as the general b
37 Through its dual action in this pathway, adenylosuccinate lyase plays an integral part in cellula
38 ase (hpt), adenylosuccinate synthase (purA), adenylosuccinate lyase (purB), auxiliary protein (nrdI),
39 he de novo purine biosynthesis pathway, ASL (adenylosuccinate lyase, Step 8) and ATIC (5-aminoimidazo
42 ying His141 in the substrate-binding site of adenylosuccinate lyase, where it may serve as a general
43 position 276 result in structurally impaired adenylosuccinate lyases which are assembled into defecti