ライフサイエンスコーパス: adenylyl

1 ses, including membrane-integral and soluble adenylyl and guanylyl cyclases, are central components i

2 amp enzyme conformations locked by either 5'-adenylyl beta,gamma-imidodiphosphate or the anticancer d

3 GRK5 in complex with the ATP analog 5'-adenylyl beta,gamma-imidodiphosphate or the nucleoside s

4 pha A486V crystallized in the presence of 5'-adenylyl beta,gamma-imidodiphosphate.

5 h a nonhydrolyzable ATP analog, adenosine 5'-adenylyl-beta,gamma-imidodiphosphate (AMP-PNP), was dete

6 ivity and activation by the weak agonist, 5'-adenylyl-beta,gamma-imidodiphosphate (AMP-PNP).

7 in four catalytically relevant complexes, 5'-adenylyl-beta,gamma-imidodiphosphate (AMPPNP).Mg(2+), AM

8 2 bound to the nonhydrolyzable ATP analog 5'-adenylyl-beta,gamma-imidodiphosphate exhibits altered DN

9 Adenylyl cyclase (AC) activity relies on multiple effect

10 2 receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosin

11 le cells, prostaglandin E2 (PGE2) stimulates adenylyl cyclase (AC) and attenuates the increase in int

12 ptake inhibitors, SSRIs) treatment increased adenylyl cyclase (AC) and BDNF gene expression in LCLs.

13 I-induced SA requires continuing activity of adenylyl cyclase (AC) and cAMP-dependent protein kinase

14 eptors via D4 receptors (D4R), which inhibit adenylyl cyclase (AC) and reduce PKA activity.

15 Here, adenylyl cyclase (AC) and the alpha-subunit of the AC-st

16 Adenylyl cyclase (AC) converts ATP into cyclic AMP (cAMP

17 There are abundant adenylyl cyclase (AC) coupled GPCRs for these neuromodul

18 cAMP analogues and stimulation of adenylyl cyclase (AC) directly or through G-protein-coup

19 CyaA bears an N-terminal adenylyl cyclase (AC) domain linked to a pore-forming RT

20 Although the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenos

21 g heterotrimeric Gi/Go proteins resulting in adenylyl cyclase (AC) inhibition.

22 Several adenylyl cyclase (AC) isoforms could mediate cAMP accumu

23 Membrane-bound adenylyl cyclase (AC) isoforms have distinct regulatory

24 We have previously identified a subset of adenylyl cyclase (AC) isoforms that interact with Yotiao

25 acts not only with PKA but also with various adenylyl cyclase (AC) isoforms.

26 th a G(alphas) inhibitor and an inhibitor of adenylyl cyclase (AC) prevented stimulating effects of O

27 PTH activates adenylyl cyclase (AC) through PTH 1 receptors and stimul

28 Adenylyl cyclase (AC) toxin is an essential toxin that a

29 n mammalian cells, an intramitochondrial CO2-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A

30 ncrease was blocked by G15, linking GPR30 to adenylyl cyclase (AC).

31 0 facilitates a complex containing TPRV1 and adenylyl cyclase (AC).

32 dorant receptor response was not mediated by adenylyl cyclase (AC)/cyclic nucleotide-gated (CNG) chan

33 anion exchanger 2 (Cl(-) /HCO3 (-) AE2), and adenylyl cyclase (AC)8 (proteins regulating large biliar

34 coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.

35 udy in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3) in MDD.

36 reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in hear

37 Intriguingly, type III adenylyl cyclase (ACIII), a key protein in olfactory sig

38 We found that SSTR3 and type III adenylyl cyclase (ACIII), proteins normally enriched in

39 ntify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, l

40 sion protein consisting of a light-activated adenylyl cyclase (bPAC) and luciferase (nLuc).

41 enic mouse model expressing a photoactivated adenylyl cyclase (bPAC) in sperm.

42 The failure of cells lacking adenylyl cyclase (cyr1Delta) to form hyphae has suggeste

43 We hypothesized that a photoactivatable adenylyl cyclase (PAC) can be employed to modulate cAMP

44 cAMP sources, involving the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane aden

45 Soluble adenylyl cyclase (sAC) is a novel source of cAMP subject

46 addition, the cAMP-producing enzyme soluble adenylyl cyclase (sAC) is expressed in pigment cells, an

47 study, significant overexpression of soluble adenylyl cyclase (sAC), an alternative source of cAMP, w

48 increased expression and activity of soluble adenylyl cyclase (sAC), an evolutionarily conserved bica

49 e Ca(2+)/HCO(3)(-)-sensitive enzyme, soluble adenylyl cyclase (sAC), links Ca(2+) influx in human cor

50 brane adenylyl cyclases (tmACs), and soluble adenylyl cyclase (sAC).

51 ly and biochemically distinct enzyme soluble adenylyl cyclase (sAC).

52 TASK, ROMK), and the bicarbonate-stimulated adenylyl cyclase (sAC).

53 d the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion c

54 mimics the action of the endogenous soluble adenylyl cyclase (SACY) that is required for motility an

55 ck gene Npas2, and the clock-controlled gene adenylyl cyclase 1 (Adcy1) in a subset of retinal gangli

56 gh frequency of calcium input is filtered by adenylyl cyclase 1 and phosphodiesterases in this pathwa

57 lase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiatio

58 ATF5 induces the transcription of adenylyl cyclase 3 (Adcy3), which relieves the UPR.

59 and that this was specifically dependent on adenylyl cyclase 5 (AC5) activity.

60 , whose synthesis is catalysed by the enzyme adenylyl cyclase 5 (AC5), which is itself regulated by t

61 ated basal ciliary cAMP level is a result of adenylyl cyclase 5 and 6 activity that depends on ciliar

62 this study, the fecal bacterial community of adenylyl cyclase 5 knock-out (AC5KO, n = 7) mice or thei

63 tan and pasireotide, which indirectly reduce adenylyl cyclase 6 (AC6) activity, have hence proven eff

64 enerated intestinal epithelial cell-specific adenylyl cyclase 6 (AC6) knockout mice to study its role

65 Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enrich

66 roximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) are both expressed

67 heterotrimeric G-protein subunit G(s) alpha, adenylyl cyclase 6, and activation of the cAMP-regulated

68 Binding of Ca(2+)-activated adenylyl cyclase 8 (AC8) to the N-terminus of ORAI1 posi

69 d for chemoattractant-mediated activation of adenylyl cyclase 9 (AC9), which converts ATP into cAMP a

70 Synthesis of cAMP receptor and adenylyl cyclase A (ACA) is inhibited, and activation of

71 iological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combinat

72 although salmeterol shows weak efficacy for adenylyl cyclase activation and G protein-coupled recept

73 CB1b blockade by JD-5037 results in stronger adenylyl cyclase activation compared to rimonabant and i

74 cate that morphine tolerance is dependent on adenylyl cyclase activation.

75 f PGI2 on stress fibres were mimicked by the adenylyl cyclase activator forskolin and prevented by in

76 Furthermore, treatment with the adenylyl cyclase activator forskolin diminishes cytosoli

77 The adenylyl cyclase activator forskolin facilitates synapti

78 Repeated microinjections of morphine or the adenylyl cyclase activator NKH477 into the vlPAG decreas

79 ntractile agonist acetylcholine (ACh) or the adenylyl cyclase activator, forskolin (FSK), a dilatory

80 inhibitors, two calpain inhibitors, and one adenylyl cyclase activator, forskolin.

81 thermore, we demonstrated that forskolin, an adenylyl cyclase activator, significantly increased the

82 ive against MEK2 cleavage by lethal toxin or adenylyl cyclase activity by edema toxin in human kidney

83 cyclase, partly due to reduced inhibition of adenylyl cyclase activity by pertussis toxin-sensitive G

84 cellular cAMP consistent with an increase in adenylyl cyclase activity for both mutants relative to w

85 to the field, CB1b is a potent regulator of adenylyl cyclase activity in peripheral metabolic tissue

86 DOR-KOR heteromer agonist 6'-GNTI inhibited adenylyl cyclase activity in vitro as well as PGE(2)-sti

87 Rv0891c had very low adenylyl cyclase activity so it could represent a pseudo

88 eft ventricles (LVs), whereas NKH477-induced adenylyl cyclase activity was equivalent to WT.

89 tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degrad

90 has been of interest because the product of adenylyl cyclase activity, cAMP, is relevant to cilia-re

91 ed in mu agonist-induced G protein coupling, adenylyl cyclase activity, receptor internalization and

92 two compounds are equipotent for inhibiting adenylyl cyclase activity, these results suggest that Co

93 cAMP levels through effects on transmembrane adenylyl cyclase activity.

94 Furthermore, bPAC replaces endogenous adenylyl cyclase activity.

95 mitochondrial ROS and subsequent increase of adenylyl cyclase activity.

96 istration is associated with upregulation of adenylyl cyclase activity.

97 etaAR desensitization as measured by cardiac adenylyl cyclase activity.

98 tant pertussis toxin-sensitive inhibition of adenylyl cyclase activity.

99 hibit prostaglandin E(2) (PGE(2))-stimulated adenylyl cyclase activity.

100 Although the HCO3(-)-dependent soluble adenylyl cyclase Adcy10 plays a role in motility, less i

101 lls (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increa

102 CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits megakaryocyt

103 l because PGE2 could be substituted with the adenylyl cyclase agonist forskolin, and CCR8 expression

104 ugh Galphas G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but

105 in) agonists to inhibit forskolin-stimulated adenylyl cyclase and increase mitogen-activated protein

106 educes the negative regulation by Galphai of adenylyl cyclase and its production of cAMP, independent

107 In addition, we report that CRY1 binds to adenylyl cyclase and limits cAMP production.

108 AR(2) causes Galphas-dependent activation of adenylyl cyclase and PKA, which activates TRPV4 and sens

109 Adenylyl cyclase and PKA-mediated elastase-induced activ

110 ction potential through PAR(2) Inhibitors of adenylyl cyclase and protein kinase A (PKA) prevented th

111 is induced by neuronal activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

112 that express a mutated PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha

113 Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed v

114 and stimulated neuronal hyperexcitability by adenylyl cyclase and protein kinase A-dependent mechanis

115 obutamine, reflecting its better coupling to adenylyl cyclase and the reliance of dopamine on dopamin

116 ue, Inda et al. show that different forms of adenylyl cyclase are activated at the plasma membrane ve

117 These 2 receptors have opposing actions on adenylyl cyclase because of differential G-protein coupl

118 falciparum through conditional disruption of adenylyl cyclase beta (ACbeta) and its downstream effect

119 fiers of cAMP signaling, the photo-activated adenylyl cyclase bPAC and the light-activated phosphodie

120 tal terminal segments enhanced activation of adenylyl cyclase by 50-75% and diminished activation of

121 mal cAMP resulting from direct activation of adenylyl cyclase by forskolin (15,689 +/- 7038% of contr

122 ensable, but Ras1 is found to associate with adenylyl cyclase Cac1 through the conserved Ras associat

123 A transmembrane adenylyl cyclase cAMP-dependent protein kinase cascade m

124 component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF).

125 These results show that the upregulation of adenylyl cyclase caused by repeated vlPAG morphine admin

126 hese studies was to test the hypothesis that adenylyl cyclase contributes to opioid tolerance by modu

127 e cytosolic portion of the membrane-integral adenylyl cyclase Cya from Mycobacterium intracellulare i

128 ified an S-helix of about 25 residues in the adenylyl cyclase CyaG from Arthrospira maxima.

129 Moreover, the adenylyl cyclase Cyr1 activity is present in mitochondri

130 ization consisting of an N-terminal putative adenylyl cyclase domain fused to a nucleotide-binding ad

131 The two-metal catalysis by the adenylyl cyclase domain of the anthrax edema factor toxi

132 is abolished in a strain lacking MT1302, an adenylyl cyclase encoding gene.

133 omains, where it is less likely to couple to adenylyl cyclase for cAMP production.

134 Feedback inhibition of adenylyl cyclase III (ACIII) via Ca(2+)-induced phosphor

135 This study used immunohistochemistry for adenylyl cyclase III (ACIII), a marker of primary cilia,

136 tivation of odorant receptors (ORs) leads to adenylyl cyclase III activation, cAMP increase, and open

137 2 and Gli3 repressors and early depletion of adenylyl cyclase III in neuroepithelial cilia, implicati

138 whereas the presence of the effector enzyme adenylyl cyclase III remained largely unaltered.

139 localization of ciliary proteins ARL13B and adenylyl cyclase III.

140 e of UDP-glucose for promoting inhibition of adenylyl cyclase in C6 glioma cells stably expressing th

141 on activation of NMDA and AMPA receptors and adenylyl cyclase in D1 receptor-expressing cells.

142 queductal gray, nor a super-sensitization of adenylyl cyclase in the striatum, which are hallmarks of

143 ex, implicating enhanced Galpha(i)-dependent adenylyl cyclase inhibition as a possible causative fact

144 Transmembrane adenylyl cyclase inhibition had no effect on the SOCE-in

145 n of G proteins with all Galphai/o subunits, adenylyl cyclase inhibition, and beta arrestin recruitme

146 otein activation, beta-arrestin recruitment, adenylyl cyclase inhibition, and extracellular signal-re

147 r functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and b

148 was attenuated by PAR2 or TRPV4 deletion and adenylyl cyclase inhibition.

149 Here we showed that adenylyl cyclase inhibitor 2',5'-dideoxyadenosine and PK

150 ocked by the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein k

151 Conversely, microinjection of the adenylyl cyclase inhibitor SQ22536 reversed both the dev

152 Activation of adenylyl cyclase is necessary and sufficient for down-re

153 or more of the nine different transmembrane adenylyl cyclase isoforms that generate the cAMP signal

154 t Plin5 is phosphorylated, and activation of adenylyl cyclase leads to phosphorylation of Plin5, sugg

155 f betaARs as well as Gi inhibition of type 1 adenylyl cyclase may underlie the experimental observati

156 s of ADCY5-the first definitive link between adenylyl cyclase mutation and human disease.

157 Inhibition of adenylyl cyclase or PKA activity blocked p65 and CREB ph

158 Par(2) deletion, LI-1, and inhibitors of adenylyl cyclase or protein kinase A (PKA) prevented the

159 roperties toward the beta(1)AR in either the adenylyl cyclase or the mitogen-activated protein kinase

160 T6) receptor constitutively activates the Gs/adenylyl cyclase pathway in various cell types, includin

161 nistic actions of the canonical G protein -> adenylyl cyclase pathway that is initiated by G-protein-

162 The inhibitory effects of agonists on the adenylyl cyclase pathway were investigated.

163 ciated with a decrease in the sensitivity of adenylyl cyclase production of cAMP to inhibitory Galpha

164 in NMJ growth and plasticity, including the adenylyl cyclase Rutabaga, the Ig-CAM Fasciclin II, the

165 These findings indicate that cilia-dependent adenylyl cyclase signaling represses the Hedgehog pathwa

166 nonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of b

167 Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA i

168 ic receptor (beta2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the

169 The rutabaga-adenylyl cyclase synthesizes cAMP in a Ca(2+)/calmodulin

170 2 as a repressor of the Hedgehog pathway via adenylyl cyclase targeting.

171 s the enzyme to a specific, light-stimulated adenylyl cyclase that catalyzes the formation of cAMP fr

172 l of c-di-AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiest

173 CD99 signals through soluble adenylyl cyclase to activate PKA to trigger ongoing targ

174 oups converge on the same signaling cascade--adenylyl cyclase to cAMP to protein kinase A--but with o

175 Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenes

176 creased functional coupling of Galpha(s) and adenylyl cyclase to increase intracellular cyclic adenos

177 FSI axon terminals and negatively couple to adenylyl cyclase to induce a long-term depression of GAB

178 of an activated C-Raf reduces sensitivity of adenylyl cyclase to opioids in nonexcitable HEK293 cells

179 n lipid rafts, couples less effectively with adenylyl cyclase to produce cAMP, and this is reversed b

180 N-methyl-D-aspartate receptor activation of adenylyl cyclase type 1.

181 lous DM(high)-VL(low) expression gradient of adenylyl cyclase type 3 appears, which coincides with al

182 via onset of the stimulus-transducing enzyme adenylyl cyclase type 3.

183 Adenylyl cyclase type 5 knockout (AC5KO) mice have incre

184 bited by STIM1 inhibitors or by silencing of adenylyl cyclase type 6 (AC6).

185 se this enzyme is inactive in the absence of adenylyl cyclase type 6 (ADCY6).

186 Adenylyl cyclase type 9 (AC9) is found tightly associate

187 To assess this, we studied mice deficient in adenylyl cyclase type VI specifically in the principal c

188 nctions to inhibit the production of cAMP by adenylyl cyclase upon Hh stimulation, thus maximizing si

189 In summary, these data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC

190 xperiments revealed that acute activation of adenylyl cyclase with forskolin increased the frequency

191 Inhibition of adenylyl cyclase with SQ 22,536 restored BLT1(-/-) BMN a

192 sion in YY1(T372R) tumors included ADCY1 (an adenylyl cyclase) and CACNA2D2 (a Ca(2+) channel); both

193 ependence of the enzymes that generate cAMP (adenylyl cyclase) and degrade it (phosphodiesterase).

194 e CatSper1 (Ca(2+) channel), Adcy10 (soluble adenylyl cyclase) and Slo3 (K(+) channel) KO mice.

195 t (expected to activate matrix-bound soluble adenylyl cyclase) increased intramitochondrial cAMP, but

196 D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cyclase, a recent study has shown that many APD

197 al mu-opioid signaling through inhibition of adenylyl cyclase, activation of MAPK and G protein-gated

198 gulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, and E. coli transcription factor FhlA

199 olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosphorylation.

200 -293 cells, ostensibly through inhibition of adenylyl cyclase, decreases intracellular levels of cAMP

201 rotein, followed by subsequent activation of adenylyl cyclase, elevation of cyclic AMP levels, and pr

202 R in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-tri

203 ructure of Gs, the stimulatory G protein for adenylyl cyclase, in complex with the alpha2 adrenergic

204 RPV1 via activation of TRPA1, which involves adenylyl cyclase, increased cAMP, subsequent translocati

205 sticity was dependent on the Rutabaga type I adenylyl cyclase, linking cAMP-dependent plasticity to b

206 tant residues for the enhanced activation of adenylyl cyclase, partly due to reduced inhibition of ad

207 dor receptors couple to G-protein activating adenylyl cyclase, producing cAMP.

208 stimulation (G(s)) or inhibition (G(i/o)) of adenylyl cyclase, stimulation of potassium channel curre

209 TRPV4 currents in Xenopus laevis oocytes by adenylyl cyclase- and protein kinase A (PKA)-dependent m

210 ough the activation of phospholipase Cbeta-, adenylyl cyclase-, mitogen-activated protein kinase-, an

211 alpha7 nAChR, CFTR, and adenylyl cyclase-1 are physically and functionally assoc

212 ofiles of the corresponding mutated enzymes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

213 validation of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transf

214 CAP (adenylyl cyclase-associated protein) was first identifie

215 o reduced activity of the downstream cascade adenylyl cyclase-cAMP-PKA-cAMP response element-binding

216 We observed that the adenylyl cyclase-cAMP-protein kinase A axis is involved

217 pase C-coupled D1R agonist (but not a D2R or adenylyl cyclase-coupled D1R agonist) decreased the pers

218 blocked STa/GCC-dependent, but not forskolin/adenylyl cyclase-dependent, cystic fibrosis transmembran

219 or (GPCR) that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein G(i

220 is mediated by kappaOR signaling through the adenylyl cyclase-inhibitory family of Gi protein.

221 brane-permeable 8Br-cAMP under inhibition of adenylyl cyclase-mediated cAMP production by MDL 12330A.

222 er-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemotaxis protein-pho

223 reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as

224 to biological agents involving activation of adenylyl cyclase.

225 AMP response requires mechanisms upstream of adenylyl cyclase.

226 the G-protein responsible for activation of adenylyl cyclase.

227 ecifically, we hypothesize that AMP inhibits adenylyl cyclase.

228 s measure pH via bicarbonate-sensing soluble adenylyl cyclase.

229 ich can specifically inhibit the activity of adenylyl cyclase.

230 te kinase M2 (PKM2) interaction with soluble adenylyl cyclase.

231 cium influx and Gi/o-dependent inhibition of adenylyl cyclase.

232 the beta(3a)-AR, caveolin-1, Galpha(s), and adenylyl cyclase.

233 ing to stimulation of G(i) and inhibition of adenylyl cyclase.

234 nt with reports that CO2 directly stimulates adenylyl cyclase.

235 ly rectifying potassium channels, as well as adenylyl cyclase.

236 o promote egress by activating the Galpha(s)/adenylyl cyclase/cAMP pathway.

237 a(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.

238 rusion connecting the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) and phytochrome-specific (PH

239 ne form of the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF) domain from the cyanobacteri

240 for the photosensing cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain from Thermosynechococ

241 ore buried within the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain, and a well-ordered h

242 es of the 23-kDa GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domain fragment of phytochrome fr

243 on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (H

244 terol showed weak efficacy for activation of adenylyl cyclase; however, its efficacy in the complex d

245 inase A isoform (PKAI) signaling pathway, as adenylyl-cyclase and PKAI inhibition prevented adenosine

246 choline, dopamine, and adenosine signals via adenylyl-cyclase coupled GPCRs in shaping the dopamine-d

247 In striatal neurons, D(1)R activates adenylyl-cyclase through Galpha(olf), a protein upregula

248 nction of the encoded protein, Galphaolf, an adenylyl-cyclase-stimulatory G-protein highly enriched i

249 Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate

250 d corals have both transmembrane and soluble adenylyl cyclases (AC).

251 s, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC).

252 atids and detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodiesterases (PDEs) si

253 s, nanodomain clustering of Ca(2+)-sensitive adenylyl cyclases (ACs) drives oscillations of local cAM

254 ited cAMP levels after direct stimulation of adenylyl cyclases (ACs) with forskolin (FSK), as determi

255 eptors are responsible for the activation of adenylyl cyclases (ACs), which increase intracellular cy

256 ered by the presence of at least 15 distinct adenylyl cyclases (ACs).

257 cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine transmembrane enzymes and

258 h hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis

259 that for the structurally related membranous adenylyl cyclases (mACs) 1, 2, 5 and the purified mAC ca

260 Transmembrane adenylyl cyclases (tmACs) are another possible source of

261 ylyl cyclases synthesize cAMP, transmembrane adenylyl cyclases (tmACs), and soluble adenylyl cyclase

262 l cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs).

263 termined by the balance of cAMP synthesis by adenylyl cyclases and degradation by phosphodiesterases

264 ing subcellular targeting of cAMP-generating adenylyl cyclases and processes regulated by their compa

265 We make an argument for adenylyl cyclases being central to the formation and mai

266 The role of adenylyl cyclases in ciliary function has been of intere

267 rmone- and G protein-regulated transmembrane adenylyl cyclases or via the widely expressed and struct

268 In neurons, two families of adenylyl cyclases synthesize cAMP, transmembrane adenyly

269 m channels, while in turn, calcium activates adenylyl cyclases to produce more cAMP-PKA signaling.

270 Mycobacteria harbor a unique class of adenylyl cyclases with a complex domain organization con

271 occur in mice lacking calmodulin-stimulated adenylyl cyclases, a mouse strain that learns but cannot

272 phs stimulated by forskolin, an activator of adenylyl cyclases, and by membrane-permeable cAMP analog

273 minal GAF (cGMP-specific phosphodiesterases, adenylyl cyclases, and FhlA) domain and two EAL motifs w

274 ir, where Rv0891c has sequence similarity to adenylyl cyclases, and Rv0890c harbors the NB-ARC-TPR-HT

275 Ankmy2 binds to multiple adenylyl cyclases, determining their maturation and traf

276 egion; a cytoplasmic HAMP (histidine kinase, adenylyl cyclases, methyl-accepting chemotaxis proteins,

277 otifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins,

278 uction of cAMP (G protein-coupled receptors, adenylyl cyclases, phosphodiesterases (PDEs)), and recep

279 ccurs through Ca(2+) entry and activation of adenylyl cyclases, protein kinase A, and PKC.

280 Adenylyl cyclases, the enzymatic source of cAMP producti

281 pha subunit of heterotrimeric G proteins and adenylyl cyclases.

282 ic cAMP that is mediated by Ca(2+)-sensitive adenylyl cyclases.

283 ransgenic mice lacking calmodulin-stimulated adenylyl cyclases.

284 was restricted to the transmembrane class of adenylyl cyclases.

285 ins, e.g. in histidine kinases and bacterial adenylyl cyclases.

286 ng (SOcAMPS) and activating Ca(2+) regulated adenylyl cyclases.

287 s long thought to be specifically coupled to adenylyl cyclases.

288 in inactivate GTPases through addition of an adenylyl group (also referred to as AMPylation).

289 NeqAB in complex with nucleotides, ADP, and adenylyl-imidodiphosphate (non-hydrolysable analog of AT

290 in some cases an effector domain such as an adenylyl or guanylyl cyclase, all encoded in a single pr

291 ding to validate DNA base pairing during the adenylyl transfer and nick-sealing ligation reaction ste

292 ce factor, nicotinamide mononucleotide (NAD) adenylyl transferase (NMNAT), a protein that has both NA

293 Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a key neuronal mainte

294 Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in nu

295 Nicotinamide adenylyl transferase condenses nicotinamide mononucleoti

296 application of versatile trans-acting 2'-5' adenylyl transferase ribozymes for covalent and site-spe

297 is enzyme Nmnat (nicotinamide mononucleotide adenylyl transferase), but requires the c-Jun N-terminal

298 expression studies of sat, encoding sulfate adenylyl transferase, showed increased levels in the D.

299 e level of the nicotinic acid mononucleotide adenylyl-transferase Nma1 and can be bypassed by overexp

300 ive function for nicotinamide mononucleotide adenylyl transferases (NMNATs).