ライフサイエンスコーパス: adenylyl cyclase

1 AMP response requires mechanisms upstream of adenylyl cyclase.

2 ecifically, we hypothesize that AMP inhibits adenylyl cyclase.

3 the G-protein responsible for activation of adenylyl cyclase.

4 s measure pH via bicarbonate-sensing soluble adenylyl cyclase.

5 ich can specifically inhibit the activity of adenylyl cyclase.

6 te kinase M2 (PKM2) interaction with soluble adenylyl cyclase.

7 cium influx and Gi/o-dependent inhibition of adenylyl cyclase.

8 the beta(3a)-AR, caveolin-1, Galpha(s), and adenylyl cyclase.

9 ing to stimulation of G(i) and inhibition of adenylyl cyclase.

10 nt with reports that CO2 directly stimulates adenylyl cyclase.

11 ly rectifying potassium channels, as well as adenylyl cyclase.

12 to biological agents involving activation of adenylyl cyclase.

13 pha subunit of heterotrimeric G proteins and adenylyl cyclases.

14 ransgenic mice lacking calmodulin-stimulated adenylyl cyclases.

15 was restricted to the transmembrane class of adenylyl cyclases.

16 ic cAMP that is mediated by Ca(2+)-sensitive adenylyl cyclases.

17 ins, e.g. in histidine kinases and bacterial adenylyl cyclases.

18 is mediated by calcium/calmodulin-stimulated adenylyl cyclases.

19 ng (SOcAMPS) and activating Ca(2+) regulated adenylyl cyclases.

20 s long thought to be specifically coupled to adenylyl cyclases.

21 ck gene Npas2, and the clock-controlled gene adenylyl cyclase 1 (Adcy1) in a subset of retinal gangli

22 gh frequency of calcium input is filtered by adenylyl cyclase 1 and phosphodiesterases in this pathwa

23 alpha7 nAChR, CFTR, and adenylyl cyclase-1 are physically and functionally assoc

24 The enzyme that synthesizes cAMP, adenylyl cyclase 3 (AC3), is coexpressed in olfactory se

25 lase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiatio

26 ATF5 induces the transcription of adenylyl cyclase 3 (Adcy3), which relieves the UPR.

27 and that this was specifically dependent on adenylyl cyclase 5 (AC5) activity.

28 , whose synthesis is catalysed by the enzyme adenylyl cyclase 5 (AC5), which is itself regulated by t

29 ated basal ciliary cAMP level is a result of adenylyl cyclase 5 and 6 activity that depends on ciliar

30 Activity of both adenylyl cyclase 5 and extracellular signal-regulated ki

31 this study, the fecal bacterial community of adenylyl cyclase 5 knock-out (AC5KO, n = 7) mice or thei

32 cells contains a protein complex comprising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein

33 ofiles of the corresponding mutated enzymes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

34 tan and pasireotide, which indirectly reduce adenylyl cyclase 6 (AC6) activity, have hence proven eff

35 enerated intestinal epithelial cell-specific adenylyl cyclase 6 (AC6) knockout mice to study its role

36 Previously we demonstrated that adenylyl cyclase 6 (AC6), a membrane-bound enzyme enrich

37 roximal tubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) are both expressed

38 heterotrimeric G-protein subunit G(s) alpha, adenylyl cyclase 6, and activation of the cAMP-regulated

39 Binding of Ca(2+)-activated adenylyl cyclase 8 (AC8) to the N-terminus of ORAI1 posi

40 d for chemoattractant-mediated activation of adenylyl cyclase 9 (AC9), which converts ATP into cAMP a

41 Synthesis of cAMP receptor and adenylyl cyclase A (ACA) is inhibited, and activation of

42 gnaling cascade leading to the activation of adenylyl cyclase A (ACA), the synthesis and secretion of

43 D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cyclase, a recent study has shown that many APD

44 occur in mice lacking calmodulin-stimulated adenylyl cyclases, a mouse strain that learns but cannot

45 Adenylyl cyclase (AC) activity relies on multiple effect

46 2 receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosin

47 le cells, prostaglandin E2 (PGE2) stimulates adenylyl cyclase (AC) and attenuates the increase in int

48 ptake inhibitors, SSRIs) treatment increased adenylyl cyclase (AC) and BDNF gene expression in LCLs.

49 I-induced SA requires continuing activity of adenylyl cyclase (AC) and cAMP-dependent protein kinase

50 eptors via D4 receptors (D4R), which inhibit adenylyl cyclase (AC) and reduce PKA activity.

51 Here, adenylyl cyclase (AC) and the alpha-subunit of the AC-st

52 Adenylyl cyclase (AC) converts ATP into cyclic AMP (cAMP

53 There are abundant adenylyl cyclase (AC) coupled GPCRs for these neuromodul

54 cAMP analogues and stimulation of adenylyl cyclase (AC) directly or through G-protein-coup

55 CyaA bears an N-terminal adenylyl cyclase (AC) domain linked to a pore-forming RT

56 Although the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenos

57 g heterotrimeric Gi/Go proteins resulting in adenylyl cyclase (AC) inhibition.

58 Several adenylyl cyclase (AC) isoforms could mediate cAMP accumu

59 Membrane-bound adenylyl cyclase (AC) isoforms have distinct regulatory

60 We have previously identified a subset of adenylyl cyclase (AC) isoforms that interact with Yotiao

61 acts not only with PKA but also with various adenylyl cyclase (AC) isoforms.

62 th a G(alphas) inhibitor and an inhibitor of adenylyl cyclase (AC) prevented stimulating effects of O

63 PTH activates adenylyl cyclase (AC) through PTH 1 receptors and stimul

64 Adenylyl cyclase (AC) toxin is an essential toxin that a

65 n mammalian cells, an intramitochondrial CO2-adenylyl cyclase (AC)-cyclic AMP (cAMP)-protein kinase A

66 ncrease was blocked by G15, linking GPR30 to adenylyl cyclase (AC).

67 0 facilitates a complex containing TPRV1 and adenylyl cyclase (AC).

68 dorant receptor response was not mediated by adenylyl cyclase (AC)/cyclic nucleotide-gated (CNG) chan

69 anion exchanger 2 (Cl(-) /HCO3 (-) AE2), and adenylyl cyclase (AC)8 (proteins regulating large biliar

70 Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate

71 d corals have both transmembrane and soluble adenylyl cyclases (AC).

72 iological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combinat

73 coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.

74 udy in humans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3) in MDD.

75 reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in hear

76 Intriguingly, type III adenylyl cyclase (ACIII), a key protein in olfactory sig

77 We found that SSTR3 and type III adenylyl cyclase (ACIII), proteins normally enriched in

78 s, cAMP is synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC).

79 atids and detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodiesterases (PDEs) si

80 s, nanodomain clustering of Ca(2+)-sensitive adenylyl cyclases (ACs) drives oscillations of local cAM

81 Ca(2+)-stimulated adenylyl cyclases (ACs) have recently been shown to play

82 ited cAMP levels after direct stimulation of adenylyl cyclases (ACs) with forskolin (FSK), as determi

83 eptors are responsible for the activation of adenylyl cyclases (ACs), which increase intracellular cy

84 ered by the presence of at least 15 distinct adenylyl cyclases (ACs).

85 cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine transmembrane enzymes and

86 although salmeterol shows weak efficacy for adenylyl cyclase activation and G protein-coupled recept

87 rts demonstrating that signaling by PGE2 and adenylyl cyclase activation are associated with macropha

88 CB1b blockade by JD-5037 results in stronger adenylyl cyclase activation compared to rimonabant and i

89 cate that morphine tolerance is dependent on adenylyl cyclase activation.

90 h hormonal stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis

91 al mu-opioid signaling through inhibition of adenylyl cyclase, activation of MAPK and G protein-gated

92 f PGI2 on stress fibres were mimicked by the adenylyl cyclase activator forskolin and prevented by in

93 Furthermore, treatment with the adenylyl cyclase activator forskolin diminishes cytosoli

94 The adenylyl cyclase activator forskolin facilitates synapti

95 Repeated microinjections of morphine or the adenylyl cyclase activator NKH477 into the vlPAG decreas

96 ntractile agonist acetylcholine (ACh) or the adenylyl cyclase activator, forskolin (FSK), a dilatory

97 inhibitors, two calpain inhibitors, and one adenylyl cyclase activator, forskolin.

98 thermore, we demonstrated that forskolin, an adenylyl cyclase activator, significantly increased the

99 ive against MEK2 cleavage by lethal toxin or adenylyl cyclase activity by edema toxin in human kidney

100 cyclase, partly due to reduced inhibition of adenylyl cyclase activity by pertussis toxin-sensitive G

101 cellular cAMP consistent with an increase in adenylyl cyclase activity for both mutants relative to w

102 to the field, CB1b is a potent regulator of adenylyl cyclase activity in peripheral metabolic tissue

103 DOR-KOR heteromer agonist 6'-GNTI inhibited adenylyl cyclase activity in vitro as well as PGE(2)-sti

104 Rv0891c had very low adenylyl cyclase activity so it could represent a pseudo

105 eft ventricles (LVs), whereas NKH477-induced adenylyl cyclase activity was equivalent to WT.

106 tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degrad

107 has been of interest because the product of adenylyl cyclase activity, cAMP, is relevant to cilia-re

108 ed in mu agonist-induced G protein coupling, adenylyl cyclase activity, receptor internalization and

109 two compounds are equipotent for inhibiting adenylyl cyclase activity, these results suggest that Co

110 Furthermore, bPAC replaces endogenous adenylyl cyclase activity.

111 mitochondrial ROS and subsequent increase of adenylyl cyclase activity.

112 istration is associated with upregulation of adenylyl cyclase activity.

113 etaAR desensitization as measured by cardiac adenylyl cyclase activity.

114 tant pertussis toxin-sensitive inhibition of adenylyl cyclase activity.

115 hibit prostaglandin E(2) (PGE(2))-stimulated adenylyl cyclase activity.

116 cAMP levels through effects on transmembrane adenylyl cyclase activity.

117 ntify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, l

118 Although the HCO3(-)-dependent soluble adenylyl cyclase Adcy10 plays a role in motility, less i

119 lls (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increa

120 CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits megakaryocyt

121 l because PGE2 could be substituted with the adenylyl cyclase agonist forskolin, and CCR8 expression

122 both the stimulatory G protein (Gs) for the adenylyl cyclase and arrestin pathways, synthetic ligand

123 ugh Galphas G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but

124 in) agonists to inhibit forskolin-stimulated adenylyl cyclase and increase mitogen-activated protein

125 educes the negative regulation by Galphai of adenylyl cyclase and its production of cAMP, independent

126 In addition, we report that CRY1 binds to adenylyl cyclase and limits cAMP production.

127 Recently, we discovered that adenylyl cyclase and MAPK activities undergo a circadian

128 AR(2) causes Galphas-dependent activation of adenylyl cyclase and PKA, which activates TRPV4 and sens

129 Adenylyl cyclase and PKA-mediated elastase-induced activ

130 ction potential through PAR(2) Inhibitors of adenylyl cyclase and protein kinase A (PKA) prevented th

131 is induced by neuronal activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

132 that express a mutated PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha

133 Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed v

134 and stimulated neuronal hyperexcitability by adenylyl cyclase and protein kinase A-dependent mechanis

135 obutamine, reflecting its better coupling to adenylyl cyclase and the reliance of dopamine on dopamin

136 termined by the balance of cAMP synthesis by adenylyl cyclases and degradation by phosphodiesterases

137 ing subcellular targeting of cAMP-generating adenylyl cyclases and processes regulated by their compa

138 inase A isoform (PKAI) signaling pathway, as adenylyl-cyclase and PKAI inhibition prevented adenosine

139 sion in YY1(T372R) tumors included ADCY1 (an adenylyl cyclase) and CACNA2D2 (a Ca(2+) channel); both

140 ependence of the enzymes that generate cAMP (adenylyl cyclase) and degrade it (phosphodiesterase).

141 e CatSper1 (Ca(2+) channel), Adcy10 (soluble adenylyl cyclase) and Slo3 (K(+) channel) KO mice.

142 gulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, and E. coli transcription factor FhlA

143 olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosphorylation.

144 phs stimulated by forskolin, an activator of adenylyl cyclases, and by membrane-permeable cAMP analog

145 minal GAF (cGMP-specific phosphodiesterases, adenylyl cyclases, and FhlA) domain and two EAL motifs w

146 ir, where Rv0891c has sequence similarity to adenylyl cyclases, and Rv0890c harbors the NB-ARC-TPR-HT

147 TRPV4 currents in Xenopus laevis oocytes by adenylyl cyclase- and protein kinase A (PKA)-dependent m

148 on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (H

149 ue, Inda et al. show that different forms of adenylyl cyclase are activated at the plasma membrane ve

150 validation of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transf

151 CAP (adenylyl cyclase-associated protein) was first identifie

152 These 2 receptors have opposing actions on adenylyl cyclase because of differential G-protein coupl

153 We make an argument for adenylyl cyclases being central to the formation and mai

154 falciparum through conditional disruption of adenylyl cyclase beta (ACbeta) and its downstream effect

155 fiers of cAMP signaling, the photo-activated adenylyl cyclase bPAC and the light-activated phosphodie

156 sion protein consisting of a light-activated adenylyl cyclase (bPAC) and luciferase (nLuc).

157 enic mouse model expressing a photoactivated adenylyl cyclase (bPAC) in sperm.

158 tal terminal segments enhanced activation of adenylyl cyclase by 50-75% and diminished activation of

159 mal cAMP resulting from direct activation of adenylyl cyclase by forskolin (15,689 +/- 7038% of contr

160 /- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized express

161 ensable, but Ras1 is found to associate with adenylyl cyclase Cac1 through the conserved Ras associat

162 A transmembrane adenylyl cyclase cAMP-dependent protein kinase cascade m

163 mediate cAMP-induced stimulation of chimeric adenylyl cyclases, cAMP binding did not stimulate the PD

164 o reduced activity of the downstream cascade adenylyl cyclase-cAMP-PKA-cAMP response element-binding

165 We observed that the adenylyl cyclase-cAMP-protein kinase A axis is involved

166 o promote egress by activating the Galpha(s)/adenylyl cyclase/cAMP pathway.

167 a(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway.

168 component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF).

169 These results show that the upregulation of adenylyl cyclase caused by repeated vlPAG morphine admin

170 hese studies was to test the hypothesis that adenylyl cyclase contributes to opioid tolerance by modu

171 choline, dopamine, and adenosine signals via adenylyl-cyclase coupled GPCRs in shaping the dopamine-d

172 pase C-coupled D1R agonist (but not a D2R or adenylyl cyclase-coupled D1R agonist) decreased the pers

173 e cytosolic portion of the membrane-integral adenylyl cyclase Cya from Mycobacterium intracellulare i

174 ified an S-helix of about 25 residues in the adenylyl cyclase CyaG from Arthrospira maxima.

175 Moreover, the adenylyl cyclase Cyr1 activity is present in mitochondri

176 The failure of cells lacking adenylyl cyclase (cyr1Delta) to form hyphae has suggeste

177 -293 cells, ostensibly through inhibition of adenylyl cyclase, decreases intracellular levels of cAMP

178 blocked STa/GCC-dependent, but not forskolin/adenylyl cyclase-dependent, cystic fibrosis transmembran

179 Ankmy2 binds to multiple adenylyl cyclases, determining their maturation and traf

180 ization consisting of an N-terminal putative adenylyl cyclase domain fused to a nucleotide-binding ad

181 The two-metal catalysis by the adenylyl cyclase domain of the anthrax edema factor toxi

182 rotein, followed by subsequent activation of adenylyl cyclase, elevation of cyclic AMP levels, and pr

183 is abolished in a strain lacking MT1302, an adenylyl cyclase encoding gene.

184 R in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-tri

185 rusion connecting the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) and phytochrome-specific (PH

186 ne form of the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF) domain from the cyanobacteri

187 for the photosensing cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain from Thermosynechococ

188 ore buried within the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domain, and a well-ordered h

189 es of the 23-kDa GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domain fragment of phytochrome fr

190 omains, where it is less likely to couple to adenylyl cyclase for cAMP production.

191 ivation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR

192 terol showed weak efficacy for activation of adenylyl cyclase; however, its efficacy in the complex d

193 Feedback inhibition of adenylyl cyclase III (ACIII) via Ca(2+)-induced phosphor

194 This study used immunohistochemistry for adenylyl cyclase III (ACIII), a marker of primary cilia,

195 tivation of odorant receptors (ORs) leads to adenylyl cyclase III activation, cAMP increase, and open

196 2 and Gli3 repressors and early depletion of adenylyl cyclase III in neuroepithelial cilia, implicati

197 whereas the presence of the effector enzyme adenylyl cyclase III remained largely unaltered.

198 localization of ciliary proteins ARL13B and adenylyl cyclase III.

199 e of UDP-glucose for promoting inhibition of adenylyl cyclase in C6 glioma cells stably expressing th

200 on activation of NMDA and AMPA receptors and adenylyl cyclase in D1 receptor-expressing cells.

201 r instance, expression of the Rutabaga (Rut) adenylyl cyclase in gamma neurons is sufficient to resto

202 queductal gray, nor a super-sensitization of adenylyl cyclase in the striatum, which are hallmarks of

203 The role of adenylyl cyclases in ciliary function has been of intere

204 ructure of Gs, the stimulatory G protein for adenylyl cyclase, in complex with the alpha2 adrenergic

205 t (expected to activate matrix-bound soluble adenylyl cyclase) increased intramitochondrial cAMP, but

206 RPV1 via activation of TRPA1, which involves adenylyl cyclase, increased cAMP, subsequent translocati

207 or (GPCR) that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein G(i

208 ex, implicating enhanced Galpha(i)-dependent adenylyl cyclase inhibition as a possible causative fact

209 Transmembrane adenylyl cyclase inhibition had no effect on the SOCE-in

210 n of G proteins with all Galphai/o subunits, adenylyl cyclase inhibition, and beta arrestin recruitme

211 otein activation, beta-arrestin recruitment, adenylyl cyclase inhibition, and extracellular signal-re

212 activated G-protein-dependent calcium flux, adenylyl cyclase inhibition, and the rapid activation of

213 r functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and b

214 was attenuated by PAR2 or TRPV4 deletion and adenylyl cyclase inhibition.

215 Here we showed that adenylyl cyclase inhibitor 2',5'-dideoxyadenosine and PK

216 ocked by the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein k

217 Conversely, microinjection of the adenylyl cyclase inhibitor SQ22536 reversed both the dev

218 multiple G protein alpha subunits, including adenylyl cyclase-inhibitory (Galpha(i)) subunits and tho

219 is mediated by kappaOR signaling through the adenylyl cyclase-inhibitory family of Gi protein.

220 Activation of adenylyl cyclase is necessary and sufficient for down-re

221 Edema factor (EF), a potent adenylyl cyclase, is one of the toxin components.

222 rosclerosis triggers a de novo expression of adenylyl cyclase isoform 8 (AC8), associated with the pr

223 or more of the nine different transmembrane adenylyl cyclase isoforms that generate the cAMP signal

224 t Plin5 is phosphorylated, and activation of adenylyl cyclase leads to phosphorylation of Plin5, sugg

225 sticity was dependent on the Rutabaga type I adenylyl cyclase, linking cAMP-dependent plasticity to b

226 that for the structurally related membranous adenylyl cyclases (mACs) 1, 2, 5 and the purified mAC ca

227 ent on the SCN-controlled oscillation of the adenylyl cyclase/MAPK pathway in the hippocampus.

228 f betaARs as well as Gi inhibition of type 1 adenylyl cyclase may underlie the experimental observati

229 brane-permeable 8Br-cAMP under inhibition of adenylyl cyclase-mediated cAMP production by MDL 12330A.

230 egion; a cytoplasmic HAMP (histidine kinase, adenylyl cyclases, methyl-accepting chemotaxis proteins,

231 otifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins,

232 er-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemotaxis protein-pho

233 ough the activation of phospholipase Cbeta-, adenylyl cyclase-, mitogen-activated protein kinase-, an

234 s of ADCY5-the first definitive link between adenylyl cyclase mutation and human disease.

235 Inhibition of adenylyl cyclase or PKA activity blocked p65 and CREB ph

236 Par(2) deletion, LI-1, and inhibitors of adenylyl cyclase or protein kinase A (PKA) prevented the

237 roperties toward the beta(1)AR in either the adenylyl cyclase or the mitogen-activated protein kinase

238 rmone- and G protein-regulated transmembrane adenylyl cyclases or via the widely expressed and struct

239 We hypothesized that a photoactivatable adenylyl cyclase (PAC) can be employed to modulate cAMP

240 tant residues for the enhanced activation of adenylyl cyclase, partly due to reduced inhibition of ad

241 T6) receptor constitutively activates the Gs/adenylyl cyclase pathway in various cell types, includin

242 nistic actions of the canonical G protein -> adenylyl cyclase pathway that is initiated by G-protein-

243 The inhibitory effects of agonists on the adenylyl cyclase pathway were investigated.

244 uction of cAMP (G protein-coupled receptors, adenylyl cyclases, phosphodiesterases (PDEs)), and recep

245 dor receptors couple to G-protein activating adenylyl cyclase, producing cAMP.

246 ciated with a decrease in the sensitivity of adenylyl cyclase production of cAMP to inhibitory Galpha

247 ccurs through Ca(2+) entry and activation of adenylyl cyclases, protein kinase A, and PKC.

248 First, Rutabaga adenylyl cyclase (Rut-AC), a putative molecular coincide

249 in NMJ growth and plasticity, including the adenylyl cyclase Rutabaga, the Ig-CAM Fasciclin II, the

250 work we used a HAMP containing mycobacterial adenylyl cyclase, Rv3645, as a reporter enzyme in which

251 cAMP sources, involving the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane aden

252 Soluble adenylyl cyclase (sAC) is a novel source of cAMP subject

253 addition, the cAMP-producing enzyme soluble adenylyl cyclase (sAC) is expressed in pigment cells, an

254 study, significant overexpression of soluble adenylyl cyclase (sAC), an alternative source of cAMP, w

255 increased expression and activity of soluble adenylyl cyclase (sAC), an evolutionarily conserved bica

256 e Ca(2+)/HCO(3)(-)-sensitive enzyme, soluble adenylyl cyclase (sAC), links Ca(2+) influx in human cor

257 brane adenylyl cyclases (tmACs), and soluble adenylyl cyclase (sAC).

258 ly and biochemically distinct enzyme soluble adenylyl cyclase (sAC).

259 TASK, ROMK), and the bicarbonate-stimulated adenylyl cyclase (sAC).

260 d the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion c

261 mimics the action of the endogenous soluble adenylyl cyclase (SACY) that is required for motility an

262 These findings indicate that cilia-dependent adenylyl cyclase signaling represses the Hedgehog pathwa

263 nonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of b

264 reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as

265 stimulation (G(s)) or inhibition (G(i/o)) of adenylyl cyclase, stimulation of potassium channel curre

266 Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA i

267 ic receptor (beta2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the

268 nction of the encoded protein, Galphaolf, an adenylyl-cyclase-stimulatory G-protein highly enriched i

269 In neurons, two families of adenylyl cyclases synthesize cAMP, transmembrane adenyly

270 The rutabaga-adenylyl cyclase synthesizes cAMP in a Ca(2+)/calmodulin

271 2 as a repressor of the Hedgehog pathway via adenylyl cyclase targeting.

272 s the enzyme to a specific, light-stimulated adenylyl cyclase that catalyzes the formation of cAMP fr

273 l of c-di-AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiest

274 Adenylyl cyclases, the enzymatic source of cAMP producti

275 In striatal neurons, D(1)R activates adenylyl-cyclase through Galpha(olf), a protein upregula

276 Transmembrane adenylyl cyclases (tmACs) are another possible source of

277 ylyl cyclases synthesize cAMP, transmembrane adenylyl cyclases (tmACs), and soluble adenylyl cyclase

278 l cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs).

279 CD99 signals through soluble adenylyl cyclase to activate PKA to trigger ongoing targ

280 oups converge on the same signaling cascade--adenylyl cyclase to cAMP to protein kinase A--but with o

281 Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenes

282 creased functional coupling of Galpha(s) and adenylyl cyclase to increase intracellular cyclic adenos

283 FSI axon terminals and negatively couple to adenylyl cyclase to induce a long-term depression of GAB

284 of an activated C-Raf reduces sensitivity of adenylyl cyclase to opioids in nonexcitable HEK293 cells

285 n lipid rafts, couples less effectively with adenylyl cyclase to produce cAMP, and this is reversed b

286 m channels, while in turn, calcium activates adenylyl cyclases to produce more cAMP-PKA signaling.

287 In mice missing the gene for adenylyl cyclase type 1, levels of phosphorylated GRK1 w

288 N-methyl-D-aspartate receptor activation of adenylyl cyclase type 1.

289 lous DM(high)-VL(low) expression gradient of adenylyl cyclase type 3 appears, which coincides with al

290 via onset of the stimulus-transducing enzyme adenylyl cyclase type 3.

291 Adenylyl cyclase type 5 knockout (AC5KO) mice have incre

292 bited by STIM1 inhibitors or by silencing of adenylyl cyclase type 6 (AC6).

293 se this enzyme is inactive in the absence of adenylyl cyclase type 6 (ADCY6).

294 Adenylyl cyclase type 9 (AC9) is found tightly associate

295 To assess this, we studied mice deficient in adenylyl cyclase type VI specifically in the principal c

296 nctions to inhibit the production of cAMP by adenylyl cyclase upon Hh stimulation, thus maximizing si

297 In summary, these data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC

298 xperiments revealed that acute activation of adenylyl cyclase with forskolin increased the frequency

299 Inhibition of adenylyl cyclase with SQ 22,536 restored BLT1(-/-) BMN a

300 Mycobacteria harbor a unique class of adenylyl cyclases with a complex domain organization con