ライフサイエンスコーパス: adherens junction

1 local E-cadherin dilution at the ingressing adherens junction.

2 Mer executes its function by stabilizing adherens junctions.

3 iously unrecognized component of endothelial adherens junctions.

4 ilizes TRAF2 and reduces E-cadherin-mediated adherens junctions.

5 adhesive function provided by desmosomes and adherens junctions.

6 rtical actin filaments, Kindlin-2 stabilizes adherens junctions.

7 ther correlated with the retention of normal adherens junctions.

8 marily regulated by a protein complex called adherens junctions.

9 at is a key component of tight junctions and adherens junctions.

10 -cadherin as well as other components in the adherens junctions.

11 -cadherin, resulting in impaired activity of adherens junctions.

12 establishing apical epithelial polarity and adherens junctions.

13 function, beta-catenin also plays a role at adherens junctions.

14 impregnations analogous to animal tight and adherens junctions.

15 on of cell junction scaffold afadin from the adherens junctions.

16 PDZ-binding membrane proteins to epithelial adherens junctions.

17 asal surface and impairs apical polarity and adherens junctions.

18 which is known to regulate the stability of adherens junctions.

19 ractile cytoskeletal network's attachment to adherens junctions.

20 trol, consistent with formation of defective adherens junctions.

21 role of alpha-catenin-actin interactions in adherens junctions.

22 and VE-Cadherin, two components of tight and adherens junctions.

23 tin stress fibres and decreased formation of adherens junctions.

24 the corresponding endothelial and epithelial adherens junctions.

25 mics after the proteolytic disruption of the adherens junctions.

26 tween the contractile actomyosin network and adherens junctions.

27 revealed predicted dysfunction in epithelial adherens junctions.

28 between cells through E-cadherin-containing adherens junctions.

29 actomyosin network associated with disrupted adherens junctions.

30 We explicitly modeled focal adhesions and adherens junctions.

31 ntial F-actin bands at their E-cadherin-rich adherens junctions.

32 inhibiting the disassembly of VE-cadherin at adherens junctions.

33 t on Canoe/Afadin, which links actomyosin to adherens junctions.

34 unctions, while Fhod1 and Fhod3 localized to adherens junctions.

35 as well as E-cadherin-mediated formation of adherens junctions.

36 nnections between medioapical actomyosin and adherens junctions.

37 ransmission between cells via attachments to adherens junctions.

38 g it near the top of the network-positioning adherens junctions.

39 tering and accumulation of E-cadherin to the adherens junctions.

40 structural rearrangement of alpha-catenin in adherens junctions [10] and vinculin's molecular clutch

41 for adrenal rosette formation by regulating adherens junction abundance and aggregation.

42 eta-catenin stabilization leads to increased adherens junction abundance, more rosettes, and glomerul

43 nates tissue polarization of tension-bearing adherens junction (AJ) and F-actin organization to allow

44 Adherens junction (AJ) assembly under force is essential

45 De novo formation of an adherens junction (AJ) between single epithelial cells r

46 ckdown cultured cells, staining of canonical adherens junction (AJ) components, beta-catenin and E-ca

47 The adherens junction (AJ) couples the actin cytoskeletons o

48 ces of genes encoding proteins that regulate adherens junction (AJ) integrity and determined that vas

49 associated with significant upregulation of adherens junction (AJ) protein E-cadherin and tight junc

50 alization and degradation of the endothelial adherens junction (AJ) protein VE-cadherin.

51 e cluster is also required for regulation of adherens junction (AJ) stability and dynamics.

52 KEY POINTS: N-cadherin formed punctate adherens junctions (AJ) along the borders between vascul

53 N-cadherin formed punctate adherens junctions (AJ) along the borders between VSMCs.

54 - and gamma-catenin and actin, components of adherens junctions (AJ).

55 Adherens junctions (AJs) and cell polarity complexes are

56 This process involves the fine regulation of adherens junctions (AJs) and of adhesive E-Cadherin (E-C

57 The adherens junctions (AJs) and tight junctions (TJs) provi

58 Epithelial adherens junctions (AJs) and tight junctions (TJs) under

59 Adherens Junctions (AJs) are cell-cell adhesion complexe

60 Once adherens junctions (AJs) are formed between polarized ep

61 Adherens junctions (AJs) are the major intercellular jun

62 We identify adherens junctions (AJs) as a key target of endocytosis

63 n-Dendra2 to monitor VE-cadherin dynamics at adherens junctions (AJs) in confluent endothelial monola

64 irment in HCT116-P, and dual loss of TJs and adherens junctions (AJs) in HCT116-MT.

65 ar endothelial (VE)-cadherin forms homotypic adherens junctions (AJs) in the endothelium, whereas N-c

66 Compromise in adherens junctions (AJs) is associated with several chro

67 Stability of endothelial cell (EC) adherens junctions (AJs) is central for prevention of ti

68 Modification of adherens junctions (AJs) is clearly required for budding

69 The cadherin-catenin complex at adherens junctions (AJs) is essential for the formation

70 TPase Rac1 in stabilizing mature endothelial adherens junctions (AJs) is not well understood.

71 ssed whether altered activity of endothelial adherens junctions (AJs) might contribute to this dysfun

72 dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the flui

73 During morphogenesis, adherens junctions (AJs) remodel to allow changes in cel

74 f E-cadherin, an obligatory component of the adherens junctions (AJs), at the wound edge.

75 a manipulation expected to help destabilize adherens junctions (AJs).

76 es Par3/Baz, provoking its relocalization to adherens junctions (AJs).

77 F-actin to cell membrane domains outside the adherens junctions (AJs).

78 y at occluding junctions, with none known at adherens junctions (AJs).

79 at alphaN-catenin, the neural subtype of the adherens junction alpha-catenin protein, regulates crani

80 N-cadherin and connexin-43 in adherens junction and gap junction between pericytes and

81 of MZ Crb is necessary to maintain an intact adherens junction and MZ.

82 method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delive

83 ilitated by afadin, a protein connecting the adherens junction and the actin cytoskeleton.

84 /Y949F) leads to VEGFA-resistant endothelial adherens junctions and a block in molecular extravasatio

85 s-mediated and Piezo1-mediated disruption of adherens junctions and actin remodeling.

86 alize polarity proteins such as DLG-1 within adherens junctions and at the apical surface, thereby ge

87 Here, we investigate how adherens junctions and bicellular and tricellular tight

88 ion, molecular assembly and stability of the adherens junctions and cell-cell aggregation, which was

89 amics require regulated interactions between adherens junctions and cytoskeletal networks.

90 molecules are cadherins: type 1 cadherins in adherens junctions and desmosomal cadherins in desmosome

91 cribed structural protein functioning at the adherens junctions and desmosomes, was shown to be eithe

92 signaling pathways regulating plasticity of adherens junctions and endothelial permeability.

93 complex activates RAC1 to drive assembly of adherens junctions and establish barrier function.

94 In addition, these monolayers lack adherens junctions and focal adhesions and display a dis

95 (b) Fluorescent imaging for adherens junctions and focal adhesions show the progress

96 lds qualitative degrees of cell adhesions by adherens junctions and focal adhesions, two features aff

97 Src inhibition increased VE-cadherin at adherens junctions and increased endothelial dilatation

98 show that Rho GTPase recruits Rho-kinase to adherens junctions and is required for Rho-kinase planar

99 molecule E-cadherin is a major component of adherens junctions and marks Langerhans cells (LC), the

100 se to promote the transport of E-cadherin to adherens junctions and myotactin to hemidesmosomes.

101 sphorylation resulting in the disassembly of adherens junctions and opening of the paracellular pathw

102 stream of ROR2 to reinforce coupling between adherens junctions and the actin cytoskeleton.

103 oglobin (gamma-catenin) that maintained both adherens junctions and the activation of Wnt target gene

104 a-catenin levels increased simultaneously at adherens junctions and the centrosome, and a membrane-ce

105 The crosstalk between adherens junctions and tight junctions in maintaining ba

106 rate that IGPR-1 is localized to endothelial adherens junctions and, through trans-homophilic dimeriz

107 -containing proteins known to regulate tight/adherens junctions and/or transmembrane adhesions, inclu

108 thylated profile in pathways; axon-guidance, adherens-junction and calcium-signaling, particularly at

109 unctions while actin maintains microtubules, adherens-junctions and apical end-foot dimensions.

110 ved in cell migration, extracellular matrix, adherens junction, and MAPK signaling.

111 p, which is used to restore the integrity of adherens junctions, and a negative feedback loop, which

112 signalling mechanism that drives assembly of adherens junctions, and confirm these findings in mouse

113 ures such as tight junctions, cadherin-based adherens junctions, and desmosomes.

114 osphorylation of VE-cadherin, disassembly of adherens junctions, and EC barrier failure.

115 Intercalated discs composed of desmosomes, adherens junctions, and gap junctions provide the struct

116 y regulates the formation and maintenance of adherens junctions, and in cysts the number of lumens fo

117 decreased fibronectin processing, disrupted adherens junctions, and inhibited in vitro lumen formati

118 ia peripheral actin cables and discontinuous adherens junctions, and lead migrating clusters near the

119 the cytoplasm and the nucleus, formation of adherens junctions, and reduced cell motility.

120 , restored fibronectin processing, increased adherens junctions, and rescued defective lumen formatio

121 which are connected through tight junctions, adherens junctions, and stabilizing basement membrane st

122 leton and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate

123 that connect the contractile networks to the adherens junctions, and thus mechanically connect neighb

124 t calcium-independent hyperadhesion, whereas adherens junctions appear to lack such ordered arrays, a

125 Desmosomes and adherens junctions are intercellular adhesive structures

126 Adherens junctions are not static structures; they are c

127 Tricellular adherens junctions are points of high tension that are c

128 iated during cellularization, when cell-cell adherens junctions are positioned at the future boundary

129 actin-based cytoskeleton and its associated adherens junctions are well-established contributors to

130 Scribble and Dlg are enriched in nascent adherens junctions, are essential for adherens junction

131 in at their entire shared interface, both at adherens junctions as well as along basolateral interfac

132 The pathways driving desmosome and adherens junction assembly are temporally and spatially

133 They also suggest that early events of adherens junction assembly involve interactions between

134 man umbilical endothelial cells by promoting adherens junction assembly.

135 ssary for initiating apical contractility or adherens junction assembly.

136 dependent of Src and likely occur through an adherens junction associated complex.

137 icits expression of a cassette of epithelial adherens junction-associated genes in a cell density-dep

138 We find that Vinculin is recruited to the adherens junction at the cleavage furrow, and that inhib

139 on (apical ES; a testis-specific, actin-rich adherens junction at the Sertoli cell-spermatid interfac

140 3 hemichannels are efficiently trafficked to adherens junctions at intercalated discs.

141 ay an expanded apical domain, aggregation of adherens junctions at the cell membrane, and microtubule

142 alpha(RNAi) -induced WC defect is related to adherens junctions because loss of either beta-catenin o

143 In metazoan adherens junctions, beta-catenin links the cytoplasmic t

144 ed their capacity for cleaving E-cadherin in adherens junctions between acinar cells and reduced the

145 ac1-dependent manner, thus preserving stable adherens junctions between adjacent cells.

146 Adherens junctions between RGCs are disrupted in the mut

147 adherin, and the aberrant interaction of its adherens junction binding partner, p120-catenin (p120ctn

148 versed the degradation of tight junction and adherens junction both in vivo and in vitro.

149 Furthermore, Mgc regulates adherens junction but not tight junction structure, and

150 and controlled tissue reorganization disrupt adherens junctions by cleaving the extracellular binding

151 Deregulation of adherens junctions by downregulation of E-cadherin and p

152 egulates tension acting on VE-cadherin-based adherens junctions, cell migration, and barrier formatio

153 sphorylated vascular endothelial cadherin at adherens junctions compared to endothelial cells in more

154 interactions between ZIKA-NS2A and multiple adherens junction complex (AJ) components.

155 unction complex proteins, we also quantified adherens junction complex assembly dynamics during epith

156 icle, we validate and quantify multi-protein adherens junction complex assembly in situ using light m

157 otein pairs, we quantified various stages of adherens junction complex assembly, the multiprotein com

158 ve determined the nanoscale structure of the adherens junction complex formed by the alpha-catenin*be

159 n live cells expressing fluorescently tagged adherens junction complex proteins, we also quantified a

160 ively, we identified novel components of the adherens junction complex, and we introduce a novel mole

161 n to the cell-cell contact zone, assembly of adherens junction complexes, acto-myosin tension-mediate

162 gens desmoglein (Dsg) 3 and 1 but not of the adherens junction component E-cadherin (Ecad) was depend

163 robustness of polarisation of E-cadherin- an adherens junction component- in the periderm.

164 a syndecan-TRPC4 complex controls adhesion, adherens junction composition, and early differentiation

165 so discovered that IL2 induces disruption of adherens junctions, concomitant with cytoskeletal reorga

166 Restoring the activity of adherens junctions could be of therapeutic benefit in va

167 species impairs Ca(2+)-mediated formation of adherens junctions, critical to maintaining mechanical i

168 Drosophila Canoe maintains adherens junction-cytoskeletal linkage during gastrulati

169 , alpha-pv-deficient ECs show reduced stable adherens junctions, decreased monolayer formation, and i

170 nd metastasis by promoting the disruption of adherens junctions, dedifferentiation, and an epithelial

171 lecular blueprint that is similar to that of adherens junctions, desmosomal cadherins - called desmog

172 tional complex, composed of tight junctions, adherens junctions, desmosomes, and an associated actomy

173 nected by multiprotein tight junctions (TJ), adherens junctions, desmosomes, and gap junction complex

174 This calcium influx causes adherens junction disassembly and cytoskeletal rearrange

175 egulating endothelial cell contractility and adherens junction disassembly leading to endothelial bar

176 Adherens junction disassembly within premigratory neural

177 t to modulate cytoskeletal contractility and adherens junctions disassembly during extravasation and

178 rocess, also known as delamination, involves adherens-junction disassembly and acto-myosin-mediated a

179 istamine causes the rapid formation of focal adherens junctions, disrupting the endothelial barrier b

180 Fmnl3 localizes to adherens junctions downstream of Src and Cdc42 and its d

181 though Snail is essential for disassembly of adherens junctions during epithelial-mesenchymal transit

182 ls that protect the integrity of endothelial adherens junctions during the inflammatory response, thu

183 To study this, we examined adherens junctions during WC in Drosophila larvae.

184 n endocytosis and recycling to contribute to adherens junction dynamics without resulting in junction

185 tworks infiltrating the brain thus depend on adherens junctions dynamics, the targeting of which may

186 NAs encoding tight junction protein ZO-1 and adherens junction E-cadherin, resulting in the dysfuncti

187 d NOCA-1 are recruited to hemidesmosomes and adherens junctions early in elongation.

188 how that depletion of alpha-catenin perturbs adherens junctions, enhances cell proliferation and moti

189 Pacsin2 concentrates at focal adherens junctions (FAJs) that are experiencing unbalanc

190 e are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells th

191 2 signaling in an in vitro BBB model altered adherens junction formation via activation of Rho/ROCK,

192 erface, we show that it is not essential for adherens junction formation.

193 Inhibition of VE-cadherin clustering at adherens junctions (function-blocking antibody; FBA) red

194 che interactions are mediated by heterotypic adherens junctions (hAJs) involving cancer-derived E-cad

195 functions, as a structural component of the adherens junction in cell adhesion and as the T-cell fac

196 al cells and sustains the remodelling of the adherens junction in response to mechanical forces.

197 plasmic specialization (ES) is an actin-rich adherens junction in the seminiferous epithelium of adul

198 ral analysis shows actin accumulation at the adherens junction in TOCA-1-knockout cells but unaltered

199 e analysis shows that PDZD11 is localized at adherens junctions in a PLEKHA7-dependent manner, becaus

200 aetoid and Canoe are enriched at tricellular adherens junctions in a Sidekick-dependent manner; Sidek

201 pathways that ultimately disrupt endothelial adherens junctions in diabetic retinas by causing dissoc

202 lial-mesenchymal transitions (EMTs), loss of adherens junctions in Drosophila melanogaster gastrula i

203 n protein, is highly enriched at tricellular adherens junctions in Drosophila.

204 In addition, ROS disassembles adherens junctions in epithelial cells via posttranslati

205 ide new insights into the regulatory role of adherens junctions in initiating and maintaining autocri

206 pathway transcriptional coactivator, to the adherens junctions in order to maintain cell-cell adhesi

207 tro and leads to excess actin recruitment to adherens junctions in vivo.

208 epidermis exhibit polarised distribution of adherens junctions in zebrafish.

209 rupted colonic epithelial tight junction and adherens junction, increased mucosal permeability, and e

210 y we sought to identify how contractility at adherens junctions influences apoptotic cell extrusion.

211 HD2 inducible knockout mice exhibit improved adherens junction integrity and endothelial barrier func

212 2 and VE-cadherin phosphorylation, preserved adherens junction integrity and VEGFR2.VE-cadherin compl

213 rb juxtamembrane domain was not required for adherens junction integrity, it was necessary for MZ loc

214 t cell contractility is required to maintain adherens junction integrity.

215 ction structure, and the ability to regulate adherens junctions is dependent on GAP activity and sign

216 ctive oxygen species-mediated disassembly of adherens junctions is pivotal for the acute epidermal da

217 e to the regulation of cell-cell tension and adherens junctions is unknown.

218 n pancreatic beta-cells Kirrel2 localizes to adherens junctions, is regulated by multiple post-transl

219 ial cadherin (VE-cadherin), a constituent of adherens junctions, leads to dissociation of its stabili

220 It consists of short stretches of adherens junction-like contacts inserted between interme

221 Src or cause appropriate dissolution of the adherens junctions made up of the proteins vascular endo

222 ires two major events: local dissociation of adherens junctions manifested as gaps in vascular endoth

223 thelial glycocalyx layer (EGL) and tight and adherens junction markers with plasma leakage.

224 ties, including ectopic apical expression of adherens junction markers, similar to Irf6 hypomorphic m

225 acto-myosin tension-mediated anchoring, and adherens junction maturation following de novo cell-cell

226 drenal cortex organize into rosettes through adherens junction-mediated constriction, and that rosett

227 We demonstrated reduced adherens junction molecule (CD31 and VE-cadherin) expres

228 The epithelial cells are joined by apical adherens junctions; neither tight junctions nor gap junc

229 VE-cadherin) is an adhesive protein found in adherens junctions of endothelial cells.

230 e developed, for the first time, detects the adherens junctions of epithelial cells in 3D, without th

231 symbol CTNND1) is an important component of adherens junctions of epithelial cells; however, its fun

232 nd that 18 CCARPs link to core components of adherens junctions or desmosomes.

233 epletion disrupted apical-basal polarity and adherens junction organization in mesoderm cells, sugges

234 helicase, is required for cell polarity and adherens junction organization in the Drosophila melanog

235 unctions revealed that blebbistatin impaired adherens-junction organization, particularly between tip

236 ZEB1 overexpression functionally represented adherens junction pathway.

237 RhoA signaling at adherens junctions plays a key role in this process by c

238 ascent adherens junctions, are essential for adherens junction positioning and supermolecular assembl

239 VE-cadherin clustering at adherens junctions promotes protective endothelial funct

240 pericyte cell survival; N-cadherin, the key adherens junction protein between endothelium and pericy

241 At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated, lea

242 ultured cells and enhanced expression of the adherens junction protein E-cadherin.

243 e discovery that measles virus (MV) uses the adherens junction protein nectin-4 as its epithelial rec

244 The adherens junction protein P-cadherin appears loosely dis

245 n of astrocytic gap junction and endothelial adherens junction protein using immunostaining and Weste

246 Src-related tyrosine phosphorylation of the adherens junction protein vascular endothelial cadherin

247 junction protein occludin (p < 0.05) and the adherens junction protein VE-cadherin (p < 0.05).

248 eins, reduction in expression of endothelial adherens junction protein, and reduced microvascular rea

249 ithelial cells, we demonstrated that loss of adherens junction protein, epithelial cadherin, and the

250 clustering of the main endothelial-specific adherens junction protein, VEC (vascular endothelial cad

251 Here we show that the adherens junction proteins afadin and CDH2 are critical

252 eracts with the actin cytoskeleton, gap, and adherens junction proteins and localizes to intercalated

253 r photobleaching (FRAP), we demonstrate that adherens junction proteins are stabilized at the cleavag

254 ein that co-localizes and interacts with the adherens junction proteins E-cadherin and beta-catenin i

255 Although we observed reduced expression of adherens junction proteins E-cadherin, beta-catenin, and

256 n did not affect the expression of tight and adherens junction proteins such as ZO-1, claudin, and JA

257 rection also relies on the tension-sensitive adherens junction proteins vinculin, alpha-E-catenin, an

258 The colocalization of KCNQ1 with adherens junction proteins was lost with increasing EMT

259 ificantly decreased levels of tight junction/adherens junction proteins, including ZO-1, occludin, an

260 ell periphery, limiting its interaction with adherens junction proteins.

261 he apical zonula adherens (ZA) of epithelial adherens junctions recruit the core components of the RN

262 For example, myosin-rich adherens junctions recruit the cytohesin Arf-GEF Steppke

263 ow loss of beta-catenin results in disrupted adherens junctions, reduced rosette number, and dysmorph

264 s been extensively studied in the context of adherens junction reinforcement to stabilize adhesive ce

265 tain epithelial integrity when challenged by adherens junction remodeling during germband extension a

266 This adherens junction remodeling pattern is frequently obser

267 Adherens junction remodeling regulated by apical polarit

268 pply during early stages of ciliogenesis and adherens junction remodeling.

269 for N-WASP in promoting P aeruginosa-induced adherens junction rupture.

270 r of apical stress fibers (aSFs) anchored to adherens junctions scales with cell apical area to limit

271 n of an E-cadherin/Rap1 complex required for adherens junction sealing.

272 ial for EMT, cytoskeletal rearrangement, and adherens junction signaling.

273 ases control both the actin cytoskeleton and adherens junction stability and are recognized as essent

274 othelial cells and pericytes, which disrupts adherens junction structure and function, and this was s

275 lular tight junctions (tTJs) and tricellular adherens junctions (tAJs) have been identified.

276 podocytes at the slit diaphragm, a modified adherens junction that comprises the protein filtration

277 role of APC2 and F-actin in maintaining the adherens junctions that anchor GSCs to the niche.

278 al tissue architecture is maintained through adherens junctions that are created through extracellula

279 ing A7 (PLEKHA7) is a cytoplasmic protein at adherens junctions that has been implicated in hypertens

280 central component of the cell-cell adhesion adherens junctions that transmit mechanical stress from

281 Although apical localization of the adherens junctions, the Par complex, the Crumbs complex

282 tic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanop

283 zed role for DUSP23 in regulating E-cadherin adherens junctions through promoting the dephosphorylati

284 rity requires coordination between cell-cell adherens junctions, tight junctions (TJ), and the periju

285 potential interaction partners may exist in adherens junctions, tight junctions, and focal adhesions

286 res structural and functional integration of adherens junctions, tight junctions, gap junctions (GJ),

287 the actin cytoskeleton to enable tricellular adherens junctions to maintain or transmit cell bond ten

288 helial cells transmit contractile force with adherens junctions to mediate morphological changes like

289 by downregulated proteins included cell-cell adherens junction, translation and ER to Golgi vesicle-m

290 Adherens junctions transmit forces between cells, but ho

291 intercellular barrier proteins at tight and adherens junctions, triggering epithelial alarmin cytoki

292 actomyosin networks maintain attachments to adherens junctions under tension is poorly understood.

293 tight junctions (Claudins and ZO proteins), adherens junctions (VE-cadherin, alpha-Actinin), and the

294 n contrast to the strong interactions at the adherens junction, we find that the affinity between ZO-

295 In collecting lymphatics, adherens junctions were disrupted, and the vessels leake

296 Ageing impairs the activity of adherens junctions, which contributes to endothelial dil

297 ets depends on classical cadherin-containing adherens junctions, which link actin to the plasma membr

298 These microtubules maintain adherens-junctions while actin maintains microtubules, a

299 reased radial actin stress fibers, increased adherens junction width and increased endothelial monola

300 ion, aligned with the apical actin cable and adherens-junctions within chick and mouse neuroepithelia