ライフサイエンスコーパス: adult T-cell leukemia

1 type 1 (HTLV-1) is the etiological agent of adult T cell leukemia.

2 oncogenic retrovirus etiologically causal of adult T cell leukemia.

3 play an important role in the development of adult T cell leukemia.

4 ymphotropic virus type-I (HTLV-I)-associated adult T cell leukemia.

5 evelopment of the virally associated disease adult T cell leukemia.

6 cytokine-dependent T lymphocytes and causes adult T cell leukemia.

7 in all subjects, including the patient with adult T cell leukemia.

8 related retroviruses with the former causing adult T cell leukemia.

9 myelopathy/tropical spastic paraparesis and adult T cell leukemia.

10 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia.

11 marily infects CD4+ T lymphocytes and causes adult T-cell leukemia.

12 the virus may play a role in the etiology of adult T-cell leukemia.

13 type I (HTLV-1) is the etiological agent of adult T-cell leukemia.

14 l responses in the majority of patients with adult T-cell leukemia.

15 s type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia.

16 oncogenic retrovirus etiologically causal of adult T-cell leukemia.

17 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia.

18 unctions of Tax to promote HTLV-I-associated adult T-cell leukemia.

19 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia.

20 formation contributing to the development of adult T-cell leukemia.

21 lopment of an acute T-cell malignancy termed adult T-cell leukemia.

22 human T cells, clinically manifested as the adult T-cell leukemia.

23 s type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia.

24 ocytes, which can lead to the development of adult T-cell leukemia.

25 oncovirus that is clinically associated with adult T-cell leukemia.

26 oncogenic retrovirus that is associated with adult T-cell leukemia.

27 rmation events leading to the development of adult T-cell leukemia.

28 dismal lymphoproliferative disease known as adult T-cell leukemia.

29 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia.

30 cer in humans and is etiologically linked to adult T-cell leukemia.

31 to T-cell transformation and development of adult T-cell leukemia.

32 emia virus type-1 is the causative agent for adult T-cell leukemia.

33 ic agent of the aggressive and fatal disease adult T-cell leukemia.

34 In one patient with adult T cell leukemia, a specific clone bearing Vbeta7 w

35 T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia, a disease commonly associated wit

36 ell transformation by Tax and development of adult T-cell leukemia after HTLV-1 infection.

37 virus (HTLV-I) is etiologically linked with adult T cell leukemia, an aggressive and usually fatal e

38 us type I (HTLV-I) is the etiologic agent of adult T-cell leukemia, an acute and often fatal T-cell m

39 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, an aggressive CD4(+) malignancy.

40 nd sustained diseases, such as autoimmunity, adult T cell leukemia and HIV-1.

41 nopathogenesis related to the progression of adult T cell leukemia and HTLV-1-associated myelopathy/t

42 us type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/t

43 IL-15 in HTLV-I-associated diseases such as adult T cell leukemia and HTLV-I-associated myopathy/tro

44 ell leukemia virus (HTLV) is associated with adult T cell leukemia and neurological disorders (TSP/HA

45 hotropic virus type 1 (HTLV-1) mainly causes adult T cell leukemia and predominantly immortalizes/tra

46 oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I

47 pic virus type I (HTLV-I) is associated with adult T-cell leukemia and a slowly progressive disease o

48 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and HTLV-1-associated myelopathy.

49 ll leukemia virus type 1 (HTLV-1) results in adult T-cell leukemia and HTLV-1-associated myelopathy/t

50 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/t

51 kemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia and is associated with a variety o

52 us type I (HTLV-1) is the etiologic agent of adult T-cell leukemia and lymphoma and HTLV-1-associated

53 us-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% o

54 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and lymphoma, an aggressive clonal

55 HTLV-1 is the etiologic agent of adult T-cell leukemia and lymphoma, an aggressive clonal

56 (HTLV-1), an etiological factor that causes adult T-cell leukemia and lymphoma, has a crucial role i

57 cogenic retrovirus associated primarily with adult T-cell leukemia and neurological disease.

58 ropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia and several lymphocyte-mediated in

59 ll leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia and T-cell lymphoma (ATL) are aggr

60 s type I (HTLV-I) is the etiologic agent for adult T-cell leukemia and the neurological disorder trop

61 type I (HTLV-I) is the etiological agent for adult T-cell leukemia and tropical spastic paraparesis/H

62 iated with several serious diseases, such as adult T-cell leukemia and tropical spastic paraparesis/m

63 s etiologically linked to the development of adult T-cell leukemia and various human neuropathies.

64 irus (HTLV) type 1, the etiological agent of adult T-cell leukemia, are remarkably resistant to conve

65 ax plays an integral role in the etiology of adult T cell leukemia, as expression of Tax in T lymphoc

66 y by HBZ is important for the development of adult T-cell leukemia associated with HTLV-1 infection.

67 -dependent cells derived from a patient with adult T cell leukemia (ATL) and found enrichment of sing

68 umber of pathologic abnormalities, including adult T cell leukemia (ATL) and HTLV-1-associated myelop

69 ly occurs in T/B cell malignancies including adult T cell leukemia (ATL) caused by human T-cell leuke

70 Adult T cell leukemia (ATL) is a serious form of cancer

71 cked spontaneous proliferation of smoldering adult T cell leukemia (ATL) T cells.

72 uses a fatal hematopoietic malignancy termed adult T cell leukemia (ATL).

73 HTLV-1 is associated with adult T-cell leukemia (ATL) and a variety of immune-medi

74 us type I (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL) and HTLV-1 associated myelop

75 pic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1-associated myelop

76 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelop

77 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelop

78 Adult T-cell leukemia (ATL) and human T-cell lymphotropi

79 c virus-1 (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL) and the neurological disorde

80 the group that first identified a cluster of adult T-cell leukemia (ATL) cases in Japan, provided con

81 of interleukin-10 (IL-10), in patients with adult T-cell leukemia (ATL) caused by human T-cell leuke

82 Adult T-cell leukemia (ATL) cells contain integrated hum

83 athway is also activated in freshly isolated adult T-cell leukemia (ATL) cells that often lack detect

84 (HTLV-1)-transformed lymphocyte cell lines, adult T-cell leukemia (ATL) cells, and in other hematolo

85 In most adult T-cell leukemia (ATL) cells, Tax oncoprotein expre

86 Adult T-cell leukemia (ATL) consists of an overabundance

87 Adult T-cell leukemia (ATL) develops in a small proporti

88 Adult T-cell leukemia (ATL) develops in a small proporti

89 Adult T-cell leukemia (ATL) develops in a small proporti

90 Adult T-cell leukemia (ATL) develops in a small proporti

91 antibodies, which recognize CD25, for human adult T-cell leukemia (ATL) in a murine model.

92 Adult T-cell leukemia (ATL) is a fatal malignancy caused

93 Adult T-cell leukemia (ATL) is a highly chemoresistant a

94 Adult T-cell leukemia (ATL) is a lymphoid neoplasm cause

95 Adult T-cell leukemia (ATL) is an aggressive hematologic

96 Adult T-cell leukemia (ATL) is an aggressive lymphoproli

97 Adult T-cell leukemia (ATL) is an aggressive malignancy

98 Adult T-cell leukemia (ATL) is an aggressive T-cell mali

99 Adult T-cell leukemia (ATL) is caused by human T-cell ly

100 The etiologic agent of adult T-cell leukemia (ATL) is human T cell lymphotropic

101 irus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells bot

102 Adult T-cell leukemia (ATL), a heterogeneous disease, ca

103 us type I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), a rapidly progressing, clon

104 roteins are implicated in the development of adult T-cell leukemia (ATL), a T-cell malignancy caused

105 mia virus type 1 (HTLV-I) is associated with adult T-cell leukemia (ATL), an aggressive lymphoprolife

106 us type-I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), an aggressive lymphoprolife

107 irus type I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL), and is indispensable for ma

108 irus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL), is estimated to affect 10-2

109 rved on chromosome 6q in acute/lymphoma-type adult T-cell leukemia (ATL), suggesting a putative tumor

110 emia virus type 1 (HTLV-1) that recapitulate adult T-cell leukemia (ATL)-like leukemic symptoms and d

111 irus that induces a fatal T-cell malignancy, adult T-cell leukemia (ATL).

112 s type I (HTLV-I) is the causative agent for adult T-cell leukemia (ATL).

113 virus type I (HTLV-I) are characteristics of adult T-cell leukemia (ATL).

114 us considered to be the etiological agent of adult T-cell leukemia (ATL).

115 in hematological cancers, including Pim-1 in adult T-cell leukemia (ATL).

116 ople worldwide and is the causative agent of adult T-cell leukemia (ATL).

117 can cause a rare form of leukemia designated adult T-cell leukemia (ATL).

118 type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL).

119 oncogenic retrovirus etiologically causal of adult T-cell leukemia (ATL).

120 uman retrovirus and the etiological agent of Adult T-cell Leukemia (ATLL).

121 genes have been found in only one-fourth of adult T-cell leukemia cases.

122 Consistently, human adult T cell leukemia cells that acquire elevated APC(Cd

123 planation for the highly aneuploid nature of adult T-cell leukemia cells.

124 7 amino acids and is 59% homologous to human adult T cell leukemia-derived factor/TRX, originally des

125 The cellular redox factors Ref-1 and adult T-cell leukemia-derived factor stimulated the DNA

126 en linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predispo

127 us type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, encodes unique regulatory and acc

128 irus (HTLV) type 1, the etiological agent of adult T-cell leukemia, expresses the viral oncoprotein T

129 hematopoietic stem cell transplantation for adult T-cell leukemia in Japan.

130 e altered properties of cell growth found in adult T cell leukemia induced by HTLV-I.

131 an T cell leukemia virus 1 (HTLV-1)-mediated adult T cell leukemia is associated with the ability of

132 Because adult T-cell leukemia is a highly virulent cancer that i

133 Adult T-cell leukemia is caused by human T-cell leukemia

134 of Blood, Nagai et al provide evidence that adult T-cell leukemia is hierarchically organized and su

135 -cell leukemia virus type 1 (HTLV-1)-induced adult T-cell leukemia is linked to the expression of the

136 rus type 1 (HTLV-1), a virus associated with adult T-cell leukemia, is significantly lower than that

137 nsformation of T cells during the genesis of adult T-cell leukemia, it is important to understand the

138 Because adult T cell leukemia like many other human cancers is a

139 Thus, IL-15 synthesis by the adult T-cell leukemia line HuT- 102 involves an increase

140 mphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine d

141 he findings are similar to those in evolving adult T cell leukemia lymphoma and may represent a prely

142 uman T-cell leukemia virus (HTLV)-associated adult T-cell leukemia lymphoma (ATLL) can be identified

143 lishes a lifelong infection and is linked to adult T-cell leukemia lymphoma (ATLL).

144 tor (HBZ) could be used for immunotherapy in adult T-cell leukemia-lymphoma (ATL) patients.

145 obal modification of host gene expression in adult T-cell leukemia-lymphoma (ATL).

146 nd at position 88 in HTLV-1 strains from all adult T-cell leukemia-lymphoma (ATLL) cases and healthy

147 promoters in HTLV-1-infected cell lines and adult T-cell leukemia-lymphoma cells.

148 Adult T-cell leukemia-lymphoma was specifically associat

149 the IRF4 K59R mutation that is exclusive to Adult T-cell leukemia-lymphoma.

150 ell and natural killer cell lymphoma and for adult T-cell leukemia-lymphoma.

151 s type 1 (HTLV-I) is etiologically linked to adult T cell leukemia/lymphoma (ATL) and an inflammatory

152 feration has only brought limited success in adult T cell leukemia/lymphoma (ATL) and in multiple scl

153 ll leukemia virus type 1 (HTLV-1)-associated adult T cell leukemia/lymphoma (ATL) cells as a model sy

154 Adult T cell leukemia/lymphoma (ATL) is an aggressive ca

155 y/tropical spastic paraparesis (HAM/TSP), or adult T cell leukemia/lymphoma (ATL).

156 type 1 (HTLV-1) is the ethological agent of adult T cell leukemia/lymphoma (ATLL) and a number of ly

157 Adult T cell leukemia/lymphoma (ATLL) is an aggressive m

158 In adult T cell leukemia/lymphoma (ATLL), the FoxP3(+) popu

159 f an aggressive hematologic neoplasia termed adult T cell leukemia/lymphoma (ATLL).

160 a/lymphotropic virus type I (HTLV-I) induces adult T cell leukemia/lymphoma (ATLL).

161 irus type 1 (HTLV-1) is a causative agent of adult T cell leukemia/lymphoma and a variety of inflamma

162 CI, 1.1-7.1) infection, although no case of adult T cell leukemia/lymphoma was diagnosed.

163 us type 1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma.

164 in the circulation, as seen in patients with adult T cell leukemia/lymphoma.

165 y/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma.

166 s type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associat

167 ophic virus (HTLV) type I has been linked to adult T-cell leukemia/lymphoma (ATL) and HTLV-I associat

168 T-cell lymphotropic virus type I (HTLV-I) in adult T-cell leukemia/lymphoma (ATL) and HTLV-I associat

169 ropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia/lymphoma (ATL) and is associated w

170 ociated with the lymphoproliferative disease adult T-cell leukemia/lymphoma (ATL) and the neurodegene

171 In adult T-cell leukemia/lymphoma (ATL) cell lines and pati

172 1, causes the aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) in 5% of infected p

173 Adult T-cell leukemia/lymphoma (ATL) is a highly aggress

174 Adult T-cell leukemia/lymphoma (ATL) is an aggressive an

175 Adult T-cell leukemia/lymphoma (ATL) is an aggressive he

176 Adult T-cell leukemia/lymphoma (ATL) is an aggressive ma

177 Adult T-cell leukemia/lymphoma (ATL) is etiologically li

178 The majority of patients with adult T-cell leukemia/lymphoma (ATL) resulting from huma

179 uman T-cell leukemia virus type 1-associated adult T-cell leukemia/lymphoma (ATL) typically has survi

180 leukemia virus type 1 (HTLV-1) will develop adult T-cell leukemia/lymphoma (ATL), a disease frequent

181 x transactivator initiates transformation in adult T-cell leukemia/lymphoma (ATL), a highly aggressiv

182 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL), a malignancy of CD

183 al knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL).

184 in a lymphoproliferative disorder resembling adult T-cell leukemia/lymphoma (ATL).

185 1 (HTLV-1) is etiologically associated with adult T-cell leukemia/lymphoma (ATL).

186 ) results in a variety of diseases including adult T-cell leukemia/lymphoma (ATL).

187 Sixty-four patients with adult T-cell leukemia/lymphoma (ATL; 18 patients with in

188 cytic leukemia (3), hairy cell leukemia (1), adult T-cell leukemia/lymphoma (ATLL) (1), marginal zone

189 ab led to rapid progression in patients with adult T-cell leukemia/lymphoma (ATLL) (NCT02631746).

190 CL-NOS), anaplastic large-cell lymphoma, and adult T-cell leukemia/lymphoma (ATLL) and a lower incide

191 ll lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL) and a variety of l

192 e 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associa

193 1) infection is linked to the development of adult T-cell leukemia/lymphoma (ATLL) and the neuroinfla

194 ukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma (ATLL) and viral oncogeni

195 member A (RHOA) hotspot mutations among the adult T-cell leukemia/lymphoma (ATLL) category have oppo

196 Adult T-cell leukemia/lymphoma (ATLL) is an incurable di

197 the cytogenetic and clinical significance of adult T-cell leukemia/lymphoma (ATLL) is still unclear.

198 o develop the fatal and debilitating disease adult T-cell leukemia/lymphoma (ATLL) or HTLV-associated

199 In IL-2-dependent cells and adult T-cell leukemia/lymphoma (ATLL) patient samples, h

200 hotropic virus type-1 (HTLV-1) that initiate adult T-cell leukemia/lymphoma (ATLL) remain unclear, in

201 ) to primary T cells in vitro and in ex vivo adult T-cell leukemia/lymphoma (ATLL) samples, but not a

202 We recently reported the first case of adult T-cell leukemia/lymphoma (ATLL) that responded rap

203 +) and CD8(+) T cells, yet this virus causes adult T-cell leukemia/lymphoma (ATLL) that typically has

204 in the CD4+ leukemic cells of patients with adult T-cell leukemia/lymphoma (ATLL), the viral transac

205 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL).

206 Type I (HTLV-I) is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL).

207 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL).

208 munoblastic type (18.5%), NKTCL (10.4%), and adult T-cell leukemia/lymphoma (ATLL; 9.6%).

209 -negative anaplastic large cell lymphoma, 14 adult T-cell leukemia/lymphoma and 44 extranodal NK/T-ce

210 ll lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and exhibits high genetic

211 leukemia virus type 1 (HTLV-1) can result in adult T-cell leukemia/lymphoma and HTLV-1 associated-mye

212 us type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma and HTLV-1-associated mye

213 T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and is associated with a

214 us type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a

215 lymphotropic virus (HTLV) is associated with adult T-cell leukemia/lymphoma and myelopathy.

216 human retrovirus identified and causes both adult T-cell leukemia/lymphoma and tropical spastic para

217 that causes two distinct pathologies termed adult T-cell leukemia/lymphoma and tropical spastic para

218 ukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma as well as tropical spast

219 Here, using EP300-mutated adult T-cell leukemia/lymphoma cells and an EP300-select

220 ow well recognized as a potential factor for adult T-cell leukemia/lymphoma development.

221 Adult T-cell leukemia/lymphoma has a homogeneous molecul

222 Adult T-cell leukemia/lymphoma is a fatal malignancy eti

223 so studied: MT4 (derived from a patient with adult T-cell leukemia/lymphoma) and Jurkat (derived from

224 e 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma, a severe and fatal CD4+

225 mia virus type I is the etiological agent of adult T-cell leukemia/lymphoma, an aggressive and fatal

226 type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma, and it encodes a number

227 T-cell lymphoma, cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma, and other peripheral T-c

228 There is high morbidity and mortality due to adult T-cell leukemia/lymphoma, HTLV-1-associated myelop

229 for clinical use in follicular lymphoma and adult T-cell leukemia/lymphoma, respectively.

230 clude malignant infiltrates in patients with adult T-cell leukemia/lymphoma, retinal degeneration, ne

231 T-cell proliferation, which in turn leads to adult T-cell leukemia/lymphoma.

232 reproduced many elements of HTLV-associated adult T-cell leukemia/lymphoma.

233 e each had diffuse large B-cell lymphoma and adult T-cell leukemia/lymphoma.

234 ity in patients with hairy cell leukemia and adult T-cell leukemia/lymphoma.

235 kemia virus type I is the etiologic agent of adult T-cell leukemia/lymphoma.

236 quently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.

237 some cases of natural killer (NK)/T-cell and adult T-cell leukemia/lymphoma.

238 OA mutations, A161P and A161V, identified in adult T-cell leukemia/lymphoma.

239 presents a major risk for the development of adult T-cell leukemia/lymphoma.

240 ) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma.

241 , CD4+ cutaneous T-cell lymphomas (6 cases), adult T-cell leukemia/lymphomas (3 cases), T-cell chroni

242 tient), Hodgkin's disease (one patient), and adult T-cell leukemia (one patient).

243 emain asymptomatic, but a proportion develop adult T cell leukemia or inflammatory disease.

244 solated from patients with HTLV-I-associated adult T-cell leukemia or with progeria.

245 mary peripheral blood mononuclear cells from adult T-cell leukemia patients.

246 In our murine model of adult T-cell leukemia, PS-341 used alone did not yield p

247 are causative agents for cervical cancer and adult T-cell leukemia, respectively.

248 Nine patients with adult T-cell leukemia were treated.

249 Adult T-cell leukemia, which can result from infection w

250 HTLV-1 mainly causes adult T cell leukemia, while HTLV-2 is not associated wi

251 mbined immunodeficient murine model of human adult T-cell leukemia with an anti-Tac antibody-streptav

252 -2 receptor alpha (IL-2Ralpha) using a human adult T-cell leukemia xenograft model.