ライフサイエンスコーパス: adult cell

1 afficking of Nek2 to the centrosome of human adult cells.

2 cally heritable and are stably maintained in adult cells.

3 is not obligatory for the function of normal adult cells.

4 on and cdk2 expression between perinatal and adult cells.

5 tions or switching during differentiation in adult cells.

6 transmitted information on firing rate than adult cells.

7 her incidences of functional precursors than adult cells.

8 in the lungs of SCID mice reconstituted with adult cells.

9 antly affect LPS-induced cytokine release in adult cells.

10 ntigen to the high level seen among cultured adult cells.

11 rior in embryonic cells and in a fraction of adult cells.

12 three times more adherent to tenascin-C than adult cells.

13 transcripts were detected in both fetal and adult cells.

14 = .17) toward greater IL-1 secretion by the adult cells.

15 ) possessed the current, but only one in ten adult cells.

16 TX on rate or most of the same parameters in adult cells.

17 cells and across the heart and is slower in adult cells.

18 rexpressed in fetal T cells as compared with adult cells.

19 which larval epidermal cells are replaced by adult cells.

20 +) T cells were markedly lower than those of adult cells.

21 sed in CB naive CD4(+) T cells compared with adult cells.

22 nse, but it regulates the viral load only in adult cells.

23 els in CB naive CD4(+) T cells compared with adult cells.

24 m cells derived from embryos or reprogrammed adult cells.

25 s was 6-fold higher than that converted from adult cells.

26 ) insulin(+) cells during development and in adult cells.

27 ogical dysregulation of key processes within adult cells.

28 nt BM largely matched that of TdT-sufficient adult cells.

29 differentiation of terminally differentiated adult cells.

30 s present within nucleoli of most larval and adult cells.

31 cts of re-expressing an embryonic program in adult cells.

32 D and autoimmune gastritis as efficiently as adult cells.

33 ession of B7-1, B7-2, and CD40 compared with adult cells.

34 could set a block to transdifferentiation in adult cells.

35 he expression of the hormone products in the adult cells.

36 s play a role in the survival of postmitotic adult cells.

37 ogenic (neonate) and angiogenic (neonate and adult) cells.

38 Sparks in adult cells (220 events) were infrequent, yet they were

39 suppression of embryonic gene expression in adult cells, a mechanism that may underlie its tumor-sup

40 birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by

41 Deletion of the HBBP1 region in adult cells alters contact landscapes in ways more close

42 cytokines in term cells and IL-8 release in adult cells and (ii) augmented LPS-induced TNF-alpha, IL

43 ons to reconstruct developmental lineages of adult cells and demonstrate that the two daughter cells

44 persistent epigenetic response that protects adult cells and extends lifespan.

45 type cells and B1a (B-1 B) cells compared to adult cells and long-term maintenance of these initially

46 embryonic development, reprogramming normal adult cells and malignant transformation and progression

47 atal CD8+ T cells expanded more rapidly than adult cells and quickly became terminally differentiated

48 es and platelets are among a small number of adult cells and tissues that synthesize and contain FN E

49 The protein is widely distributed in adult cells and tissues.

50 ocesses that restrict fate permissibility in adult cells, and keep plasticity in check.

51 eing low in neonatal fibroblasts and high in adult cells, and treatment with transforming growth fact

52 some critical tumor suppressor mechanisms in adult cells are not required by neonatal cells.

53 Outstanding questions include whether any adult cells are viable in the absence of polzeta and whe

54 Integration of newly generated neurons into adult cell assemblies is a key mechanism for network pla

55 mice were significantly less efficient than adult cells at migrating to the draining lymph nodes aft

56 ath, we find that E93 is expressed widely in adult cells at the pupal stage and is required for many

57 lthough the differences between neonatal and adult cells became smaller with increasing time postbirt

58 y expressed in fetal cells and turned off in adult cells, becomes reactivated in the most advanced st

59 ishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early spe

60 faster in high-frequency IHCs, with that of adult cells being more rapid than immature cells.

61 hened the spark duration in wt embryonic and adult cells but not in RyR type 3-null cells.

62 GF receptors are expressed on most fetal and adult cells but their precise roles are not well known.

63 ent of TATA box-binding protein (TBP) in the adult cells, but not in embryonic cells, suggesting that

64 sible to achieve the direct conversion of an adult cell by exposing it to a demethylating agent immed

65 [(3)H]thymidine incorporation) in fetal and adult cells by 211 +/- 18% and 150 +/- 14%, respectively

66 n of kidney development from a population of adult cells by generating embryonic progenitors may be f

67 cells from tissues, or generating them from adult cells by nuclear transfer, encourages attempts to

68 a new regenerative medicine in which damaged adult cells can be replaced with new cells.

69 Recently, it has been shown that adult cells can be reprogrammed directly, without the ne

70 demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic c

71 This has made these adult cells, collectively called mesenchymal stem cells

72 The fact that a lamb was derived from an adult cell confirms that differentiation of that cell di

73 With the use of neonatal and adult cell culture systems and adult and Mosaic Analysis

74 between S and M phases to become the complex adult cell cycle.

75 nal cyclins plays a role in establishing the adult cell cycle.

76 stinct biological functions in embryonic and adult cell cycles of mammals.

77 Cdc25C protein phosphatase to embryonic and adult cell cycles, mice lacking Cdc25C were generated.

78 In adult cells, demethylation at these enhancers prevents e

79 This review summarizes currently available adult cell-derived hepatobiliary organoid models and the

80 thus rendering bulk analyses of postmitotic adult cells difficult to interpret.

81 ured embryonic dorsal pancreatic buds, these adult cells display a unique capacity to contribute to b

82 ng directly regulates stem cells to generate adult cells during metamorphosis.

83 Like their embryonic counterparts, adult cells expressing Aqp2 and V-ATPase subunits B1 and

84 g of the developmental switch from larval to adult cell fates during Caenorhabditis elegans developme

85 in-4 RNA, and transition from late larval to adult cell fates requires the 21-nucleotide let-7 RNA.

86 required prior to the third stage for normal adult cell fates, suggesting that it acts once to contro

87 identity and prevent premature expression of adult cell fates.

88 led us to examine the DNA damage response of adult cells following acute RB deletion.

89 e for reprogramming readily accessible human adult cells for cell replacement therapy.

90 re-differentiation of the full repertoire of adult cells from a single original cell of any kind.

91 , because significantly increased numbers of adult cell-generated neurons were observed in the hippoc

92 The cloning of animals from adult cells has demonstrated that the developmental stat

93 tion important for embryonic development and adult cell homeostasis.

94 s the plasticity of seemingly differentiated adult cells, identifies Fbw7 as a master regulator of ce

95 like progenitor cells during development and adult cells in barrier tissues, to harbour significantly

96 to ZIKV, although they were as efficient as adult cells in supporting viral infection.

97 ytometry, before and after 48 hr culture, to adult cells in terms of class II and costimulatory molec

98 compared with that of normal differentiated adult cells in the body.

99 manipulate both embryonic and differentiated adult cells in the context of regenerative medicine.

100 le are completely eliminated and replaced by adult cells in the corresponding tissues of the frog for

101 o compromised proliferation and viability of adult cells in vitro.

102 Other genes, expressed preferentially in adult cells in vivo, are down-regulated following injuri

103 nic fibroblasts, which is similar to that in adult cells in vivo.

104 In adult cells, inactivated and live virus invoked cytokine

105 ivin is, however, expressed in proliferating adult cells, including human hematopoietic stem cells, T

106 increase in the number of both neonatal and adult cells interacting (interacting cells = rolling + a

107 em cell technology enabled the conversion of adult cells into any other cell type passing through a s

108 erative medicine is to instructively convert adult cells into other cell types for tissue repair and

109 The reprogramming of adult cells into pluripotent cells or directly into alte

110 Direct lineage conversion of adult cells is a promising approach for regenerative med

111 ion of innate immune protective cytokines by adult cells is diminished after transfer to neonatal mic

112 ugh the reactivation of embryonic signals in adult cells is one of the characteristics of cancer, the

113 nt embryonic lethality, but the situation in adult cells is still unclear.

114 gnaling in cardiomyogenic differentiation of adult cells is unclear.

115 ned embryonic enhancers is hypomethylated in adult cells, it is unknown whether this putative epigene

116 miting for transcription, yet their roles in adult cell lineages are largely unknown since homozygous

117 (ES) cells can contribute precursors to all adult cell lineages.

118 itment and differentiation of developing and adults cell lineages.

119 urvey of ASM across 16 human pluripotent and adult cell lines using Illumina bisulfite sequencing.

120 tion, whereas both viruses equally spread in adult cells maintained in similar conditions.

121 By using different ratios of fetal and adult cell mixtures, fetal liver cells repopulated 8.2 t

122 tem cell organoid cocultures of neonatal and adult cell monolayers with damaged enterocytes replicate

123 s of these two processes are to variation in adult cell number by estimating total ganglion cell prod

124 its are observed, but rather laterally where adult cell number is nearly normal.

125 e of defined size, Engrailed-2 helps specify adult cell number.

126 ls of widely different tissue origins and in adult cells of blood lineages.

127 ploid embryonic stem-cell lines derived from adult cells of diseased human subjects, we have systemat

128 of neonatal cells that rolled compared with adult cells on both stimulated HUVECs and CHO-P-selectin

129 first instance of engineered intestine from adult cells or an engineered tissue.

130 Stem cells may be obtained from somatic (adult) cell or embryonic cell origin.

131 sses that might underlie apparent changes in adult cell phenotype.

132 lated cells may be a common theme underlying adult cell plasticity in regenerative vertebrates.

133 e BXD32, a strain that has an extremely high adult cell population, and Mus caroli (CARL/ChGo), a wil

134 reviously unreported Sox1/Sox2/Sox9 positive adult cell population, suggesting that these cells may r

135 kinetics and lineage potentials of different adult cell populations to be investigated.

136 between species, and the human juvenile and adult cell populations.

137 l stage-related event and that embryonic and adult cells possess distinct chromatin structures of the

138 Thus, hypomethylated DNA in adult cells preserves a "fossil record" of tissue-specif

139 ieve this, it is important to understand how adult cell production, migration and differentiation may

140 screen-based battery, but leads to increased adult cell proliferation in the hippocampus and enhanced

141 We examined the distribution of adult cell proliferation throughout the brain of an anur

142 oproterenol and cAMP similar to responses in adult cells, providing evidence that the beta-A cascade

143 Oligonucleotide-treated adult cells removed thymine dimers at least as rapidly a

144 t of chromatin involved, and their status in adult cell renewal systems are unknown.

145 Although isolated examples of adult cell reprogramming are known, there is no general

146 ing development and homeostatic enhancers in adult cells, respectively.

147 The synaptic GABAA receptors in immature and adult cells showed differential sensitivity to modulator

148 Both child and adult cells showed similar levels of proliferation and s

149 xplore the differences between pediatric and adult cell subtypes, revealing the genes and pathways th

150 Accessibility is important; some adult cells, such as neural stem cells, are difficult to

151 clear cells (PBMNCs) in vitro was greater by adult cells than by term cells and preterm cells.

152 ipts were approximately 40% more abundant in adult cells than in term cells and were consistent with

153 on-like process occurring in normal, diploid adult cells, that is, cytokine-induced activation of end

154 ferritin along the membrane of agglutinated adult cells, the ferritin particles on the infants' cell

155 In contrast, in adult cells, the HBBP1-BGLT3 region contacts the embryon

156 emoglobin could be more fully reactivated in adult cells, the insights obtained might lead to new app

157 B lineage cells paralleled that of wild-type adult cells, the length distribution, global amino acid

158 Animal and preliminary human studies of adult cell therapy following acute myocardial infarction

159 egenerated after injury by de-differentiated adult cells, through a process that gives rise to Sca1+

160 er or fetal cells/tissues, but not in normal adult cells/tissues.

161 nscription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent

162 Stem cells have the unique ability among adult cells to give rise to cells of different identitie

163 The ability to reprogram adult cells to induced pluripotent stem (iPS) cells has

164 r reprogramming of terminally differentiated adult cells to pluripotency.

165 We hypothesize that the ability of adult cells to synthesize renin does not occur randomly

166 emotherapeutics, RB was required for primary adult cells to undergo DNA damage checkpoint responses a

167 otent stem cell signature is associated with adult cell type differentiation.

168 onally defined medium (HDM) tailored for the adult cell type of interest.

169 , i.e. the inappropriate conversion from one adult cell type to another.

170 bryos have the potential to develop into any adult cell type, and are thus said to be pluripotent.

171 th a methylome map of a fully differentiated adult cell type, mature peripheral blood mononuclear cel

172 enitor state and then redifferentiate to the adult cell type.

173 gnaling controlled proliferation in multiple adult cell types and dictated growth rates in embryonic

174 ability to differentiate into virtually all adult cell types are not well understood.

175 s and its expression is reactivated in these adult cell types by proliferative signals or oxidative s

176 uripotent cells or directly into alternative adult cell types holds great promise for regenerative me

177 gulatory grammars across 213 human fetal and adult cell types(1,2).

178 e level requires a complete understanding of adult cell types, their origin, and precursor relationsh

179 dergo fate specification to produce over 125 adult cell types.

180 eir differentiation into several hundreds of adult cell types.

181 lls into discrete populations of specialized adult cell types.

182 ereby limiting the proliferative capacity of adult cells under low oxygen tension.

183 ept that EPS-blastoids can be generated from adult cells via cellular reprogramming.

184 n the direct reprogramming of differentiated adult cells via the expression of transcription factors

185 c stem cells by reprogramming DNA taken from adult cells was demonstrated by the cloning of Dolly, th

186 Lack of X4 HIV-1 replication in child versus adult cells was not caused by a differential expression

187 to localize to inflamed tissue compared with adult cells, we examined the neonatal neutrophil interac

188 etermine transcriptional partners of Sox2 in adult cells, we generated mice where gene expression cou

189 gate the effect of decreased Snf2h levels in adult cells, we performed antisense inhibition of Snf2h

190 ominant genes de-repressed in PRC2-deficient adult cells, where aberrant expression is proportional t

191 o reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5

192 echanisms underlying the functions of Wt1 in adult cells will reveal key cell types, pathways, and mo

193 ynamic epigenetic silencing is controlled in adults cells will allow us to address the epigenetic sta

194 mation by neonatal neutrophils, as it did in adult cells with inactivated NADPH oxidase, demonstratin

195 and induce pluripotency when coexpressed in adult cells with other Yamanaka factors.

196 espite similar proliferation by neonatal and adult cells within the recombinase-activating gene 2(-/-