ライフサイエンスコーパス: advanced age

1 iciency (diabetes, hypertension, obesity, or advanced age).

2 determinants of overall survival (other than advanced age).

3 and was attenuated throughout networks with advanced age.

4 terneurons may be particularly vulnerable in advanced age.

5 of how their functional role is affected by advanced age.

6 ith a history of severe immunosuppression or advanced age.

7 , whereas others remain asymptomatic despite advanced age.

8 orm of autoimmune diabetes in patients of an advanced age.

9 in Old, confirming signalling integrity with advanced age.

10 pport consideration of this approach despite advanced age.

11 ed genes, the majority being associated with advanced age.

12 onstrate accelerating brain tissue loss with advanced age.

13 ate and litter size compared with WT mice at advanced age.

14 isease in different arterial territories and advanced age.

15 ed with poor tissue regeneration observed in advanced age.

16 ation, a task that is negatively affected by advanced age.

17 rate adherence seemed to fade away with more advanced age.

18 in the prevalence of PAD, CAS, and AAA with advanced age.

19 critical determinants of health status with advanced age.

20 uch as fetal alcohol exposure, seizures, and advanced age.

21 arly adulthood on, and atrophy aggravated in advanced age.

22 cts of AD pathologic changes on cognition in advanced age.

23 hic pulmonary fibrosis [IPF]) increases with advanced age.

24 ned significance in Cox models that included advanced age.

25 ation remains unresolved, in particular with advanced age.

26 adulthood, and including a mild phenotype in advanced age.

27 ults with predisposing chronic conditions or advanced age.

28 in lower muscle protein synthesis rates with advanced age.

29 anges in high-level perceptual processing in advanced age.

30 inclusions increased in number and size with advanced age.

31 ation is substantially attenuated in mice of advanced age.

32 nism underlying functional defects of SCs at advanced age.

33 dates with alcohol-related liver disease and advanced age.

34 nd in population-based cohorts of similar or advanced age.

35 or risk of amyloidosis prior to the onset of advanced age.

36 probably will have more effective impact at advanced ages.

37 cantly decreased pathological progression at advanced ages.

38 shed phenotypes in Lyst-mutants, but at more advanced ages.

39 nduced cardiac hypertrophy at both young and advanced ages.

40 mmon markers of neurodegeneration present in advanced aging.

41 ly harboring elevated amyloid burden, and in advanced aging.

42 eport that this maintenance is not random in advanced aging.

43 cal record were poor surgical targets (24%), advanced age (16%), and renal insufficiency (16%).

44 At more advanced ages (16-19 months), cognitive deficits progres

45 n p73 KO mice from early embryonic life into advanced age (25 months).

46 development at both early (age 10 weeks) and advanced (age 28 weeks) stages of atherosclerosis in mic

47 gative life events, a higher literacy level, advanced age, a higher educational level, and more time

48 le infection (CDI) are identified, including advanced age, a prolonged hospital stay, and use of acid

49 velops in a few models, some associated with advanced age, a risk factor for human disease.

50 including 21 within MC who were excluded for advanced age, acquired comorbidities, or refusal and 30

51 Advanced age, acute respiratory failure, and sepsis were

52 -deshydrogenase level (P = .0006) and a more advanced age adjusted international prognostic index (P

53 Whether or not advanced age affects the ability of PRC principal cells

54 ution to cardiac fibrosis, which occurs with advanced age, after acute injury (e.g., myocardial infar

55 Advanced age alone does not appear to be a contraindicat

56 thermore, mice that received treatment at an advanced age also showed remarkable preservation of reti

57 To evaluate how advanced age alters the host immune response to cutaneou

58 D-19-induced morbidity and mortality include advanced age, an impaired immune system, cardiovascular

59 frequent but more prevalent in patients with advanced age and a PS of >/= 2, underscoring the need to

60 Given the advanced age and comorbidities of these patients, improv

61 n the multivariable Cox regression analysis, advanced age and comorbidities were significant determin

62 n five ICU survivors die within 1 year, with advanced age and comorbidity being significant predictor

63 Patient characteristics, including advanced age and comorbidity, and tumor anatomy are bein

64 e coronavirus disease-2019 (COVID-19) due to advanced age and comorbidity.

65 Advanced age and complex mitral valve pathologies increa

66 ality of autologous CD34+ cells decline with advanced age and diminished cardiovascular health.

67 n 3 years, reflecting a population with more advanced age and disease than seen in trial populations

68 Although advanced age and elevated metabolic syndrome risk were a

69 rom outbreaks of Covid-19, owing to both the advanced age and frequent chronic underlying health cond

70 gher torsion, though the association between advanced age and greater torsion was more pronounced in

71 These responses may increase with advanced age and have been linked to an "immune risk pro

72 surgery, and patient-related factors such as advanced age and immobilization.

73 s increased in number and became larger with advanced age and increasing CGG repeat length, supportin

74 ounding tissues, and is associated with both advanced age and joint injury.

75 Increase in polyp size, advanced age and location in the distal colon were assoc

76 hough risk factors for pulmonary NTM such as advanced age and low BMI are known, the mechanisms under

77 al in patients considered "too ill/old" were advanced age and low functional status.

78 nt predictors for excess DCS mortality, with advanced age and male sex being associated with higher e

79 Mutant cases were associated with advanced age and monosomy 7/deletion 7q (-7/del(7q)) con

80 ne in clinical status that often accompanies advanced age and multimorbidity.

81 ay be a good option among patients with very advanced age and multiple comorbidities.

82 en in brain samples from humans with autism, advanced age and neurodegeneration (Alzheimer's disease

83 should be kept in mind that in patients with advanced age and pain in the left quadrant of the abdome

84 Advanced age and pneumonia are the main clinical feature

85 His risk factors for cholecystitis included advanced age and previous abdominal surgeries.

86 AF-TR is not rare and is associated with advanced age and right atrial enlargement.

87 Advanced age and severe fibrosis at HCV diagnosis are pr

88 Advanced age and severe fibrosis were significant risk f

89 Advanced age and splenectomy are risk factors for PAH in

90 The relation between muscle mass in advanced age and telomere length, however, has rarely be

91 s of the world provide care to patients with advanced age and terminal illness at different rates and

92 an elevated risk of CDI simply due to their advanced age and the fact that they are receiving care i

93 Due to the general health condition, advanced age and the large size of the aneurysm we decid

94 In addition to advanced age and the presence of comorbidities, there ar

95 on the basis of traditional factors, such as advanced age and thrombosis history.

96 Advanced age and unhealthy dietary habits contribute to

97 d endothelial dysfunction can prevail during advanced age and we questioned how calcium signalling ma

98 acroglobulinemia (WM), most of which were of advanced age and with adverse prognostic factors.

99 or potentially curative treatment because of advanced age and/or clinically relevant comorbidities an

100 e study period: 73 for acute disease, 18 for advanced age and/or comorbidities, and 17 to avoid the r

101 ch that the beneficial effects are lost with advanced age and/or with extended hormone deprivation.

102 risk stratification protocol for patients of advanced age and/or with preexisting cardiac disease.

103 104 significantly improves motor function at advanced ages and also mildly extends lifespan.

104 an anatomical breakdown of the MZ occurs in advanced age, and a reduction in frequency of MZM may af

105 Left ventricular size, renal dysfunction, advanced age, and atrial fibrillation/flutter were signi

106 ta-regression showed that male sex, smoking, advanced age, and comorbidities contributed to higher in

107 wer lung function, current smoking, obesity, advanced age, and having nonatopic asthma.

108 s age-associated diseases, improve health at advanced age, and increase life span.

109 r mortality were low total lymphocyte count, advanced age, and male sex.

110 -19 is a function of baseline comorbidities, advanced age, and multisystem organ dysfunction, similar

111 In contrast, female gender, advanced age, and nonwhite race, all risk factors for in

112 including male sex, NSAID coadministration, advanced age, and prior diagnoses contributing to drug r

113 iring the perirhinal cortex are disrupted in advanced age, and suggest that at least some of these im

114 we uncover in CRPS does not break down with advanced age, and surprisingly, remains stable across su

115 t were African American race, female gender, advanced age, and the presence of medical comorbidities.

116 xposure, such as in early development and at advanced age; and, second, the potential of stress-induc

117 Advanced age appeared to be of advantage for both bindin

118 k factors of family history, black race, and advanced age are associated with increased risk for POAG

119 who have substantial comorbidities or are of advanced age are at high risk of both relapse and nonrel

120 obesity, diabetes mellitus, hypertension and advanced age, are at the highest risk of death from COVI

121 as cholangiocarcinoma (n = 594); patients of advanced age at diagnosis had an increased incidence com

122 on are altered during this 10-year period of advanced aging at a population and individual level.

123 etween young and old mice via alphaARs; with advanced age, attenuated dilatation of upstream branches

124 iated with higher readmission rates included advanced age, body mass index, cardiovascular/pulmonary

125 Outcomes using advanced age brain-dead or cardiac-dead donor kidneys ar

126 for atrial fibrillation were associated with advanced age but were fairly infrequent.

127 Thus, microvascular endothelium can adapt to advanced age by reducing Ca(2+) influx during elevated o

128 These patients were more likely to have advanced age, cardiac disease, chronic obstructive pulmo

129 predictors of DNR status at enrollment were advanced age, chronic obstructive pulmonary disease, pre

130 In multivariable analyses, advanced age, comorbidities, and disease severity were s

131 Given advanced age, comorbidities, and immune dysfunction, chr

132 However, advanced age, comorbidities, and myocardial injury in pa

133 lack race (odds ratio [OR], 0.76; P < .001), advanced age, comorbidity, and Medicare insurance.

134 t greatest risk for LATE-NC, and subjects of advanced age constitute a rapidly growing demographic gr

135 In advanced age, decreased CD8(+) cytotoxic T-lymphocyte (C

136 duals with a variety of conditions including advanced age, dementia, and cancer.

137 ity score adjustment for surgery showed that advanced age, diabetes mellitus, health care-associated

138 the hypothesis that "exceptional agers" with advanced ages do not have significant ADP because they h

139 Advanced age does not impair bone marrow engraftment, th

140 sts regarding the prognosis of recipients of advanced age donor hearts, especially in young recipient

141 independent baseline predictors (female sex, advanced age, elevated serum creatinine and white blood

142 ugh those with more vulnerabilities (such as advanced age, exposures to other stressors like infectio

143 Advanced age, features of the metabolic syndrome, and ch

144 Clinical features of AF-TR included advanced age, female sex, greater right atrial than left

145 Mimicking the effect of advanced aging, genetic disruption of lysosomal function

146 of more hypomethylated DNA sequences in the advanced age group.

147 Participants were stratified by advanced age (>/=70 years), sex, and diagnosed hypertens

148 death, severe comorbidity, refusal of care, advanced age (>/=80 years), or prior malignancy.

149 In our cohort, advanced age (>67) was the strongest predictor of overal

150 e identified: obesity (body mass index >30), advanced age (>70 years), diabetes mellitus, preoperativ

151 Patients with advanced age (>74 years) had a higher risk of extraction

152 fluenced by limited education (<8 years) and advanced age (>80 years, P < 0.001).

153 Patients with ischaemic stroke who were of advanced age, had increased neurological impairment, or

154 Whether patients of more advanced age harbor similar risks is unresolved, often c

155 myocardial infarction, who typically are of advanced age, have comorbidities and are receiving sever

156 ly associated with 1-year mortality included advanced age (hazard ratio [HR] for >/=95 vs <75 years,

157 Because of his advanced age, he is not considered a candidate for lung

158 antation risk score, based on combination of advanced age, high HCT-CI, very poor-risk cytogenetic an

159 Thus, advanced age, high-fat diet, and decreased CFH induce su

160 nt cardiovascular disease, heart failure, or advanced age (higher risk).

161 to worsen over time and was associated with advanced age, higher baseline insulin level, and hemodyn

162 Among those with more advanced age, higher pulse pressure was also associated

163 Multivariate analysis demonstrated that advanced age, history of coronary artery disease, prolon

164 Advanced age, history of myocardial infarction, dementia

165 sk factors for BI/NAP1/027 infection include advanced age, hospitalization, and exposure to specific

166 ed with severe disease and mortality include advanced age, hypertension, diabetes, and obesity.

167 h in 2 individuals compared with survival to advanced age in 6 individuals).

168 dial infarction was increased in patients of advanced age in both CEA and CAS (OR, 1.64; 95% CI, 1.57

169 ffect the gammadelta T cell compartment with advanced age in humans.

170 lts indicate a decline in whole body EE with advanced age in mice, independent of changes in body wei

171 ly associated with increased creatinine, and advanced age in PMF (P < .001) and hemoglobin less than

172 g cardiovascular structure and function with advanced age in women.

173 e prophylactic defibrillator implantation at advanced ages in HCM.

174 , and it was driven by positive selection at advanced ages in the presence of microenvironmental decl

175 ease in Alpl (-/-) mice prevents analysis at advanced ages, including studies to target rescue of den

176 ty of patients with heart failure presenting advanced age, infirmity, and impaired regenerative capac

177 on cause of hospital-acquired infection, and advanced age is a risk factor for C. difficile infection

178 Advanced age is an important risk factor for discharge t

179 Advanced age is associated with alterations in innate an

180 Advanced age is associated with an increased risk of vas

181 Advanced age is associated with elevated oxidative stres

182 Advanced age is associated with immune system deficits t

183 f the current study was to determine whether advanced age is associated with specific inflammatory CR

184 Surprisingly, even though selection at advanced age is expected to be weak, a CD33 allele prote

185 he hypothesis that attenuation of ROV during advanced age is most effective in proximal branches of m

186 resistance networks, attenuation of ROV with advanced age is most effective in proximal branches via

187 Outcome of treatment for patients of advanced age is often compromised by comorbid conditions

188 Advanced age is related to left ventricular (LV) remodel

189 Advanced age is the greatest risk factor for neurodegene

190 ects an estimated 5.8 million Americans, and advanced age is the greatest risk factor.

191 Advanced age is the main risk factor for most chronic di

192 Advanced age is the most important risk factor for atria

193 ether this function is impaired in humans of advanced age is unknown.

194 be predicted by clinical factors, including advanced age, ischemic cardiomyopathy, more severe heart

195 ia donor, high Kidney Donor Profile Index or advanced age kidneys are poorer than those with standard

196 ew of outcomes of expanded criteria donor or advanced age kidneys, we assessed the value of the Kidne

197 tically significant recurrence risk factors: advanced age, largest basal diameter, and the use of adj

198 ith a higher revascularization rate, whereas advanced age, left main disease, and smoking were associ

199 Advanced age, length of stay, and duration of life suppo

200 With advanced age, loss of dilatory signalling mediated throu

201 tients with atrial fibrillation and isolated advanced age, low body weight, or renal dysfunction have

202 Among baseline factors, advanced age, lower body mass index, poorer performance

203 Among patients with SVR, advanced age, male gender, cirrhosis, decreased platelet

204 Advanced age, male sex, and cigarette smoking contribute

205 Studies have established that advanced age, male sex, and European ancestry are promin

206 In prognostic analyses, advanced age, male sex, poorer PS, increasing ratio of p

207 fusal in patients considered "too well" were advanced age, male sex, university hospital admission, c

208 sk factors for complications of GERD include advanced age, male sex, white race, abdominal obesity, a

209 ophagus include chronic GERD, hiatal hernia, advanced age, male sex, white race, cigarette smoking, a

210 associated with specific fixation patterns, advanced age manifested itself in a longer reorientation

211 Advanced age may act as a partial surrogate for conditio

212 Microvascular adaptation to advanced age may protect endothelial cells during elevat

213 ified 248 patients with Bcc BSI, who were of advanced age (mean, 68 years), chronically ill, and had

214 Patients with class 2 tumors had more advanced age (mean: 64 years vs 57 years; P = .001), had

215 , a similar relationship was present only at advanced ages (men aged > or = 80 years and women aged >

216 ring to interval appointments were having an advanced age (odds ratio, 1.02; 95% CI, 1.01-1.04) and k

217 ty at the end of follow up period, including advanced age [odds ratio (OR), 1.1/years increase (p < 0

218 rimordial follicle stage to ensure SCC up to advanced age of mice.

219 erm outcome, is often not possible given the advanced age of patients at time of diagnosis and freque

220 ted signs of cellular senescence despite the advanced age of the donors and exhibited significantly y

221 ic deletion of IL-10 mimicked the effects of advanced age on cell survival.

222 To assess the role of advanced age on survival and dialysis dependency after i

223 Uncertainty exists about the influence of advanced age on the outcomes of carotid revascularizatio

224 nd is precluded for many patients because of advanced age or comorbidities.

225 rse diastolic and longitudinal function with advanced age or elevated load in both sexes, a significa

226 tients are poor surgical candidates owing to advanced age or medical comorbidities.

227 ith a limited life expectancy as a result of advanced age or severe comorbidity for whom dialysis wil

228 whether to perform colonoscopy in persons of advanced age or those with comorbid conditions.

229 adults, especially affecting individuals of advanced age or with neurodegenerative disease.

230 ndividuals--eg, those with comorbidities, of advanced age, or receiving immunosuppressive treatment--

231 stage renal disease, heart failure, obesity, advanced age, or with documentation of volume "overload"

232 is, and Baastrup disease as a product of his advanced age, osteoarthritis, and lordosis.

233 ere demonstrated between SRSF2 mutations and advanced age (P < .01), IDH mutations (P < .01), and hig

234 On multivariate analysis, advanced age (P = 0.0021), extended resection (P = 0.000

235 Patients with advanced age (p = 0.01) and descending aorta grafting (p

236 Advanced age (P = 0.012), extended resection (P = 0.012)

237 tatistically significant decline of CCT with advanced age (P = 0.02).

238 follow-up was poor, which may be related to advanced age, poor initial VA, and the high incidence of

239 e the ADT Alzheimer's disease association in advanced age populations given the greater potential cli

240 e entorhinal cortex (EC), which is common in advanced age, predicts memory decline in older adults in

241 s shared common clinical features, including advanced age, predominantly motor involvement, aggressiv

242 d propensity toward morbidity and mortality (advanced age, presence of cardiovascular risk factors, m

243 matologists frequently encounter patients of advanced age presenting with chronic eczematous eruption

244 ctive therapies is hampered by the fact that advanced age, primary age-related tauopathy or comorbidi

245 We tested the hypothesis that advanced age protects microvascular endothelium by atten

246 ross the genome increased significantly with advanced age (r = 0.224, P =8 x 10(-30)).

247 Advanced age, radiographic pneumonia, requirement for ve

248 upheld in other human tissues and reveals an advanced aging rate in tumor tissue.

249 With advanced age, rats show deficits on PER-dependent behavi

250 patients with ARVC spans from adolescence to advanced age, reaching its peak between ages 21 and 40 y

251 We conclude that advanced age reduces Ca(2+) influx that triggers apoptos

252 to cellular senescence, which contributes to advanced age-related disorders, it is unclear how Kruppe

253 Nineteen subjects, 12 with intermediate or advanced age-related macular degeneration (AMD) (AREDS c

254 Current prediction models for advanced age-related macular degeneration (AMD) are base

255 betes (T2D), myocardial infarction (MI), and advanced age-related macular degeneration (AMD) as examp

256 inc supplementation decreases progression to advanced age-related macular degeneration (AMD) in patie

257 vitamins and minerals on the development of advanced age-related macular degeneration (AMD) in perso

258 Advanced age-related macular degeneration (AMD) is the l

259 Advanced age-related macular degeneration (AMD) is the l

260 To define the role of rare variants in advanced age-related macular degeneration (AMD) risk, we

261 mentation in reducing the risk of developing advanced age-related macular degeneration (AMD).

262 n shown to reduce the risk of progression to advanced age-related macular degeneration (AMD).

263 ciated with progression from intermediate to advanced age-related macular degeneration (AMD).

264 ntermediate and large drusen usually precede advanced age-related macular degeneration (AMD).

265 atments that prevent or delay development to advanced age-related macular degeneration (AMD).

266 etina as well as reducing the progression to advanced age-related macular degeneration in higher risk

267 d 50 to 85 years, at risk for progression to advanced age-related macular degeneration.

268 cts on the primary outcome of progression to advanced age-related macular degeneration.

269 ay vary in conferred risk for progression to advanced age-related macular disease.

270 hether they induce chronic inflammation with advanced age remains unclear.

271 Patients with advanced age represent a substantial subgroup of patient

272 Because advanced age represents a risk factor for complications

273 obic exercise training, initiated even at an advanced age, restores muscle blood flow distribution pa

274 Exercise training, initiated at an advanced age, reverses age-related diastolic and microva

275 Advanced age should not be used as an independent contra

276 displayed exacerbated nuclear aging, showing advanced aging signatures already at the Juvenile stage.

277 to the patient (ie, poor performance status, advanced age, significant weight loss, severe comorbid d

278 inked to coronary artery disease and include advanced age, smoking, diabetes mellitus, hyperlipidemia

279 Independent risk factors include advanced age, smoking, peripheral arterial disease, high

280 In advanced age, some individuals maintain a stable cogniti

281 neurodegeneration were not observed even at advanced ages, supporting the hypothesis that RNA foci a

282 Advanced age, systolic blood pressure, and diabetes were

283 e exhibit a higher fat to lean mass ratio at advanced ages than age-matched wild type mice.

284 IAV-specific CD8(+) T-cell populations with advanced age that parallel age-associated changes in the

285 est that these brain regions are affected by advanced age, the extent to which aging alters appetitiv

286 With advanced age, the loss of sensory nerve function and dim

287 Together these data suggest that with advanced age there may be reduced afferent drive from ex

288 Despite their advanced age, these clones are euglycaemic, insulin sens

289 Among risk factors for CDI, the advanced age threshold was younger for Chinese patients

290 ROV) in skeletal muscle is attenuated during advanced age via alpha-adrenoreceptor (alphaAR) activati

291 Advanced age was a major risk factor for all adverse out

292 Advanced age was associated with a significantly greater

293 Advanced age was associated with greater LV concentricit

294 Advanced age was the strongest risk factor for uterine c

295 As Alzheimer's disease is a disease of advanced age, we hypothesize that older individuals on A

296 York Heart Association class IV status, and advanced age were powerful adjusted predictors of poor o

297 l degeneration relative to wild-type mice at advanced ages, when bred on the light-sensitive BALB/c b

298 y age-related tauopathy are commonly of more advanced ages with milder cognitive dysfunction.

299 th concomitant coronary artery disease, with advanced age, with chronic kidney disease, or with valvu

300 ase, and sarcomere gene carriers can live to advanced ages without developing HCM.