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1 cal and biological perspective regarding the advent and clinical implementation of cancer immunothera
2 ated are dramatically changing thanks to the advent and constant improvement of high-throughput profi
3  life history has greatly benefited from the advent and development of molecular epidemiology.
4                                     With the advent and increased accessibility of deep neural networ
5                                          The advent and proliferation of mass drug administration (MD
6          In this Perspective, we discuss the advent and recent advances of this concept.
7 ereal grains, a fundamental component of the advent and spread of farming.
8                                   Due to the advent and success of antiretroviral therapy (ART), the
9                                          The advent and wide-spread adoption of electric lighting ove
10                    Recent years have seen an advent in population-based studies in children, adolesce
11 ertise of an anatomic pathology program, the advent of "liquid biopsy" has driven a shift in molecula
12            Indeed, in recent years, with the advent of "non-classical" theories, a primary focus of r
13                                     With the advent of 16s rRNA sequencing replacing traditional cult
14 tunability of MOFs, these results herald the advent of a new generation of supercapacitors whose acti
15    This progress has been facilitated by the advent of a range of specialist techniques based around
16                       Herein we describe the advent of a reductive diselenide-selenoester ligation (r
17                                          The advent of a viable vaccine and its deployment, coupled w
18                                     With the advent of accelerator mass spectrometry (AMS) and furthe
19                                    Since the advent of additive manufacturing, known commonly as 3D p
20                       Observations: With the advent of advanced molecular diagnostic methods, a new p
21                                          The advent of advanced statistical and machine learning meth
22                                          The advent of affordable, large-scale DNA sequencing methods
23                 Yet, the extent to which the advent of agriculture affected the evolution of the huma
24  that shifts in pathogen exposure due to the advent of agriculture imposed radically heightened selec
25  has been a struggle for humankind since the advent of agriculture.
26 ntrolling the COVID-19 pandemic prior to the advent of an effective treatment.
27 e past several decades, culminating with the advent of and improvements in rechargeable lithium-ion b
28                             To this end, the advent of anionic redox, that is, the sequential or simu
29                                          The advent of anti-vascular endothelial growth factor treatm
30 ck at how infections were treated before the advent of antibiotics, namely using phage therapy.
31                                          The advent of antibody-drug conjugates as pharmaceuticals ha
32 ritional homeostasis, as demonstrated by the advent of antidiabetes therapies that alter gastrointest
33 ritis in MSM has not been examined since the advent of antiretroviral therapy and molecular diagnosti
34                                          The advent of array-based genome-wide DNA methylation method
35  whole-slide images of tissue has led to the advent of artificial intelligence (AI) and machine learn
36                                   The recent advent of atomically precise nanochemistry has opened ne
37 d is expected to grow significantly with the advent of autonomous driving, which might render on-dema
38                                          The advent of biocatalysts designed computationally and opti
39                                          The advent of biologic therapies has transformed care for se
40                                   Before the advent of biologic therapies, conventional synthetic DMA
41                                          The advent of biosimilars has sparked a renewed interest in
42 elanoma has substantially improved after the advent of BRAF inhibitors and ICIs (ipilimumab, nivoluma
43 ted here, will be markedly enhanced with the advent of brighter, coherent X-ray sources.
44 ping alloys for thousands of years since the advent of bronze.
45  evolutionary leap in SPECT imaging with the advent of camera systems that use solid-state crystals a
46                                          The advent of cancer immunotherapy has generated renewed hop
47                                     With the advent of carbon nanotechnology, which initiated signifi
48  the treatment of CF patients has marked the advent of causative CF therapy.
49                                          The advent of cell culture-based methods for the establishme
50                                 However, the advent of cell-engineering approaches is ushering in a n
51                                          The advent of checkpoint blockade immunotherapy over the pas
52 lized olefins, from the first reports to the advent of chiral Crabtree-like catalysts.
53 ctionalized substrates, respectively, to the advent of chiral phosphoramidite ligands.
54       This review will summarize the current advent of clinical cardiovascular molecular imaging and
55                                    While the advent of combination antiretroviral therapy (ART) has s
56                   Over the past 5 years, the advent of combination therapeutic strategies has substan
57                                     With the advent of commercial genomic screening, who is ethically
58                                   The recent advent of commercial microwave source in the terahertz r
59                                          The advent of complex multicellularity (CM) was a pivotal ev
60                                   The recent advent of condensed-matter systems with Dirac-like excit
61                                          The advent of continuous glucose monitoring (CGM) technology
62                                          The advent of counterfactual-based mediation analysis has tr
63                                     With the advent of covalent organic frameworks (COFs), the chemis
64                                     With the advent of CRISPR technology, it is now possible to build
65                                          The advent of CRISPR-based technologies has revolutionized g
66                                     With the advent of CRISPR-Cas9, a comprehensive study has investi
67  exploded in the early 20th century with the advent of critical scientific advancements in organic ch
68                                       At the advent of cross-coupling chemistry, carbon electrophiles
69 lution structures remained elusive until the advent of cryogenic electron microscopy (cryo-EM) techni
70 with classical polymer networks, such as the advent of crystalline "framework" materials.
71                                          The advent of deep sequencing technologies led to the identi
72                                          The advent of deep-sequencing techniques has revealed that m
73                                          The advent of diffusion compartment imaging (DCI) to probe t
74                                          The advent of diffusion MRI tractography in recent years has
75                          However, the recent advent of direct electron detectors has greatly improved
76                                          The advent of direct-acting antiviral agents to treat hepati
77                                     With the advent of direct-acting antiviral agents, there has been
78                                          The advent of direct-acting antivirals (DAAs) has transforme
79 ing, preparing the healthcare system for the advent of disease-modifying therapies against AD is impe
80                                              Advent of dissolution dynamic nuclear polarization (DNP)
81 luids, which is especially relevant with the advent of DNA-based vaccines.
82 hlighting its effectiveness in combating the advent of drug resistance.
83                                   Before the advent of effective antiviral agents, the primary treatm
84                                          The advent of effective retroviral therapy and use of rituxi
85 hough increased awareness of ATTR-CM and the advent of effective therapy have led to rapid adoption o
86                                     With the advent of efficient, easy-to-use genome editing by CRISP
87                                          The advent of Electronic Medical Records (EMR) with large el
88 tection system has been accelerated with the advent of emerging miniaturization techniques, advanced
89 atients and at least partly explained by the advent of endocrine therapy that is less effective in Af
90                                 However, the advent of endothermy likely contributed to the dominance
91                                          The advent of endothermy, which is achieved through the cont
92                                Yet, with the advent of endovascular thrombectomy and the ability to i
93                                          The advent of engineered DNA methyltransferases (MTases) to
94 be incompatible with life; however, with the advent of ex-utero intrapartum procedure, a few cases of
95 extent of environmental influence before the advent of farming.
96                            Specifically, the advent of flexible electronic formats coupled with micro
97 ub-Saharan Africa, particularly prior to the advent of food production, remains limited.
98                                          The advent of frequency combs advances the frontiers of prec
99 led to challenges to old orthodoxies and the advent of fresh perspectives on how crop domestication a
100 blems were anticipated to be solved with the advent of fully biodegradable devices.
101 ssed in recent years, we anticipate that the advent of further innovations enabling minimal handling
102                                     With the advent of gene therapy and the numerous ongoing clinical
103 Needham's ideas fell by the wayside with the advent of genetic studies of embryogenesis, they demonst
104                                     With the advent of genetic testing in adults, disease-related, st
105                                   The recent advent of genome editing technologies (especially CRISPR
106                                          The advent of genome editing technology provides new opportu
107 f disease risk has greatly advanced with the advent of genome-wide association studies (GWAS), which
108 nced rapidly during the past decade with the advent of genome-wide association studies (GWAS).
109 nce of decanalization, but we argue that the advent of genome-wide polygenic risk assessment now make
110 ith new insights made possible by the recent advent of genomic approaches.
111                                     With the advent of genomic technologies, recurrent genomic amplif
112                                          The advent of hard x-ray free electron lasers (XFELs) capabl
113  Of note, risk factors have changed with the advent of hematopoietic cytokines (especially granulocyt
114                                          The advent of high-dimensional cellular analyses, such as si
115                                          The advent of high-throughput (omics) technologies gives opp
116                                     With the advent of high-throughput -omics technologies and more a
117                                          The advent of high-throughput data generation, data mining,
118                                          The advent of high-throughput DNA methylation profiling tech
119                                          The advent of high-throughput genome sequencing platforms, a
120                                          The advent of high-throughput next generation sequencing tec
121 itrarily proposed several decades before the advent of high-throughput omic techniques, and it is unc
122                           Recently, with the advent of high-throughput sequencing and new aDNA protoc
123 and interrogated, and changes brought by the advent of high-throughput techniques for the analysis of
124                                   The recent advent of high-throughput techniques, such as single-cel
125                                     With the advent of high-throughput technologies leading to big da
126            It was only recently, through the advent of high-throughput technologies, that scientists
127                                     With the advent of high-throughput, next-generation sequencing (N
128                                          The advent of high-throughput/high-content single cell techn
129                                          The advent of high-yield electrophysiology using Neuropixels
130                                 Although the advent of highly effective and tolerable direct-acting a
131                                          The advent of human induced pluripotent stem cells (iPSCs) p
132                                   The recent advent of human pluripotent stem cell (PSC)-derived 3D b
133                                    Since the advent of human-made light sources, it has been importan
134                                          The advent of hybrid cameras that combine MRI with either SP
135  aldosterone system inhibitor therapy in the advent of hyperkalemia likely contributes the observed r
136                                          The advent of ICIs has been a major breakthrough in the fiel
137                                          The advent of image-activated cell sorting and imaging-based
138                                   The recent advent of immune checkpoint inhibitor (CPI) antibodies h
139                                          The advent of immune checkpoint inhibitors (ICIs), which hav
140                                          The advent of immunotherapy in recent years has shown the po
141                                  Despite the advent of immunotherapy, metastatic melanoma represents
142                                          The advent of in vitro differentiation protocols for generat
143                                          The advent of in vivo automated techniques for single-cell l
144                                          The advent of in vivo automated techniques for single-cell l
145 c reactions could have set the stage for the advent of increasingly sophisticated pathways operating
146                                          The advent of induced pluripotent stem cells means that it m
147                                          The advent of inexpensive, clinical exome sequencing (ES) ha
148                                     With the advent of innovative technologies, new threats are conti
149                                     With the advent of integrated electronics, microfabrication and n
150                           ABSTARCT: With the advent of intelligent manufacturing, phase measuring def
151  growth rate in four of the clades since the advent of interventions, while other clades have continu
152 mergence of CSF1 later in lineages after the advent of Jawed/Jawless fish.
153                                          The advent of K(+) and Na(+) ion channel structure determina
154 sion and its treatment has advanced with the advent of ketamine as a rapid-acting antidepressant and
155 mutant GIST has been revolutionized with the advent of KIT-directed cancer therapies.
156                                     With the advent of large photometric surveys(8) and the astrometr
157 e transistors and photodetectors, the recent advent of large-area synthesis of these atomically thin
158                       Specifically, with the advent of machine perfusion preservation ex vivo, treatm
159                                     With the advent of magnetic resonance imaging (MRI), in-vivo anal
160 es to genetic diversity before and after the advent of management programs.
161 h techniques have been revolutionized by the advent of mass spectrometers with detectors that afford
162       The ubiquity of DNA sequencing and the advent of medical imaging, electronic health records, an
163             With the discovery of l-dopa the advent of medical therapy began and surgical approaches
164           These advances were enabled by the advent of mesoporous thin films, comprised of anatase Ti
165                                          The advent of metal processing was one of the key technologi
166                                Recently, the advent of metasurfaces has revolutionized design concept
167 or anti-microbial susceptibility testing and advent of microbial fuel cell biosensors, cell-based bio
168   This discipline promises to facilitate the advent of microbiome-based precision medicine approaches
169                                          The advent of miniaturized biologging devices has provided e
170 metabolism was largely ignored following the advent of modern molecular biology.
171 -2 regulation were largely unknown until the advent of modern protein mass spectrometry techniques th
172 sociated with arthritis, at least before the advent of modern rheumatologic medications.
173                                     With the advent of modern sequencing technologies and increasing
174          These approaches, together with the advent of modern technologies and coupled with machine l
175                            We argue that the advent of modern technologies such as in-depth molecular
176                                     With the advent of modern technology, there is the potential for
177                            The first was the advent of molecular biology and reverse genetics, which
178 al of vector monitoring has grown due to the advent of molecular methods capable of increasing the se
179                                     With the advent of molecular phylogenetics, arthropods were found
180                                    Since the advent of molecular techniques and high-throughput seque
181                                          The advent of molecular tension probes for real-time mapping
182 xperienced a brief fall from grace, with the advent of molecular tools, planarians, such as Schmidtea
183                                          The advent of molecularly targeted therapeutic agents has op
184                                 Although the advent of monoclonal antibody therapy has had a positive
185                              With the recent advent of more sensitive detection techniques, 6mA has a
186                                  Despite the advent of more specific biologic therapies, a notable pr
187                                     With the advent of more successful chemotherapies, the number of
188                                          The advent of multi-omics data enables measurement of both D
189                                          The advent of multiple exciton harvesting schemes and prolon
190              An incipient fourth wave is the advent of multispecific drugs.
191                                    While the advent of nanostructuring provided a general design para
192                                          The advent of nanotechnology, and the need to understand the
193                                          The advent of neuroimaging has provided foundational insight
194                                          The advent of new approaches making use of antibody and TCR
195  insights into disease biology and, with the advent of new data and methodologies, the path from gene
196 ion has recently come into focus through the advent of new genomic technologies; however, it is still
197 n to highly aggressive forms of CLL, and the advent of new therapies targeting crucial biological pat
198                                          The advent of new tobacco products such as electronic cigare
199       The increasing diabetes prevalence and advent of new treatments for its major visual-threatenin
200 more prevalent in modern society despite the advent of new treatments, representing a major global he
201 "wiring diagrams." This has changed with the advent of new, transformative neuroscientific tools.
202                                     With the advent of next generation high-throughput DNA sequencing
203                                     With the advent of next generation sequencing (NGS) technologies,
204                                          The advent of Next-Generation Sequencing (NGS) technologies
205 tly, and slow to yield new insights, but the advent of next-generation sequencing (NGS) technologies
206 s in diagnostic technology, particularly the advent of next-generation sequencing (NGS).
207                                     With the advent of next-generation sequencing and advanced tools
208                                          The advent of next-generation sequencing has allowed researc
209                                          The advent of next-generation sequencing has introduced new
210                                          The advent of next-generation sequencing technologies enable
211                                     With the advent of next-generation sequencing technologies, the h
212                                     With the advent of next-generation sequencing, activating hotspot
213                                     With the advent of next-generation sequencing, we have an unprece
214                                          The advent of nicking endonucleases (NEases) as signal ampli
215                                          The advent of NIS-based in vivo imaging and theranostic stra
216                                Recently, the advent of non-Hermitian topological systems-wherein ener
217                                          The advent of non-vitamin K antagonist oral anticoagulants,
218                                          The advent of novel biologic therapies represents a giant le
219                                     With the advent of novel biomarkers promising improved prediction
220                                     With the advent of novel chemotherapeutics and targeted molecular
221                                          The advent of novel genomic technologies has enabled rapid p
222 static prostate cancer has occurred with the advent of novel hormonal agents and life-prolonging chem
223 nerative disease enable us to accelerate the advent of novel modalities in the clinical setting for t
224 nderstanding of treatment effects, while the advent of novel techniques such as multitissue compartme
225                                     With the advent of novel treatment options that will potentially
226                                     With the advent of patient-focused drug development, the US Food
227                                 However, the advent of platform technologies offers vaccine manufactu
228                                Now, with the advent of pluripotent stem cells, CRISPR-Cas9 and other
229                                     With the advent of portable touchscreen devices, this association
230           Within the last 30 years, with the advent of positional cloning, the human genome project,
231 s can be much faster and safer thanks to the advent of powerful electron accelerators and high-rate e
232 n the era of precision medicine and with the advent of powerful imaging and proteomics technologies,
233                                          The advent of precision medicine has obscured this concept,
234 ement of allergic diseases and asthma in the advent of precision medicine together with global access
235                                     With the advent of precision oncology, there is an urgent need to
236                               Rationale: The advent of precision treatment for cystic fibrosis using
237                                    Since the advent of protein crystallography, atomic-level macromol
238                                          The advent of protein sequence information provides an oppor
239                                          The advent of quantum computation brings new pathways to nav
240                                          The advent of quantum computing brings new possibilities for
241          In 1929, only three years after the advent of quantum mechanics, von Neumann and Wigner show
242                                    Given the advent of quantum technologies, a design for a quantum m
243  in both research and industry and, with the advent of quantum technology, it is a crucial challenge
244 eatment available for many cancers until the advent of radiation and chemotherapy.
245 ned, has now been greatly facilitated by the advent of reduced-representation sequencing protocols.
246             Maintenance of HSR function with advent of reproductive potential is unique among inverte
247                                     With the advent of reversible covalent chemistry the study of the
248                                     With the advent of ruthenium-catalyzed ring-closing metathesis an
249 s field has been dramatically changed by the advent of safe and effective direct-acting antiviral the
250 e locations of the grounding line before the advent of satellite monitoring in the 1990s are poorly d
251                                     With the advent of screening mammography, the incidence of DCIS h
252                                          The advent of SELEX (systematic evolution of ligands by expo
253 cing data has been greatly simplified by the advent of sequencing technologies that generate long rea
254                                   The recent advent of serial crystallography, which spreads the abso
255                               Meanwhile, the advent of several high-throughput sequencing techniques
256                                          The advent of single cell RNA sequencing (scRNA-seq) enabled
257 development of single-cell technologies, the advent of single-cell Hi-C makes interrogating the spati
258                                     With the advent of single-cell RNA sequencing (scRNA-seq), it is
259 ly, advances in imaging and genetics and the advent of single-cell technologies provided new insights
260                             Accordingly, the advent of single-cell technologies will be crucial in en
261                                     With the advent of single-cell-based technologies, a new 'worldvi
262 tions has been extensively studied since the advent of single-molecule electronics and is now well un
263                                          The advent of single-molecule nanomechanical techniques, oft
264                                          The advent of social media and microblogging platforms has r
265                                          The advent of stem cell-derived retinal organoids has brough
266         In the past 5 yr or so, and with the advent of superresolution microscopy, the diversity of t
267                                    Since the advent of superresolution techniques, it has become clea
268 f metabolite biomarkers that can predict the advent of T2DM and give insight to its pathogenic mechan
269 ntinues to be highly sought after due to the advent of targeted needle-free techniques, especially fo
270 g cause of cancer-related death, despite the advent of targeted therapies and immunotherapies.
271                      Furthermore, the recent advent of tau positron emission tomography and novel flu
272                                          The advent of tau-targeted PET tracers such as flortaucipir
273                                          The advent of techniques for labeling specific DNA, RNA, and
274                            However, with the advent of The Cancer Genome Atlas (TCGA), there has been
275                                          The advent of the first metal based therapeutic agent, cispl
276                                     With the advent of the Genomics Era, there is an unprecedented op
277                                     With the advent of the Internet of Everything (IoE) era, our civi
278                                     With the advent of the Internet, drug discovery has become more d
279                                     With the advent of the new IFN-free regimens, highly effective an
280                                          The advent of the newer classes of antihyperglycemic agents,
281                                          The advent of the two-dimensional (2D) family of halide pero
282                                    Since the advent of the vascular anastomosis by Alexis Carrel in t
283                                 Prior to the advent of these new agents, peripheral blood autologous
284                                   The recent advent of third-generation sequencing technologies bring
285                          Notwithstanding the advent of this and other therapies for SMA, it is unclea
286  agents, play a pivotal role in enabling the advent of this new paradigm of "biological-small molecul
287  labs historically use manual processes, the advent of total laboratory automation and the adoption o
288  systematic echocardiographic follow-up, the advent of transcatheter heart valve (THV) technologies c
289                                     With the advent of transcranial Doppler, measurement of cerebral
290                                     With the advent of ultra-high field (7T and higher) MRI scanners,
291 barrier was reignited in recent years by the advent of ultrafast lasers and attosecond metrology(6).
292                                          The advent of unnatural amino acid mutagenesis opens up a ne
293                                     With the advent of whole genome sequencing we are in the midst of
294                                     With the advent of whole genome-sequencing (WGS) studies, family-
295 genes between species) has exploded with the advent of whole-genome sequencing and emerging methods t
296                                 Prior to the advent of whole-genome sequencing, it was clear that hyb
297                                          The advent of whole-slide imaging, availability of faster ne
298  of the developing techniques enabled by the advent of X-ray free electron laser (FEL).
299                                    Since the advent of X-rays, food scientists have been evaluating t
300                    Baumard suggests that the advent, through phenotypic plasticity mechanisms, of fut

 
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