ライフサイエンスコーパス: age of onset

1 in logistic regression are cases with a late age of onset.

2 cade to chorioretinal dystrophy with a later age of onset.

3 ease that determine disease presentation and age of onset.

4 ral mechanism of AD that is independent from age of onset.

5 ual age of subjects rather than with disease age of onset.

6 complex cognitive-emotional with increasing age of onset.

7 ants associated with a significantly younger age of onset.

8 T promoter are bidirectional modifiers of HD age of onset.

9 ther a selected variant is fixed or not) and age of onset.

10 use was identified inversely correlated with age of onset.

11 or PLCE1, specific mutations correlated with age of onset.

12 neuron (FS-->SP) synapses, depending on the age of onset.

13 marijuana users was associated with earlier age of onset.

14 both of anticipation and of heritability of age of onset.

15 ume, (11)C-Pittsburgh Compound B binding, or age of onset.

16 d 10 and 5 y, respectively, before estimated age of onset.

17 f the population, the foods involved and the age of onset.

18 ry cortical region 15 y before the estimated age of onset.

19 um (11)C-PBR28 binding correlated with lower age of onset.

20 lerate disease progression and may influence age of onset.

21 disease (AD) and is associated with earlier age of onset.

22 and variation in downstream methylation and age of onset.

23 nitor allele length is the major modifier of age of onset.

24 es with no family history of BD and an early age of onset.

25 is pigmentosa is characterized by a variable age of onset.

26 Leukemia phenotypes vary with age of onset.

27 influenced by age, duration of diabetes, or age of onset.

28 for predicting Alzheimer's disease dementia age of onset.

29 ons remained significant after adjusting for age of onset.

30 t amyloid deposition in human brain and LOAD age-of-onset.

31 ncers, but the latter at significantly later ages of onset.

32 e, with longer expansions leading to earlier ages of onset.

33 ioration in SARA was associated with younger age of onset (-0.02 points per year [0.01] per year of a

34 Age of onset 21 was associated with a smaller hippocampu

35 was exacerbated by Trp53 co-deletion (median age of onset 275 days, penetrance 82% at 1 year), with c

36 PPs facilitated melanoma development (median age of onset 308 days, penetrance 40% at 1 year).

37 impairment (mean visual acuity, 20/40; mean age of onset, 42 years), even in the sporadic case of fa

38 nary artery disease was common (33%; average age of onset, 49.4 years), and untreated LDL-C concentra

39 oimaging evaluations 2.4 years apart [median age of onset = 67 years (range: 49-76), seven females].

40 in the study (367 girls and 408 boys; median age of onset, 7.5 months [interquartile range, 4.2-16.5

41 ADAD (odds ratio 1.09 per 1 year increase in age of onset, 95% CI 1.04-1.14, p=0.0003); and motor sym

42 ed SBA cases were characterized by a younger age of onset, a higher prevalence in female gender and a

43 's disease (AD) and the "AD phenome": AD, AD age of onset (AAOS), hippocampal volume, cortical surfac

44 People with familial ALS have an age of onset about 5 years younger than those with appar

45 Alzheimer's disease (AD) age of onset (ADAOO) varies greatly between individuals,

46 according to a number of variables, such as age of onset, age at assessment, SMN2 copy number, and f

47 clinical manifestations of JMML in terms of age of onset, aggressiveness, and organ infiltration wit

48 h differentiated the clusters in two models: age of onset, allergic sensitization, severity, and rece

49 Variation in age of onset among COA-affected individuals had a low he

50 The older age of onset among female cases in general, and among fe

51 8%) occurred, but with a large left shift in age of onset among residual deaths.

52 Age-of-onset analysis shows not only the effect of the F

53 nts with biallelic MAK mutations had a later age of onset and a milder retinal phenotype compared wit

54 etected variable expressivity in relation to age of onset and a possible case of incomplete penetranc

55 s presented a common phenotype with an early age of onset and a prompt macular degeneration, whereas

56 Highly variable age of onset and absence of established prodromal biomar

57 The median age of onset and age at examination of 40 patients with

58 ts as a potent genetic modifier for AD risk, age of onset and conversion.

59 ed greatly among the mouse models concerning age of onset and cortical brain region.

60 17 individuals with the mutation) to analyze age of onset and death in affected and censored individu

61 T carriers were characterised by earlier FMD age of onset and decreased connectivity between the righ

62 ich is second only to congenital NCL for its age of onset and devastating progression.

63 Mean age of onset and disease duration were 70.6 (SD+/- 6.42)

64 logy underlying wheezing phenotypes based on age of onset and duration of disease.

65 atrophy enlargement and BCVA, adjusting for age of onset and duration of disease.

66 ociations between asthma phenotypes based on age of onset and duration of symptoms, and (i) spirometr

67 According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive

68 ther synucleinopathies, resulting in a lower age of onset and exacerbating disease progression.

69 iation with the acute phase response and its age of onset and female preponderance appear to have evo

70 campal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode

71 ffects of rs13102260 on HTT expression to HD age of onset and have implications for HTT silencing tre

72 hology and likely contributes to the earlier age of onset and increased cognitive decline associated

73 ound heterozygotes had significantly earlier age of onset and increased diabetes mellitus, compared t

74 t of patients with a variety of CHD: (1) the age of onset and initial treatment of AF, coexistence of

75 which may explain the marked differences in age of onset and manifestations.

76 onian phenotypes but tend to have an earlier age of onset and more associated cognitive changes than

77 n of family members presenting with an early age of onset and multiple primary tumors.

78 reported in multiple families with variable age of onset and N98S that has been described as an earl

79 The similar age of onset and neurological decline in the two unrelat

80 rative disorders of white matter with a wide age of onset and phenotypic spectrum.

81 shown that the severity of disease symptoms, age of onset and progression are related to the length o

82 n control mice, it significantly accelerates age of onset and progression of HD pathogenesis.

83 partially functional mutant frataxin delays age of onset and reduces diabetes mellitus, compared to

84 ominant blinding retinopathies with variable age of onset and severity.

85 urological symptoms and the contributions of age of onset and specific mutation type on symptoms.

86 Mean age of onset and the presence of cardiomyopathy and diab

87 rogeneity with respect to clinical severity, age of onset and the primary cell type that is affected

88 d 'in the last 12 months', doctor diagnosis, age of onset and treatments of asthma, rhinitis and ecze

89 h riluzole-treated ALS cases with an earlier age of onset and with a shorter diagnostic delay display

90 also partitioned patients according to their age-of-onset and evaluated the predictability of GRS in

91 elates with poorer prognostic factors: young age-of-onset and lupus nephritis.

92 or neurodevelopmental disorders with diverse ages of onset and socioemotional symptoms.

93 erebellar neurons contribute to the distinct ages of onset and timing of cerebellar degeneration in i

94 type, laterality and degree of hearing loss, age of onset, and additional variables such as exposure

95 correlated with the risk of prostate cancer, age of onset, and aggressiveness at diagnosis.

96 eatures of multiple sclerosis that differ by age of onset, and made recommendations regarding the tre

97 exhibit a sex bias in rates of presentation, age of onset, and symptom severity.

98 effect of FA on AD severity, chronicity, and age of onset, and the temporal relationship between the

99 the CAG repeat is inversely correlated with age of onset (AO) in HD patients, while environmental an

100 of this repeat is inversely correlated with age of onset (AOO), it does not fully explain the variab

101 Finally, age of onset appears to affect the mutational landscape

102 peat diseases in which both disease risk and age of onset are strongly dependent on the repeat length

103 cannabis use parameters, including a younger age of onset, are frequently reported.

104 Atypical clinical traits included an earlier age of onset (around 30 years), aggressiveness (three ha

105 ear female preponderance (76.5%) with a mean age of onset at 54 years.

106 se chi(2) meta-analysis across ten pediatric-age-of-onset autoimmune diseases (pAIDs) in a case-contr

107 atypical form of gastric NET has an earlier age of onset, behaves more aggressively and has atypical

108 here were no significant differences in mean age of onset between homozygotes and the minimal and mod

109 Secondary outcomes included age of onset, body mass index, and effect on protein fun

110 We assessed Parkinson's disease age of onset both as a categorical variable (dichotomise

111 opsychiatric disorders vary substantially in age of onset but are best understood within the context

112 ing antisense oligonucleotides (ASOs) at the age of onset can extend survival and rescue the neurolog

113 GWAS informed by age of onset can identify subtype-specific risk variants

114 categories, which differ in cell of origin, age of onset, clinical and histologic presentation, patt

115 high incidence of breast cancer and younger age of onset compared to the general population, it is r

116 d poorer tumor-specific survival and earlier age of onset compared with patients homozygous for the m

117 We evaluate how age of onset could indicate the need for germline mutati

118 in CD is associated with osteoporosis and an age of onset dependent influence towards underweight, hi

119 s of AD that take into consideration varying age of onset (early versus late) and the influence of ag

120 Despite the observed age of onset effects, longitudinal studies are needed to

121 ed with the estimated presbyopia prevalence, age of onset, employment rate, gross domestic product (G

122 and AIS, smoking is a risk factor for early age of onset, even among those with few vascular risk fa

123 Genetic variability in DNM3 modifies age of onset for LRRK2 Gly2019Ser parkinsonism and infor

124 before age 6 (P = .0008 compared to expected age of onset for psoriatic arthritis in childhood).

125 ith ND individuals in psychosis symptoms and age of onset for psychosis proneness; this continues to

126 tifying a complex condition according to the age of onset for the identification of deleterious varia

127 We used data for age of onset (from first report of cognitive decline), d

128 ar subgroups that reflect differences in the age of onset, gender predominance and response to therap

129 -generational kindreds, and by analysing the age of onset, gender ratio and survival in a large cohor

130 multiple system atrophy-cerebellar ataxia), age of onset, gender, and early autonomic symptoms, on t

131 r duration among essential tremor cases with age of onset >40 years.

132 oungest generation had significantly earlier age of onset (>10 years) compared with the next oldest g

133 The reported age of onset has important implications for the diagnosi

134 ed progression of ataxia symptoms related to age of onset have implications for the design of clinica

135 g the penetrance of cardiac involvement, and age of onset have not been well established.

136 et (hazard ratio 1.28, P < 0.014); (v) older age of onset (hazard ratio 1.02, P = 0.001); and (vi) de

137 FEV(1) was also dependent on exacerbations, age of onset, height, age, sex, and log10 sputum eosinop

138 ly mirror the human disease in regard to the age of onset, histological appearance, invasiveness and

139 to well-established findings implicating the age of onset in alcohol use in the development of alcoho

140 sease alleles had a dose-dependent effect on age of onset in all forms of pustular psoriasis (P = .00

141 VEGFA seems to be associated with a younger age of onset in combination with poor response rates to

142 es the natural history of AD typified by the age of onset in E280A mutation carriers.

143 nia is a complex mental disorder with a peak age of onset in early adulthood.

144 The mean age of onset in familial ALS was 5.3 years younger than

145 D disease allele was associated with delayed age of onset in familial cases, whereas the presence of

146 Anticipation is the phenomenon whereby age of onset in genetic disease decreases in successive

147 There was no difference between the mean age of onset in genetic sporadic ALS and familial ALS (p

148 -type HTT allele was associated with earlier age of onset in HD patients in an extreme case-based coh

149 isk for Parkinson's disease (PD) and younger age of onset in men.

150 gating contribute significantly to an early age of onset in SCA13.

151 ncrease in risk for CRC incidence and death; age of onset in the FDR was not significantly associated

152 fespan calendar predicted the characteristic age of onset in young adults and sex differences in schi

153 d with measures of striatal degeneration and age-of-onset in a cohort of 25 HD brains (r = 0.56, P =

154 thy with wide variation in both severity and age of onset, including demyelinating and axonal forms o

155 ed phenotype to major psychosis with younger age of onset indicate congruence between the linkage and

156 Subjects were categorized by age of onset into visually immature (<=8 years) and visu

157 Average age of onset is 7 months, with delay to diagnosis of 9.1

158 We sought to determine whether this younger age of onset is a result of ascertainment bias or has a

159 Median age of onset is in the late teens to early 20s for both

160 28-year difference between parent and child age of onset is observed (p = 0.002), but including indi

161 Age of onset is often between 6 months and 7 years.We as

162 ies, since symptom onset is near certain and age of onset is predictable.

163 th African Arab-Berber populations, although age of onset is variable.

164 define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early o

165 The median age of onset/latest examination was 45.0/62.5 years (ran

166 tients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depres

167 ABCA4 mutations as well as age of onset <20 years were significantly associated wit

168 survival ranged from 1 to 17 years, with the age of onset <40 years in six (10%) and >60 in 19 (30%).

169 0(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p <

170 AF (unstratified p = 1 x 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p =

171 or persistent PTSD, 69.6% for pre-late life (age of onset <55 years and age at last diagnosis <55 yea

172 a, 1.8% had persistent PTSD into later life (age of onset <55 years as well as a recent diagnosis).

173 family members, especially in patients with age-of-onset <50 years, family history of thoracic aorti

174 We hypothesized that BPD cases with an early age of onset (</=21 years old) would be particularly lik

175 urvival rate is negatively impacted by older age of onset, male sex, scleroderma renal crisis, pulmon

176 Early age of onset might be a sign of hereditary RCC.

177 gested genetic variability within DNM3 as an age-of-onset modifier of disease (n=232; rs2421947; hapl

178 eristics than typical TTS, including younger age of onset, more frequent ST-segment depression, highe

179 because of differences, such as the younger age of onset, multi-focality of P-NETs, and concomitant

180 d motor symptoms were more common at younger age of onset (myoclonus 0.93, 0.90-0.97, p=0.0007; seizu

181 had a more severe phenotype with an average age of onset of 10 months, an average corrected QT inter

182 (232 eyes; 102 male [77.3%]) evaluated with age of onset of 36.9 +/- 11.4 years.

183 nifestations and personal/family history, an age of onset of 46 years or younger should trigger consi

184 ntially fatal arrhythmic event with a median age of onset of 7 years (95% CI, 6-11).

185 e 20 in all but one patient, with an average age of onset of 7.9 years.

186 ed eight females and four males, with a mean age of onset of 73 years (range: 49-82).

187 significantly associated as modifiers of the age of onset of AD (CD44, rs187116, P=1.29 x 10(-)(1)(2)

188 le negative (G-) AD subjects exhibit delayed age of onset of AD (P=0.017) and significantly reduced r

189 LG LOF status and age-of-onset, with earlier age of onset of AD observed in the FLG LOF carrier group

190 es, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there w

191 rs [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 1

192 We determined the age of onset of amenorrhea after breast cancer for women

193 lationship between the log incidence and log age of onset of amyotrophic lateral sclerosis is consist

194 SNP did not associate significantly with the age of onset of angiographically verified coronary arter

195 been no genome-wide association study of the age of onset of asthma in children.

196 ver-expression, and also correlated with the age of onset of cancer, aggressiveness of the disease an

197 lower 40 Hz power correlated with an earlier age of onset of cannabis use (p<0.04).

198 77, p < .001) and positively associated with age of onset of cannabis use (r = .51, p = .027) but was

199 cular risk) underlies the relatively earlier age of onset of cardiovascular diseases among African Am

200 nicities had a higher prevalence and earlier age of onset of cataract than Europeans.

201 e first genome-wide association study of the age of onset of childhood asthma among participants in t

202 These brain changes are associated with age of onset of depression, as well as cumulative life-t

203 by patients with recurrent MDD and an adult age of onset of depression.

204 The increasing prevalence and younger age of onset of diabetes foreshadow greater diabetes-att

205 There was no correlation between age of onset of disease and prevalence of these mtDNA SN

206 so consistently identified the importance of age of onset of disease and the presence of eosinophils

207 A in adults with CVS and correlate this with age of onset of disease.

208 Age of onset of dystonia, duration of disease prior to s

209 ues, differing only in the amplitude and the age of onset of expression.

210 The mean age of onset of genetic sporadic ALS was 2.9 years young

211 The disease risk and age of onset of Huntington disease (HD) and nine other r

212 Nonwhite patients had later age of onset of HVLPD than white patients (median age, 8

213 ferent phenotypes: D923N, which has a median age of onset of hypotonia or dystonia at 3 years, and L9

214 esence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their pre

215 1383 in BPIFB1 were also associated with the age of onset of lung cancer (p = 0.001 and 0.006, respec

216 Age of onset of major symptoms (syncope or cardiac arres

217 particular, we focus on the effects that the age of onset of male puberty and rates of spermatogenesi

218 Age of onset of multiple sclerosis (MS) peaks in the 3rd

219 ior cortical regions but also with the young age of onset of PCA.

220 Pathways associated with age of onset of persistent P. aeruginosa infection were

221 phenotypes, including lung disease severity, age of onset of persistent Pseudomonas aeruginosa (P. ae

222 In short-term users, a younger age of onset of regular cannabis use and greater frequen

223 ndophenotype, which normalize by the typical age of onset of schizophrenia unless there has been more

224 ulthood, which temporally coincides with the age of onset of schizophrenia.

225 No correlations between the age of onset of SCZ and linear HOMER1 mRNA were observed

226 cHomer1a were positively associated with the age of onset of SCZ in both the dorsolateral prefrontal

227 cipants with sodium mutations had an earlier age of onset of stiffness (5 years versus 10 years), fre

228 Preliminary data suggests that age of onset of symptoms (pediatric vs. adult) may be a

229 es of 25 patients were reviewed to determine age of onset of symptoms and the results of ophthalmosco

230 mean [SD] age, 29.9 [14.7] years; mean [SD] age of onset of symptoms, 21.9 [13.3] years) showed atro

231 The age of onset of the affected family members was the seco

232 wever, the inclusion of individuals past the age of onset of the defining behaviors complicates inter

233 variables (lung function, reversibility and age of onset of the disease) or by biomarkers (eosinophi

234 cteristics and whether these SNPs affect the age of onset of the disease, recurrence, and survival.

235 st (LYLs), a measure that takes into account age of onset of the disorder.

236 The average age of onset of the monogenic forms of autoimmune endocr

237 Although the age of onset of these diseases range from juvenile [i.e.

238 nal anisotropy in this region was related to age of onset of training and sensorimotor synchronizatio

239 The age of onset of type 2 diabetes is decreasing.

240 In cannabis-dependent subjects, earlier age of onset of use correlated with lower [DeltaBP(ND)]

241 tivity; and (3) the severity rather than the age of onset of vestibular dysfunction differentiates wh

242 n variants in association with self-reported age-of-onset of AD.

243 Here, the age-of-onset of association between genetic variants at

244 men with truncating MLH1 mutations had later ages of onset of endometrial cancer than those with nont

245 ischaemic stroke was more prevalent at older ages of onset of symptoms of ADAD (odds ratio 1.09 per 1

246 higher dosage, longer duration, and earlier age of onset) or with distinct cannabinoid compounds (i.

247 her obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC.

248 ssion status, antidepressant medication use, age of onset, or symptom severity).

249 various characteristics, including age, sex, age of onset, oral symptoms, histologic features, plasmi

250 ons (1.48E-13) and correlated with a younger age of onset (p = 0.0018).

251 icular disease was associated with a younger age of onset (p = 0.02).

252 C9P cases had an earlier age of onset (p=0.047) and, in the subset of patients wh

253 implicate disease severity and persistence, age of onset, parental atopic history, filaggrin (FLG) m

254 Asthma is a heterogeneous disease in which age of onset plays an important role.

255 x, recurrent MDD, recurrent early-onset MDD, age of onset, pre-pubertal onset MDD or typical-like MDD

256 Young age of onset, presence of ANA, and elevated ESR appeared

257 e sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes

258 trophic lateral sclerosis (ALS) with varying ages of onset, progression and severity.

259 reased dosewise (Ptrend<0.0001) with earlier age of onset (Ptrend=0.0009), independently.

260 Age of onset ranged from 3 to 7 years (mean, 5.3 years).

261 subjects from the 43 families (n = 63), the age of onset ranged from 33 to 72 years (median 52 years

262 Age of onset ranged from 6 to 71 years, without apparent

263 sult of Mendelian gene variants lowering the age of onset, rather than ascertainment bias.

264 t temporally primary (based on retrospective age-of-onset reports) fear/anger, distress, disruptive b

265 sthma, a heterogeneous disease with variable age of onset, results from the interplay between genetic

266 The GRPS also differentiates classic age of onset schizophrenia from early onset and late-ons

267 rences, including differences in prevalence, age of onset, severity or disease progression.

268 Later age of onset, specific complicating features, and the SP

269 % CI, 1.12-1.45), with significantly younger age of onset (survey linear regression; adjusted beta, -

270 Age of onset, survival, ALS Functional Rating Scale (ALS

271 Familial ALS has a younger age of onset than apparently sporadic ALS.

272 rom one another; ALS cases exhibited earlier age of onset than FTD cases; and individuals with spinal

273 ividuals with spinal-onset exhibited earlier age of onset than those with bulbar-onset.

274 r trinucleotide repeat mutations can have an age of onset that varies by decades.

275 n by recognition of family history and early age of onset, the rates of such findings among individua

276 Intriguingly, both aggregation and age of onset trend with repeat length in similar ways, e

277 ystem is affected, phenotypes, severity, and age of onset varies depending on which mt-aaRS is mutate

278 Age of onset was </=3 years in 25 cases.

279 The earliest reported age of onset was 16 years (median, 46 years).

280 The mean age of onset was 16 years (range 3 to 39).

281 The median age of onset was 2.45 years with a male-to-female ratio

282 ld remember, whereas for the others the mean age of onset was 21 +/- 9 years.

283 Mean age of onset was 28 years (range 12-51) with bimodal pea

284 Non-CLIPPERS patients' median age of onset was 52 years (interquartile range, 39-59) a

285 CLIPPERS patients' median age of onset was 58 years (interquartile range, 24-72) a

286 Older age of onset was associated with slower VA loss: Patient

287 o determine the effect of genetic variation, age of onset was compared in people with sporadic ALS ca

288 Average age of onset was earlier in multiple system atrophy-cere

289 n ACH, P < .0005 for both), whereas the mean age of onset was earliest in GPP (31.0 vs 43.7 years in

290 The age of onset was highly variable, from early adulthood,

291 rk conditions, self-reported ever asthma and age of onset was obtained by household interview.

292 The latest age of onset was recorded at 64 years, in a patient diag

293 Greater dose and earlier age of onset were associated with these alterations.

294 blindness (P < 0.001), and those with older age of onset were more likely to develop ambulatory disa

295 ients (P = 0.009), and patients with younger age of onset were more likely to have optic neuritis rel

296 Genetic mutations differed by age of onset with prespacer mutations more likely to be

297 ount sibling relations, sex of siblings, and age of onset, with respect to ischemic stroke incidence.

298 icant association between FLG LOF status and age-of-onset, with earlier age of onset of AD observed i

299 D not associated with a single variant, were age of onset younger than 2 years (odds ratio [OR], 6.30

300 nsidered in atypical dementia cases, such as age of onset younger than 65 years, rapid symptom onset,