ライフサイエンスコーパス: ageing

1 al for maintaining cognitive function during ageing.

2 ghting its possible contribution in cochlear ageing.

3 erences in grey matter were more specific to ageing.

4 reased in sporadic PD brains and with normal ageing.

5 a measure of both reproductive and systemic ageing.

6 the National Study of Health, Wellbeing and Ageing.

7 Autophagy also has a role in kidney ageing.

8 acts normal development, stress survival and ageing.

9 ontrol, two processes inextricably linked to ageing.

10 TR, which are used to build barrels for wine ageing.

11 e are disproportionally mis-expressed during ageing.

12 EoE also appears to accelerate cellular ageing.

13 ss to semantic knowledge may be sensitive to ageing.

14 ex at a rate more than double that of normal ageing.

15 ue and metabolic homeostasis and for healthy ageing.

16 nd for understanding the genetics of healthy ageing.

17 sis pattern compared to control straight-dry-ageing.

18 SIRT1 protein during senescence and in vivo ageing.

19 ity change to those attributed to population ageing.

20 ping therapeutics for cancer and for healthy ageing.

21 lic disorders, neurodegeneration, cancer and ageing.

22 lobally as a result of population growth and ageing.

23 y negative consequences of climate change on ageing.

24 est in early-reproduction resulting in rapid ageing.

25 he maintenance of semantic memory in healthy ageing.

26 ironment contribute to haematopoietic system ageing.

27 ndividuals via deviations from typical brain ageing.

28 ears) from the English Longitudinal Study of Ageing.

29 e deterioration in memory performance across ageing.

30 ing the use of multiple features to quantify ageing.

31 ronic age-associated diseases and organismal ageing.

32 dults from the English Longitudinal Study of Ageing.

33 lizing the rate of atrophy to that of normal ageing.

34 ve thinning than that observed during normal ageing.

35 e affected differently in disease and during ageing.

36 ursor compartment, as demonstrated in normal ageing.

37 and sustained myelopoiesis that occur during ageing.

38 re the same underlying risk factor - namely, ageing.

39 ve role in multiple diseases associated with ageing.

40 rodegenerative diseases and in healthy brain ageing.

41 ree longitudinal cohort studies of cognitive ageing.

42 P < 0.01) showed an association with healthy ageing.

43 MET apparatus could play a role in cochlear ageing.

44 and skin pigmentation associated with photo-ageing.

45 somopathies and neurodegeneration as well as ageing.

46 ntial biomolecules, accelerating the rate of ageing.

47 ncluding metabolism, the immune response and ageing(1-5).

48 and more recently in immunotherapy(2,3) and ageing(4).

49 molecules that target the pace of metabolic ageing(9-12).

50 nce of co-morbidities, immunosuppression and ageing, a detailed analysis of their effects in large st

51 rn diet accelerates and exacerbates vascular ageing across the lifespan in sedentary mice They also s

52 Ageing affects a wide range of phenotypes at all scales,

53 propose that a complete understanding of how ageing affects haematopoiesis depends on the analysis of

54 We discuss how ageing affects the development of myeloid cells leading

55 g, Biomarker and Lifestyle Flagship Study of Ageing (AIBL) (n = 382), the Framingham Heart Study (n =

56 n throughout the lifespan, in the setting of ageing alone, as well as ageing compounded by Western di

57 acid can be considered markers of olive oil ageing, although they can also provide information about

58 amines cellular senescence in the context of ageing and AD, and discusses which of the processes - ce

59 al therapies, the unification of research in ageing and ALS requires high fidelity models to better r

60 Ageing and Alzheimer's disease contributed additive effe

61 These results suggest both ageing and Alzheimer's disease involve widespread atroph

62 late the tau immunophenotypes encountered in ageing and Alzheimer's disease.

63 s and across the whole-brain organization in ageing and Alzheimer's disease.

64 atter organization and volume differences in ageing and Alzheimer's disease.

65 elderly population is increasing because of ageing and because of its minimal impact on life span.

66 ccumulation of MMA represents a link between ageing and cancer progression, suggesting that MMA is a

67 l muscle and metabolic regulation as well as ageing and cancer.

68 stress, mitochondrial dysfunction, premature ageing and epigenetic changes are common features of CKD

69 ine the most promising interventions to slow ageing and group them into two tiers based on the robust

70 the next three decades, driven by population ageing and high and increasing obesity levels.

71 tential in vivo connection between cognitive ageing and higher regional levels of glia-related metabo

72 ar mechanism dictating its expression during ageing and in AD remains incompletely clear.

73 The expression of IFITM3 is increased with ageing and in mouse models that express familial Alzheim

74 function, may play an important role healthy ageing and in neurodegenerative conditions.

75 Ageing and inflammation strongly drive the risk of cardi

76 er (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-acces

77 he molecular mechanisms underlying cartilage ageing and osteoarthritis through the dysregulation of s

78 treatment, and demographic changes, such as ageing and population growth.

79 ining wine oxidative stability during barrel ageing and shelf life storage remains a challenge.

80 In China, the population is rapidly ageing and the capacity of the system that cares for old

81 g' interventions have been proposed to delay ageing and the onset of age-associated decline and disea

82 ses the epigenetic changes that occur during ageing and the rapidly increasing knowledge of how these

83 what underpins the poor Tfh cell response in ageing and whether it is possible to correct it.

84 oluble factors in the context of senescence, ageing, and age-related diseases.

85 ecular changes in non-cancerous cells during ageing, and how these may contribute towards a tumour pe

86 otal deaths to population growth, population ageing, and mortality change between 1990 and each subse

87 that snoRNA expression changes in cartilage ageing, and osteoarthritis and in osteoarthritis-like co

88 m wave 2 of the 19 country Survey of Health, Ageing, and Retirement in Europe (SHARE) and included no

89 the distillate and from the wood used in its ageing, and the interactions that take place in the proc

90 ional sympatholysis are preserved in healthy ageing, and thus the age-related impairment in functiona

91 ever-growing number of TFs whose effects on ageing are evolutionarily conserved.

92 tent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human popu

93 We quantified the rate of ageing as how quickly animals moved through a phenotypic

94 pants from the English Longitudinal Study of Ageing, assessed three times over 8 years of follow-up,

95 ion, material from a range of autopsy-proven ageing-associated and primary tauopathies in which there

96 Many of these ageing-associated diseases can be slowed down and even r

97 tissues and organs and the increased risk of ageing-associated disorders.

98 Ageing-associated microbiome alterations towards a disea

99 onstrated independent association to healthy ageing (beta -0.02 and 0.68 respectively, P < 0.01).

100 about how NAD(+) influences human health and ageing biology.

101 Out of the 1019 features extracted, 896 are ageing biomarkers, defined as those that show a signific

102 Under persistent stress, as occurs in ageing, both postmitotic cells - including neurons - and

103 In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progr

104 Tissue regeneration declines with ageing but little is known about whether this arises fro

105 cused on the genetic determinants of healthy ageing, but there is no public resource of whole genome

106 for population dynamics and the evolution of ageing, but these remain poorly understood.

107 eported varying health impacts of population ageing, but they focused only on limited countries and d

108 or countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energe

109 in biomechanical properties associated with ageing Caenorhabditis elegans in addition to capturing h

110 onment and the gut microbiome, phenotypes of ageing can be slowed sufficiently to mitigate age-relate

111 Some aspects of ageing can be studied directly in humans and have reveal

112 uggest that allocentric strategy deficits in ageing can result from difficulties related to landmark

113 accompanying Tabula Muris Senis(2)-or 'Mouse Ageing Cell Atlas'-which follows on from the original Ta

114 morphological and biophysical changes in the ageing cochlea.

115 , in the setting of ageing alone, as well as ageing compounded by Western diet consumption Overall, t

116 ts pancreatic beta cells, it declines during ageing concomitant with increased expression of the gap

117 n diseases, but the mechanisms through which ageing confers this risk are largely unknown(1).

118 aths in 2017 were associated with population ageing, corresponding to 27.9% of total global deaths.

119 Chronic disease and ageing create an O(2) delivery (i.e. blood flow x arteri

120 Although major categories of ageing damage have been identified-such as altered inter

121 In both ageing dimensions, we found that short lived-animals age

122 predicted to be maladaptive by accelerating ageing disproportionally, decreasing fitness.

123 Thus, ageing disrupts thymic progenitor differentiation and im

124 a comprehensive, whole-organism analysis of ageing dynamics has been lacking.

125 Ageing effects on spatial navigation are characterized m

126 r autophagy restoration can counteract these ageing effects.

127 Here, we show that ageing elicits a marked increase of SUMO levels in C. el

128 older from the English Longitudinal Study of Ageing (ELSA) and the Bage Cohort Study of Ageing (SIGa-

129 0,388 from the English Longitudinal Study of Ageing (ELSA), from 2002 to 2013.

130 During beer ageing, endogenous barrel microbes grow spontaneously an

131 e growing health needs related to population ageing, especially targeting the diseases associated wit

132 he increases in deaths related to population ageing for the whole world, as well as in 55.3% (84/152)

133 nt information to distinguish the effects of ageing forests from variable climate.

134 e structural changes related to normal brain ageing from those specific to Alzheimer's disease.

135 y 2050, principally owing to our growing and ageing global population.

136 e JAK gene JAK2 is frequently mutated in the ageing haematopoietic system(3,4) and in haematopoietic

137 between disease-microbiome associations and ageing has not been explored in detail.

138 Indeed, ageing has proved to be modifiable; by intervening in bi

139 e preservation of semantic memory in healthy ageing have reported mixed findings.

140 cally discriminated Alzheimer's disease from ageing, heterogeneity in grey matter volumes across morp

141 ROs) to improve the treatment and care of an ageing HIV population with increasing comorbidities and

142 anding of how systemic factors mediate brain ageing, how these factors are regulated and how we can t

143 Ageing immatures gradually changed from a more explorato

144 nts are currently used to study how maternal ageing impacts aneuploidy risk, however the differences

145 Ageing impaired nitric oxide-mediated EDD (peak EDD 88 +

146 al dysfunction, a universal feature of human ageing, impairs osteogenesis and is associated with acce

147 toring of Sherry vinegar during a whole year ageing in American oak, French oak, Spanish oak and ches

148 e the effect of oxygen on wine colour during ageing in barrels and bottles during different times.

149 has been tied to colour modifications during ageing in barrels and bottles.

150 Wine ageing in barrels is conditioned, among other factors, b

151 A simulation process of ageing in bottles was used to study the impact of bottli

152 s (55% and 68%) were studied during one-year ageing in cherry and oak barriques.

153 ncy similarly in two longitudinal studies of ageing in England and the United States.

154 n differences may contribute to sex-specific ageing in flies.

155 eterochromatin at repetitive elements during ageing in male flies, and a general loss of repressive c

156 dual variation in reproductive and actuarial ageing in nature.

157 sponders and test for accelerated epigenetic ageing in oesophageal cells of EoE patients.

158 of warming on animal life histories, and on ageing in particular, needs to be incorporated into the

159 sent an in-depth analysis of homeostasis and ageing in the antennal ears of the fruit fly Drosophila

160 entify phenotypes associated with biological ageing in the brain.

161 his study is the first to investigate normal ageing in these brain regions using 7T (1)H-MRS and find

162 ategy to prevent cardiovascular disease with ageing in women as well as men.

163 n older people but their impact on cognitive ageing in younger, healthy brains is less clear.

164 s of snoRNAs differentially expressed due to ageing (including SNORD96A, SNORD44) and osteoarthritis

165 ne as freshness marker versus safranal as an ageing indicator.

166 hat can identify both advanced and resilient ageing individuals via deviations from typical brain age

167 ar intrinsic and extrinsic mechanisms of how ageing influences the pathology of atherosclerosis.

168 eral age-related diseases, suggesting shared ageing influences.

169 hlighting pathways for the discovery of anti-ageing interventions that may be applicable in humans.

170 ing with perinatal HIV infection who are now ageing into adulthood and becoming pregnant.

171 understanding the events that convert normal ageing into neurodegeneration.

172 Hematopoietic ageing involves declining erythropoiesis and lymphopoies

173 Ageing is a degenerative process that leads to tissue dy

174 Healthy cognitive ageing is a societal and public health priority.

175 Remarkably, ageing is accompanied by a gradual decline in tissue and

176 bolites.SIGNIFICANCE STATEMENT Neurochemical ageing is an integral component of age-related cognitive

177 Human ageing is associated with high susceptibility to disease

178 Our data suggest ageing is associated with higher TSPO but a diagnosis of

179 Ageing is characterised by cellular senescence, leading

180 Ageing is characterized by the functional decline of tis

181 Ageing is independently associated with 4D flow derived

182 ed directly in humans and have revealed that ageing is influenced by many factors, including genetics

183 ia-sensitive gene expression supporting that ageing is necessary, but insufficient, for AD occurrence

184 Since ageing is not programmed, the conservation of their effe

185 recent studies have demonstrated that brain ageing is sensitive to circulatory proteins(4,5).

186 A proposed cause of ageing is the accumulation of epigenetic noise that disr

187 As ageing is the main risk factor for dementia-related neur

188 Ageing is the major risk factor for Alzheimer's disease

189 y to identify genes possibly associated with ageing is to build a classification model (from the mach

190 effort decreases somatic state, accelerating ageing, is central to our understanding of life-history

191 bone mineral density, a universal feature of ageing, is not fully understood.

192 In the ageing kidney there is nephron loss and lesions of focal

193 Here, we show that mouse ageing leads to less efficient T cell selection, decreas

194 data from the English Longitudinal Study of Ageing linked with Hospital Episode Statistics.

195 r exploration and research in endocrinology, ageing, matrix and vascular biology.

196 Ageing may be due to mutation accumulation across the li

197 some potential applications of the study of ageing mechanisms for the implementation of conservation

198 hich posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the appearanc

199 In this Review, we address the role of the ageing microenvironment in the promotion of tumour progr

200 r nature of the cellular hallmarks of normal ageing might be key to understanding the events that con

201 et of age-related phenotypes, the effects of ageing might in fact prove a prerequisite to ALS, render

202 , we show evidence that moderately fit brain ageing models may provide brain age estimates that are m

203 nants of stem-cell heterogeneity that resist ageing more than previously anticipated and are only los

204 own degree of functional compensation in the ageing mouse cochlea.

205 oximal femora of three groups (n = 10 each): ageing non-fractured donors (Controls); untreated fractu

206 In humans, vascular ageing occurs in the presence of differences in diet and

207 a high alcohol content and a minimum barrel ageing of 10 years.

208 In-bag dry-ageing of beef improved its lipids and protein oxidative

209 ogical modifications occurring during barrel ageing of beer, in controlled fermentation processes.

210 t that the predictive validity for cognitive ageing of polygenic scores derived from genome-wide asso

211 hway contributes to the loss of SIRT1 during ageing of several tissues related to the immune and haem

212 m of heart failure worldwide, in tandem with ageing of the general population and the increasing prev

213 With the ageing of the global population, interest is growing in

214 ith CNS disorders continues to grow with the ageing of the population thus demanding for more effecti

215 aths increased likely due to the progressive ageing of the population, this calling for a continuous

216 plasma, thus potentially contributing to the ageing of the systemic circulation.

217 The parent MFI zeolite was prepared by rapid ageing of the zeolite sol gel synthesis mixture.

218 e wood types other than American oak for the ageing of this type of vinegar.

219 ion of free SO(2) and acetic acid during the ageing of wines is proposed in this work.

220 ical, physiological and molecular changes in ageing OHCs (9-12 kHz cochlear region).

221 Ageing OHCs also exhibited the progressive loss of affer

222 Although the ageing OHCs retained a normal basolateral membrane prote

223 oelectrical transducer current is reduced in ageing OHCs, highlighting its possible contribution in c

224 ccurate conclusions regarding the effects of ageing on blood-forming stem cells; we suggest instead t

225 markers, we identified the effect of healthy ageing on eigenvector centrality, a measure of each voxe

226 he influence of fermented sugarcane molasses ageing on lees and the distillation process used for the

227 the distillation process, regardless of the ageing on lees of fermented molasses.

228 ehensively quantify the impact of population ageing on mortality for 195 countries/territories and 16

229 f theirs levels to other wine features (wine ageing or alcoholic content) were found.

230 78 genes, and find these to be enriched for ageing pathways previously highlighted in model organism

231 impact of bottling in wines after differing ageing periods in barrels.

232 a promising therapeutic venue to target the ageing phenotype and, thus, prevent or mitigate ageing-r

233 Ageing phenotypes, such as years lived in good health (h

234 genetic and environmental influences on the ageing plasma lipidome.

235 A rapidly ageing population and a limited therapeutic toolbox urge

236 revalence of atrial fibrillation (AF) in the ageing population and its associated life-changing healt

237 With an ageing population comes an inevitable increase in the pr

238 hosis and LT waitlisting, especially with an ageing population with increasing prevalence of fatty li

239 lid tumours, earlier diagnosis by MRI and an ageing population.

240 care challenge in an active and increasingly ageing population.

241 se changes to responses to cancer therapy as ageing predicts outcomes of therapy, including survival.

242 The results suggest that the ageing process is accelerated by the alternative ageing

243 ying the factors that cause and modulate the ageing process often requires experimental interventions

244 zen lean beef produced using stepwise in-bag ageing process suggest potential for the process to be u

245 e similar to those aged in French oak as the ageing process was progressing.

246 , yet it is unknown if this is causal in the ageing process, and whether autophagy restoration can co

247 To measure the ageing process, we characterized the sequence of alterat

248 allows the winemaker to globally control the ageing process.

249 emed to be satisfactory alternatives for the ageing process.

250 have long sought to alter the course of the ageing process.

251 can be also useful in the development of new ageing processes of distillates for which cherry barrels

252 r and cellular mechanisms underpinning these ageing processes remain unclear.

253 ntions to rejuvenate the epigenome and delay ageing processes.

254 ronous inter- and intra-organ progression of ageing, providing a foundation from which to track syste

255 rated the strongest association with healthy ageing (r = -0.53, P < 0.01) when compared to all RV fun

256 species with different average lifespan and ageing rate.

257 pact of global climate change on patterns of ageing rates in wild populations of ectotherms facing wa

258 data have been used to develop biomarkers of ageing, referred to as 'epigenetic clocks', which have b

259 reveal chemical markers associated with the ageing regardless of the origin or the production proces

260 Increased air velocities and stepwise ageing regime had no effect (P > 0.05) on dry-aged beef

261 To assess whether HO-1 can attenuate ageing - related lesions, rats with GEC-targeted HO-1 ov

262 challenging because of competing health and ageing-related conditions that can influence treatment d

263 Compared to ageing-related cortical thinning in healthy subjects, we

264 ations for the treatment of bone disease and ageing-related degeneration.

265 sources of biological data to predict which ageing-related diseases a gene is associated with (if an

266 ing phenotype and, thus, prevent or mitigate ageing-related diseases.

267 field and five high-dimensional datasets of ageing-related genes, where the predictors are Gene Onto

268 of podocyte-targeted HO-1 overexpression on ageing-related renal pathology and point to increased re

269 er's disease, primary age-related tauopathy, ageing-related tau astrogliopathy and multiple subtypes

270 s at all scales, but an objective measure of ageing remains challenging, even in simple model organis

271 owever, the cell biology of endocrine tissue ageing remains poorly understood.

272 We hypothesise that healthy ageing requires maintaining normal RV intra-cavity blood

273 ed bone microarchitecture and turnover in an ageing series of wild type mice with that of the PolgA(m

274 The roles of ageing, sex, the gut microbiome and organ transplantatio

275 f Ageing (ELSA) and the Bage Cohort Study of Ageing (SIGa-Bage).

276 d metabolites could be valuable in cognitive ageing studies.

277 isease (CVD) were recruited from the Cardiac Ageing Study.

278 Our model comprises an ageing subducting plate, nonlinear rheology and major ph

279 We speculate that vascular and myeloid cell ageing synergize, via IL-6 signalling, to accelerate ath

280 ng process is accelerated by the alternative ageing technology and the chestnut wood, and the corresp

281 Brain ageing, the key risk factor for neurodegeneration, invol

282 n FTLD, Alzheimer's disease (AD) and healthy ageing; their role as markers of disease severity assess

283 ential impact of global warming on ectotherm ageing through its effects on reactive oxygen species pr

284 n format (F), temperature (T), and "on lees" ageing time (t) factors were evaluated on the compositio

285 amino acids (FAAs) increased (P > 0.05) with ageing time.

286 The 2 largest contributions of population ageing to disease-specific deaths globally between 1990

287 dentified many loci that influence key human ageing traits, including lifespan.

288 diversified samples from which typical brain ageing trajectories were derived, and by limited reprodu

289 ed fermentation process for mimicking barrel ageing transformations.

290 9) of countries for females where population ageing was associated with increased death burden.

291 Population ageing was associated with increases in deaths in high-,

292 19.3 +/- 5.2 years (P < .0001); accelerated ageing was not observed in the oesophageal cells of heal

293 The effect of ageing was remarkably evident on spring migratory perfor

294 ne of the main features characterizing brain ageing, we also evaluated interindividual heterogeneity

295 th increases in deaths related to population ageing, we calculated the ratio of deaths attributed to

296 and cause-specific mortality and population ageing were responsible for most of the reductions in di

297 rogenitor cells are the principal targets of ageing, whereas the function of individual mature thymic

298 Due to time and cost inherent of ageing wine spirits in wooden barrels, research has soug

299 d nonlinear shifts in gene expression during ageing, with the associated genes clustered in consisten

300 In a tight labour market with an ageing workforce, employee flexibility and choice are ke