ライフサイエンスコーパス: aggregation

1 P1 (residues 36-42), that controls alphaSyn aggregation.

2 t binds unfolded proteins and prevents their aggregation.

3 ercoming this challenge, with partial relief aggregation.

4 feature that promotes LLPS while inhibiting aggregation.

5 levels of tau expression, phosphorylation or aggregation.

6 otent than those of idiopathic PD in seeding aggregation.

7 cytotoxicity apparently via enhancing p-tau aggregation.

8 neurodegenerative diseases involving protein aggregation.

9 e cells in which it templates misfolding and aggregation.

10 hic units including uncertainties of spatial aggregation.

11 sposes these methods for spontaneous protein aggregation.

12 nto fibrils and catalyzed amylin and Abeta42 aggregation.

13 ncentration to 10 mM, also prevented protein aggregation.

14 , as RPT fibrils did not influence alpha-syn aggregation.

15 48/80 or substance P but not by FcepsilonRI aggregation.

16 an also exert inhibitory effects on platelet aggregation.

17 er B6 (DNAJB6), efficiently inhibits amyloid aggregation.

18 D binding with soluble alphaSyn prevents its aggregation.

19 r the disparity is nonspecific inhibition by aggregation.

20 g factor (PAF) and thrombin-induced platelet aggregation.

21 r stress by reversing stress-induced protein aggregation.

22 itigating the risk of protein misfolding and aggregation.

23 on (LLPS), which initiates hydrogelation and aggregation.

24 cellular adhesion, thereby reducing cellular aggregation.

25 le for betaArg'169 (UniProt: 196) in lateral aggregation.

26 n of molecular geometries and supramolecular aggregation.

27 surrogate marker of non-amyloid-beta protein aggregation.

28 ies were however unaffected by the extent of aggregation.

29 ith monomeric Abeta to their effects on bulk aggregation.

30 nd "seed" for further translationally active aggregation.

31 ggesting that DMNDC does not inhibit insulin aggregation.

32 inding sites on Malat1 and subsequent TDP-43 aggregation.

33 stress in dopaminergic neurons and alpha-Syn aggregation.

34 l but also impact SOC stability through soil aggregation.

35 onverts on timescales comparable to those of aggregation.

36 c and eukaryotic cells in tau misfolding and aggregation.

37 Aggregation across multiple networks highlights robust c

38 , with the latter appearing capable of rapid aggregation, albeit initially forming smaller, weakly se

39 e that hAPP overexpression aggravates EC-Tau aggregation and accelerates pathological tau spread into

40 Platelet aggregation and activation were assessed by aggregometry

41 ng (mislocalized) cytoplasmic TDP-43, TDP-43 aggregation and cell toxicity.

42 AD) and other tauopathies is the misfolding, aggregation and cerebral accumulation of tau deposits.

43 lective group of prescription drugs in p-tau aggregation and cytotoxicity assays.

44 mportantly, sHsps were shown to prevent aSyn aggregation and cytotoxicity.

45 strointestinal tract can accelerate alphaSyn aggregation and disease in the gut and the brain.

46 omers present at different stages of protein aggregation and establish a relationship between morphol

47 r sequence motif that controls both alphaSyn aggregation and function-a region that could be targeted

48 e epidemic) is strongly shaped by population aggregation and heterogeneity, such that epidemics in cr

49 Here, we present a single-cell aggregation and integration (scAI) method to deconvolute

50 fferent pharmacological interventions on the aggregation and internalization of tau and aSyn.

51 nd evaluate therapeutics targeting alpha-syn aggregation and LB formation.

52 e presence of monovalent cations resulted in aggregation and minor coalescence, while divalent cation

53 nfection, had significantly reduced platelet aggregation and NET release.

54 s target misfolded proteins to prevent toxic aggregation and neurodegeneration(1).

55 bserved marked reductions in alpha-synuclein aggregation and neurotoxicity, thus validating that 4E-B

56 the capture of transient species during the aggregation and secondary nucleation of the Abeta42 pept

57 anding of factors associated with faster tau aggregation and spread.

58 the contribution of glia to alpha-synuclein aggregation and spread.

59 es with different chemical properties on the aggregation and spreading of aSyn and tau will be import

60 play further complementary roles in catalyst aggregation and substrate binding.

61 Surprisingly, the reduced propensity toward aggregation and the stabilization of oligomeric intermed

62 normal phosphorylation is thought to precede aggregation and therefore to promote aggregation, but th

63 oposed as indicative of beta-amyloid (Abeta) aggregation and thus potential biomarkers for Alzheimer'

64 effects of IAPP peptides in modulating Abeta aggregation and toxicity and provide new insight into th

65 motor neurons are more vulnerable to TDP-43 aggregation and toxicity compared with their astrocyte c

66 of cocoa hindering Abeta peptide on-pathway aggregation and toxicity in a human neuroblastoma SH-SY5

67 aDelta) also prevents age-dependent alphaSyn aggregation and toxicity in C. elegans models and preven

68 uitin-interacting motifs (UIMs) that enhance aggregation and toxicity.

69 and subsequently apply a novel two-component Aggregation and Uncaging Focused Ultrasound Sequence (AU

70 learning, memory, mood regulation, platelet aggregation and vasoconstriction, but its involvement in

71 atant from VZV-infected cells induced amylin aggregation and, to a lesser extent, Abeta42 aggregation

72 lizing the viral envelope, and driving virus aggregation and/or intervirion envelope fusion.

73 with and differentially modulate TDP-43 CTD aggregation and/or liquid-liquid phase separation in vit

74 GLIA, and hemolysis, platelet activation and aggregation, and complement activation or coagulation we

75 tituent favorably tunes catalyst solubility, aggregation, and conformation while modulating substrate

76 mic instability, epigenetic changes, protein aggregation, and down-regulation of quality control mech

77 ion effectively proteins must avoid aberrant aggregation, and hence they are expected to be expressed

78 ing water solubility, eliminating probe self-aggregation, and increasing probe stability.

79 TTR binds Abeta, alters its aggregation, and inhibits its toxicity both in vitro and

80 EV generation, prevented platelet-neutrophil aggregation, and restored microvascular blood flow in lu

81 that epigallocatechin gallate decreases aSyn aggregation, and that dynasore reduces tau internalizati

82 hey also show distinct structural stability, aggregation, and toxicity profiles.

83 orylation alters LC interaction specificity, aggregation, and toxicity.

84 os by thermal (E/Z)-isomerization, lyotropic aggregation, and two different formulation techniques, c

85 enhanced CD4+ T cell maturation and monocyte aggregation are features of HAM, reflecting widespread i

86 )) into scrapie PrP (PrP(Sc)) and subsequent aggregation are key events associated with the onset of

87 iation and progression of tau misfolding and aggregation are largely unclear.

88 f DNA both increasing and preventing protein aggregation are observed to stem from this enhanced olig

89 nal Tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive defic

90 effect, this work assessed a novel cyclical aggregation as a means of expanding MSCs to maintain ste

91 talytic data, but also acts to alleviate RGO aggregation as disclosed by scanning electron microscopy

92 ization of C difficile and F nucleatum in an aggregation assay using adult patients and stool of pedi

93 aceutical compounds with the HEK293 cell tau aggregation assay, we obtained only a low number of hit

94 apeutic potential to protect against protein aggregation-associated cellular defects.

95 itution of this 'master controller' prevents aggregation at pH 7.5 in vitro.

96 iative properties of Periphilin promote HUSH aggregation at target loci.

97 Their aggregation, binding mode, and morphology can be tuned b

98 ngly, we find that Hsp33 not only suppresses aggregation but also guides the folding process.

99 Both agents inhibit human platelet aggregation but preserve clot retraction.

100 rones are known to be central to suppressing aggregation, but how they affect substrate conformations

101 precede aggregation and therefore to promote aggregation, but the nature and extent of phosphorylatio

102 y reduced the rate of polycatechol formation/aggregation by a factor of 1.3 +/- 0.4 in AS solution in

103 strained by the solubility and the undesired aggregation-caused quenching effect of the hydrophobic c

104 thered to naphthalic anhydride with the ACQ (aggregation-caused quenching) feature.

105 planations for the empirically unpredictable aggregation characteristics of GO and provide computatio

106 These aggregation chemicals can be manufactured into a lure th

107 nt regulator of its localization, structure, aggregation, clearance and toxicity.

108 Under such circumstances, the aggregation commences after approximately an hour and co

109 tive individuals showed an impaired platelet aggregation, confirming a role for ABCC4 in platelet fun

110 ced in diagnostic laboratories and the Exome Aggregation Consortium database for replication and meta

111 T10A missense variants reported in the Exome Aggregation Consortium database.

112 urring as a result of protein misfolding and aggregation contributes to the pathogeneses of neurodege

113 The increase in platelet activation and aggregation could partially be attributed to increased M

114 -based classification, nomenclature and data aggregation could serve as an example for cell type atla

115 on-Finnish European subjects from the Genome Aggregation Database (gnomAD) as control subjects.

116 omains (18 of 22, 82%, P<0.001 versus Genome Aggregation Database common variants) and were associate

117 signal generation mechanism is based on the aggregation/de-aggregation of phthalocyanine chromophore

118 l-ion bound state appears to be incapable of aggregation, effectively reducing the available monomeri

119 solvent reduces protein stability and causes aggregation, even though the interface makes no detectab

120 as molecular chaperones that prevent protein aggregation, even under extreme conditions.

121 iated a reduction in tau phosphorylation and aggregation following proteasome inhibition, suggesting

122 sion of ICAM1, CD11b, PD-L1, and the reduced aggregation following the prolonged LPS challenge as com

123 aired glutathione regulation underlies BisAb aggregation formation in a CHO cell process.

124 PSMalpha3 initiates the aggregation, forming unstable aggregates capable of seed

125 ive cellular uptake, allowing us to decouple aggregation from cellular, receptor-mediated internaliza

126 esulted from imperfect synthesis conditions, aggregation from product instability, or degradation dur

127 d proteins may accelerate reciprocal amyloid aggregation in a prion-like fashion.

128 but their utilization is compromised by self-aggregation in aqueous media.

129 we found that Hsp27 reduced MGO-induced aSyn aggregation in cells, leading to the formation of nontox

130 nal assembly of FUS and prevent pathological aggregation in cells.

131 LLPS was shown to facilitate tau amyloid aggregation in certain cases, while being independent of

132 ouse model of SAH, the degree of erythrocyte aggregation in CLNs is significantly lower, while the as

133 hown that nucleic acids can nucleate protein aggregation in disease-related proteins, but in other ca

134 n-a region that could be targeted to prevent aggregation in disease.

135 iation between neuroinflammation and protein aggregation in frontotemporal dementia.

136 ondensation and toxicity in yeast and TDP-43 aggregation in human cells.

137 rion protein is significantly decreased upon aggregation in infected cells.

138 he factors that cause protein misfolding and aggregation in metazoans.

139 Integrin activation and platelet aggregation in mice whose platelets express only talin-1

140 reen for germline modifiers of polyglutamine aggregation in muscle cells.

141 s, which were able to induce alpha-synuclein aggregation in neurons, further supporting the translati

142 es, these exosomes further increased protein aggregation in neurons.

143 mechanism related to pathological alpha-syn aggregation in oligodendrocytes, and the OEMVs found in

144 in certain cases, while being independent of aggregation in other cases.

145 ggregation prone sequence motifs can trigger aggregation in peptide and protein sequences.

146 lready exist during the lag phase of protein aggregation in the brain.

147 Although R-DPRs induce widespread protein aggregation in this in vitro system, transport disruptio

148 have demonstrated both beta-amyloid and tau aggregation, including neurofibrillary tangles, with age

149 geted areas revealed intra- and inter-strand aggregation indicating the fiber to be collagen losing i

150 py showed that the process of casein micelle aggregation induced by CpCP3 was similar to that caused

151 zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for

152 NPS as a donor shows significant aggregation induced emission enhancement (AIEE) after as

153 ce and supramolecular chemistry due to their aggregation-induced emission (AIE) properties.

154 Herein, we designed aggregation-induced emission gold clustoluminogens (AIE-

155 plain both aggregation-induced quenching and aggregation-induced emission phenomena.

156 -p-cyanophenyl-substituted psoralen exhibits aggregation-induced emission properties.

157 This model can also explain both aggregation-induced quenching and aggregation-induced em

158 aving enzyme-1 (BACE-1), and Abeta42 and tau aggregation inhibition).

159 ignificantly superior for patients receiving aggregation inhibitors after LT.

160 aggregation and, to a lesser extent, Abeta42 aggregation into amyloid fibrils.

161 Tau aggregation into insoluble filaments is the defining pat

162 n neuroblastoma cell cultures, where Abeta42 aggregation into large insoluble deposits is reproduced.

163 Our findings suggest that protein aggregation is a major driver of aging and cell death du

164 Protein aggregation is a major unsolved problem in biochemistry

165 HisC aggregation is facilitated by Dishevelled and depends on

166 ffords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains.

167 Protein misfolding and aggregation is the hallmark of numerous human disorders,

168 d this setup to investigate the salt-induced aggregation kinetics of gold (Au) and silver (Ag) nanopa

169 The aggregation kinetics of insulin were not significantly a

170 ar systems, we investigated the urease-bound aggregation kinetics of the Au and Ag NPs which has not

171 , while GSK-2606414 mitigated the effects of aggregation leading to in vitro aging.

172 g diversity among farms, but at intermediate aggregation levels (counties) it is possible to estimate

173 Simulated aggregation levels at the group and individual level wer

174 We observe that computer-simulated aggregation levels mimic true disease patterns in ALS pa

175 ncluding mapping epitopes, following protein aggregation, locating small molecule binding, measuring

176 Normal versus pathological aggregation may be distinguished by the capacity of cell

177 This dimer-induced aggregation mechanism may be of relevance for human amyl

178 However, the intrinsic aggregation mechanism of beta-parvalbumin has not yet be

179 t the early urban development stage, whereas aggregation metrics determine such trends mostly in mid-

180 nisms include alpha-synuclein misfolding and aggregation, mitochondrial dysfunction, impairment of pr

181 strategies that are specific for solid-phase aggregation observed in disease.

182 senting non-severe and severe symptoms, with aggregation occurring at suboptimal thrombin concentrati

183 and electron microscopy we found that the co-aggregation of Abeta and ferritin resulted in the conver

184 The aggregation of alpha-synuclein (alphaS), a protein abund

185 to experiments on membrane-catalyzed amyloid aggregation of alpha-synuclein, a protein implicated in

186 at reduced GCase activity does not result in aggregation of alpha-synuclein.

187 Preventing aggregation of amyloid beta (Abeta) peptides is a promis

188 is susceptible to oxidative degradation with aggregation of apo species.

189 Biofilm, an aggregation of bacteria, fungi, algae, and protozoans an

190 ine methods for dielectrophoresis-based cell aggregation of both suspension and adherent cell lines,

191 The models allowed for residual familial aggregation of breast and ovarian cancer and were adjust

192 itionally, a critical perspective of how the aggregation of CuNCs can efficiently improve the floresc

193 de the I(T)-state as the origin of the rapid aggregation of D76N-beta(2)m, suggesting that other nonn

194 ity is at least in part due to the selective aggregation of data from different databases and the dom

195 ones in the search area which leads to local aggregation of debris in those zones and hence reduction

196 nces in translation, solubility, and protein aggregation of DPRs between c9ALS/FTD and SCA36.

197 ind the transadhesive interface, blocked the aggregation of Dsg1/Dsc1 and Dsg3/Dsc3 beads, respective

198 eBD2 and -3 also caused the aggregation of EHV1 virions on the cell surface of RK13

199 by misfolded protein forming a template for aggregation of endogenous alphasyn.

200 ression-based predictive models involves the aggregation of gene-level data into biological pathways.

201 mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrill

202 and we demonstrated that BON1 could mediate aggregation of liposomes in response to Ca(2+) .

203 is, assisting protein folding and preventing aggregation of misfolded proteins.

204 Aggregation of mobile monitoring data in space and time

205 HSP-17 of Caenorhabditis elegans facilitates aggregation of model substrates, such as malate dehydrog

206 At pH 4, aggregation of MoS(2) increased with increasing MoS(2)/c

207 ckade of CXCL1 inhibited the recruitment and aggregation of neutrophils at FALCs during zymosan-induc

208 ion mechanism is based on the aggregation/de-aggregation of phthalocyanine chromophores controlled by

209 scape at the eddy front which can affect the aggregation of plankton and particles.

210 These plaques are formed by aggregation of polypeptides that are derived from the Am

211 rgans, where its overexpression promotes the aggregation of polyQ proteins and of the endogenous kina

212 turnover, and decreased RAN toxicity and co-aggregation of proteasome and autophagy proteins to GA a

213 The misfolding and aggregation of proteins leading to amyloid formation has

214 ) domain, we systematically investigated the aggregation of repeated segments within the core.

215 in the amyotrophic lateral sclerosis-linked aggregation of SOD1.

216 ut rather as increased passive inhibition of aggregation of specific substrates.

217 Aggregation of such digital traces may make it possible

218 Aggregation of tau has been implicated in neurodegenerat

219 The aggregation of the Ag NPs could be reliably adjusted by

220 Arsenic removal was achieved upon aggregation of the As(V)-Fe(III) polymers.

221 imple yet effective way to modulate the self-aggregation of the commonly used naphthalene diimide (ND

222 e use osmolytes to probe the structuring and aggregation of the intrinsically disordered mutant Hunti

223 The aggregation of the intrinsically disordered tau protein

224 However, the unwanted aggregation of the light-absorbing nanoparticles in the

225 Aggregation of the peptide hormone amylin into amyloid d

226 generative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are cu

227 The aggregation of the protein alpha-synuclein (alpha-Syn) l

228 s(III) was oxidized rapidly by OH(*) and the aggregation of the resulting As(V)-Fe(III) polymers was

229 g that TRAF6-mediated polyubiquitination and aggregation of the SOD1 variants are independent events.

230 Large-scale family studies on the co-aggregation of these disorders are lacking.

231 sociated with the prion-like propagation and aggregation of toxic proteins.

232 terior distribution of each estimation step; aggregation of uncertainty across age, sex, and location

233 In contrast, groups formed through the aggregation of unrelated adults are smaller and lack spe

234 Whereas the noncovalent aggregation of various BODIPY dyes has been studied in d

235 e magnetosomes, which are aligned in complex aggregations of multiple chains within the cell.

236 nvolving habitat-forming marsh cordgrass and aggregations of ribbed mussels.

237 LDs) of 25 diseases, impairments, or bespoke aggregations of sequelae that were selected as amenable

238 y on junctional activity, enabling temporary aggregations of topological defects in cell packing.

239 L mutations are proposed to trigger CSPalpha aggregation/oligomerization, but the mechanism of oligom

240 Mutant HTT (mHTT) toxicity is caused by its aggregation/oligomerization.

241 ic TARDBP mutations in the absence of TDP-43 aggregation or loss of nuclear protein.

242 ly accepted that the complex and fascinating aggregation pathway involves a series of steps during wh

243 identify some exceptional properties of the aggregation pathway which make it a likely contributor t

244 haviour of monomers, with a possible link to aggregation pathways and toxicity.

245 Individuals near the aggregation periphery exhibited flexibility, whereas oth

246 We identified the chemical properties of the aggregation pheromone that signals nestmate presence and

247 udy was to identify and quantify the bed bug aggregation pheromone.

248 These identified aggregation pheromones have great potential for exploita

249 etimes limited due to poor water solubility, aggregation, photodegradation, and slow clearance from t

250 h as airports, trains, boats, and any public aggregation places.

251 -terminal ubiquitin modification changes the aggregation process of both proteins, resulting in the f

252 illation on cells suggested that the amyloid aggregation process per se exerts cytotoxic effects thro

253 ordered fibrils dominating at the end of the aggregation process.

254 t intermediate species are formed during the aggregation process.

255 designed to identify novel effectors of the aggregation process.

256 ning of the NAC region of aSyn are, the more aggregation prone monomeric aSyn conformations become.

257 Short aggregation prone sequence motifs can trigger aggregatio

258 Moreover, hBEX3 aggregation-prone features and the specificity in intera

259 Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within thes

260 progressively changed to the point that many aggregation-prone proteins are now considered bona fide

261 f cytoplasmic aggresomes in cells expressing aggregation-prone proteins, and (iii) thermoprotection a

262 n influence protein homeostasis of cytosolic aggregation-prone proteins.

263 esponse to starvation or the accumulation of aggregation-prone proteins.

264 Whereas the coiled-coil domain and aggregation-prone region additively contribute to compet

265 g protein 43) and FUS (fused in sarcoma) are aggregation-prone RNA-binding proteins that in ALS can m

266 ggests that F-actin potentially triggers the aggregation-prone structural transition of a short CPEB3

267 s the concentration of the isoform with high aggregation propensity, reducing the rate of its fibrill

268 rmation of monomeric aSyn in relation to its aggregation propensity.

269 ability of the native state is a hallmark of aggregation propensity.

270 If so, could the enhanced aggregation rate of Abeta42 compared to Abeta40 be ratio

271 between predicted and experimental change in aggregation rate upon mutation (P-value <0.0001).

272 t other nonnative states must cause its high aggregation rate.

273 ingle point mutations that lead to change in aggregation rates for 23 polypeptides and proteins.

274 ucing agents, resulting in faster and slower aggregation rates, respectively.

275 addition of preformed dimers accelerates the aggregation reaction of monomers.

276 late features of human ALS (ie, SOD1 protein aggregation, reduced cell viability, perturbations in mi

277 ctures, and the ability to recognize generic aggregation-related epitopes formed by unrelated amyloid

278 us-induced aberrant proteostasis and protein aggregation resemble the cellular pathology of sporadic

279 ion screen, we demonstrate the generation of aggregation resistant scFv sequences when reformatted as

280 Platelet aggregation responses, as well as thrombus formation und

281 he loss of cell surface protrusions and poor aggregation, resulting in increased dissemination of sma

282 by sRPT fibrils accelerates the rate of lRPT aggregation, resulting in propagation of an sRPT-like tw

283 ture and assess the levels of relatedness at aggregation sites of reef manta rays (Mobula alfredi) in

284 sed yields of recombinant LPL, prevented LPL aggregation, stabilized LPL against spontaneous inactiva

285 that for dyes, the transition underlying an aggregation state has more optoacoustic signal generatio

286 w a high and dependable correlation with the aggregation state.

287 label-free tool to explore in-vitro protein aggregation that takes place during the progression of n

288 le138b and fulvic acid decrease aSyn and tau aggregation, that epigallocatechin gallate decreases aSy

289 ildren with SDB exhibited increased platelet aggregation to TRAP (thrombin receptor-activating peptid

290 es in HSP70 and HSC70 client association and aggregation toward polypeptides with predicted disorder,

291 The size and aggregation types of PIN clusters were determined by ele

292 tivating peptide) (children with SDB = 114.8 aggregation units [AU] vs. control subjects = 98.0 AU; P

293 e mechanistic consequences of delaying Abeta aggregation via weak metal-ion binding, quantitatively l

294 d sample was taken, and whole-blood platelet aggregation was measured.Measurements and Main Results:

295 m infected cells to induce amylin or Abeta42 aggregation was quantitated.

296 compound (OBOC) library to inhibit Abeta(40) aggregation, we investigated eight (8) analogues and eva

297 here that lsr2 participates in intercellular aggregation, while groEL1 was required for biofilm matur

298 he initiation of a thrombus through platelet aggregation with its subsequent viscoelastic responses t

299 hat astrocytes are neuroprotective to seeded aggregation within motor neurons by reducing (mislocaliz

300 itude, a follow-up study evaluating platelet aggregation would be instructive.