ライフサイエンスコーパス: airway epithelial cell

1 if19a into autophagosomes for degradation in airway epithelial cells.

2 plified itself and ST2 protein expression in airway epithelial cells.

3 r protein and Cas RNP delivery to refractory airway epithelial cells.

4 well as their ability to replicate in human airway epithelial cells.

5 g this innate immune response in human small airway epithelial cells.

6 sm of a discrete population of multiciliated airway epithelial cells.

7 2 strain three times in differentiated swine airway epithelial cells.

8 levels of silencing, particularly in primary airway epithelial cells.

9 fluenza virus replication in human bronchial airway epithelial cells.

10 various cell types, including primary human airway epithelial cells.

11 ocrine cells (PNECs) are the only innervated airway epithelial cells.

12 compartment or selectively lacking the GR in airway epithelial cells.

13 ncreases oxidative and nitrosative stress in airway epithelial cells.

14 odulation following a mechanical stimulus in airway epithelial cells.

15 cocorticoids in regulation of BK channels in airway epithelial cells.

16 2 in Clara cell secretory protein-expressing airway epithelial cells.

17 rus spreads rapidly and efficiently in human airway epithelial cells.

18 ced CXCL-10 via IRAK-1 depletion at least in airway epithelial cells.

19 s that are infectious in well-differentiated airway epithelial cells.

20 induced expression of both ST2 and IL-33 in airway epithelial cells.

21 ation of beta-catenin to induce EMT in human airway epithelial cells.

22 n of noggin, BAMBI, and FSTL1 in human small airway epithelial cells.

23 rity to the transcriptome for intrapulmonary airway epithelial cells.

24 Il33, and muc5ac mRNA expression in cultured airway epithelial cells.

25 E shRNA inhibited HMGB1-induced EMT in human airway epithelial cells.

26 EMT-related gene expression in human primary-airway epithelial cells.

27 excessive levels at the apical surface of CF airway epithelial cells.

28 cle DNA with plasmid DNA in transfections of airway epithelial cells.

29 P-regulated ion and fluid transport in human airway epithelial cells.

30 induced IL-33 in the induction of CXCL-10 in airway epithelial cells.

31 is study, we deleted the mouse Kif3a gene in airway epithelial cells.

32 s and dendritic cells, transfer infection to airway epithelial cells.

33 given the strict tropism of HBoV1 for human airway epithelial cells.

34 atory effects of R507 were analyzed on human airway epithelial cells.

35 y dependent on IL-33/ST2/IRAK-1 signaling in airway epithelial cells.

36 type-II interferon-gamma (IFNgamma) in human airway epithelial cells.

37 ,3-linked sialic acids on complex glycans on airway epithelial cells.

38 y observed in lung airway using primary lung airway epithelial cells.

39 es but can also inhibit influenza entry into airway epithelial cells.

40 ell-differentiated primary cultures of human airway epithelial cells.

41 d release of chemokines, including CCL20, by airway epithelial cells.

42 on TNF-regulated gene expression in cultured airway epithelial cells.

43 d its degradation in the proteasome of human airway epithelial cells.

44 racts with RV RNA and poly(I.C) in polarized airway epithelial cells.

45 a role in proinflammatory gene induction in airway epithelial cells.

46 ected differentiation of hPSCs into lung and airway epithelial cells.

47 ion are due to infection of nectin4-positive airway epithelial cells.

48 e and regulator of inflammatory signaling in airway epithelial cells.

49 ansepithelial resistance (R(T)) in polarized airway epithelial cells.

50 shedding of the ADAM17 substrate TNFR1 from airway epithelial cells.

51 CFTR by attenuating its endocytosis in human airway epithelial cells.

52 rate with IL-13 in the induction of IL-25 in airway epithelial cells.

53 g a higher proliferative capacity than large airway epithelial cells.

54 primarily on the apical surfaces of ciliated airway epithelial cells.

55 and increased TMPRSS2 expression ex vivo in airway epithelial cells.

56 screen and confirmed in primary human small airway epithelial cells.

57 P expression in edited 16HBE14o- and primary airway epithelial cells.

58 rs2076295 regulates DSP expression in human airway epithelial cells.

59 esenchymal transition in primary human small airway epithelial cells.

60 ous studies have focused on abnormalities in airway epithelial cells.

61 rhinovirus (RV)-induced IFN response in the airway epithelial cells.

62 ttachment to sialosides and entry into human airway epithelial cells.

63 on, normalized RV-induced IFN levels in COPD airway epithelial cells.

64 dent of rhythmic glucocorticoid signaling in airway epithelial cells.

65 -liquid interface cultures of differentiated airway epithelial cells.

66 alling pathways triggered by the allergen in airway epithelial cells.

67 e of DMSe-derived SOA as a stressor in human airway epithelial cells.

68 In addition, human airway epithelial cells (16HBE) were challenged with HDM

69 action of extracellularly released HMGB1 in airway epithelial cells (A549 and small airway epithelia

70 Selective depletion of CSF1 in airway epithelial cells abolished the production of alle

71 Thus, HBoV1 infection of human airway epithelial cells activates antiapoptotic proteins

72 s triggered by rDer p 5 were investigated in airway epithelial cell activation assays in vitro.

73 basophil degranulation assays, and in vitro airway epithelial cell activation assays.

74 Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of

75 status in early pregnancy is associated with airway epithelial cell (AEC) responses in new born infan

76 Airway epithelial cell (AEC) signaling might regulate HL

77 Airway epithelial cells (AEC) are increasingly recognize

78 that air-liquid interface cultures of murine airway epithelial cells (AECs) also actively synthesize

79 a responses in vitro in primary human infant airway epithelial cells (AECs) and in vivo using nasal a

80 is necessary for HRV-C infection of primary airway epithelial cells (AECs) and to identify molecular

81 Pulmonary airway epithelial cells (AECs) form a critical interface

82 Innate immune responses to allergens by airway epithelial cells (AECs) help initiate and propaga

83 DNA methylation (DNAm) profiles in central airway epithelial cells (AECs) may play a key role in pa

84 Airway epithelial cells (AECs) play a critical role in t

85 In this study, we looked at how the airway epithelial cells (AECs) regulate the flagellin-de

86 Challenging lung airway epithelial cells (AECs) with LBCs decreased (by m

87 DNA methylation profiles of cultured primary airway epithelial cells (AECs) would differ between cell

88 In airway epithelial cells (AECs), stimulation of PAR2 by a

89 of chronic asthma and in vitro human primary airway epithelial cells (AECs).

90 ate and maintain intracellular H2S levels in airway epithelial cells (AECs).

91 rface media than in media with mock-infected airway epithelial cells (AECs).

92 In human airway epithelial cells, alternative splicing of the IL-

93 of P. aeruginosa grown in sputum gels using airway epithelial cells and a murine infection model.

94 sed expression of inhibitory ligands by both airway epithelial cells and APCs, further establishing a

95 lly differentiated cultures of primary human airway epithelial cells and cocultures with Pseudomonas

96 genic mice conditionally expressing Foxa3 in airway epithelial cells and developed human bronchial ep

97 ent data has highlighted the cross talk with airway epithelial cells and environmental factors (aller

98 and osmotic stress were assessed in primary airway epithelial cells and ex vivo murine lung tissue.

99 Influenza A virus (IAV) targets airway epithelial cells and exploits the host cell machi

100 erferon-stimulated gene (ISG) in vitro using airway epithelial cells and extend our findings to in vi

101 the effects of coculture of NTHI with human airway epithelial cells and heme availability on Tfp exp

102 l role for p52 in cell survival/apoptosis of airway epithelial cells and implicate noncanonical NF-ka

103 -beta2, periostin and endothelin-1, by human airway epithelial cells and in mice exposed to A fumigat

104 n expression was determined in primary human airway epithelial cells and in mice.

105 expression of pro-inflammatory mediators in airway epithelial cells and in the lung of mice by enhan

106 as attenuated in two models of primary human airway epithelial cells and in the upper and lower airwa

107 human surfactant protein A and annexin A2 on airway epithelial cells and is internalized, leading to

108 ssion in bronchial biopsies was increased in airway epithelial cells and lamina propria inflammatory

109 sociated kinase-1 (IRAK-1) depletion in both airway epithelial cells and macrophages.

110 livery to cultured human well-differentiated airway epithelial cells and mouse lungs with engineered

111 but lowers mRNA levels in O(3)-exposed human airway epithelial cells and mouse lungs.

112 on quantitative trait loci of TMEM9 in nasal airway epithelial cells and MROH3P in esophagus mucosa.

113 s for presentation at the plasma membrane of airway epithelial cells and recognition by CD8(+) T cell

114 get the master IFN signal regulator STAT1 in airway epithelial cells and tested these mice for contro

115 severe asthma and primarily associated with airway epithelial cells and tissue neutrophils.

116 ease inhibitor (SLPI), which is expressed by airway epithelial cells, and IFN-gamma inversely correla

117 lveolar macrophages, monocytes, neutrophils, airway epithelial cells, and in mouse lungs.

118 ctivation was assessed in human neutrophils, airway epithelial cells, and peripheral blood monocytes

119 transcription factor NF-kappaB in conducting airway epithelial cells, and used a combination of in vi

120 ndicating that Runx3 plays a crucial role in airway epithelial cell apoptosis induced by IAV infectio

121 s study, we investigated the hypothesis that airway epithelial cells are a source of CTSS, and mechan

122 However, although airway epithelial cells are frontline sentinels in detec

123 on gene expression changes in BEAS-2B human airway epithelial cells are reported and discussed in re

124 Although human airway epithelial cells are the main target of respirato

125 Airway epithelial cells are the major target for rhinovi

126 ibroblasts and altered relative frequency of airway epithelial cells as hallmarks of lung aging.

127 iptome-wide gene expression changes in human airway epithelial cells (BEAS-2B) after exposure to DMSe

128 of isoprene SOA on gene expression in human airway epithelial cells (BEAS-2B) through an air-liquid

129 accinia virus (VACV) initially replicates in airway epithelial cells before spreading to secondary si

130 t shown to preserve the barrier integrity of airway epithelial cells better than the human AMP LL-37.

131 In airway epithelial cells, blocking TLR2 enhanced RV-induc

132 Using cell lines and primary airway epithelial cells (both submerged and well-differe

133 on, and competitive fitness in primary human airway epithelial cells but maintains similar morphology

134 tic lesions in type 2 CPAM occur not only in airway epithelial cells, but also in adjacent mesenchyma

135 ic mucin MUC1 is elevated by inflammation in airway epithelial cells, but the contributions of MUC1 t

136 ductance regulator (CFTR) abundance in human airway epithelial cells by a mechanism that requires ser

137 This study indicates that HBoV1 kills airway epithelial cells by activating genes that suppres

138 roposed to be critical for host defense, and airway epithelial cell capacity for IFN signal transduct

139 inished ENaC-mediated Na(+) absorption in CF airway epithelial cells caused by internalization of a p

140 Mechanical stimulation of airway epithelial cells causes apical release of ATP, wh

141 dexamethasone to modulate gene expression in airway epithelial cells coincided with its potency to re

142 thylation levels from DNA derived from nasal airway epithelial cells collected from 12 African Americ

143 Under normal circumstances, airway epithelial cells connected by tight junctions sec

144 s upon pharmacological activation of AMPK in airway epithelial cells correlated with elongated cilia

145 sulatum-infected canine and feline lungs and airway epithelial cells could serve as higher animal mod

146 and its expression was associated with total airway epithelial cell count and thickness.

147 lled direct pH measurements in primary human airway epithelial cell culture models, which also sugges

148 sions: Sphingolipid metabolism is altered in airway epithelial cells cultured from people with cystic

149 Differentiated primary airway epithelial cell cultures (F508del homozygotes) we

150 pulmonary ACE2 expression in vitro in human airway epithelial cell cultures and in vivo in mouse mod

151 inistration attenuated expression of ACE2 in airway epithelial cell cultures from patients with COPD

152 ection in this model system found that human airway epithelial cell cultures induce a strong proinfla

153 Exposure of primary human airway epithelial cell cultures to IFN-gamma for 48 h di

154 Human and murine airway epithelial cell cultures were also infected with

155 nfant and adult lungs, rhesus monkey primary airway epithelial cell cultures were infected with pande

156 We also examined if NETs cause airway epithelial cell damage that can be prevented by D

157 t at both temperatures, NTHI cocultured with airway epithelial cells demonstrated significantly great

158 acking MIWI2 exhibited an altered balance of airway epithelial cells, demonstrating fewer multiciliat

159 reatment-resistant asthma via neutrophil and airway epithelial cell-dependent pathways.

160 tegy is verified in intestinal organoids and airway epithelial cells derived from CF patients carryin

161 m donated blood and (ii) well-differentiated airway epithelial cells derived from donor lungs.

162 of different CFTR-modulating drugs in human airway epithelial cells derived from subjects with cysti

163 initiation of TH 2 responses is regulated by airway epithelial cell-derived factors, including TRAIL

164 In siRNA-MUC4 BEAS-2B airway epithelial cells dexamethasone produced higher an

165 Further analysis showed that airway epithelial cells did not produce glucocorticoids

166 Finally, HMGB1 released by airway epithelial cells due to RSV infection appears to

167 ve Rhizopus and Mucor strains and with human airway epithelial cells during fungal invasion, to revea

168 to potentiate its cytoprotective signals in airway epithelial cells during influenza infection.

169 Knockdown of TRIM29 in airway epithelial cells enhances type I interferon produ

170 gulated after allergen challenge, notably in airway epithelial cells, eosinophils, and neutrophils.

171 Here we report that in human airway epithelial cells Epstein-Barr virus induces TRIM2

172 Airway epithelial cells express FOXO3a and play an impor

173 Human airway epithelial cells express pannexin 1 (Panx1) chann

174 suggested that, when approximately 10-50% of airway epithelial cells expressed CFTR, they generated n

175 r work in IL-13 biology to determine whether airway epithelial cell expression of 2 key mediators cri

176 Airway epithelial cells form a barrier to the outside wo

177 In cultured airway epithelial cells, FP treatment inhibited IL-13-in

178 performed RNA sequencing on upper and lower airway epithelial cells from 63 children with or without

179 ntaining gene expression data from nasal and airway epithelial cells from children and adults with as

180 e proof of concept that miR-200b-3p protects airway epithelial cells from EMT.

181 Studies using pendrin knockout mice and airway epithelial cells from hearing-impaired subjects w

182 t in well-differentiated primary cultures of airway epithelial cells from human donors (HAE), MV infe

183 d to primary cultures of well-differentiated airway epithelial cells from human donors (HAE).

184 accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans with CF.

185 ell-differentiated primary cultures of human airway epithelial cells from non-CF and CF subjects, tre

186 E2 and TMPRSS2 expression ex vivo in primary airway epithelial cells from participants with and witho

187 Airway epithelial cell gene expression from 155 subjects

188 Of these participants, 100 had accompanying airway epithelial cell gene expression.

189 Lung and airway epithelial cells generated in vitro from human pl

190 al infection and suggest a specific role for airway epithelial cells given the limitation of EV-D68 r

191 ne IL-13 on beta2AR desensitization in human airway epithelial cells (HAECs) and determine whether 15

192 Under Type 2 inflammatory conditions, human airway epithelial cells (HAECs) generate proferroptotic

193 ce of AC6, we demonstrated that AC6 knockout airway epithelial cells have longer cilia compared with

194 using primary, fully redifferentiated human airway epithelial cells homozygous for F508del and in vi

195 alveolar macrophages and primary human small airway epithelial cells (HSAEpCs) from patients with COP

196 RSV infection of human airway epithelial cell, human lung fibroblast, and U937

197 s were shown to transform immortalized human airway epithelial cells in a sorafenib-sensitive manner.

198 -13 modulates ACE2 and TMPRSS2 expression in airway epithelial cells in asthma and atopy.

199 egulatory mechanisms of ferroptotic death in airway epithelial cells in asthma, kidney epithelial cel

200 we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet c

201 Using ex vivo modeling of primary airway epithelial cells in organotypic coculture with ma

202 was significantly increased in the nasal and airway epithelial cells in type 2 asthma and allergic rh

203 protein either incubated with cultured human airway epithelial cells in vitro, or provided as an aero

204 bits SARS-CoV-2 replication in primary human airway epithelial cells in vitro-both prophylactic and t

205 ir effects on innate interferon responses of airway epithelial cells in vitro.

206 f tools to analyze IFN signaling specific to airway epithelial cells in vivo.

207 3(Delta2-3/Delta2-3)/CC10 mice as well as in airway epithelial cells in which ORMDL3 was inhibited wi

208 Knocking out these genes in mammalian airway epithelial cells increased levels of infection.

209 RNA isolated from primary normal human small airway epithelial cells indicated that IL-17A (100 ng/ml

210 g results showed that RSV infection of human airway epithelial cells induced a significant release of

211 In addition, conditioned media from human airway epithelial cells infected with Pseudomonas aerugi

212 he transcriptional response of primary mouse airway epithelial cells infected with rhinovirus at 33 d

213 hagy as has been the reported scenario in CF airway epithelial cells, infectious diseases, and lysoso

214 ase 6 (AC6), a highly abundant AC isoform in airway epithelial cells, inhibits degradation of Kif19a

215 IL-1beta secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NET

216 The delivery of biologic cargoes to airway epithelial cells is challenging due to the formid

217 hat stimulation of EGFR activation by ATP in airway epithelial cells is closely associated with dynam

218 ivity of Vero cell-derived virus for primary airway epithelial cells is increased 5-fold if the virus

219 However, the role of HMGB1 in EMT of human airway epithelial cells is still unclear.

220 he potential dysregulation of methylation in airway epithelial cells is unknown.

221 Ns, and this pathway is dysregulated in COPD airway epithelial cells, leading to exaggerated IFN prod

222 observations, deletion of IGF-1 receptor in airway epithelial cells led to exacerbated lung inflamma

223 oreover, using both clonal cells and a human airway epithelial cell line endogenously expressing beta

224 siRNA-based knock down of these TFs in an airway epithelial cell line model demonstrated significa

225 -/-) mice and a stable FOXO3a knockout human airway epithelial cell line.

226 s on airway branching and differentiation of airway epithelial cell lineages.

227 uated wound closure and mucous expression in airway epithelial cell lines.

228 IL-13 levels were increased in airway epithelial cells, macrophages, type 2 innate lymp

229 When applied directly to polarized airway epithelial cells, mature aCif triggers a reductio

230 ed interferon response to viral infection by airway epithelial cells may be a mechanism leading to lu

231 d, ozone (O3) interacts with cholesterols of airway epithelial cell membranes or the lung-lining flui

232 es DSP expression and the function of DSP in airway epithelial cells.Methods: Using CRISPR (clustered

233 ects on asthma pathophysiology, including on airway epithelial cells, mucus hypersecretion, and airwa

234 Thus, in airway epithelial cells, MV spread requires the nectin-4

235 A549 cells and were all cytotoxic for small airway epithelial cells, NCI-H441, and normal human lung

236 Using human airway epithelial cells obtained from young children, we

237 so used to reconstitute ORMDL3 expression in airway epithelial cells of Ormdl3 knockout mice.

238 bout the interactions of M. haemolytica with airway epithelial cells of the respiratory mucosa which

239 and repair in large (LAEC) and small (SAEC) airway epithelial cells of transplant patients.

240 Cultured human or murine airway epithelial cells or mice were subjected to acute

241 to supernatants from IL-1beta-stimulated CF airway epithelial cells (P < .01).

242 (2020) describe a novel distal airway epithelial cell population with high regenerative

243 Active H(+) and HCO(3) (-) secretion by airway epithelial cells produce an ASL that is acidic co

244 Together, these results suggest beta2ARs on airway epithelial cells promote the asthma phenotype and

245 The results show that airway epithelial cells regulate local immune responses,

246 Therefore, airway epithelial cells release less ATP in response to

247 Many cells, including murine airway epithelial cells, respond to a variety of inflamm

248 hat hRV infection of polarized primary human airway epithelial cells resulted in increased adherence

249 channel (VDCC)-intervened calcium influx in airway epithelial cells, resulting in a rapid IGF2 secre

250 nt stem cells (iPSC) from normal human small airway epithelial cells (SAEC) to investigate epigenetic

251 e CS on the differentiation of primary small airway epithelial cells (SAEC) were investigated, using

252 e physiologically relevant cell lines--small airway epithelial cells (SAECs), macrophages (THP-1 cell

253 nce in both human lung fibroblasts and small airway epithelial cells (SAECs).

254 ucing factor in the RSV-infected human small airway epithelial cell secretome and was differentially

255 pregnancy and aspects of stimulated neonatal airway epithelial cell secretory function that may in tu

256 FOXO3a K/O airway epithelial cells show attenuated IFN responses to

257 COPD airway epithelial cells showed attenuated IL-8 responses

258 Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

259 regulating antiviral responses, we generated airway epithelial cell-specific Foxo3a knockout (Scga1b1

260 In cultured normal human primary airway epithelial cells, ST2 overexpression (OE) increas

261 We report location-dependent airway epithelial cell states and a novel subset of tiss

262 ally, experiments using human cord blood and airway epithelial cells suggested that DEP might induce

263 nt-resistant membrane fraction prepared from airway epithelial cells, suggesting that it may partitio

264 gamycin and quercetin is lower in CF-derived airway epithelial cells than in non-CF cells.

265 monary neuroendocrine cells (PNECs) are rare airway epithelial cells that also uniquely harbor neuron

266 ntrinsic developmental differences in infant airway epithelial cells that may contribute to the incre

267 n vitro studies, NETs caused cytotoxicity in airway epithelial cells that was prevented by disruption

268 ed G protein are less infectious for primary airway epithelial cells, the natural RSV target.

269 also demonstrated that compared with normal airway epithelial cells, those from patients with chroni

270 MiR-570-3p is induced by oxidative stress in airway epithelial cells through p38 MAP kinase-c-Jun sig

271 nd following short-term in vitro exposure of airway epithelial cells to cigarette smoke (FDR < 0.05).

272 l type 2 (Th2) cytokine, transforms cultured airway epithelial cells to goblet cells, and this is not

273 TNF signaled through airway epithelial cells to reprogram them and promote Th

274 adapt the protocol to expose living ciliated airway epithelial cells to smoke generated by electronic

275 and regulating the innate immune response of airway epithelial cells to viral infection.

276 moke and other environmental stimuli acts on airways epithelial cells to induce neutrophil chemotaxin

277 1 in airway epithelial cells (A549 and small airway epithelial cells) to establish its role in RSV in

278 the susceptibility of cells, especially the airway epithelial cells, to hRSV infection.

279 bunit of NF-kappaB, and RNA polymerase II in airway epithelial cells treated with dexamethasone, TNF,

280 Airway epithelial cells treated with IL-4 followed by AD

281 was the only PYHIN protein expressed in both airway epithelial cell types.

282 protein connexin43 (Cx43) in polarized human airway epithelial cells upon infection by PAO1.

283 ibition of elevated miR-570-3p in COPD small airway epithelial cells, using an antagomir, restores si

284 steroid-resistant inflammatory signature in airway epithelial cells via constitutively expressed LTb

285 to date suggest that these viruses kill the airway epithelial cells via the apoptotic or necrotic pa

286 x-dependent regulation of EGFR activation in airway epithelial cells was found to strongly depend on

287 sis of Clara cell secretory protein-positive airway epithelial cells was observed in transgenic mice

288 While replication kinetics in human airway epithelial cells was on par with that of seasonal

289 proteins unique to RSV-infected human small airway epithelial cells was regulated by the transcripti

290 global run-on sequencing (GRO-seq) in human airway epithelial cells, we show that glucocorticoid sig

291 Numbers of necrotic airway epithelial cells were elevated and correlated wit

292 on IFN-gamma treatment, fully differentiated airway epithelial cells were exposed to ammonium chlorid

293 Airway epithelial cells were obtained from bronchial and

294 Airway epithelial cells, which are the first line of def

295 obustly localizes within the motile cilia of airway epithelial cells, which likely represents the ini

296 Here we show that infection of human airway epithelial cells with Streptococcus pneumoniae le

297 he cells express markers of various lung and airway epithelial cells, with a predominance of cells id

298 infection down-regulated FOXA2 expression in airway epithelial cells, with concomitant overexpression

299 y(I:C) to selectively upregulate IFN-beta in airway epithelial cells without a concomitant inflammato

300 s feasible to augment IFN-beta production in airway epithelial cells without excessive costimulation