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1 GHRP-6 leads, which were further examined by alanine scanning.
2      The binding epitope was determined with alanine scanning.
3 3% in the first 50 attempts using systematic alanine scanning.
4 otein inhibitors and was further verified by alanine scanning.
5 n interactions using computational interface alanine scanning.
6 am positive pathogens was identified through alanine scanning.
7 mplex, we targeted 20 positions in Prp28 for alanine scanning.
8                       In previous work using alanine scanning (1), we identified residues Leu-53, Asp
9                                     Using an alanine-scanning 3A mutant, we show that Golgi targeting
10 n trafficking motifs in the channel and with alanine scanning across aa 610-620.
11           Using 167 sequences from a shotgun alanine scanning analysis of Site1, we have determined t
12 fected HEK-293 cells, we demonstrate through alanine scanning and amino acid substitutions that the p
13  and sequence, and it provides computational alanine scanning and change in solvent-accessible surfac
14                                              Alanine scanning and conservative substitutions identifi
15       Structure-function analysis of Ecm1 by alanine scanning and conservative substitutions identifi
16  and HhH domains of Escherichia coli LigA by alanine scanning and conservative substitutions, entaili
17                                              Alanine scanning and crystallographic structural analysi
18 a core determinant defined using a series of alanine scanning and deletion mutant variants.
19 inding, as well as computational analysis of alanine scanning and DMC data.
20 cin DNases through a combination of E9 DNase alanine scanning and double-mutant cycles (DMCs) coupled
21 bed via standard and nonstandard techniques (alanine scanning and hydrophile scanning, respectively),
22 ution of critical residues identified by the alanine scanning and NMR spectroscopy, along with the el
23 might contact RNA polymerase, we carried out alanine scanning and random mutagenesis of oxyR.
24 lix 3 of EntB-ArCP were generated by shotgun alanine scanning and selected for their ability to suppo
25                                 We generated alanine scanning and single and multiple amino acid subs
26 rved amino acids of Escherichia coli LigA by alanine scanning and thereby identified five new residue
27 raction, demonstrating that structure-guided alanine-scanning and computational modeling can serve as
28                            Using the Rosetta alanine-scanning and design algorithms to predict destab
29 hin the target peptide through computational alanine scanning anticipates not only the key residues f
30      We have developed a novel computational alanine scanning approach that involves analysis of ense
31                                              Alanine-scanning assays suggested the absence of known h
32                                              Alanine scanning-based shotgun mutagenesis epitope mappi
33                       Furthermore, in silico alanine scanning calculations of the last 21 residues of
34  Lyp substrate recognition using an "inverse alanine scanning" combinatorial library approach.
35 gar binding and catalysis were identified by alanine scanning, D36 being a critical residue for F6P b
36 scence polarization displacement assays, and alanine scanning data all suggest that they bind to the
37                                              Alanine scanning defined seven individual amino acids as
38                                              Alanine scanning demonstrated that the epitope involves
39 idging may explain the previous finding from alanine scanning experiments that R333 contributes signi
40 s is also in line with systematic, in silico Alanine scanning free-energy simulations, which indicate
41 is using recombinant proteins and a panel of alanine-scanning GPC mutants revealed that F100G5 bindin
42 In silico affinity maturation, together with alanine scanning, has allowed us to fine-tune the protei
43                                              Alanine scanning helped resolve the boundaries of this c
44 OS-PDZ complex that correlated well with the alanine scanning identified regions of dystrophin.
45                                      Through alanine scanning, immunofluorescence cell staining and c
46                                Using shotgun alanine scanning in conjunction with this selection, we
47                                              Alanine scanning insertion mutagenesis was used to exami
48              Mutating residues into alanine (alanine scanning) is one of the fastest experimental mea
49                       Using this plasmid, an alanine scanning library has been constructed and the mu
50                   To do so, we created a tri-alanine scanning library that covers all of sigma(70) R4
51 activities are underscored by the results of alanine-scanning, limited proteolysis, and deletion anal
52 he hot spot residues known from experimental alanine scanning measurements.
53                                        Using alanine scanning, molecular dynamics simulations, and tr
54                                              Alanine scanning mutagenesis analysis shows that four co
55                          In combination with alanine scanning mutagenesis and activity measurements w
56 kappaB pathway signaling, using experimental alanine scanning mutagenesis and also the FTMap method f
57                                        Using alanine scanning mutagenesis and crystallographic approa
58 cid residues of a prototypic PPPSP motif via alanine scanning mutagenesis and demonstrate that each o
59 LIAGCITSTDPVLSALI(152)) in activity by using alanine scanning mutagenesis and examining salt toleranc
60                                              Alanine scanning mutagenesis and kinetic analysis reveal
61                       We performed saturated alanine scanning mutagenesis and other amino acid substi
62 5) to envelope function has been examined by alanine scanning mutagenesis and subsequent characteriza
63                In this work, we have used an alanine scanning mutagenesis approach to identify whethe
64                    Here, we use a systematic alanine scanning mutagenesis approach to understand the
65 the vinylogous urea binding site, horizontal alanine scanning mutagenesis between p51 residues Lys-27
66                                              Alanine scanning mutagenesis confirms that these residue
67 o and TgRON2L1-bound forms complemented with alanine scanning mutagenesis data reveal an unexpected a
68                                              Alanine scanning mutagenesis demonstrated that positivel
69                                              Alanine scanning mutagenesis determined that the key res
70                      Using 2C6 and variants, alanine scanning mutagenesis identified three amino acid
71                                              Alanine scanning mutagenesis in sGC indicates that the H
72                                        Using alanine scanning mutagenesis in the activity subdomain o
73                                              Alanine scanning mutagenesis maps a novel epitope to a s
74                                              Alanine scanning mutagenesis of 12 Arg/Lys residues of e
75                  We thus performed extensive alanine scanning mutagenesis of A1AR-ECL2 to explore the
76 rformed the first complete charge-cluster-to-alanine scanning mutagenesis of an ARP and compared the
77                                              Alanine scanning mutagenesis of areas flanking Leu(172),
78                   In this work, we performed alanine scanning mutagenesis of aromatic residues locate
79                                 We performed alanine scanning mutagenesis of AuIB and alpha3beta4 nAC
80        To test this possibility, we employed alanine scanning mutagenesis of CB1 EC2 and identified t
81                                   Charged-to-alanine scanning mutagenesis of CSM4 yielded one allele,
82                                              Alanine scanning mutagenesis of hVbeta2.1 wild-type and
83 ctions and receptor activation, we performed alanine scanning mutagenesis of loop residues and assess
84                                        Using alanine scanning mutagenesis of MBM1, we found that the
85                                              Alanine scanning mutagenesis of MPER indicates that it h
86 nd cofactor activity were assessed following alanine scanning mutagenesis of residues 555-571 that bo
87                                              Alanine scanning mutagenesis of residues 64-70, within f
88                                              Alanine scanning mutagenesis of the alpha-region reveals
89                                              Alanine scanning mutagenesis of the C-terminal region of
90                                              Alanine scanning mutagenesis of the conserved residues o
91                  In this study, we performed alanine scanning mutagenesis of the ExsA alpha-helix (re
92  of chimeras between these OCLN proteins and alanine scanning mutagenesis of the extracellular domain
93                                              Alanine scanning mutagenesis of the LIM interaction doma
94 f recombinant mutant CSFVs was created using alanine scanning mutagenesis of the p7 gene harboring se
95  random mutagenesis results, we performed an alanine scanning mutagenesis of the TLR2 DD loop and par
96                                              Alanine scanning mutagenesis of this region revealed tha
97                                 We performed alanine scanning mutagenesis of this region, and we quan
98                                              Alanine scanning mutagenesis of three to five consecutiv
99               Towards this end, we performed alanine scanning mutagenesis on selected residues in the
100 ole of NS4A in these processes, we conducted alanine scanning mutagenesis on the C-terminal acidic do
101                                              Alanine scanning mutagenesis revealed a requirement for
102                                              Alanine scanning mutagenesis revealed four classes of mu
103                                              Alanine scanning mutagenesis revealed that amino acids K
104                                              Alanine scanning mutagenesis revealed that the K/R-R/x-x
105                                              Alanine scanning mutagenesis studies revealed that the T
106 e, we performed a comprehensive deletion and alanine scanning mutagenesis study of this protein in th
107 (ATR) and curcumin (CCM), here we perform an alanine scanning mutagenesis study.
108 ides that bound Gbetagamma were subjected to alanine scanning mutagenesis to determine their relevanc
109              We have used structure-directed alanine scanning mutagenesis to identify determinants in
110 ther analyzed by combining triple and single alanine scanning mutagenesis to identify individual resi
111                  We used NMR experiments and alanine scanning mutagenesis to identify residues in the
112                       In this study, we used alanine scanning mutagenesis to identify the key residue
113                                 We then used alanine scanning mutagenesis to locate the epitopes.
114                                      We used alanine scanning mutagenesis to replace selected amino a
115                       The current study used alanine scanning mutagenesis to understand the selectivi
116  motif centered around the sequence "SQELD." Alanine scanning mutagenesis was carried out on the T(35
117                                              Alanine scanning mutagenesis was performed for the resid
118                                   Systematic alanine scanning mutagenesis was performed on the substr
119                                              Alanine scanning mutagenesis was performed to assess the
120 s parainfluenza virus 5 F protein TM domain, alanine scanning mutagenesis was performed.
121                               In this study, alanine scanning mutagenesis was used in combination wit
122                                              Alanine scanning mutagenesis was used to determine the r
123 ansport of Dbp5 in Saccharomyces cerevisiae, alanine scanning mutagenesis was used to generate point
124                                              Alanine scanning mutagenesis was used to map the specifi
125                                              Alanine scanning mutagenesis within the region of amino
126                     Using in vitro assembly, alanine scanning mutagenesis, and biophysical analyses,
127            Using an in vitro assembly assay, alanine scanning mutagenesis, and biophysical techniques
128      Using computational docking algorithms, alanine scanning mutagenesis, and surface plasmon resona
129 side chains at this interface, identified by alanine scanning mutagenesis, are conserved among DSX ho
130  probed the in vivo role of the linker using alanine scanning mutagenesis, assaying stressosome outpu
131 ude random peptide phage display mapping and alanine scanning mutagenesis, to identify residues in th
132                                        Using alanine scanning mutagenesis, we demonstrate that the bi
133                                        Using alanine scanning mutagenesis, we show that a pore helix
134                                        Using alanine scanning mutagenesis, we show that two distinct
135 gp41 HR1 has been systematically examined by alanine scanning mutagenesis, with subsequent characteri
136 esults from loss-of-binding studies using an alanine scanning mutagenesis-based epitope mapping appro
137            We subjected HD5 to comprehensive alanine scanning mutagenesis.
138 ng of the epitopes was accomplished by using alanine scanning mutagenesis.
139 bution of the arm to folding was obtained by alanine scanning mutagenesis.
140 2 cytoplasmic tail were identified by single-alanine scanning mutagenesis.
141 helix 11, Thr978, as an essential residue by alanine scanning mutagenesis.
142  GABPbeta interface residues were chosen for alanine scanning mutagenesis.
143 nal mutagenesis, carbohydrate shielding, and alanine scanning mutagenesis.
144                                  Deletion or alanine- scanning mutagenesis through this domain signif
145 t of programmes for performing computational alanine-scanning mutagenesis (CASM) to guide experiments
146 nteracts with GP, here we used comprehensive alanine-scanning mutagenesis (shotgun mutagenesis), neut
147 yruvate kinase as obtained from full-protein alanine-scanning mutagenesis (systematic mutation) studi
148  explore this molecular environment, we used alanine-scanning mutagenesis across residues 660 to 680
149                                              Alanine-scanning mutagenesis along the entire length of
150 ne the Rab5-p110beta interface, we performed alanine-scanning mutagenesis and analyzed Rab5 binding w
151 L binding site of AFABP/aP2 a combination of alanine-scanning mutagenesis and fluorescence resonance
152 ity binding at different DNA sequences using alanine-scanning mutagenesis and identified several key
153                                              Alanine-scanning mutagenesis and kinetic analysis identi
154                                      Peptide alanine-scanning mutagenesis and modeling of receptor-bo
155                                              Alanine-scanning mutagenesis and neutralization escape m
156                                      We used alanine-scanning mutagenesis and patch clamp photometry
157 pes on VEGF for these three antibodies using alanine-scanning mutagenesis and structural analyses.
158 1) to envelope function has been examined by alanine-scanning mutagenesis and subsequent characteriza
159 lex as a guide, we undertook a comprehensive alanine-scanning mutagenesis approach at the TCR-pMHC-I
160 tersubunit interactions of K33, we performed alanine-scanning mutagenesis at charged residues in the
161  of flat beta-sheets, we performed extensive alanine-scanning mutagenesis experiments on the single-l
162                 Isolated A2 was subjected to alanine-scanning mutagenesis followed by expression of a
163                                              Alanine-scanning mutagenesis identified a functional TIL
164                                              Alanine-scanning mutagenesis identified an acidic-residu
165         In experimental protein engineering, alanine-scanning mutagenesis involves the replacement of
166 ght interact and bind alpha2-AP, and used an alanine-scanning mutagenesis method to select residues h
167          We have performed surface acidic-to-alanine-scanning mutagenesis of 3C to identify the surfa
168                                              Alanine-scanning mutagenesis of 48 amino acids combined
169                  In this report we have used alanine-scanning mutagenesis of a putative coiled coil a
170                                              Alanine-scanning mutagenesis of B. subtilis alphaCTD unc
171                                              Alanine-scanning mutagenesis of DC-SIGN revealed that hi
172                                              Alanine-scanning mutagenesis of FNR amino acid residues
173                                              Alanine-scanning mutagenesis of HVEM was used to further
174                                 Results from alanine-scanning mutagenesis of hydrophobic residues in
175                                              Alanine-scanning mutagenesis of predicted catalytic resi
176                                              Alanine-scanning mutagenesis of Qtip shows that its loca
177                                              Alanine-scanning mutagenesis of residues predicted to li
178 he same TCR, complemented with computational alanine-scanning mutagenesis of SEA, SEB, SEC3, SEE, and
179                                        Using alanine-scanning mutagenesis of sigma32 and in vivo and
180 pe residues to CNTO607 binding, we performed alanine-scanning mutagenesis of the A-D region of IL-13.
181                                  We combined alanine-scanning mutagenesis of the A1AR second extracel
182                                              Alanine-scanning mutagenesis of the alternatively splice
183                                              Alanine-scanning mutagenesis of the intracellular C term
184                                              Alanine-scanning mutagenesis of the Na(v)1.6 N terminus
185 rlying biochemical mechanism by carrying out alanine-scanning mutagenesis of the PKR activation domai
186                                              Alanine-scanning mutagenesis of these nine side chains s
187                                 We performed alanine-scanning mutagenesis of this motif ((14)TFPLF(18
188                                              Alanine-scanning mutagenesis of this region suggested th
189             Here, we performed comprehensive alanine-scanning mutagenesis on csrA of E. coli and test
190                   In this report, we conduct alanine-scanning mutagenesis on the 14 other conserved s
191 s) on gp120, and its footprint as defined by alanine-scanning mutagenesis overlaps that of b12.
192                                              Alanine-scanning mutagenesis revealed five additional re
193                                              Alanine-scanning mutagenesis revealed that an F protein
194                                              Alanine-scanning mutagenesis revealed that residues 1773
195                                              Alanine-scanning mutagenesis revealed that the affinitie
196                                              Alanine-scanning mutagenesis revealed the molecular basi
197  containing mutations was generated using an alanine-scanning mutagenesis strategy.
198                                              Alanine-scanning mutagenesis studies targeting residues
199  have contact residues within aa 412 to 423, alanine-scanning mutagenesis suggested that one subset,
200 te in CA for Ubc9 was mapped by deletion and alanine-scanning mutagenesis to a consensus motif for SU
201 orescence correlation spectroscopy (FCS) and alanine-scanning mutagenesis to characterize the interac
202                        In this work, we used alanine-scanning mutagenesis to elucidate the structural
203                          In this work we use alanine-scanning mutagenesis to explore the contribution
204                                      We used alanine-scanning mutagenesis to identify regions of huma
205                           This study applied alanine-scanning mutagenesis to investigate the role of
206             Herein, we used structure-guided alanine-scanning mutagenesis to map the functional epito
207                                    First, 32 alanine-scanning mutagenesis variants of dystrophin R16-
208                                              Alanine-scanning mutagenesis was applied to the correspo
209                                              Alanine-scanning mutagenesis was previously performed to
210                                              Alanine-scanning mutagenesis was previously performed to
211                                              Alanine-scanning mutagenesis was used to confirm that th
212                    In this study, charged to alanine-scanning mutagenesis was used to generate condit
213                                              Alanine-scanning mutagenesis was used to identify YscF m
214                                        Using alanine-scanning mutagenesis we found four residues, all
215               Through extensive deletion and alanine-scanning mutagenesis we have mapped key residues
216                                By performing alanine-scanning mutagenesis we identified a dilysine se
217                 For this study, by employing alanine-scanning mutagenesis, (125)I-SDF-1alpha competit
218 ccompanying article, we demonstrate, through alanine-scanning mutagenesis, a key role for extracellul
219  by a combination of cysteine cross-linking, alanine-scanning mutagenesis, and computational simulati
220 d its membrane binding properties, performed alanine-scanning mutagenesis, and identified residues im
221                                        Using alanine-scanning mutagenesis, in cellulo bioluminescence
222                                        Using alanine-scanning mutagenesis, loss-of-function recombina
223                                        Using alanine-scanning mutagenesis, we have made mutations in
224                                        Using alanine-scanning mutagenesis, we identified two clusters
225                                        Using alanine-scanning mutagenesis, we probed the roles of two
226 s explored by cross-competition analysis and alanine-scanning mutagenesis.
227  G1 and G2, we performed point mutations and alanine-scanning mutagenesis.
228 im101 and ESCRT pathways, which we tested by alanine-scanning mutagenesis.
229  the residues within this loop, we performed alanine-scanning mutagenesis.
230 tide and peptide agonists were studied using alanine-scanning mutagenesis.
231 e-chains to GrpE-DnaK binding were probed by alanine-scanning mutagenesis.
232 the control of specific traits, we performed alanine-scanning mutagenesis.
233 f conserved switch II residues by performing alanine-scanning mutagenesis.
234  we generated the entire histone H2A and H2B alanine-scanning mutant strains in another background, w
235 pare the kinetic rates and affinities for 18 alanine scanning mutants comprising epitope residues 50-
236                             Binding of X5 to alanine scanning mutants of gp120JR-CSF complexed with C
237  species variants, (2) species chimeras, (3) alanine scanning mutants, and (4) site-specific mutants.
238 we measured their binding to a panel of 11 G alanine-scanning mutants and identified two mutants, P18
239  We constructed a t-toxin library of ProTx-I alanine-scanning mutants and screened this library again
240 In addition, it was found that when the BLIP alanine-scanning mutants were tested in the strain, the
241 -sulfated analogues, truncated peptides, and alanine-scanning mutants, suggested that each of the 12-
242                                              Alanine scanning mutation of Epep revealed residues crit
243                          We describe here an alanine scanning mutational analysis of the Abeta(1-40)
244                                              Alanine-scanning mutational analysis of the first 62 ami
245 thermostabilized mutant GPCRs via systematic alanine scanning mutations has been a successful strateg
246 ain by single amino acid substitutions and 3-alanine scanning mutations identified important but not
247                                  A series of alanine scanning mutations of hot-spot residues at the i
248                                  Most of the alanine-scanning mutations in the CT had little effect o
249 rotein (CP) rescued RNA synthesis by several alanine-scanning mutations in the N-terminal alpha helix
250 of glycoprotein incorporation, we introduced alanine-scanning mutations into this region of the trans
251 function has been systematically examined by alanine scanning of all gp41 loop residues and the subse
252                                              Alanine scanning of AP-Cav-B revealed that Thr-90 and -9
253                              Second, shotgun alanine scanning of BCMA was used to map critical residu
254                                     Finally, alanine scanning of CDR1 and CDR2 sequences of TRBV4-1 r
255                                              Alanine scanning of GpTx-1 revealed that residues Trp(29
256                                  Comparative alanine scanning of Im2 and Im9 residues involved in bin
257                                              Alanine scanning of MPER residues 664 to 680 revealed th
258                                              Alanine scanning of the active-site residues shows that
259 ucture-activity relations of the Spt5 CTD by alanine scanning of the consensus nonapeptide.
260                                              Alanine scanning of the E6AP-UbcH7 binding interface ide
261 ar determinants of interaction, we performed alanine scanning of the Kv4.3 S3b region.
262                                              Alanine scanning of the last five residues revealed the
263                                              Alanine scanning of the loops surrounding the protease a
264                                              Alanine scanning of the peptide sequence, combined with
265                                 Furthermore, alanine scanning of the RBD has identified several resid
266                                              Alanine scanning of their complementarity-determining re
267                                              Alanine scanning of this interface has identified the ho
268                                              Alanine-scanning of the peptide identified three key res
269                                              Alanine scanning revealed decreased inhibition by the ap
270                                              Alanine scanning revealed that hydrophobic amino acids i
271 of the TCR-peptide-HLA ternary complexes and alanine scanning revealed that the autologously derived
272  of UBL-containing proteins and IKKbeta, and alanine scanning revealed that the leucine at position 3
273                                 Furthermore, alanine scanning reveals modest differences in the ssDNA
274                                              Alanine scanning reveals residues crucial for GEF activi
275                                  An unbiased alanine-scanning screen covering the entire region combi
276                               We identify by alanine scanning seven functionally important amino acid
277 ium exchange mass spectrometry (H/DXMS), and alanine scanning site-directed mutagenesis.
278  per-residue decomposition calculations, and alanine scanning studies are done to provide further ins
279                                              Alanine scanning studies of the secreted recombinant rec
280                     We found from exhaustive alanine scanning studies that fibrillation of this WW do
281 analyzing the binding of Brd4 to a series of alanine-scanning substitution mutants of the human papil
282 characterized using overlapping peptides and alanine scanning substitutions and were localized to two
283 itope for gp120, as previously identified by alanine scanning substitutions on the gp120 surface.
284                                Here, we used alanine scanning substitutions spanning residues 1023 to
285 stigate the bioactive surface of ProTx-II by alanine-scanning the toxin and analyzing the interaction
286  box C/D small RNP complex, we have employed alanine scanning to evaluate the interaction between the
287              We have performed computational alanine scanning to gain insight into thermodynamic aspe
288                             Finally, we used alanine scanning to identify determinants in the C-termi
289 ting affinities of protein variants (shotgun alanine scanning) to analysis of GB1 stability.
290                                Computational alanine scanning using the molecular mechanics Poisson-B
291                                Computational alanine scanning was also conducted to identify putative
292 r association in vivo, serial truncation and alanine scanning was performed on NKAP to identify the m
293    Each of the 23 BLIP positions examined by alanine scanning was randomized to create libraries cont
294                                              Alanine scanning was used to construct mutants of hOAT1,
295                                Computational alanine scanning was used to identify key residues in th
296                        Combinatorial shotgun alanine-scanning was used to assess intramolecular coope
297       By sequence analysis and computational alanine scanning we identify key residues and motifs inv
298                                        Using alanine scanning, we demonstrated that Leu-127 and Leu-1
299                                           By alanine scanning, we identified a single mutation in the
300 p these determinants, we performed global E2 alanine scanning with a panel of 16 human monoclonal ant

 
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