ライフサイエンスコーパス: alcohol consumption

1 e-time physical activity, smoking, diet, and alcohol consumption.

2 (MC) are the most accepted models of chronic alcohol consumption.

3 ioid receptor antagonist, in the BLA reduced alcohol consumption.

4 s or iMSNs of mice and measured the level of alcohol consumption.

5 aine intake, nor did access to cocaine alter alcohol consumption.

6 3782886 (BRAP) reduced the risk of excessive alcohol consumption.

7 in the BNST in an adaptive response to limit alcohol consumption.

8 abstain from alcohol or continue their usual alcohol consumption.

9 isms were used as instrumental variables for alcohol consumption.

10 luate the effects of this change on RTAs and alcohol consumption.

11 inase (ERK) in an adaptive response to limit alcohol consumption.

12 ic Aldh2 deficiency did not affect voluntary alcohol consumption.

13 r rats and mice, and in turn, FGF2 increases alcohol consumption.

14 e dorsomedial striatum (DMS), which promotes alcohol consumption.

15 ons that occur from suddenly ceasing chronic alcohol consumption.

16 central and unanticipated role in excessive alcohol consumption.

17 position and function of LPLs independent of alcohol consumption.

18 titative phenotype based on maximum habitual alcohol consumption.

19 es may play a causal role on AAF mediated by alcohol consumption.

20 eved hyperalgesia and decreased relapse-like alcohol consumption.

21 ed negative binomial regression analysis for alcohol consumption.

22 ity, education, marital status, smoking, and alcohol consumption.

23 trasound criteria for fatty liver and absent alcohol consumption.

24 er liver function, which is a marker of high alcohol consumption.

25 sed on histologic analysis, compared with no alcohol consumption.

26 isms underlying the development of excessive alcohol consumption.

27 regulatory and tolerance-inducing effect of alcohol consumption.

28 ied by ADH1B*2, even after we controlled for alcohol consumption.

29 icate that ghrelin receptor blockade reduces alcohol consumption.

30 lved in the negative regulation of excessive alcohol consumption.

31 s connecting metabolic shifts with excessive alcohol consumption.

32 categorical variables in the case of sex and alcohol consumption.

33 re associated with heart failure and chronic alcohol consumption.

34 blood could serve as a robust biomarker for alcohol consumption.

35 epigenome-wide significance on self-reported alcohol consumption.

36 3 blocks GalphasDREADD-dependent increase in alcohol consumption.

37 3 (95% CI 0.61-0.88; p < 0.001) for moderate alcohol consumption, 0.66 (95% CI 0.54-0.81; p < 0.001)

38 NA-damaging metabolite that is produced upon alcohol consumption(1).

39 hol than controls and consistently increased alcohol consumption after repeated alcohol deprivation p

40 y of these thresholds indicate assessment of alcohol consumption alone may be inadequate for identify

41 Excessive alcohol consumption also remains an intractable risk fac

42 Chronic heavy alcohol consumption, also referred to as chronic heavy d

43 smoking, body mass index, physical activity, alcohol consumption, Alternative Healthy Eating Index, a

44 of a causal relationship between smoking and alcohol consumption and 19 site-specific cancers.

45 Genetic correlation between maximum habitual alcohol consumption and alcohol dependence was 0.87 (p =

46 variants associated with a proxy measure of alcohol consumption and alcohol misuse and to explore th

47 TSPAN5 SNPs were also associated with alcohol consumption and alcohol use disorder (AUD) risk.

48 be used to explore the genetic basis of both alcohol consumption and alcohol use disorders.

49 tatistically significant association between alcohol consumption and any other site-specific cancer.

50 and environmental factors, such as smoking, alcohol consumption and body mass index.

51 ical mechanisms driving associations between alcohol consumption and chronic diseases might include e

52 cate an inverse association between moderate alcohol consumption and chronic inflammatory diseases; h

53 y diseases; however, the association between alcohol consumption and chronic obstructive pulmonary di

54 Among females, no association between alcohol consumption and clinical AL progression was obse

55 dual differences, revealing latent traits in alcohol consumption and compulsive drinking despite equa

56 a potentially nonlinear relationship between alcohol consumption and CVD risk, and the generalizabili

57 population is low, with a poor knowledge of alcohol consumption and dietary guidelines.

58 nalysis showed an association with liters of alcohol consumption and drinkers among population once a

59 ver, the association of age at initiation of alcohol consumption and duration of alcohol drinking wit

60 , sex, study center, education, smoking, and alcohol consumption and for the respective other exposur

61 ohol consumption by jointly measuring weekly alcohol consumption and gamma-GT levels.

62 ys an important role in regulating excessive alcohol consumption and highlight the need for future st

63 the association between ADH1B*2 and moderate alcohol consumption and histologic severity of NAFLD.

64 interventions for those at risk due to high alcohol consumption and increased body mass index (BMI).

65 Smoking, alcohol consumption and increased level of blood cholest

66 ence of a causal relationship between higher alcohol consumption and increased risk of stroke and per

67 We investigated the associations of total alcohol consumption and intake of specific alcoholic bev

68 nvestigate if climate has a causal effect on alcohol consumption and its weight on alcoholic cirrhosi

69 The relationship between alcohol consumption and mortality generally exhibits a U

70 rease in burden of liver disease from excess alcohol consumption and obesity, with high levels of hos

71 ffer by socioeconomic status, accounting for alcohol consumption and other health-related factors.

72 nt association between genetically predicted alcohol consumption and overall cancer (n = 75,037 cases

73 o evidence supporting a relationship between alcohol consumption and overall or site-specific cancer

74 its infusion into the DMS of rats, decreased alcohol consumption and preference, with no effects on n

75 in the basolateral amygdala (BLA) decreased alcohol consumption and reduced conditioned place prefer

76 i.e., limbic memory, that promote escalated alcohol consumption and relapse.

77 an important role of NBCn1 in regulation of alcohol consumption and sensitivity to alcohol-induced s

78 Here, we examined alcohol consumption and sensitivity to the sedative effe

79 2 modifies the relationship between moderate alcohol consumption and severity of NAFLD.

80 some analyses, particularly for analyses of alcohol consumption and site-specific cancers.

81 The relationship between alcohol consumption and sleep disturbance is complex.

82 an randomization (MR) methods, and secondary alcohol consumption and smoking datasets were used.

83 ultaneously assess the independent impact of alcohol consumption and smoking on a wide range of CVD r

84 Alcohol consumption and smoking, 2 major risk factors fo

85 We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that

86 evidence that an individual's self-reported alcohol consumption and their genotype at rs1229984, a m

87 asal amygdala to CeA projections showed that alcohol consumption and withdrawal were associated with

88 egression, genetic overlap was found between alcohol consumption and years of schooling (rG=0.18, s.e

89 ogic features of NAFLD severity and moderate alcohol consumption and/or ADH1B*2.

90 ate hypothetical effects of habits (smoking, alcohol consumption, and fat and carbohydrates consumpti

91 icant correlation with sex, body mass index, alcohol consumption, and fatty liver status.

92 tidylethanol (PEth), an objective measure of alcohol consumption, and for self-reported alcohol consu

93 67:TA was amplified by increasing adiposity, alcohol consumption, and genetic risk of fatty liver dis

94 the association of RBA with tobacco smoking, alcohol consumption, and genetic variants.

95 re education, higher income, moderate vs low alcohol consumption, and low material deprivation were e

96 ce had positive direct effects on income and alcohol consumption, and negative direct effects on mode

97 d was previously associated with depression, alcohol consumption, and neuroticism.

98 nd handgrip strength), behavioural (smoking, alcohol consumption, and physical activity), socioeconom

99 social and leisure activity, smoking status, alcohol consumption, and physical activity.

100 luded socioeconomic status, medical history, alcohol consumption, and smoking habits) and had their h

101 enarche, age at first birth, family history, alcohol consumption, and smoking status, which suggests

102 nd social activity, physical activity, diet, alcohol consumption, and smoking-and cognition, adjustin

103 signaling pathway, which promotes excessive alcohol consumption, and that inhibition of FGFR1 may pr

104 receptor, FGF receptor-1 (FGFR1), suppresses alcohol consumption, and that the effects of FGF2-FGFR1

105 oking initiation (ever smoked regularly) and alcohol consumption, and the corresponding associations

106 nment had positive direct effects on income, alcohol consumption, and vigorous physical activity, and

107 4)(3)(beta2)(2) subtype of nAChRs can reduce alcohol consumption, and when administered in combinatio

108 ctors investigated were age, sex, education, alcohol consumption, anxiety, apolipoprotein E epsilon4

109 Murine models of chronic alcohol consumption are frequently used to investigate a

110 The associations with heart attack and alcohol consumption are new findings.

111 eta signaling dramatically reduced excessive alcohol consumption, as did selective inhibition of D1-M

112 In the multivariate analysis, liters of alcohol consumption associated with AAF.

113 oid receptor-mediated signaling in escalated alcohol consumption associated with dependence and stres

114 f aging, we sought to identify the amount of alcohol consumption associated with the longest telomere

115 as abstainers showed a greater reduction in alcohol consumption at 12-month follow-up than those cla

116 A history of alcohol consumption at baseline was protective of indivi

117 for the difference in the effect of moderate alcohol consumption between alleles).

118 We assessed the weekly rate of RTAs and alcohol consumption between Jan 1, 2013, and Dec 31, 201

119 tatus, diabetes mellitus, educational level, alcohol consumption, body mass index, physical activity,

120 biologically proximal environmental factors alcohol consumption, body mass index, smoking and matern

121 LDH2 and ADH1B, are strongly associated with alcohol consumption but have limited impact in European

122 Participants in both groups decreased their alcohol consumption, but at week 24 we did not detect a

123 ekly alcohol consumption increases partner's alcohol consumption by 0.26 units (95% C.I. 0.15, 0.38;

124 y the susceptibility gene loci for excessive alcohol consumption by jointly measuring weekly alcohol

125 Alcohol consumption by women who parent is damaging to c

126 hysical activity, healthy diet, and moderate alcohol consumption, categorized into favorable, interme

127 Furthermore, chronic alcohol consumption caused NBCn1 downregulation in the h

128 Chronic alcohol consumption causes increased intestinal permeabi

129 Chronic alcohol consumption causes liver injury, inflammation an

130 se disorder.SIGNIFICANCE STATEMENT Long-term alcohol consumption causes neuroadaptations in the mesos

131 cardiopulmonary fitness, physical activity, alcohol consumption, cigarette smoking, diabetes risk an

132 dy suggests that genetic variants related to alcohol consumption, coffee consumption and obesity were

133 ted loci, 12 have been associated with total alcohol consumption, coffee consumption, plasma caffeine

134 ro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls.

135 mechanisms that prompt or mitigate excessive alcohol consumption could be partly explained by metabol

136 Alcohol consumption data, pattern of drinking, health in

137 family history of dementia, non-smoking, low alcohol consumption, depression, daytime somnolence, epi

138 for future investigation, in order to reduce alcohol consumption, develop markers for diagnosis and p

139 Alcohol consumption did not alter cocaine intake, nor di

140 rom 5 modifiable lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body f

141 Even in the absence of binge drinking, alcohol consumption during pregnancy can leave offspring

142 independent phenotypes reflecting subjects' alcohol consumption during the past year, based on self-

143 ese data fail to demonstrate any benefits of alcohol consumption, even when consumed in moderation.

144 f-report severe periodontitis was noted when alcohol consumption exceeding > 20 g/day for women and >

145 984, suggesting that spousal concordance for alcohol consumption existed prior to cohabitation.

146 Using a mouse model of chronic alcohol consumption followed by forced abstinence (CDFA)

147 The causal role of alcohol consumption for cardiovascular disease remains u

148 Indeed, the optimal amount of alcohol consumption for health has yet to be determined.

149 The causal role of alcohol consumption for other cardiovascular diseases re

150 We identify alcohol consumption frequency and bowel movement quality

151 bsets from EWAS on PEth and on self-reported alcohol consumption from Cohort 1 were separately tested

152 hould continue to be advised to abstain from alcohol consumption from conception throughout pregnancy

153 eekly on-trade (eg, in bars and restaurants) alcohol consumption from market research data.

154 ociated with a small reduction in per-capita alcohol consumption from on-trade alcohol sales.

155 alysis of genome-wide association studies of alcohol consumption (g d(-1)) from the UK Biobank, the A

156 Moderate alcohol consumption (g/d) reduced the severity of NAFLD

157 Also, excessive alcohol consumption greatly influences elastography, lea

158 hort, healthy behaviors-nonsmoking, moderate alcohol consumption, >=2.5 hours per week of moderate to

159 Alcohol consumption has been inconsistently associated w

160 Because alcohol consumption has been previously linked to DNA me

161 ur previous work in a mouse model of chronic alcohol consumption has detailed that the primary influe

162 th psychiatric disorders, whereas aspects of alcohol consumption have shown stronger links to metabol

163 ociations were independent of age, sex, BMI, alcohol consumption, history of diabetes, left ventricul

164 he patient should be asked about the current alcohol consumption (i.e. active vs. abstinence, determi

165 s included in the models included; age, sex, alcohol consumption, IBS diagnosis, family history of ga

166 Here, we test the hypothesis that chronic alcohol consumption impairs retinoic acid signaling in b

167 Voluntary prolonged and excessive alcohol consumption in a 2-bottle choice procedure incre

168 ignaling in the CeA contributes to excessive alcohol consumption in a binge-drinking model.

169 signaling in the BNST is linked to excessive alcohol consumption in a manner distinct from behavioral

170 However, prolonged and excessive voluntary alcohol consumption in a two-bottle choice procedure inc

171 f alcohol consumption, and for self-reported alcohol consumption in Cohort 1.

172 It is unknown whether chronic alcohol consumption in humans alters hepatic PDE4 expres

173 ime-series design by use of data on RTAs and alcohol consumption in Scotland (the interventional grou

174 -regulated transcriptional network regulates alcohol consumption in the BLA.

175 xamine the influence of DYN/KOR signaling on alcohol consumption in the drinking-in-the-dark (DID) mo

176 ed a genome-wide association study (GWAS) of alcohol consumption in the large Genetic Epidemiology Re

177 od pressure, physical activity, smoking, and alcohol consumption) in late adolescence using a cross-c

178 at a unit increase in an individual's weekly alcohol consumption increases partner's alcohol consumpt

179 Additionally, excessive alcohol consumption induced a long-lasting potentiation

180 Chronic alcohol consumption induces adipose tissue atrophy.

181 frequency protein-coding variants in gene by alcohol consumption interactions associated with fasting

182 Alcohol consumption is a consistent protective factor fo

183 Compulsive alcohol consumption is a core, treatment-resistant featu

184 Alcohol consumption is a heritable complex trait.

185 ts demonstrate that an objective measure for alcohol consumption is a more informative phenotype than

186 Among patients with NAFLD, modest alcohol consumption is associated with a significant dec

187 GT-catalytic metabolic reaction in excessive alcohol consumption is associated with ALDH2, BRAP and C

188 Chronic alcohol consumption is associated with an increased inci

189 Excessive alcohol consumption is associated with incident atrial f

190 Alcohol consumption is associated with increased risk of

191 We explored the hypothesis that alcohol consumption is associated with methylation in an

192 Moderate alcohol consumption is associated with reduced severity

193 Excessive alcohol consumption is associated with spontaneous burni

194 It is well known that alcohol consumption is associated with type 2 diabetes m

195 e association study-defined genomic risk for alcohol consumption is enriched for genes that are prefe

196 Chronic alcohol consumption is linked to the development of alco

197 Excessive alcohol consumption is one of the main causes of death a

198 al study but provide assurance that moderate alcohol consumption is safe for patients with prostate c

199 ents with no time or option to withdraw from alcohol consumption is still a matter of debate.

200 and sCD163 were higher among ED with recent alcohol consumption (last drink <10 days before enrollme

201 BACKGROUND & AIMS: Chronic, excessive alcohol consumption leads to alcoholic liver disease (AL

202 Excessive alcohol consumption leads to overproduction of urates an

203 Alcohol consumption level and alcohol use disorder (AUD)

204 nsula GMV represent promising biomarkers for alcohol-consumption liability and related psychiatric an

205 nal genome-wide-significant maximum habitual alcohol consumption loci: on chromosome 17, rs77804065 (

206 Further, the results suggest that alcohol consumption may activate endothelial EVs towards

207 Low dosages (</=1.37 g of alcohol/day) of alcohol consumption may be beneficial to prevent periodo

208 The longevity observed with moderate alcohol consumption may be explained by other confoundin

209 ypothesised that genetic variants related to alcohol consumption may, via their effect on alcohol beh

210 -1.7 to 1.1; p=0.71), but a 0.7% decrease in alcohol consumption measured by per-capita on-trade sale

211 in Scotland was associated with no change in alcohol consumption, measured by per-capita off-trade sa

212 ng three meals a day, having a regular diet, alcohol consumption, moderate exercise, depression, and

213 rall, these results demonstrate that chronic alcohol consumption negatively affects the resting memor

214 unacceptable harmful consequences of excess alcohol consumption, obesity, and viral hepatitis.

215 cant SNP-based heritability of self-reported alcohol consumption of 13% (se=0.01).

216 randomization (MR) to predict the effect of alcohol consumption on 8 cardiovascular diseases.

217 f this study is to investigate the impact of alcohol consumption on clinical attachment loss (AL) pro

218 ioprotective impact of genetically predicted alcohol consumption on CVD outcomes.

219 We evaluated the effects of heavy, chronic alcohol consumption on epigenetic age acceleration (EAA)

220 ittle is known about the impact of excessive alcohol consumption on kidney function in critically ill

221 w-frequency genetic variants interacted with alcohol consumption on lipid levels.

222 ut it is difficult to disentangle effects of alcohol consumption on mate-selection from social factor

223 However, the effects of chronic alcohol consumption on pre-existing immune responses (i.

224 The effect of alcohol consumption on survival in patients with NAFLD i

225 nal hazards models to evaluate the effect of alcohol consumption on survival of patients with NAFLD.

226 demonstrate that the genetic architecture of alcohol consumption only partially overlaps with the gen

227 including 23 CpGs previously associated with alcohol consumption or alcohol use disorder.

228 ially more pronounced in those with elevated alcohol consumption or body mass index.

229 Alcohol consumption or direct alcohol administration int

230 ersons with VLVL and cirrhosis had excessive alcohol consumption or immunosuppression.

231 eptible to the hepatotoxic effects of excess alcohol consumption or obesity.

232 ange of CVD risk factors and outcomes of any alcohol consumption or smoking MR study to date, we fail

233 after toilet (OR = 1.8, 95% CI; 1.19-2.72), alcohol consumption (OR = 1.34, 95% CI; 1.03-1.74) and g

234 hosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were pres

235 ticipant age, body mass index, sex, smoking, alcohol consumption, or dietary factors.

236 of negative binomial panel regression and on alcohol consumption outcomes by use of seasonal autoregr

237 inactivity (p < 0.0005 for both genders) and alcohol consumption (p < 0.0005 for men).

238 ing-type families showed higher caffeine and alcohol consumption (p < 0.001).

239 of education (P = 0.26), smoking (P = 0.11), alcohol consumption (P = 0.52), history of cardiovascula

240 mong men, risk declined linearly with higher alcohol consumption (P-trend = 0.002).

241 ngs suggest EA may have important effects on alcohol consumption patterns and may provide potential m

242 While future studies incorporating alcohol consumption patterns are necessary, our data sug

243 annual sunshine hours with liters of annual alcohol consumption per capita (Spearman's rho -0.5 and

244 sly reported SNP rs1229984 in ADH1B and both alcohol consumption phenotypes (OR=0.79, P=2.47 x 10(-20

245 ndex, socioeconomic position, diet, smoking, alcohol consumption, physical activity level, and C-reac

246 associated with colorectal cancer (smoking, alcohol consumption, physical activity, and total meat c

247 e, sex, comorbidity, mood disorder, smoking, alcohol consumption, physical activity, body mass index,

248 omposite score (range, 0-20) involving diet, alcohol consumption, physical activity, body mass index,

249 odium intake, low potassium intake, obesity, alcohol consumption, physical inactivity and unhealthy d

250 rget, the actin-severing protein cofilin, in alcohol consumption preference.

251 IT showed positive genetic correlations with alcohol consumption (r(g)=0.76-0.92) and DSM-IV alcohol

252 ogical mechanism underpinning its effects on alcohol consumption remains to be determined.

253 by alcohol use disorder (AUD), and excessive alcohol consumption represents the most common cause of

254 s with no or modest, moderate, and increased alcohol consumption, respectively (P(interaction) < .001

255 Information on sex, age, tobacco/alcohol consumption, sex practices, specimen collection,

256 Alcohol consumption showed a dose-dependent risk increas

257 s preselected from the EWAS on self-reported alcohol consumption showed a poor prediction of HAD with

258 Cannabis use, but not alcohol consumption, showed lagged (neurotoxic) effects

259 central and unanticipated role in excessive alcohol consumption.SIGNIFICANCE STATEMENT The bed nucle

260 In comparison, after adjusting for alcohol consumption, smoking retained its association wi

261 ss index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excreti

262 occurrence of four behavioural risk factors (alcohol consumption, smoking, physical inactivity and ob

263 After we adjusted for confounders, including alcohol consumption status, ADH1B*2 was associated with

264 fibrosis in adults with NAFLD regardless of alcohol consumption status.

265 ts enrolled between 2006 and 2010, we tested alcohol consumption (stratified by the Centers of Diseas

266 tinct cohort studies, we found no pattern of alcohol consumption that was associated with longer telo

267 SVMR showed genetic predisposition for alcohol consumption to be associated with CVD risk facto

268 ialty, waist circumference, body mass index, alcohol consumption, tobacco smoking, and physical activ

269 t work aims to evaluate the relation between alcohol consumption trends over a period of 15 y with al

270 oups of smoking intensity, years of smoking, alcohol consumption, trial supplementation, and duration

271 Alcohol consumption uniformly increases blood pressure a

272 Two dichotomous self-reported alcohol consumption variables, current drinker, defined

273 e range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and

274 Alcohol consumption was also associated with increased m

275 ng the Desire for Alcohol Questionnaire, and alcohol consumption was assessed using the timeline foll

276 Alcohol consumption was assessed with a self-administere

277 Alcohol consumption was associated with AF (hazard ratio

278 in this population of younger women, higher alcohol consumption was associated with increased risk o

279 We also found that high alcohol consumption was associated with significantly lo

280 Moderate alcohol consumption was associated with the lowest risk

281 Genetically predicted alcohol consumption was consistently associated with str

282 Alcohol consumption was not associated with breast cance

283 Genetically predicted alcohol consumption was statistically significantly asso

284 history of heart attack at baseline, and no alcohol consumption were associated with a greater likel

285 er disease or that did not screen for excess alcohol consumption were excluded.

286 moderating effects of physical activity and alcohol consumption were greater in women than men (thre

287 late MSN activity, and their consequences on alcohol consumption were measured.

288 Histories of alcohol consumption were obtained from answers to standa

289 ctivity, healthy diet, and light-to-moderate alcohol consumption were positively associated with cogn

290 ative exposure to estrogen, BMI, and dietary alcohol consumption were the most common influential fac

291 al position, smoking, physical activity, and alcohol consumption were used to estimate total and sex-

292 haviour) and an independent causal effect of alcohol consumption when controlling for smoking (IVW OR

293 In these 2 US cohorts, low to moderate alcohol consumption, when compared with no consumption,

294 in cognitive abilities associated with heavy alcohol consumption, whereas increased cerebellar connec

295 wn of Lmo4 in the nucleus accumbens enhanced alcohol consumption, whereas knockdown in the basolatera

296 seeking/low anxiety associated with enhanced alcohol consumption, which may be related to cortex func

297 s671 (ALDH2) increased the risk of excessive alcohol consumption, while one or two copies of the C al

298 sitive associations of genetically predicted alcohol consumption with coronary artery disease (OR, 1.

299 nce of associations of genetically predicted alcohol consumption with heart failure (OR, 1.00 [95% CI

300 aim to investigate the associations between alcohol consumption with meals, daily frequency of consu