ライフサイエンスコーパス: alcohol dependence

1 contribute to the behavioral consequences of alcohol dependence.

2 riatal dopamine release and D2R binding with alcohol dependence.

3 brain regions that play a functional role in alcohol dependence.

4 rs in rats 3 weeks into abstinence following alcohol dependence.

5 CeA) underlies key behaviors associated with alcohol dependence.

6 g that high D2R function may protect against alcohol dependence.

7 ether nicotine facilitates the transition to alcohol dependence.

8 a that is recruited during the transition to alcohol dependence.

9 in the development of pharmacotherapies for alcohol dependence.

10 nd molecular changes induced by a history of alcohol dependence.

11 on, likely contributing to the transition to alcohol dependence.

12 dict the response to naltrexone treatment of alcohol dependence.

13 or occasionally using alcohol and those with alcohol dependence.

14 ent evidence for the involvement of XRCC5 in alcohol dependence.

15 ir presynaptic afferents in the evolution of alcohol dependence.

16 emotional and motivational state observed in alcohol dependence.

17 nce had to meet the criteria from DSM-IV for alcohol dependence.

18 that drives excessive alcohol consumption in alcohol dependence.

19 ANP might be involved in the symptomology of alcohol dependence.

20 ssociated with the psychological symptoms of alcohol dependence.

21 ion in the prefrontal cortex in persons with alcohol dependence.

22 sly unidentified target in the management of alcohol dependence.

23 -to-brain interactions in the development of alcohol dependence.

24 eversible, minimally invasive treatments for alcohol dependence.

25 efforts aimed at reducing the occurrence of alcohol dependence.

26 plicated in psychiatric disorders, including alcohol dependence.

27 inhibition is a key feature of patients with alcohol dependence.

28 educing alcohol consumption in patients with alcohol dependence.

29 p), may moderate naltrexone (NTX) effects in alcohol dependence.

30 l is a promising target for the treatment of alcohol dependence.

31 tion of mood symptoms with the occurrence of alcohol dependence.

32 mmercial development of medications to treat alcohol dependence.

33 ution in schizophrenia, major depression and alcohol dependence.

34 issues in the conduct of clinical trials in alcohol dependence.

35 may be an early index of neuroadaptation in alcohol dependence.

36 in human brain, some of which contribute to alcohol dependence.

37 ticipants, consistent with prior findings in alcohol dependence.

38 r in people with a family history of drug or alcohol dependence.

39 rate stress resilience and susceptibility to alcohol dependence.

40 identifying genetic variants associated with alcohol dependence.

41 or patients with co-occurring depression and alcohol dependence.

42 1q have been implicated in human studies of alcohol dependence.

43 usly associated with increased risk of adult alcohol dependence.

44 isease in Mestizo subjects with a history of alcohol dependence.

45 ymptoms; 254 participants were found to have alcohol dependence.

46 combinations for the outpatient treatment of alcohol dependence.

47 d receptor, are associated with the risk for alcohol dependence.

48 least part of the association of OPRK1 with alcohol dependence.

49 that has been performed for the treatment of alcohol dependence.

50 te individual differences in the etiology of alcohol dependence.

51 receptor antagonist used to treat opiate and alcohol dependence.

52 ications could be useful in the treatment of alcohol dependence.

53 thylated region, DMR-DLGAP2, associated with alcohol dependence.

54 oxytocin effects on CeA GABA transmission in alcohol dependence.

55 rovides novel molecular targets for studying alcohol dependence.

56 limbic memory observed during withdrawal in alcohol dependence.

57 at optimize genetic correlations with DSM-IV alcohol dependence.

58 ntribute to various deficits associated with alcohol dependence.

59 g the neuroimmune system as therapeutics for alcohol dependence.

60 plays a critical role in the development of alcohol dependence.

61 ecently been approved in Europe for treating alcohol dependence.

62 reased anxiety-like behavior associated with alcohol dependence.

63 terations in the binding to NOP receptors in alcohol dependence.

64 lar to those observed following a history of alcohol dependence.

65 factor for excessive alcohol consumption and alcohol dependence.

66 vels and subsequent reduction in the risk of alcohol dependence.

67 ut alterations in nociceptin transmission in alcohol dependence.

68 ects of acute ethanol and the development of alcohol dependence.

69 d with an improved response to naltrexone in alcohol dependence.

70 , 7.9%; posttraumatic stress disorder, 9.8%; alcohol dependence, 11.2%; and nonalcohol psychoactive s

71 D was found among 30.1% of participants with alcohol dependence, 30.8% with cannabis use disorder, an

72 Because of extensive associations with alcohol dependence, a secondary contrast was also perfor

73 e implicated in vulnerability for developing alcohol dependence (AD) and high mu-opioid receptor (MOR

74 Alcohol dependence (AD) and major depression (MD) are le

75 meeting current diagnostic criteria for both alcohol dependence (AD) and PTSD were randomly assigned

76 Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with sig

77 Studies of alcohol dependence (AD) have consistently found evidence

78 We report a GWAS of alcohol dependence (AD) in European-American (EA) and Af

79 Alcohol dependence (AD) is a common, chronic, relapsing

80 Alcohol dependence (AD) is a multiorgan disease in which

81 Randomized trials of medications for alcohol dependence (AD) often report no differences betw

82 sociation studies in the literature with two alcohol dependence (AD) samples, including 1691 cases an

83 identified genetic variants associated with Alcohol Dependence (AD), but how they link to genes, the

84 espite a significant genetic contribution to alcohol dependence (AD), few AD-risk genes have been ide

85 terplay of risky sexual behaviors (RSBs) and alcohol dependence (AD), we conducted genome-wide gene-b

86 orders, Fourth Edition (DSM-IV) criteria for alcohol dependence (AD), we conducted structural equatio

87 AS) data sets reported several risk loci for alcohol dependence (AD), which have not yet been well re

88 as environmental factors in the etiology of alcohol dependence (AD).

89 m to identify novel genes affecting risk for alcohol dependence (AD).

90 l effects of EA on alcohol use behaviors and alcohol dependence (AD).

91 bstinence from alcohol in an animal model of alcohol dependence alters the functional architecture of

92 Defining how alcohol dependence alters the transcriptome of different

93 modafinil as an adjunct in the treatment of alcohol dependence, although clinical studies are needed

94 We explored genetic influences on alcohol dependence among 1,897 European-American and Afr

95 Drinkers at risk for alcohol dependence among the 43 093 adults surveyed in 2

96 MGLUR5 have the greatest relevance for human alcohol dependence among the genes selected with odds ra

97 n NR2A have the greatest relevance for human alcohol dependence among the glutamatergic genes selecte

98 Sixteen participants with alcohol dependence and 16 healthy control subjects under

99 bstance-naive youth with a family history of alcohol dependence and 20 well-matched controls without

100 ission in 21 recently abstinent persons with alcohol dependence and 21 matched healthy comparison sub

101 population of 1333 male patients with severe alcohol dependence and 939 controls.

102 By contrast, a detailed review of alcohol dependence and a briefer review of major depress

103 neurocircuitry may be a major consequence of alcohol dependence and a key pathophysiological mechanis

104 iched for genome-wide association signals in alcohol dependence and a meta-analysis of alcohol self-a

105 , non-treatment-seeking heavy drinkers, with alcohol dependence and a positive family history (FHP) o

106 Alcohol dependence and alcohol abuse or harmful use caus

107 ay be involved in the molecular processes of alcohol dependence and comorbidity of anxiety and alcoho

108 he DYN/KOR system is heavily dysregulated in alcohol dependence and contributes to the excessive alco

109 st a role for ghrelin in the neurobiology of alcohol dependence and craving.

110 sion of ketamine administered to adults with alcohol dependence and engaged in motivational enhanceme

111 comprehensive miRNA expression data set for alcohol dependence and identify the causal miRNAs for al

112 mptoms is associated with the development of alcohol dependence and its persistence once dependence d

113 calisation of tracts potentially affected in alcohol dependence and its recovery.

114 appears to be involved in the development of alcohol dependence and may represent a potential pharmac

115 ated genes, which are known to play roles in alcohol dependence and neurodegeneration.

116 traumatic stress disorder, and past 12-month alcohol dependence and nonalcohol psychoactive substance

117 ed in four groups (n = 22): individuals with alcohol dependence and periodontitis (ADP), individuals

118 Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in gene

119 ld underlie the behavioral manifestations of alcohol dependence and potentially contribute to the pat

120 Alcohol dependence and protracted withdrawal did not alt

121 In this study of patients with alcohol dependence and PTSD, naltrexone treatment result

122 37 [95% confidence interval {CI}, .16-.84]), alcohol dependence and recreational drug use (aPR, 0.45

123 Animal models of alcohol dependence and relapse demonstrate an important

124 nt role of the CeA in the pathophysiology of alcohol dependence and represents a new potential avenue

125 nce is probably inapplicable to persons with alcohol dependence and selective reporting may have occu

126 -Penn genetic studies of opioid, cocaine and alcohol dependence and the Study of Addiction: Genetics

127 function often observed in those at risk for alcohol dependence and those who develop alcohol use dis

128 mediator of behavioral stress responses, in alcohol dependence and treatment.

129 ree patients who met the DSM-IV criteria for alcohol dependence and who were admitted for medically s

130 echanisms involved in the pathophysiology of alcohol dependence and withdrawal.

131 our results can facilitate human research on alcohol dependence and withdrawal.

132 ce and periodontitis (ADP), individuals with alcohol dependence and without periodontitis (ADNP), ind

133 nd alcohol-related problems (ie, symptoms of alcohol dependence and/or alcohol-related harm).

134 penditure, peak blood alcohol concentration, alcohol dependence, and access to help and information.

135 There is a large treatment gap in alcohol dependence, and current treatments are only mode

136 conduct disorder, adult antisocial behavior, alcohol dependence, and drug dependence) on childhood di

137 5 [95% CI, .20-.99]), and severe depression, alcohol dependence, and recreational drug use (aPR, 0.23

138 as alterations in pain sensitivity, drug and alcohol dependence, and social behaviors.

139 sion, diabetes, obesity, dyslipidemia, gout, alcohol dependence, and tobacco use).

140 der, and married; an earlier age of onset of alcohol dependence; and self-reported depression symptom

141 e, attention-deficit hyperactivity disorder, alcohol dependence, anorexia nervosa, autism spectrum di

142 Alcohol abuse and alcohol dependence are key factors in the development of

143 ed into a maladaptive response that leads to alcohol dependence are not well understood.

144 ts in GABRA2 have been associated with adult alcohol dependence as well as phenotypic precursors, inc

145 eus of the amygdala (CeA) is a key player in alcohol-dependence associated behaviors.

146 gnoses of depression, anxiety disorders, and alcohol dependence at age 45; psychological distress and

147 ssociated with an increased odds of incident alcohol dependence at follow-up (adjusted odds ratio [AO

148 processes associated with the transition to alcohol dependence at the molecular level.

149 -0.15] for two levels), and among those with alcohol dependence at Wave 1 (0.29 [0.15-0.57] for one l

150 level predicted significantly lower odds of alcohol dependence at Wave 2, particularly among very-hi

151 nking risk levels between Waves 1 and 2, and alcohol dependence at Wave 2.

152 l consumption (WHO drinking risk levels) and alcohol dependence (at least three of seven DSM-IV crite

153 al medications have been approved for use in alcohol dependence but have only limited effectiveness a

154 ve been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanism

155 ue Dawley rats using an established model of alcohol dependence (chronic intermittent alcohol vapor e

156 we applied our methods to a family study of alcohol dependence (COGA) and performed individual genot

157 cent trial for comorbid major depression and alcohol dependence, combination treatment with a medicat

158 eiotropic genes contributing to the risk for alcohol dependence commonly expressed by four correlated

159 Alcohol dependence comorbid with posttraumatic stress di

160 -American and African-American subjects with alcohol dependence compared with 1,932 unrelated, alcoho

161 variant has the strongest effect on risk for alcohol dependence compared with any other tested varian

162 se to naltrexone hydrochloride treatment for alcohol dependence could improve clinical care for patie

163 For alcohol, we provide data on alcohol dependence, damage to families, and the document

164 OEt were recently identified as relevant for alcohol dependence, DCUK-OEt should be further evaluated

165 der [ADHD], bipolar disorder, schizophrenia, alcohol dependence disorder, and lifetime cannabis use)

166 Alcohol dependence disrupts this LTCC-based mechanism; i

167 dings suggest that poor treatment outcome in alcohol dependence does not simply result from a shift f

168 Naltrexone, an efficacious medication for alcohol dependence, does not work for everyone.

169 rapy for the treatment of mood disorders and alcohol dependence, drugs such as LSD showed initial the

170 riate management includes measures to reduce alcohol dependence (eg, behavioral or pharmacological th

171 improve measures of drinking in persons with alcohol dependence engaged in motivational enhancement t

172 Consistent with this finding, alcohol dependence enhanced the intrinsic excitability o

173 th alcohol intake levels in BXD strains, and alcohol dependence enhanced the strength of this associa

174 study, using a well-established rat model of alcohol dependence, ex vivo electrophysiology and ISH, p

175 Alcohol dependence exacts a toll on brain white matter m

176 Mood disorders and alcohol dependence frequently co-occur.

177 Yale-Penn study of the genetics of drug and alcohol dependence from February 14, 1999, to January 13

178 ons endorsing psychiatrists for treatment of alcohol dependence (from 61% in 1996 to 79% in 2006) and

179 Collectively, our data indicate that alcohol dependence functionally alters the molecular mec

180 306),>/=18 years of age, with a diagnosis of alcohol dependence,>/=6 heavy drinking days, and average

181 Participants diagnosed with alcohol dependence had to meet the criteria from DSM-IV

182 fifty-two treatment-seeking individuals with alcohol dependence, half preselected to carry at least o

183 ity of large cohort samples for nicotine and alcohol dependence has resulted in significant progress

184 Alcohol dependence has traditionally been considered a b

185 scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample also provided its st

186 complex for association with a diagnosis of alcohol dependence in a human population identified alle

187 n the CAMK2A gene for their association with alcohol dependence in a population of 1333 male patients

188 ative Study of the Genetics of Alcoholism on alcohol dependence in a sample of moderate-size pedigree

189 on associated with psychological symptoms of alcohol dependence in alcohol-dependent subjects.

190 haplotype was also associated with increased alcohol dependence in an independent European cohort.

191 re associated with a quantitative measure of alcohol dependence in both African Americans and Europea

192 ptomic patterns in the brain associated with alcohol dependence in both humans and animal models.

193 c and Statistical Manual of Mental Disorders Alcohol Dependence in COGA AA families, and two (rs13093

194 suggests an involvement of CB1 receptors in alcohol dependence in humans.

195 e the efficacy of contingency management for alcohol dependence in outpatients with serious mental il

196 essive alcohol drinking and somatic signs of alcohol dependence in rats.

197 early adolescence, and development of DSM-IV alcohol dependence in young adulthood.

198 RA2, a gene previously associated with adult alcohol dependence, in a community sample of children fo

199 p effects were found except among those with alcohol dependence, in whom CCM was associated with fewe

200 increased negative affect, other symptoms of alcohol dependence include compromised impulse control.

201 ntion-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are posi

202 of naltrexone vs placebo in individuals with alcohol dependence (intent-to-treat analysis).

203 Alcohol dependence is a chronic relapsing illness; stres

204 Alcohol dependence is a common, complex and debilitating

205 Alcohol dependence is a complex disorder that initiates

206 Alcohol dependence is a heterogeneous psychiatric disord

207 Physiological alcohol dependence is a key adaptation to chronic ethano

208 Alcohol dependence is a major public health challenge in

209 Alcohol dependence is associated with a widespread reduc

210 Alcohol dependence is associated with impaired control o

211 Alcohol dependence is associated with inhibitory control

212 cutely increases GABA release in the CeA and alcohol dependence is characterized by increased baselin

213 A key deficit in alcohol dependence is disrupted prefrontal function lead

214 dify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning.

215 Alcohol dependence is often untreated.

216 role of 5-HT regulating rat CeA activity in alcohol dependence is poorly investigated.

217 als, but their potential role in humans with alcohol dependence is poorly understood.

218 des the full spectrum from risky drinking to alcohol dependence, is a leading cause of preventable de

219 fied a functional role of DNA methylation in alcohol dependence-like behavioral phenotypes and a cand

220 vation for alcohol drinking that develops in alcohol dependence likely via a central mechanism that m

221 I present four paradigmatic cases involving alcohol dependence, major depression, general externaliz

222 on to factors associated with remission from alcohol dependence may be important in designing more ef

223 symptoms in individuals with depression and alcohol dependence, most studies have not found antidepr

224 d in community-recruited adults with current alcohol dependence (N=100) with varying levels of alcoho

225 medications for depression (sertraline) and alcohol dependence (naltrexone) in treating patients wit

226 Hazards for alcohol dependence, nicotine dependence, and nondependen

227 ificant associations between CAMK2A SNPs and alcohol dependence, one of which in an autophosphorylati

228 th alcohol abstinence are causal features of alcohol dependence or a consequence of excessive drinkin

229 stenosis, aortic valve disease, smoking, and alcohol dependence or abuse were positive predictors of

230 whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele i

231 ALDH2 on lifetime measures, such as risk of alcohol dependence, our study adds further evidence of t

232 Generalized anxiety disorder (P = 0.003) and alcohol dependence (P = 0.02) were five times more likel

233 [(11)C]PBR28 data revealed a main effect of alcohol dependence (P=0.034), corresponding to 10% lower

234 nkers (16 women) who met DSM-IV criteria for alcohol dependence participated in two alcohol drinking

235 Here, we found that a history of alcohol dependence persistently decreased the expression

236 ohol consumption (r(g)=0.76-0.92) and DSM-IV alcohol dependence (r(g)=0.33-0.63).

237 ificant high genetic correlation with DSM-IV alcohol dependence (r(g)=0.82) while retaining most subj

238 outpatients with serious mental illness and alcohol dependence receiving treatment as usual complete

239 Alcohol dependence recruits neurons in the central nucle

240 Alcohol dependence reduces CeA LTCC membrane abundance a

241 d jcBNST LTP-IE in animals with a history of alcohol dependence; repeated, but not acute, administrat

242 d the associations of NF1 polymorphisms with alcohol dependence risk and severity in humans.

243 conduct disorder, and 102 [15.9%] of 641 for alcohol dependence), risk events (160 [25.0%] of 641 for

244 conduct disorder, and 41 [25.6%] of 160 for alcohol dependence), risk events (78 [48.8%] of 160 for

245 or = 60 years vs 18-29 years), and lifetime alcohol dependence (RR, 1.34; 95% CI, 1.14-1.57).

246 levels in the hippocampus and striatum with alcohol dependence severity (P<0.035).

247 ngly correlated (R(2) = 0.48, P < .001) with alcohol dependence severity.

248 bstance-naive youth with a family history of alcohol dependence show less frontoparietal functional c

249 Youth with a family history of alcohol dependence showed significantly less functional

250 Individuals with alcohol dependence showed worse periodontal status and h

251 cotherapies and Behavioral Interventions for Alcohol Dependence) study, a randomized, double-blind pl

252 m that may be required for the transition to alcohol dependence, suggesting that focusing on the neur

253 l changes associated with the development of alcohol dependence, suggesting that microglia may also b

254 urobiological mechanism that is required for alcohol dependence, suggesting that targeting dependence

255 f53 that are strongly associated with DSM-IV alcohol-dependence symptom counts (P=4.5 x 10(-8), infla

256 NPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826,

257 on Test (indication of alcohol-related harm, alcohol dependence symptoms, or score >/=8).

258 type, measured in all individuals: number of alcohol-dependence symptoms endorsed (symptom count (SC)

259 or binding was 20-30% lower in patients with alcohol dependence than in control subjects in all brain

260 BS) have a higher risk of inpatient care for alcohol dependence than those who have undergone restric

261 e central role of chromatin modifications in alcohol dependence that integrates epigenetic regulation

262 a novel neurosurgical treatment modality for alcohol dependence that is reversible and externally tit

263 ress the unmet medical need in patients with alcohol dependence that need to reduce their alcohol con

264 WS) is a potentially fatal outcome of severe alcohol dependence that presents a significant challenge

265 ation of monetary rewards and impulsivity in alcohol dependence, the current study explored whether a

266 Standard criteria for alcohol dependence-the more severe disorder-can be used

267 Together with findings in alcohol dependence, these results suggest that impulsive

268 ' for the performance of clinical trials for alcohol dependence, they vary considerably, in the type

269 s are critical factors in the development of alcohol dependence through the dysregulation of a set of

270 ome-wide association studies recently showed alcohol dependence to be associated with a single-nucleo

271 ria for schizophrenia, major depression, and alcohol dependence to explore whether more of the public

272 We used an established rat model of alcohol dependence to investigate oxytocin's effects on

273 es ranged from 0.070 (between drug abuse and alcohol dependence) to 1.032 (between drug abuse and dys

274 We scanned 18 male in-patients with alcohol dependence twice, within 3-7 days of admission f

275 ed the role of microglia in a mouse model of alcohol dependence using a colony stimulating factor 1 r

276 symptoms with incident and persistent DSM-IV alcohol dependence using logistic regression and the pro

277 and CREB were analyzed for association with alcohol dependence using multivariate statistical analys

278 lvement of the GATA4 gene in the etiology of alcohol dependence via its influence on ANP and amygdala

279 een maximum habitual alcohol consumption and alcohol dependence was 0.87 (p = 4.78 x 10(-9)).

280 Genetic association with alcohol dependence was also recently shown.

281 Remission from alcohol dependence was associated with being female, old

282 rican-American case-control studies in which alcohol dependence was defined by the Diagnostic and Sta

283 a medication for depression and another for alcohol dependence was found to reduce depressive sympto

284 egional [(11)C]NOP-1A distribution volume in alcohol dependence was not significantly different compa

285 nalysis, association of hPer1 rs3027172 with alcohol dependence was shown.

286 nd women (n=150) who met criteria for DSM-IV alcohol dependence were recruited across four sites.

287 depressive disorder, anxiety disorders, and alcohol dependence were the most common mental, neurolog

288 349 patients who met the criteria for DSM-IV alcohol dependence when they entered residential treatme

289 suggest the existence of a gut-brain axis in alcohol dependence, which implicates the gut microbiota

290 Habitual alcohol use can be an indicator of alcohol dependence, which is associated with a wide rang

291 ohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance,

292 igation as factors to identify patients with alcohol dependence who are responsive to naltrexone.

293 nking and heavy drinking in individuals with alcohol dependence whose goal was to stop drinking.

294 The association of alcohol dependence with insomnia is likely to be bidirec

295 lysis in study 2 confirmed an association of alcohol dependence with NR2A (odds ratio, 2.01) but show

296 used to predict the outcome of treatment of alcohol dependence with ondansetron.

297 95% confidence interval (CI) 0.24, 0.48) on alcohol dependence, with genome-wide significance (6.6 x

298 All participants met DSM-IV criteria for alcohol dependence, with no concurrent psychotic or mani

299 sessive-compulsive disorder, and smoking and alcohol dependence, with promising preliminary results.

300 Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not fo