ライフサイエンスコーパス: alcohol use

1 scover brain regions that may be involved in alcohol use.

2 y for alcohol use or a causal consequence of alcohol use.

3 r, and local rates of obesity, diabetes, and alcohol use.

4 have been implicated in different aspects of alcohol use.

5 ve memory for understanding real-world heavy alcohol use.

6 he cell-type specificity of Fyn's actions in alcohol use.

7 icrostructure early in adolescence, prior to alcohol use.

8 core (NAcc) of rhesus macaques after chronic alcohol use.

9 ng punishment imposed voluntary cessation of alcohol use.

10 tailed questionnaire information on lifetime alcohol use.

11 nce mediated the relationship between SP and alcohol use.

12 tential substance use risk behavior, such as alcohol use.

13 ntributes to the heritability of smoking and alcohol use.

14 vel insight regarding the biology of harmful alcohol use.

15 xist to provide advice about other levels of alcohol use.

16 ed the relationship between SP and hazardous alcohol use.

17 eported drug use, and 10.9% reported harmful alcohol use.

18 , we identified replicable GMV correlates of alcohol use.

19 factors for, as opposed to consequences of, alcohol use.

20 wanese people, including 1945 with excessive alcohol use.

21 fter adjustment for confounders were harmful alcohol use, 1.4 (0.9-2.0, p = 0.10) and obesity, 1.4 (0

22 lower rate of smoking (62 vs 73%) and heavy alcohol use (12 vs 19%) but a higher rate of previous me

23 oxidation of primary and secondary aliphatic alcohols using a pair of flavin and dialkylthiourea cata

24 Alcohol use above the current US recommendations was ass

25 d insula GMVs were associated with increased alcohol use across samples.

26 We previously showed that heavy alcohol use activates mTORC1 in the orbitofrontal cortex

27 t, 16% had slips only, and 10% had sustained alcohol use after a median 1.6 (interquartile range [IQR

28 aitlist) and life years lost attributable to alcohol use after receiving the liver transplant.

29 with 3.62 years for patients with sustained alcohol use after transplantation (7.23 life years lost)

30 Sustained alcohol use after transplantation significantly reduced

31 s, regardless of estimated risk of sustained alcohol use after transplantation.

32 ents with severe AH and different amounts of alcohol use after transplantation: abstinence, slip (alc

33 ere offered early transplantation and had no alcohol use afterward were predicted to survive 10.85 ye

34 than TAU-Plus in reducing IPV and hazardous alcohol use among high-risk couples in Zambia.

35 The exposure in 2000 was alcohol use (amount [g/week], frequency [any alcohol or

36 rom 173 participants with self-reported high alcohol use and / or BMI >=25 kg/m(2) comprising all 58

37 rstanding of the genetic factors influencing alcohol use and abuse has progressed tremendously; numer

38 ociation between closing alcohol outlets and alcohol use and alcohol-related violence, using an agent

39 and suggest pharmaceutical interventions for alcohol use and comorbid disorders may be more effective

40 ets for future research and demonstrate that alcohol use and dependence remodel brain-wide functional

41 r genetic and epigenetic factors controlling alcohol use and dependence.

42 olescence is a common time for initiation of alcohol use and development of alcohol use disorders.

43 tegrated stepped alcohol treatment (ISAT) on alcohol use and HIV outcomes among patients living with

44 We examined patterns of drug and alcohol use and injection equipment sharing among people

45 e are evident, some open questions regarding alcohol use and its consequences in the US population re

46 usted hazard ratios (HRs), focusing on heavy alcohol use and neutrophil function-altering comorbiditi

47 ed, novel brain regions that are involved in alcohol use and novel biomarkers of alcohol use need to

48 Associations of ACEs with harmful alcohol use and obesity were weak.

49 of the amygdala plays a significant role in alcohol use and other affective disorders; however, the

50 15, 2008, from ten areas of China, recording alcohol use and other characteristics.

51 l-documented to be associated with increased alcohol use and problems, leading to the policy recommen

52 ociations between reported maternal prenatal alcohol use and psychological, behavioral, and neurodeve

53 spite a clear relationship between excessive alcohol use and PTSD, how alcohol impacts the expression

54 ce experience and recent suicidal behaviour, alcohol use and recent suicidal behaviour, illicit drug

55 arenting status should be screened for heavy alcohol use and referred to specialty care as appropriat

56 Alcohol use and smoking are leading causes of death and

57 nvironment, explained phenotypic variance in alcohol use and smoking behaviour in the Generation Scot

58 withdrawal factor was positively correlated; alcohol use and social anxiety were unrelated to model-b

59 e association was found between frequency of alcohol use and the number of teeth with periodontal poc

60 454 individuals representing the spectrum of alcohol use and use disorders.

61 had less severe angiographic disease, lower alcohol use, and a lower burden of comorbidities.

62 eutrophil-lymphocyte ratio, smoking history, alcohol use, and Charlson Comorbidity Score were perform

63 city, older age, history of mental disorder, alcohol use, and civil/legal issues.

64 s findings in the literature concerning age, alcohol use, and depression-related changes in brain vol

65 on, depressive symptoms, nonmilitary trauma, alcohol use, and prior head injury.

66 ciation and interactions between depression, alcohol use, and recreational drug use on viral suppress

67 The frequency of alcohol use (any alcohol or different beverages) had an

68 nce ratio [aPR] 2.2, 95% CI 1.5-3.2), recent alcohol use (aPR 1.75, 95% CI 1.2-2.5), and higher numbe

69 ence ratio [aPR] 2.2, 95%CI 1.5-3.2), recent alcohol use (aPR 1.75, 95%CI 1.2-2.5), and higher number

70 le the increased health risks resulting from alcohol use are evident, some open questions regarding a

71 V) infection, illegal drug use and hazardous alcohol use are hypothesized to be strong risk factors f

72 Tobacco and alcohol use are leading causes of mortality that influen

73 Hepatitis C virus (HCV) and alcohol use are patient risk factors for accelerated fib

74 imitations of using quantitative measures of alcohol use as proxy measures for AUD, and we outline ho

75 eal squamous cell carcinoma from tobacco and alcohol use-associated squamous cell carcinoma.

76 imeline followback method was used to assess alcohol use at baseline and 3, 6, and 12 months.

77 omical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain stru

78 condition: namely voluntary abstinence from alcohol use because of contingent punishment.

79 hese same variants were also associated with alcohol use behavior and posterior corpus callosum volum

80 18q23 in regulating neural connectivity and alcohol use behavior, potentially via dysregulated myeli

81 ipants to assess the causal effects of EA on alcohol use behaviors and alcohol dependence (AD).

82 gs to reveal important relationships between alcohol use behaviors and both physical and mental healt

83 ted with EA were tested for association with alcohol use behaviors.

84 lammation-related genes were associated with alcohol use behaviors.

85 attainment (EA) may be associated with risky alcohol use behaviors; however, these findings may be bi

86 were also apparent increases in past-30-day alcohol use, by 5.9 percentage points (95% CI: 0.3, 12.2

87 Habitual alcohol use can be an indicator of alcohol dependence, w

88 osure to contexts previously associated with alcohol use can trigger relapse.

89 uded depression, self-rated health, drug and alcohol use, cardiovascular risk factors, experience of

90 use of mortality in the United States, where alcohol use consistently increased over the last decades

91 er anxiety, greater sleep disturbance, heavy alcohol use, current tobacco use, and larger initial opi

92 ng of the relationship between pregnancy and alcohol use, demonstrating that even a severe condition

93 ipopolysaccharide challenge (8 subjects), in alcohol use disorder (14 patients, 15 controls), in firs

94 Relevant to liver disease, patients with alcohol use disorder (AUD) and alcohol-associated liver

95 Alcohol use disorder (AUD) and anxiety disorders are fre

96 sociations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Fil

97 d in distinguishing between individuals with Alcohol use Disorder (AUD) and controls.

98 tifaceted approach that includes recognizing alcohol use disorder (AUD) and existing treatments for A

99 e expression and hippocampal degeneration in alcohol use disorder (AUD) and other mental diseases is

100 The authors examined the association between alcohol use disorder (AUD) and risk of suicide, before a

101 elucidate the exact role of PCSK9 in ALD and alcohol use disorder (AUD) and to evaluate efficacy and

102 ICANCE STATEMENT The risks for developing an alcohol use disorder (AUD) are strongly determined by ge

103 Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately heri

104 Alcohol use disorder (AUD) has been associated with impa

105 To investigate the potential role of alcohol use disorder (AUD) in aging processes, we employ

106 ical and economic consequences of coexisting alcohol use disorder (AUD) in patients with cirrhosis, l

107 The development of alcohol use disorder (AUD) involves binge or heavy drink

108 Alcohol use disorder (AUD) is a chronic condition with d

109 Alcohol use disorder (AUD) is a chronic debilitating dis

110 Alcohol use disorder (AUD) is a devastating illness defi

111 Alcohol use disorder (AUD) is a leading cause of global

112 and palatable fluids.SIGNIFICANCE STATEMENT Alcohol use disorder (AUD) is a major health burden worl

113 Alcohol use disorder (AUD) is associated with neuroadapt

114 Alcohol use disorder (AUD) is defined by several symptom

115 The efficacy of naltrexone to treat alcohol use disorder (AUD) is modest.

116 ded pedigrees selected for high-densities of alcohol use disorder (AUD) or drug abuse (DA).

117 Alcohol use disorder (AUD) persists as a devastating pub

118 yet we know little about what patients with alcohol use disorder (AUD) remember of alcohol-related e

119 also associated with alcohol consumption and alcohol use disorder (AUD) risk.

120 n a multicenter observational study, 36 with alcohol use disorder (AUD), and 17 persons without AUD (

121 30% of the world's population is affected by alcohol use disorder (AUD), and excessive alcohol consum

122 of 25 pairs of control and individuals with alcohol use disorder (AUD), using the Infinium((R)) Meth

123 arly efficacy testing of novel compounds for alcohol use disorder (AUD).

124 = 30) and treatment-seeking individuals with alcohol use disorder (AUD: N = 29) encoded associations

125 Subjects who met DSM-5 criteria for alcohol use disorder (AUD; n = 17) were admitted inpatie

126 pregnant women also exhibited reductions in alcohol use disorder (odds ratio, 0.45).

127 Pregnancy was inversely associated with alcohol use disorder across all analyses (odds ratios, 0

128 ariation in this sample of participants with alcohol use disorder and control subjects, but the three

129 the pathophysiological role of PPARgamma in alcohol use disorder and help clarify the mechanisms by

130 for future drinking behavior in established alcohol use disorder and in at-risk states.

131 Efforts to untangle the associations between alcohol use disorder and other disorders across the life

132 The causal pathways between alcohol use disorder and other psychiatric disorders are

133 xy-phenotype meta-analysis of PAU, combining alcohol use disorder and problematic drinking, in 435,56

134 higher ASCA levels compared to patients with alcohol use disorder and to nonalcoholic controls.

135 harmacotherapy and behavioral treatments for alcohol use disorder are limited in their effectiveness,

136 Heavy drinking and alcohol use disorder are major public health problems.

137 They further compared rates of alcohol use disorder between pregnant women and their pa

138 tive, English speaking, and met criteria for alcohol use disorder by the Diagnostic and Statistical M

139 ms, autism spectrum disorder, psychosis, and alcohol use disorder compared with the control sample.

140 individuals who met criteria for a past-year alcohol use disorder did.

141 individuals who met criteria for a past-year alcohol use disorder had a psychiatric comorbidity, whil

142 ealthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acq

143 surgery, participants completed the 10-item Alcohol Use Disorder Identification Test (AUDIT), which

144 n studies of these traits using longitudinal Alcohol Use Disorder Identification Test-Consumption (AU

145 Efficacy of gabapentin for the treatment of alcohol use disorder in patients with alcohol withdrawal

146 in female mice suggests that treatments for alcohol use disorder in women may need to account for th

147 Alcohol use disorder is a significant global burden.

148 A clinical hallmark of alcohol use disorder is persistent drinking despite pote

149 henotypic risk factor for the development of alcohol use disorder is sensitivity to the rewarding eff

150 trating that even a severe condition such as alcohol use disorder is subject to the protective effect

151 e AI.SIGNIFICANCE STATEMENT A key feature of alcohol use disorder is that sufferers show an enduring

152 ibutes to the transition from alcohol use to alcohol use disorder or is a consequence of alcohol inta

153 onsequence" environment, akin to humans with alcohol use disorder relapsing in the face of adversity.

154 likely causal, motivational role in reducing alcohol use disorder risk among women and, to a lesser e

155 Humans with alcohol use disorder typically abstain because of the ne

156 e negative association between pregnancy and alcohol use disorder was especially pronounced, but no m

157 Within individuals, rates of alcohol use disorder were substantially decreased during

158 , we recruited people living with HIV and an alcohol use disorder who were not otherwise receiving fo

159 ents with alcoholic hepatitis, patients with alcohol use disorder, and nonalcoholic controls using fu

160 aptive responses to stress are a hallmark of alcohol use disorder, but the mechanisms that underlie t

161 e main psychiatric disorders associated with alcohol use disorder, including the prevalence of co-occ

162 ith polygenic risk scores for schizophrenia, alcohol use disorder, major depressive disorder, a combi

163 rdize measures of neurofunctional domains in alcohol use disorder, to extend these findings to other

164 ndence are key factors in the development of alcohol use disorder, which is a pervasive societal prob

165 ted in many psychiatric disorders, including alcohol use disorder, yet our understanding of their fun

166 itions such as major depressive disorder and alcohol use disorder.

167 on is a core, treatment-resistant feature of alcohol use disorder.

168 ing plays a critical role in the etiology of alcohol use disorder.

169 immune cells of the brain, are implicated in alcohol use disorder.

170 a mechanism to further our understanding of alcohol use disorder.

171 The greatest effects were associated with alcohol use disorder.

172 receptor antagonist used as a treatment for alcohol use disorder.

173 re implicated, such as gambling disorder and alcohol use disorder.

174 outcomes among patients living with HIV and alcohol use disorder.

175 iation between pregnancy and reduced risk of alcohol use disorder.

176 s a potential pharmacological agent to treat alcohol use disorder.

177 and craving following naltrexone therapy in alcohol use disorder.

178 identifying, and treating heavy drinking and alcohol use disorder.

179 d for the treatment of excessive drinking in alcohol use disorder.

180 r a personal or maternal parental history of alcohol use disorder.

181 ously associated with alcohol consumption or alcohol use disorder.

182 ic acetylcholine receptors (nAChRs) to treat alcohol use disorder.

183 tical for the development and progression of alcohol use disorder.

184 ed pharmacotherapy-behavioral treatments for alcohol use disorder.

185 g the neural basis of compulsive drinking in alcohol use disorder.

186 .g., 5-HT2C and 5-HT1A) critically linked to alcohol use disorder.

187 is critically implicated in the etiology of alcohol use disorder.

188 1 may provide a novel therapeutic target for alcohol use disorder.SIGNIFICANCE STATEMENT Long-term al

189 A lower V(ND) was found for individuals with alcohol-use disorder (34%, P = 0.00084) and Parkinson di

190 h non-alcoholic individuals or patients with alcohol-use disorder, patients with alcoholic hepatitis

191 Individuals with alcohol use disorders (1.7%, 1,406/82,731) and drug use

192 8.78 [20.04-41.33]; p<0.0001) and those with alcohol use disorders (6.52 [3.83-11.10]; p<0.0001) had

193 In contrast to our findings in humans with alcohol use disorders (AUD), our animal model experiment

194 on studies (GWAS) of complex traits, such as alcohol use disorders (AUD), usually identify variants i

195 rks has been observed among individuals with alcohol use disorders (AUDs) as well as in those at risk

196 ol exposure increases the risk of developing alcohol use disorders (AUDs), yet the mechanisms respons

197 nd every year millions of people suffer from alcohol use disorders (AUDs).

198 d as a promising therapeutic target to treat alcohol use disorders (AUDs).

199 or all substance use disorders (F10.X-19.X), alcohol use disorders (F10.X), cannabis use disorders (F

200 d disorders, depression, drug use disorders, alcohol use disorders and bipolar and affective mood dis

201 ed psychiatric comorbidities associated with alcohol use disorders and tobacco use disorders among he

202 Alcohol use disorders are common conditions that have en

203 condary outcome, male alcohol misuse, by the Alcohol Use Disorders Identification Test (AUDIT).

204 The results showed that SP and Alcohol Use Disorders Identification Test scores were bo

205 Median alcohol use was 2 (Alcohol Use Disorders Identification Test-Consumption; r

206 of a screening and natural history study of alcohol use disorders in 454 individuals representing th

207 ere both six times higher, and prevalence of alcohol use disorders was double that of the general pop

208 .8) for major depression, 3.8% (1.2-7.6) for alcohol use disorders, and 5.1% (2.9-7.8) for drug use d

209 tric diagnoses: psychosis, major depression, alcohol use disorders, and drug use disorders.

210 For alcohol use disorders, prevalence was higher in the sout

211 initiation of alcohol use and development of alcohol use disorders.

212 enetic basis of both alcohol consumption and alcohol use disorders.

213 s in the underlying basis for development of alcohol use disorders.

214 mplicated in the pathophysiology of pain and alcohol use disorders.

215 atic stress disorder (PTSD), depression, and alcohol-use disorders, in association with advanced epig

216 Any alcohol use during pregnancy is associated with subtle y

217 membered rings can be achieved from the free alcohols using fluoride or silanolate, allylic acetate p

218 use after transplantation: abstinence, slip (alcohol use followed by sobriety), or sustained use.

219 Alcohol use following the infusion was assessed with tim

220 e new mechanistic insight into how excessive alcohol use, following exposure to a traumatic event, ca

221 y and specificity of potential thresholds of alcohol use for identifying alcohol-related problems in

222 Alcohol use has been reliably associated with smaller su

223 Chronic alcohol use has important effects on the glutamate syste

224 tanding of the neurocircuitry that underlies alcohol use has improved, novel brain regions that are i

225 Smoking and alcohol use have been associated with common genetic var

226 everal common risk factors of NCDs (tobacco, alcohol use, high systolic blood pressure, dietary risks

227 ictors for OF were female gender (HR, 2.22), alcohol use (HR, 2.02), and viral coinfection (HR, 1.37)

228 ated the pooled RR for risk factors (harmful alcohol use, illicit drug use, smoking, and obesity) and

229 nking experiences may powerfully drive later alcohol use in familiar drinking contexts, yet we know l

230 We investigated the impact of alcohol use in fatty liver disease on incident liver, ca

231 The effects of alcohol use in nonalcoholic fatty liver disease are uncl

232 However, the impact of mild to moderate alcohol use in patients with mild or nonadvanced forms N

233 iscussion of potential risks and benefits of alcohol use in patients with NAFLD.

234 pies of NAFLD, and the consensus position on alcohol use in patients with NAFLD.

235 ndex, blood pressure, history of smoking and alcohol use in POAG patients and control participants we

236 maternal psychosocial risk factors including alcohol use in pregnancy (n = 95; 14.5%), smoking (n = 2

237 anges in self-reported cigarette smoking and alcohol use in the 30 days prior to survey among underre

238 e involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopa

239 Alcohol use increased during the period 1999-2014.

240 e outline the overlapping effects of chronic alcohol use, inflammation and microbiome alterations on

241 Our data suggest that alcohol use is associated with differential methylation

242 itions, such that increased genetic risk for alcohol use is associated with lower disease risk.

243 Low to moderate alcohol use is associated with reduced mortality and CVD

244 Alcohol use is common among older people in many societi

245 tal health problems and to excess or harmful alcohol use is considerable.

246 Alcohol use is correlated within spouse-pairs, but it is

247 Alcohol use is highly prevalent in the United States and

248 Excessive alcohol use is the third leading cause of mortality in t

249 The acquisition of drug, including alcohol, use is associated with activation of the mesoli

250 e ((18)F-FPEB) PET has revealed that chronic alcohol use leads to decreased limbic mGluR5 availabilit

251 delta-C(sp(3))-N bond formation in aliphatic alcohols using mild basic conditions and readily availab

252 arge Genome-wide Association Study (GWAS) of alcohol use/misuse and two family history (mother DSM-5

253 olved in alcohol use and novel biomarkers of alcohol use need to be identified.

254 HCC risk was also higher in patients with alcohol use, older age, and infection with HCV genotype

255 bly reflect a predispositional liability for alcohol use or a causal consequence of alcohol use.

256 ultrasonography in the absence of excessive alcohol use or any other identifiable cause of liver dis

257 t outlets was not associated with changes in alcohol use or related problems.

258 Overall, the amount of alcohol use or use over the risk limit in 2000 was incon

259 t injecting (OR, 0.98; 95% CI, 0.94-1.02) or alcohol use (OR, 0.99; 95% CI, 0.95-1.04).

260 moderator of prazosin treatment response for alcohol use outcomes and for associated symptoms of alco

261 Problematic alcohol use (PAU) is a leading cause of death and disabi

262 Dietary factors and alcohol use play important roles in the U-shaped relatio

263 Reevaluation of Medicaid alcohol use policies may be warranted, to align more clo

264 se of alcohol post-LT, forming the Sustained Alcohol Use Post-LT (SALT) score (range: 0-11): >10 drin

265 ictive value (95% CI: 89%-98%) for sustained alcohol use post-LT.

266 identify variables associated with sustained alcohol use post-LT.

267 r early LT who are at low risk for sustained alcohol use posttransplant.

268 This study investigates whether alcohol use predicts the periodontal pocket development

269 Alcohol use-related cerebellar growth trajectory differe

270 relationship with punishment sensitivity and alcohol use remain unclear.

271 osing risk factors or causal consequences of alcohol use remains poorly understood.

272 obesity, hypertension [HTN], hyperlipidemia, alcohol use, renal impairment, chronic kidney disease [C

273 ue-added chemicals, such as hydrocarbons and alcohols, using renewable energy, but the efficiency of

274 ive genetic correlation between insomnia and alcohol use (rG = 0.56, se = 0.14, p < 0.001), nicotine

275 The present study supports five novel alcohol-use risk loci, with particularly strong statisti

276 ears were predictive of stronger increase in alcohol use score over 5 years.

277 ral MRI data at age 14, predicting change in alcohol use score over time.

278 Screening for drug and alcohol use should become part of the standard clinical

279 on of carbonyl moieties to the corresponding alcohol using simply hydrazine hydrate has been consider

280 Quantitative estimates of alcohol use, smoking, adiposity and physical activity we

281 t age 17 years (depression, obesity, harmful alcohol use, smoking, and illicit drug use; n = 4,917).

282 ain and is most commonly caused by excessive alcohol use, smoking, or genetic mutations.

283 , clinical comorbidities, including drug and alcohol use, STEMI acuity (cardiac arrest and cardiogeni

284 ting, and substance use (current tobacco and alcohol use) than heterosexual women.

285 k for alcohol-related problems, the level of alcohol use that should prompt further screening for alc

286 odemographic and health confounders, such as alcohol use, this study identifies distinct associations

287 ctivation contributes to the transition from alcohol use to alcohol use disorder or is a consequence

288 Alcohol use typically begins in adolescence, increasing

289 ical characteristics identified nicotine and alcohol use variables as well as impulsivity inhibitory

290 fter excluding participants with significant alcohol use, viral hepatitis, or increased transferrin s

291 Median alcohol use was 2 (Alcohol Use Disorders Identification

292 ); and that associated with recent hazardous alcohol use was 8.5% (95% CrI: 3.2, 14.4).

293 Heavy alcohol use was associated with an increased risk of sev

294 Heavy alcohol use was associated with an increased risk of sev

295 Genomic risk for alcohol use was enriched in gene sets that were preferen

296 related with many health conditions, whereas alcohol use was negatively correlated with these conditi

297 Alcohol use was not consistently associated with the per

298 f IPV and their male partners with hazardous alcohol use were enrolled as a couple and randomized to

299 After adjusting for age, sex and alcohol use, white and other vs. black race (odds ratio

300 iation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic associ