ライフサイエンスコーパス: aldose reductase

1 se related to metabolism of hexose sugars by aldose reductase.

2 the cavity sites and was especially true for aldose reductase.

3 ascular cell adhesion molecule (VCAM)-1, and aldose reductase.

4 undergoing apoptosis were immunoreactive for aldose reductase.

5 severe hyperglycemia and/or high activity of aldose reductase.

6 is most likely caused by S-nitrosylation of aldose reductase.

7 , sodium/chloride/betaine cotransporter, and aldose reductase.

8 e drug Alrestatin bound to a mutant of human aldose reductase.

9 cofactor binding characteristics observed in aldose reductase.

10 ion catalyzed in vitro by homogenous cardiac aldose reductase.

11 y suppressed the heat-induced aggregation of aldose reductase.

12 s in the retina and inadequate inhibition of aldose reductase.

13 educe inflammatory responses downstream from aldose reductase.

14 including aquaporin-2, urea transporter, and aldose reductase.

15 e challenge were suppressed by inhibition of aldose reductase.

16 esulted in hyperglycemia, activation of lens aldose reductase 2 (ALR2) and accumulation of sorbitol i

17 we investigated whether uric acid regulates aldose reductase, a key enzyme in the polyol pathway.

18 Aldose reductase, a member of the aldo-keto reductase fa

19 models, we report that hyperglycemia-induced aldose reductase activation and subsequent reactive oxyg

20 hyperactivation, mitochondrial dysfunction, aldose reductase activation, reactive oxygen species pro

21 Aldose reductase activity and polyols were below our lim

22 monstrate that ischemia increases myocardial aldose reductase activity and that these increases are,

23 ring of blood glucose and inhibition of lens aldose reductase activity because of which there was a c

24 Excess aldose reductase activity can be a mechanism for human d

25 The results support the role for increased aldose reductase activity in functional and structural c

26 Diabetic mice, known to have much lower aldose reductase activity in other tissues when compared

27 These data indicate that inhibition of aldose reductase activity preserves high-energy phosphat

28 Inhibition of aldose reductase activity substantially diminished myo-i

29 5); GAPDH activity was higher; and G-3-P and aldose reductase activity were lower.

30 ent, the hexose monophosphate shunt pathway, aldose reductase activity, and levels of sorbitol and ga

31 The increased aldose reductase activity, higher sorbitol content and l

32 Aldose reductase (AKR1B1) is a critical drug target beca

33 es involved in BH(4) biosynthesis, including aldose reductase (AKR1B1), carbonyl reductase (CBR1 and

34 he expression of antioxidant enzymes such as aldose reductase (AKR1B1), underscoring the relationship

35 lant, is a potent and selective inhibitor of aldose reductase (AKR1B1).

36 The role of aldose reductase (ALR2) in causing diabetic complication

37 -one with natural alcohols, and synthesis of aldose reductase (ALR2) inhibitor and histamine-4 recept

38 Aldose reductase (ALR2) is the first and rate-limiting e

39 Aldose reductase (ALR2), a NADPH-dependent aldo-keto red

40 e of FR-1 shows striking homology with human aldose reductase, an enzyme linked to the pathogenesis o

41 Two distinct peaks corresponding to aldose reductase and aldehyde reductase, the latter bein

42 ORE/TonE reporter activity, and induction of aldose reductase and betaine transporter mRNAs.

43 ic histidine residues in the key proteins in aldose reductase and heat-shock protein-70 within living

44 bitors that are able to discriminate between aldose reductase and other members of the aldo-keto redu

45 mice, glucose consumption is accompanied by aldose reductase and polyol pathway activation in steato

46 data also support the idea of activation of aldose reductase and polyol pathway as an important mech

47 endogenous genes, GRE3 and SOR1, that encode aldose reductase and sorbitol (xylitol) dehydrogenase, r

48 The presence of aldose reductase and sorbitol dehydrogenase in these cel

49 To study aldose reductase and the sorbitol pathway in periodontit

50 reductase)-null, cardiospecific-akr1b4 (rat aldose reductase), and akr1b8 (FR-1)-transgenic mice.

51 probe vibration to the active site of human aldose reductase, and the response of the nitrile stretc

52 dehydrogenase flavoprotein [SDH Fp] subunit, aldose reductase, and TIM17 preprotein translocase); (4)

53 inhibitor (zopolrestat) or transfection with aldose reductase antisense oligonucleotide blocked the p

54 vas deferens protein (MVDP) (76%), and human aldose reductase (AR) (62%).

55 he sodium/myo-inositol cotransproter (SMIT), aldose reductase (AR) and heat shock protein 70 (HSP70)

56 that inhibition of the polyol pathway enzyme aldose reductase (AR) by two structurally unrelated inhi

57 -carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the e

58 Aldose reductase (AR) catalyzes the reduction of several

59 and structural changes in recombinant human aldose reductase (AR) due to modification by S-nitrosogl

60 is study, the selectivity and specificity of aldose reductase (AR) for glutathionyl aldehydes was exa

61 Increased glucose utilization by aldose reductase (AR) has been implicated in the develop

62 Aldose reductase (AR) has been implicated in the etiolog

63 Aldose reductase (AR) has been implicated in the etiolog

64 ion of glucose via the polyol pathway enzyme aldose reductase (AR) has been linked to the development

65 The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and

66 This study examined the functions of aldose reductase (AR) in mediating acute lung inflammati

67 cidate the role of the polyol pathway enzyme aldose reductase (AR) in the mediation of ocular inflamm

68 of this study was to evaluate the effect of aldose reductase (AR) inhibition on posterior capsular o

69 Sorbinil, an aldose reductase (AR) inhibitor, attenuated GS-DHN level

70 Our recent studies indicate that aldose reductase (AR) inhibitors such as fidarestat inhi

71 hibition of the aldehyde-metabolizing enzyme aldose reductase (AR) inhibits NF-kappa B activation dur

72 Aldose reductase (AR) is a member of the aldo-keto reduc

73 Aldose reductase (AR) is a multifunctional enzyme that c

74 Aldose reductase (AR) is a multifunctional enzyme that r

75 Aldose reductase (AR) is an aldo-keto reductase that has

76 e stress and an earlier study has shown that aldose reductase (AR) mediates oxidative stress signals,

77 Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabet

78 The aldose reductase (AR) polyol pathway contributes to thes

79 y, the authors showed that the inhibition of aldose reductase (AR) prevents bacterial endotoxin-induc

80 that inhibition of the polyol pathway enzyme aldose reductase (AR) prevents the increase in ICAM-1 an

81 Aldose reductase (AR) reduces cytotoxic aldehydes and gl

82 rated that, in response to multiple stimuli, aldose reductase (AR) regulates the inflammatory signals

83 Aldose reductase (AR) was immunohistochemically localize

84 Induction of aldose reductase (AR) was observed in human cells treate

85 Aldose reductase (AR), a member of the aldo-keto reducta

86 Aldose reductase (AR), a member of the aldo-keto reducta

87 Aldose reductase (AR), a member of the aldo-keto reducta

88 e activity and on expression and activity of aldose reductase (AR), a primary enzyme of polyol metabo

89 We have recently shown that inhibition of aldose reductase (AR), an enzyme that catalyzes the redu

90 The gene encoding aldose reductase (AR), an enzyme that mediates the gener

91 ee enzymes: triosephosphate isomerase (TIM), aldose reductase (AR), and phosphomannose isomerase (PMI

92 glucose were more potent: Inhibiting NOS or aldose reductase (AR), scavenging superoxide or peroxyni

93 Inhibition of aldose reductase (AR), the first enzyme of the polyol pa

94 The enzyme aldose reductase (AR), which is implicated in the regula

95 e studies reported here, we examined whether aldose reductase (AR), which reduces hydrophobic aldehyd

96 Sorbitol synthesis is catalyzed by aldose reductase (AR).

97 rnosine-propanals is catalyzed by the enzyme aldose reductase (AR).

98 r endogenous), its metabolite uric acid, and aldose reductase (AR, the only endogenous enzyme that pr

99 hibition of the aldehyde-metabolizing enzyme aldose reductase (AR; AKR1B3) modulates NF-kappaB-depend

100 inhibitors with the carboxy-terminal loop of aldose reductase are critical for the development of inh

101 eover, osmotic stress response genes such as aldose reductase are not induced upon T cell activation.

102 ihydroxyphenylethanol (DOPET) by aldehyde or aldose reductase (ARs).

103 transgenic mice broadly overexpressing human aldose reductase (ARTg) driven by the major histocompati

104 We identify AKR1B1 (aldose reductase) as one of the Pkd1 gene mutation-assoc

105 aracterize the kinetic properties of cardiac aldose reductase, as well as to study the impact of flux

106 ion of mRNA for hypertonicity-induced genes (aldose reductase, betaine/gamma-amino-n-butyric acid tra

107 enes of the aldo-keto reductase superfamily (aldose reductase, bile acid binder, and type I and type

108 ed NF-kappaB and increased the expression of aldose reductase but not ICAM-1 and VCAM-1.

109 Ablation of aldose reductase by small interference RNA (siRNA) preve

110 tudy show that pharmacological inhibition of aldose reductase by sorbinil or knockdown of the enzyme

111 Our data suggest that aldose reductase can compensate for the loss of GLO1.

112 Aldose reductase catalyzed the reduction of chemically s

113 Aldose reductase-catalyzed reduction is an important pat

114 The crystal structure of aldose reductase complexed with 13 revealed an interacti

115 tat, an acetic acid-type inhibitor, bound to aldose reductase complexed with either NADPH or NADP+.

116 However, the crystal structure of aldose reductase complexed with inhibitor unambiguously

117 Aldose reductase contributes to diabetes-mediated mitoch

118 In this regard, we show that aldose reductase-deficient mice are protected against gl

119 affinity for cofactor than the related human aldose reductase does.

120 Aldose reductase (EC 1.1.1.21) catalyzes the NADPH-media

121 effects of reducing both the Km and Vmax of aldose reductase (EC 1.1.1.21), an enzyme whose function

122 hyde reductase (EC 1.1.1.2, Akr1a4 (GR)) and aldose reductase (EC 1.1.1.21, Akr1b3 (AR)) as the enzym

123 A new and essential cis-element AEE (aldose reductase enhancer element), necessary for the co

124 Two representative genes are the aldose reductase enzyme (AR, EC 1.1.1.21), which is resp

125 hat vitamin K1 is a potent inhibitor of lens aldose reductase enzyme and we made an attempt to unders

126 lens homogenate as well as recombinant human aldose reductase enzyme.

127 Transgenic mice overexpressing human aldose reductase exhibited increased JAK2 and STAT5 acti

128 valuated whether soluble uric acid regulates aldose reductase expression both in cultured hepatocytes

129 Uric acid dose-dependently stimulated aldose reductase expression in the HepG2 cells, and this

130 yperuricemic rats exhibited elevated hepatic aldose reductase expression, endogenous fructose accumul

131 romol/l zopolrestat, a specific inhibitor of aldose reductase, for 10 min, followed by 20 min of glob

132 The aldose reductase gene is controlled by a tonicity-respon

133 , using an ORE.AP-1 reporter from the target aldose reductase gene or the same reporter with a mutate

134 levels, we partially characterized the human aldose reductase gene promoter present in a 4.2-kb fragm

135 Recently, we cloned the rabbit aldose reductase gene, characterized its structure, and

136 rosmotic stress induces transcription of the aldose reductase gene.

137 drophobic region of the active site of human aldose reductase (hALR2).

138 are enriched in an "activated" form of human aldose reductase (hAR), a NADPH-dependent oxidoreductase

139 and in alcohol oxidation activities of human Aldose reductase (hAR).

140 In the spinal cord, aldose reductase immunoreactivity was present solely in

141 t and human retinal endothelial cells showed aldose reductase immunoreactivity, and human retinas exp

142 ase inhibitor, the presence and influence of aldose reductase in cardiac tissue remain unknown.

143 lic regulation due to increased flux through aldose reductase in diabetic hearts may influence the ab

144 safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains controv

145 Inhibition of aldose reductase in GLO1(-/-) cells is associated with a

146 d a western blot confirmed a higher level of aldose reductase in mutant mitochondria.

147 further test the possible pathogenic role of aldose reductase in the development of diabetic retinopa

148 ndogenous fructose production by stimulating aldose reductase in the polyol pathway.

149 means of osmotic stress induced by activated aldose reductase in the sorbitol pathway.

150 , a function of renal medullary genes, e.g., aldose reductase, in diabetes.

151 Inhibition of aldose reductase increased survival in mice injected wit

152 Even though inhibition of aldose reductase increases vascular oxidative stress, th

153 Aldose reductase inhibited hearts, when subjected to isc

154 nil Retinopathy Trial, a randomized trial of aldose reductase inhibition among patients aged 18-56 ye

155 The plant was evaluated for aldose reductase inhibition and anti-diabetic action.

156 INSIM, with the conclusion that all reported aldose reductase inhibition can be rationalized in terms

157 In conclusion, aldose reductase inhibition counteracts diabetes-induced

158 using baseline data from the ARISE-HF trial (Aldose Reductase Inhibition for Stabilization of Exercis

159 To determine if aldose reductase inhibition improves tolerance to ischem

160 tion cannot be regarded as an alternative to aldose reductase inhibition in eliminating antioxidant a

161 Aldose reductase inhibition increased glycolysis and glu

162 This study evaluated the effects of aldose reductase inhibition on diabetes-induced oxidativ

163 Aldose reductase inhibition with fidarestat (16 mg . kg(

164 pathway, and PKCbetaII were all sensitive to aldose reductase inhibition.

165 lected from commercial databases for testing aldose reductase inhibition.

166 (butylated hydroxytoluene; 1% by diet) or an aldose reductase inhibitor (ARI) (sorbinil; 25 mg/kg/day

167 abetic rats were treated with or without the aldose reductase inhibitor (ARI) fidarestat (16 mg . kg(

168 ARI-809 is a recently discovered aldose reductase inhibitor (ARI) of a new structural cla

169 trol and galactose-fed rats treated with the aldose reductase inhibitor (ARI) Ponalrestat.

170 onic treatment with insulin or ICI222155, an aldose reductase inhibitor (ARI) previously shown to pre

171 erous attempts over 16 years, the results of aldose reductase inhibitor (ARI) trials for the treatmen

172 containing 50% galactose with or without an aldose reductase inhibitor (ARI) were investigated.

173 Rats treated with the aldose reductase inhibitor AL01576 for the duration of t

174 se transporter inhibitor cytochalasin B, the aldose reductase inhibitor alrestatin, and the advanced

175 Normal chow containing the aldose reductase inhibitor fidarestat (16 mg x kg(-1) x

176 ilure) trial is assessing the efficacy of an aldose reductase inhibitor for exercise capacity preserv

177 the potential of vitamin K1 as a novel lens aldose reductase inhibitor in a streptozotocin-induced d

178 The aldose reductase inhibitor sorbinil (2.5 mg/ml) when add

179 We then tested whether the aldose reductase inhibitor sorbinil and aspirin, which h

180 lglyoxal-treated HUVECs was prevented by the aldose reductase inhibitor sorbinil.

181 ecedented non-hydantoin, non-carboxylic acid aldose reductase inhibitor, 24, which shows remarkably p

182 abetic rats treated with a p38 inhibitor, an aldose reductase inhibitor, and insulin.

183 determine whether AT-001, a highly selective aldose reductase inhibitor, can stabilize exercise capac

184 ly prevented by 12 weeks' treatment with the aldose reductase inhibitor, fidarestat.

185 efficacy of govorestat (NCT05397665), a new aldose reductase inhibitor, is currently ongoing.

186 on by sorbinil, a classic negatively charged aldose reductase inhibitor, results from binding to the

187 The coadministration of the aldose reductase inhibitor, sorbinil, with 40 mM galacto

188 strating protection of ischemic hearts by an aldose reductase inhibitor, the presence and influence o

189 Aldose reductase inhibitors (ARIs) prevent peripheral ne

190 11A mutant by several commercially available aldose reductase inhibitors (ARIs) was variable, with to

191 were treated with three structurally diverse aldose reductase inhibitors (ARIs).

192 Aldose reductase inhibitors (tolrestat or sorbinil) or a

193 es have demonstrated that negatively charged aldose reductase inhibitors act primarily by binding to

194 Insulin and aldose reductase inhibitors can prevent excess polyol pa

195 se results are confirmed in patient tissues, aldose reductase inhibitors could have some therapeutic

196 dependent manner by treating these dogs with aldose reductase inhibitors from the onset of galactosem

197 Aldose reductase inhibitors have shown promise in animal

198 group suggests an efficacious application of aldose reductase inhibitors in treating diabetic retinop

199 een nonsteroidal anti-inflammatory drugs and aldose reductase inhibitors like zopolrestat.

200 Reducing the polyol influx by treatment with aldose reductase inhibitors normalized intracellular sor

201 Treatment with aldose reductase inhibitors or aldose reductase siRNA di

202 ent of vascular smooth muscle cells with the aldose reductase inhibitors tolrestat and sorbinil preve

203 ion of extant literature findings with other aldose reductase inhibitors, including zopolrestat, resu

204 ol in pericytes that was markedly reduced by aldose reductase inhibitors.

205 rugs but had little effect on the binding of aldose reductase inhibitors.

206 furoxane derivatives, 5a-k,m, synthesized as aldose reductase inhibitors.

207 zothiazol-2-yl)methyl]indole-N-alkanoic acid aldose reductase inhibitors.

208 the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value o

209 ity and alpha-amylase, alpha-glucosidase and aldose reductase inhibitory activity were assessed.

210 ng activity and a-amylase, a-glucosidase and aldose reductase inhibitory activity were assessed.

211 studies of the novel compounds clarified the aldose reductase inhibitory profile observed, thus ratio

212 These findings indicate that aldose reductase is a component of ischemic injury and t

213 Recently, we demonstrated that aldose reductase is a component of myocardial ischemic i

214 Aldose reductase is also overexpressed in diabetic retin

215 Aldose reductase is an NADPH-dependent oxidoreductase th

216 One product of aldose reductase is sorbitol, which has been linked to o

217 ctase, these results support the notion that aldose reductase is the key relay that converts hypergly

218 Sorbitol, synthesized through aldose reductase, is a predominant osmolyte induced unde

219 s alpha-glucosidase (K(i) = 166.9 ug/mL) and aldose reductase (K(i) = 127.5 ug/mL) through non-compet

220 The kinetic parameter of cardiac aldose reductase (Kcat) was significantly higher in isch

221 ially docked to the expanded conformation of aldose reductase, known to bind larger ligands.

222 viously, to explore the mechanism regulating aldose reductase levels, we partially characterized the

223 metabolism of the GS-HNE conjugate involves aldose reductase-mediated reduction, a reaction catalyze

224 determine whether the polyol pathway enzyme aldose reductase mediates diabetes abnormalities in vasc

225 The present demonstration that aldose reductase mediates endotoxin-induced inflammation

226 of inducible NO synthase, cyclooxygenase-2, aldose reductase, Mn superoxide dismutase, and probably

227 GT1) and sodium-myo-inositol transporter and aldose reductase mRNA expression under hypertonic condit

228 s we report that the hypertonic induction of aldose reductase mRNA in HepG2 cells as well as the osmo

229 ibitors (tolrestat or sorbinil) or antisense aldose reductase mRNA prevented hyperproliferation of cu

230 in inhibition of the hypertonic induction of aldose reductase mRNA, ORE-driven reporter gene expressi

231 moprotective genes, including those encoding aldose reductase, Na+/Cl--coupled betaine/gamma-aminobut

232 When exposed to sorbinil, an inhibitor of aldose reductase, no GS-DHN was recovered in the coronar

233 al cells (HUVECs) and C57 wild-type, akr1b3 (aldose reductase)-null, cardiospecific-akr1b4 (rat aldos

234 To rigorously test the effect of aldose reductase on myocardial ischemia-reperfusion inju

235 Pharmacological inhibition of aldose reductase or sorbitol dehydrogenase blocked JAK2

236 Specifically, the influence of the aldose reductase pathway flux on JAK-STAT signaling was

237 The aldose reductase pathway has been demonstrated to be a k

238 time, demonstrate JAK-STAT signaling by the aldose reductase pathway in ischemic hearts and is, in p

239 ctional recovery similar to that observed in aldose reductase pathway inhibited mice hearts.

240 cytosolic NADH/NAD+ ratio independent of the aldose reductase pathway inhibition, also blocked JAK2 a

241 vestigated signaling mechanisms by which the aldose reductase pathway mediates myocardial ischemic in

242 ucts; and increased glucose flux through the aldose reductase pathway.

243 tion of neutral endopeptidase, inhibition of aldose reductase plus lipoic acid supplementation, and i

244 njury and that pharmacological inhibitors of aldose reductase present a novel adjunctive approach for

245 Sorbinil, an inhibitor of aldose reductase, prevented all abnormalities.

246 ly, these results suggest that inhibition of aldose reductase prevents glucose-induced stimulation of

247 uciferase reporter gene construct containing aldose reductase promoter sequence from -1,094 base pair

248 and D-xylose), and a mutation in recombinant aldose reductase protein (C298A).

249 through hyperglycemia-induced activation of aldose reductase, reactive oxygen species, and c-Myc.

250 response to ischemia and that inhibition of aldose reductase reduces myocardial ischemic injury.

251 Pharmacological inhibition of aldose reductase significantly reduced ischemic injury a

252 reatment with aldose reductase inhibitors or aldose reductase siRNA did not affect mannitol-induced N

253 idney cortex characterized by high levels of aldose reductase, sorbitol and endogenous fructose.

254 Both the aldose reductase specific inhibitor (zopolrestat) or tra

255 In human platelets, aldose reductase synergistically modulated platelet resp

256 e sodium/chloride/betaine cotransporter, and aldose reductase (synthesis of sorbitol).

257 ction for the introduction of specificity to aldose reductase-targeted drugs.

258 studies have demonstrated that activation of aldose reductase, the first enzyme of the polyol pathway

259 An inhibitor of aldose reductase, the rate-limiting enzyme in the pathwa

260 Aldose reductase, the rate-limiting enzyme of the polyol

261 09 is a novel chemotype highly selective for aldose reductase, these results support the notion that

262 Three genes-aldose reductase, thioredoxin reductase 1, and glucose-6

263 thione conjugate, which has to be reduced by aldose reductase to stimulate cell growth.

264 chieved by increased catalytic efficiency of aldose reductase toward hemithioacetal (product of gluta

265 Notably, the aldose reductase transcript was overexpressed in LHON cy

266 normoglycemic levels via rapid increases in aldose reductase transcription and expression, which hav

267 The induction of aldose reductase transcription and the accumulation of s

268 ivity and the osmotic stress response of rat aldose reductase transcription in a rat liver cell line,

269 However, the introduction of a human aldose reductase transgene into a GK-deficient backgroun

270 petitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot.

271 excess glucose is metabolized to sorbitol by aldose reductase via the polyol pathway.

272 With northern blot analysis, aldose reductase was detected in pericytes but not in en

273 Previously studied inhibitors of aldose reductase were largely from two chemical classes,

274 ological inhibition or antisense ablation of aldose reductase (which catalyzes the reduction of GS-HN

275 CD was also screened against the drug target aldose reductase, which can undergo large conformational

276 s pathway, we examined whether inhibition of aldose reductase, which catalyzes the first step of the

277 sepsis depend on the activity of the enzyme aldose reductase, which catalyzes the reduction of lipid

278 t-derived sorbitol is produced by the enzyme aldose reductase, which is expressed by diverse immune c

279 ly, these results suggest that inhibition of aldose reductase, which prevents PKC-dependent nonosmoti

280 ndole-N-acetic acid (lidorestat, 9) inhibits aldose reductase with an IC(50) of 5 nM, while being 540