ライフサイエンスコーパス: alkenyl

1 the in situ synthesis of (E)-3-substituted 6-alkenyl-1,2,4,5-tetrazine derivatives through an elimina

2 n includes a rhodium-catalyzed reaction of 4-alkenyl-1-sulfonyl-1,2,3-triazoles featuring an unusual

3 Vinyl-, E-, or Z-disubstituted alkenyl-, 1,1-disubstituted alkenyl-, acyclic, or hetero

4 atalyzed system; in the Rh(III) catalysis, 3-alkenyl-1H-isochromen-1-one and 3,4-dialkylideneisochrom

5 rmation to the preparation of a variety of N-alkenyl 2-pyridonyl ether analogues, which have the pote

6 nal studies suggest that the desired 5-exo N-alkenyl 2-pyridonyl ethers are formed reversibly in the

7 tramolecular ring closures by inclusion of 2-alkenyl, 2-aryl, or 2-oximinyl functionality reacted rat

8 icantly increases the yield of the desired 4-alkenyl-3,4,5-trisubstituted isoxazoles.

9 Disubstituted malonyl chlorides gave 2-alkenyl-4,4-dialkyl-3,5-isoxazolidinediones (8a-f) and 2

10 tereospecifically the E or Z isomer of the 5-alkenyl-4-iminohydantoin products from the corresponding

11 Appropriately substituted 1-alkenyl-5-pentyn-1-ols bearing gem-dialkyl substituents

12 r these reactions to occur, as unactivated 1-alkenyl-5-pentyn-1-ols fail to undergo 6-exo-dig cycliza

13 ge of functional groups on alkyl iodides and alkenyl acetates are well tolerated, thus furnishing fun

14 ive C-C coupling reaction with stereodefined alkenyl acetates proceeds in a stereoretentive fashion.

15 lkylmagnesium halides with readily available alkenyl acetates.

16 Z-disubstituted alkenyl-, 1,1-disubstituted alkenyl-, acyclic, or heterocyclic trisubstituted alkeny

17 he three-component addition cascade, and the alkenyl addition product can readily be converted into d

18 ere a rhodium-catalyzed asymmetric conjugate alkenyl addition with subsequent silyl trapping and a Mu

19 id and more subtle electronic effects of the alkenyl alcohol.

20 n of highly substituted allylic alcohols and alkenyl alcohols by means of a single catalytic system.

21 An alkoxide-catalyzed directed diboration of alkenyl alcohols is described.

22 as it disengages during the isomerization of alkenyl alcohols when additional substituents are presen

23 lecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids.

24 Alkenyl aldehydes did not react, but an alkynyl aldehyde

25 Alkenyl aldehydes undergo a chiral thiiranium ion initia

26 sses to provide aryl-aryl, alkenyl-aryl, and alkenyl-alkenyl coupled products by exploiting a common

27 o)aromatic acids to the corresponding alkyl, alkenyl, alkynyl, and (hetero)aryl halides.

28 n cross-coupling reactions between aromatic, alkenyl, alkynyl, and alkyl substrates in library or ind

29 Aryl-, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phospha

30 Aryl-, heteroaryl-, alkenyl-, alkynyl-, and alkyltrifluoroborates were conve

31 Alkyl-, alkenyl-, alkynyl-, aryl- or heteroaryl-substituted trif

32 boronates add to alkynyl imines to form 1,3-alkenyl allenes.

33 Accordingly, aryl, heteroaryl, alkynyl, alkenyl, allyl, or alkyl ketones that contain an alpha-s

34 sigma-bond metathesis between the resultant alkenyl aluminum species and HBpin, which acts to drive

35 to these core structures from non-conjugated alkenyl amides and ortho-iodoanilines/phenols.

36 lyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines.

37 der acid conditions reveals quaternary alpha-alkenyl amino acids with stereodivergent control of both

38 A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticle

39 l group along with an aryl, a heteroaryl, an alkenyl, an alkynyl, or an alkyl substituent.

40 as performed under neutral conditions with 2-alkenyl and 2-cycloalkenyl acetates.

41 Here, we report the formation of new alkenyl and alkyl C-F bonds in the coordination sphere o

42 ed-anti-[2.2]metacyclophanedienes (CPD) with alkenyl and alkynyl internal (8,16) groups is described

43 ples of intermolecular oxidative addition of alkenyl and alkynyl iodides to Au(I) are reported.

44 cyclic ketones from the coupling reaction of alkenyl and allenyl cycloalkanols with aryl diazonium sa

45 .1 mol % loading, providing protected alkyl, alkenyl and aryl amines in high yields with gaseous N(2)

46 zed to form radicals from unactivated alkyl, alkenyl and aryl iodides.

47 played a striking longitudinal gradient with alkenyl and hydroxyalkenyl glucosinolates enriched in th

48 fers regiospecific access to acyl/aryl, acyl/alkenyl, and acyl/alkoxy gold carbenes by in situ expuls

49 he hydroacylation of vinylphenols with aryl, alkenyl, and alkyl aldehydes to form branched products w

50 oselective protocol can be extended to aryl, alkenyl, and alkyl aldehydes with up to 99:1 d.r.

51 s afforded three organic cages with alkynyl, alkenyl, and alkyl edges, respectively.

52 as amenable to a broad range of alkyl, aryl, alkenyl, and alkynyl organomagnesium, -zinc, -aluminum,

53 studies have shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromat

54 f electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles.

55 , that is, products bearing versatile amino, alkenyl, and borane functionality.

56 allylic amines that exhibit versatile amino, alkenyl, and boryl units.

57 hyde input; electron rich and poor aromatic, alkenyl, and branched and unbranched alkyl aldehydes all

58 ve stereochemically well-defined 3-hydroxy-4-alkenyl- and 3-hydroxy-2-methyl-4-alkenyl imides.

59 Aryl-, alkenyl- and alkynylboronic acids and their derivatives

60 methods for C-C bond formation using aryl-, alkenyl- and alkynylboronic acids under transition-metal

61 is illustrated herein for the synthesis of o-alkenyl- and o-arylphenones, which have potential for th

62 Aryl-, heteroaryl-, alkenyl-, and alkyl-substituted aldehydes and enynes can

63 Starting from aryl-, heteroaryl-, alkynyl-, alkenyl-, and alkyltrifluoroborates, a library of highly

64 romethyl-substituted and aryl-, heteroaryl-, alkenyl-, and alkynyl-substituted homoallylic alpha-tert

65 e function of the tautomerization rate of an alkenyl anion intermediate.

66 counterintuitive Lewis base stabilization of alkenyl anions in anionic cyclization) and nanomaterials

67 Substituted alkenyl aryl tetrafluoro-lambda(6) -sulfanes have been p

68 stituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts combine to form syn-1,3-car

69 ono-selective installation of diverse alkyl, alkenyl, aryl, alkynyl, fluoro, hydroxyl and amino group

70 ry, secondary and tertiary alkyl, as well as alkenyl, aryl, allenyl and alkynyl groups.

71 cessfully applied to the synthesis of alkyl, alkenyl, aryl, heteroaryl, and cyclopropyl ethers, mixed

72 oss-coupling processes to provide aryl-aryl, alkenyl-aryl, and alkenyl-alkenyl coupled products by ex

73 dipolar cycloaddition using beta-fluoroalkyl alkenyl arylsulfones as dipolarophiles and glycine/alani

74 1)-cheletropic reaction of styrene with the alkenyl-Au(I) carbene intermediate to afford the cis-dis

75 y, reversibly and stereospecifically to give alkenyl-Au(III) complexes.

76 n metal catalyzed C-H functionalization of C-alkenyl azoles is disclosed.

77 e performed to afford structurally complex Z-alkenyl-B(pin) as well as Z-alkenyl iodide compounds rel

78 erted to products bearing a Z-trisubstituted alkenyl-B(pin) moiety, a vinyl group, a beta,gamma-unsat

79 NHC-Cu-catalyzed EAS with alkenyl-B(pin) reagents containing a conjugated carboxyl

80 Chemoselective modifications involving the alkenyl-B(pin), the vinyl, or the 1,2-disubstituted olef

81 variety of robust alkenyl-(pinacolatoboron) [alkenyl-B(pin)] compounds that can be either purchased o

82 Here, we show that dienes containing an E-alkenyl-B(pinacolato) group, widely used in catalytic cr

83 approach to reductive Heck hydroarylation of alkenyl benzaldehyde substrates that proceeds under mild

84 y ring-closing metathesis of the resultant N-alkenyl beta-amino esters, reduction to the correspondin

85 Highly arylated alpha-alkenyl-beta-diketones are synthesized via a two-step se

86 mediated dihydroxylation of a range of beta-alkenyl-beta-hydroxy-N-acyloxazolidin-2-ones results in

87 ene-cyclopropenes with Cp*RuCl(cod) leads to alkenyl bicyclo[3.1.0]hexanes, bicyclo[4.1.0]heptanes, a

88 tively high barriers to rotation round the N-alkenyl bond (DeltaG() rotation >20 kcal mol(-1)) were s

89 Barriers to rotation of the N-alkenyl bond in a series of N-cycloalkenyl-N-benzyl acet

90 The barrier to rotation around the N-alkenyl bond of 38 N-alkenyl-N-alkylacetamide derivative

91 This reaction employs nonsymmetric bis(alkenyl)borates as substrates and appears to occur by a

92 p(2)-C-B bond in 2-ammoniophenyl(aryl)- or -(alkenyl)borates.

93 variety of boronic esters, amides, and other alkenyl boron adducts.

94 organozinc reagents and alkyl halides across alkenyl boron reagents in an enantioselective catalytic

95 n electrophilic radical to the electron-rich alkenyl boronate complex, leading to an alpha-boryl radi

96 l radical, or electrophilic activation of an alkenyl boronate complex.

97 iated ring contraction of five-membered-ring alkenyl boronate complexes into cyclobutanes.

98 d by alpha-leaving groups or by reactions of alkenyl boronates with electrophiles.

99 yl substitutions, hydride-allyl additions to alkenyl boronates, and additions of boron-containing all

100 ynes couple with various substituted alkynyl/alkenyl boronates/boronic acids by this procedure to fur

101 enables the formal homologation of aryl and alkenyl boronic acid pinacol esters.

102 Alkenyl boronic acid pinacolates were found to be more s

103 the Csp-Csp2 coupling of alkynyl bromide and alkenyl boronic acid to provide conjugated 1,3-enynes.

104 o-step process involves etherification of an alkenyl boronic acid with N-hydroxyphthalimide followed

105 ws for the coupling of aryl, heteroaryl, and alkenyl boronic acids and gives access to functionalized

106 Two in two: Dioxygenation of alkenyl boronic acids has been achieved with N-hydroxyph

107 atalyzed conversion of aryl, heteroaryl, and alkenyl boronic acids into sulfinate intermediates, and

108 sertion of sulfur dioxide into (het)aryl and alkenyl boronic acids.

109 d sterically diverse cyclopropanols and aryl/alkenyl boronic derivatives (39 examples, 65-94% yield)

110 + 2] photocycloaddition of the corresponding alkenyl boronic derivatives and maleimides or maleic anh

111 e to primary, secondary, tertiary, aryl, and alkenyl boronic esters and occurs with complete stereosp

112 Alkenyl boronic esters are important reagents in organic

113 nyl carboxylic acids, aryl iodides, and aryl/alkenyl boronic esters is reported.

114 the conversion of terminal alkenes to trans-alkenyl boronic esters using commercially available cate

115 insertion reaction to give 1,1-disubstituted alkenyl boronic esters when treated with stoichiometric

116 2-iodoglycal partners and diverse aryl- and alkenyl-boronic acids is presented, leading to original

117 s-coupling of the vinylic stannane 4 and the alkenyl bromide 5 to produce a highly functionalized die

118 The reaction affords terminal E-alkenyl bromides in high yield and with excellent regio-

119 Diverse cyclic and acyclic alkenyl bromides or triflates with a wide range of funct

120 phenyl and benzyl Grignards are coupled with alkenyl bromides.

121 Both aromatic and alkenyl C(sp(2) )-H bonds undergo the three-component ad

122 w access to desirable functionality, such as alkenyl C(sp(2))-F or chiral C(sp(3))-F centers.

123 nnulation onto allylic alcohols initiated by alkenyl C-H activation of N-enoxyphthalimides to furnish

124 A distal-selective alkenyl C-H arylation method is reported through a direc

125 le of Co(III)-catalyzed functionalization of alkenyl C-H bonds.

126 1]nonane and syn-diboration of the resultant alkenyl carbocycle.

127 ylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand

128 ckel-catalyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides, and aryl/alkenyl

129 Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)

130 Triacsin C, with an alkenyl chain resembling but not identical to either acy

131 of aromatic residues making contact with the alkenyl chain.

132 What is more, trisubstituted Z-alkenyl chloride moiety can be accessed with similar eff

133 ned to generate thermodynamically disfavored alkenyl chlorides and fluorides in high yield and with e

134 vides access to a broad array of substituted alkenyl chlorides in excellent yields and with high regi

135 Many isomerically pure E-alkenyl chlorides, applicable to catalytic cross-couplin

136 We obtain many alkenyl chlorides, bromides and fluorides in up to 91 pe

137 A range of stereochemically defined Z- and E-alkenyl chlorides, bromides, fluorides, and boronates or

138 res dinuclear (NHCCu)2(mu-H)(OTf) (X = F, H, alkenyl) complexes as key catalytic intermediates.

139 hat NHCCuOTf rapidly traps NHCCuX (X = F, H, alkenyl) complexes to produce (NHCCu)2(mu-X)(OTf) (X = F

140 es to produce (NHCCu)2(mu-X)(OTf) (X = F, H, alkenyl) complexes.

141 pha,alpha'-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthes

142 cupration of an alkyne, and alkylation of an alkenyl copper intermediate.

143 n alkyne, followed by the bromination of the alkenyl copper intermediate.

144 iodide and promotes cross coupling with the alkenyl copper intermediate.

145 the structure, stability, and reactivity of alkenyl copper intermediates, as well as insight into th

146 kylation of tertiary allylic carbonates with alkenyl cyanohydrin pronucleophiles is described.

147 rectly couple di-, tri- and tetrasubstituted alkenyl cyanohydrin pronucleophiles to prepare the corre

148 on of N(2) and HBr, affording 1-azadienes (2-alkenyl cyclic imines).

149 n, we report the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-t

150 Using SnCl4 as the catalyst, alkenyl cyclopropyl ketones undergo ring-opening cycliza

151 + 2]-cycloaddition between an alkyne and an alkenyl derivative, a reaction which has a long history.

152 addition between wide variety of alkynes and alkenyl derivatives, two of the most abundant classes of

153 l group on the nitrogen atom of the tethered alkenyl diazo amido indolo ester seemingly provides bett

154 They are also linked by the A rings by an alkenyl diester bridge to restrict the conformational fl

155 s-coupling processes had used either aryl or alkenyl electrophiles as one of the coupling partners.

156 However, compared to aryl or alkenyl electrophiles, the cross-coupling of unactivated

157 allylic boronates bearing a Z-trisubstituted alkenyl fluoride is disclosed.

158 Similarly, E-alkenyl fluorides can be synthesized from simpler compou

159 ed enantioselective Heck reaction of acyclic alkenyl fluorides with arylboronic acids.

160 es that bind substrates containing alkyl and alkenyl functional groups.

161 new method affords stable luminescent alkyl/alkenyl-functionalized SiNCs.

162 11 days (X = CHO) to 36 years (X = CN), with alkenyl functions being from 56 days to 10 years.

163 A variety of novel, bench-stable alkenyl gem-diboronate esters are synthesized.

164 Winspit plants produced higher quantities of alkenyl glucosinolates, such as sinigrin.

165 liphatic glucosinolate genes, no increase in alkenyl glucosinolates.

166 followed by cross-coupling of the resulting alkenyl Grignard reagent with aryl halide to give tetras

167 -99% when cyclopropanes with a 2-substituted alkenyl group as a donor underwent isomerization.

168 For cyclopropanes bearing a trisubstituted alkenyl group either the corresponding cyclopent-3-enes

169 wn-6 induces intramolecular migration of the alkenyl group from N' to Calpha with retention of double

170 The insertion of an alkenyl group into aromatic and heteroaromatic rings by

171 dehyde, an epoxide, a carboxylic acid, or an alkenyl group may be used.

172 f chromium with a propargyl ether bearing an alkenyl group on the propargylic carbon.

173 hich undergo intramolecular migration of the alkenyl group to the carbanionic center.

174 oceeding by stereospecific transfer of the E-alkenyl group within a transient, mu-B-H-B bridged, 2-el

175 The metathesis step serves to remove a beta-alkenyl group, which facilitated the aldol step.

176 k of the lithionitrile derivatives on the N'-alkenyl group.

177 tions permit installation of a wide range of alkenyl groups at positions beta, gamma, or delta to a c

178 afforded 1,2-dihydrophosphetes with P-bound alkenyl groups by catalyst-free hydrophosphination of al

179 yl-, acyclic, or heterocyclic trisubstituted alkenyl groups may be added in up to >98% yield, >98:2 S

180 the first solution to the problem of ECA of alkenyl groups to acyclic trisubstituted enones, an adva

181 rated a general trend in porosity: alkynyl > alkenyl > alkyl.

182 tetrasubstituted olefins can be realized via alkenyl halide- or triflate-mediated palladium/norbornen

183 ds, alkynes, and halogenating agents to give alkenyl halides is reported.

184 nd Pd-catalyzed cross-coupling with aryl and alkenyl halides proceeded smoothly with essentially comp

185 ziridinyl stannatrane 8 couples with aryl or alkenyl halides RX under modified Stille conditions to a

186 s into a variety of (hetero)aryl and complex alkenyl halides such as glycals, nucleosides, and nucleo

187 al method for the selective hydrogenation of alkenyl halides to alkyl halides is described.

188 an aryl bromide, an activated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitab

189 place of alkynes to furnish tetrasubstituted alkenyl halides, showcasing the first halo-arylation of

190 with a number of functional groups including alkenyl halides, sulfides, triflates, and phosphonates a

191 ions that afford acyclic 1,2-disubstituted Z-alkenyl halides.

192 ocesses that can be used to generate acyclic alkenyl halides.

193 cross-couplings between boronic acids and Z-alkenyl halides.

194 es in the thermal cycloadditions of suitable alkenyl-hydrazine derivatives.

195 sequently the Markovnikov vinyl sulfides via alkenyl-hydride reductive elimination.

196 )2 in the oxidation of a series of alkyl and alkenyl hydrocarbons as well as of an aromatic sulfide w

197 Several reactions are applied to alkenyl imidazoles, pyrazoles, and triazoles to provide

198 -hydroxy-4-alkenyl- and 3-hydroxy-2-methyl-4-alkenyl imides.

199 The initially formed 5-alkenyl iminohydantoins may be hydrolyzed and oxidativel

200 urally complex Z-alkenyl-B(pin) as well as Z-alkenyl iodide compounds reliably, efficiently, and with

201 For disubstituted (Z)-alkenyl iodide D, 2c was identified as an acceptable Ni

202 e hydrozirconation/iodine quench afforded an alkenyl iodide which is employed in the NHK coupling wit

203 ng process between either an (hetero)aryl or alkenyl iodide with ethenesulfonyl fluoride (ESF).

204 For three types of alkenyl iodides A-C, a satisfactory Ni catalyst(s) was f

205 2) complexes 1a-c and 2a-c and five types of alkenyl iodides A-E were chosen for the study, thereby d

206 s described, in which ortho-acylanilines and alkenyl iodides converted to multisubstituted quinolines

207 zed synthesis of acyl pyrroles from aryl and alkenyl iodides is reported.

208 oxidative addition of geometrically defined alkenyl iodides occurs readily, reversibly and stereospe

209 pyrroles in good to excellent yields, while alkenyl iodides provide the corresponding acyl pyrroles

210 it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reac

211 ws the direct conjugate addition of aryl and alkenyl iodides, bromides, and to a lesser extent, chlor

212 aromatic halogenated ketones or imines, and alkenyl iodides.

213 The first conjugate addition/alkylation to alkenyl isocyanides is described, which addresses this d

214 ta- and beta,beta-disubstituted arylsulfonyl alkenyl isocyanides to rapidly assemble diverse isocyani

215 rochannels on a paper substrate, followed by alkenyl ketene dimer treatment to hydrophobize the paper

216 yntheses of natural and unnatural conjugated alkenyl(methyl)maleic anhydrides have been described.

217 ic alcohols were transformed into conjugated alkenyl(methyl)maleic anhydrides via oxidation followed

218 nyl link could be exploited to access 2-aryl/alkenyl-methylene-alpha-glucopyranoside scaffolds via a

219 veloped for the sigmatropic rearrangement of alkenyl-methylenecyclopropanes.

220 bile molecule of water and an iridium-bonded alkenyl moiety (-C(R) horizontal lineC(R)-(R=CO2Me)) as

221 donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse electron-withdrawing group(s)

222 the cleavage of the terminal C-H bond of the alkenyl moiety and the dearomatization of the phenol rin

223 ct is determined by the configuration of the alkenyl moiety of the substrate.

224 (SuFEx) click chemistry, in which either the alkenyl moiety or the sulfonyl fluoride group can be the

225 the cleavage of the terminal C-H bond of the alkenyl moiety, generates highly valuable benzoxepine sk

226 d to proceed with the assistance of an ortho-alkenyl moiety, which is formed by the initial alkyne co

227 h binding of the acyl moiety of atRE via the alkenyl moiety.

228 er of (hetero)aromatic group attached to the alkenyl moiety.

229 ly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates.

230 The boron-centered radicals derived from alkenyl N-heterocyclic carbene (NHC)-boranes bearing est

231 Alkenyl N-pivaloylhydroxamates undergo an Ir(III)-cataly

232 o rotation around the N-alkenyl bond of 38 N-alkenyl-N-alkylacetamide derivatives was measured (Delta

233 The radical cyclizations of a subset of N-alkenyl-N-benzyl-alpha-haloacetamides exhibiting relativ

234 or the [4+2] anionic annulation to give 3-(2-alkenyl)naphthoates in regiospecific manner.

235 nes was developed involving treatment of the alkenyl NHC-boranes with AIBN and tert-dodecanethiol.

236 Tetra-substituted alkenyl nitriles are obtained providing useful boron-die

237 ype reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allyl

238 of terminal alkynes to furnish E-configured alkenyl nitriles.

239 or the preparation of di- or tri-substituted alkenyl nitriles.

240 ng other reducible functional groups such as alkenyl, nitro group, and even internal alkyne intact.

241 tterns, along with a wide range of boron and alkenyl nucleophiles that couple under palladium catalys

242 ts, the ring contraction and then a hydride, alkenyl, or aryl shift.

243 Alkyl, (hetero)aryl, and alkenyl organometallic reagents can all be used as the f

244 that involves the use of chiral N-protonated alkenyl oxazaborolidines as dieneophiles.

245 ocks for the preparation of functionalized 3-alkenyl-oxindoles through a Suzuki-Miyaura reaction.

246 t the reversible formation of a six-membered alkenyl palladacycle intermediate through a turnover-lim

247 IPP levels, whereas the alcohol of HMBPP and alkenyl phosphonates are directly recognized.

248 pounds-mevalonate, the alcohol of HMBPP, and alkenyl phosphonates-likely stimulate differently.

249 Reactions can involve a variety of robust alkenyl-(pinacolatoboron) [alkenyl-B(pin)] compounds tha

250 , and leading to cyclic ketones featuring an alkenyl side chain with complete diastereoselectivity.

251 btained products have been shown to react as alkenyl silanes in Hiyama coupling and electrophilic sub

252 avoring formation of 2,2-disubstituted metal-alkenyl species and subsequently the Markovnikov vinyl s

253 Tertiary enamides with four alkenyl substituents exhibited half-lives for rotation b

254 s, carbamates, and thiocarbamates bearing N'-alkenyl substituents generates carbanions which undergo

255 tiomerically pure 2-pyrones, or converted to alkenyl-substituted 2-pyrones such as naturally occurrin

256 Twenty-seven alkenyl-substituted azaborines have been synthesized thr

257 promoting the [2+2] photocycloaddition of 4-alkenyl-substituted coumarins, which led to the correspo

258 unctionalization at the C(2)-position of a N-alkenyl-substituted indole derivative that was also stud

259 cross-coupling reaction to access several N-alkenyl-substituted indoles has been developed.

260 cids to furnish C(3) aryl-, heteroaryl-, and alkenyl-substituted isoindolinones.

261 s, we identified a new class of alkynyl- and alkenyl-substituted macrolides with activities comparabl

262 Similar reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quin

263 e (NBD) readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(norbornyl) (2a or

264 corresponding aryl-, heteroaryl-, alkyl-, or alkenyl-substituted terminal alkynes with diisobutylalum

265 to a family of 2,1-borazaronaphthalenes with alkenyl substitution at the C3 position.

266 Alkenyl substrates and amides have been successfully uti

267 of tetrahydroquinoline derivatives employing alkenyl substrates in good to excellent yields.

268 Studies with geometrically pure E- and Z-alkenyl sulfide isomers reveal a likely dichotomy of rea

269 The utility of the alkenyl sulfide products is also demonstrated in simple

270 ed by either (a) a cyclization cascade of an alkenyl sulfide tethered to a 2-azido-1-allenylbenzene c

271 re or (b) cationic cyclization of a tethered alkenyl sulfide with a putative 2-indolidenium cation.

272 p, a methyl sulfide, into the products as an alkenyl sulfide.

273 uning the stereoelectronic properties of the alkenyl sulfides intermediates in order to improve the d

274 The corresponding sugar-derived alkenyl sulfides were submitted to a 6-endo [I(+)]-induc

275 intramolecular cyclocondensation of tethered alkenyl sulfides with either indolidene or indolidenium

276 ifluoroborates with a variety of substituted alkenyl sulfones through an alpha-aminomethyl radical ad

277 proteins and small molecules yielding stable alkenyl sulfoxide products at rates more than 100x great

278 -alkyl, N-allyl-, and N-benzyl-substituted S-alkenyl sulfoximines under appropriate conditions result

279 e of the alkoxy-surface groups with alkyl or alkenyl-surface groups in the presence of BH3.THF.

280 inimally affected by the substituents on the alkenyl tether.

281 ming channels decorated with the interlocked alkenyl threads.

282 Alkenyl-to-allyl 1,4-rhodium(I) migration enables the ge

283 the generation of allylrhodium(I) species by alkenyl-to-allyl 1,4-rhodium(I) migration.

284 ed mechanism of these reactions involves the alkenyl-to-allyl 1,4-rhodium(III) migration.

285 e reaction is general for a broad range of 4-alkenyl triazoles and dienes, enabling the stereoselecti

286 The alkenyl triflate products can be elaborated through cros

287 (1) addition of an NHC-boryl radical to the alkenyl triflate, (2) fragmentation to give the alpha-NH

288 tioselective intermolecular Heck reaction of alkenyl triflates and acyclic primary or racemic seconda

289 utilize a redox-relay Heck reaction between alkenyl triflates and acyclic trisubstituted alkenols of

290 A wide array of terminal (E)-alkenyl triflates are suitable for this process.

291 or PhMe(2) Si-Bpin as nucleophiles and aryl/alkenyl triflates as electrophiles, a broad range of mon

292 The requisite alkenyl triflates can be made separately or prepared in

293 The new process forms highly substituted alkenyl triflates from a range of alkynes via a pathway

294 Reactions of readily available alkenyl triflates with N-heterocyclic carbene (NHC)-bora

295 ttributed to the use of electron-withdrawing alkenyl triflates, which offer selective beta-hydride el

296 efficiently prepared from the corresponding alkenyl triflates.

297 (EAS) reactions that allow for additions of alkenyl units to readily accessible allylic electrophile

298 Both E- and Z-N'-alkenyl urea derivatives of imidazolidinones may be form

299 s from the corresponding starting E- or Z-N'-alkenyl urea, each of which may be formed from the same

300 Treatment of a [(trimethylsilylethynyl)alkenyl]ZrCp2 complex with Piers' borane [HB(C6F5)2] res