ライフサイエンスコーパス: alkyl group

1 n of racemic cyclic diolides (rac-8DL(R) , R=alkyl group).

2 CH2CH2COOH)(OCONHR)], 4, where R is a linear alkyl group.

3 ffering in size, polarity, and charge of the alkyl group.

4 onomers due to the steric requirement of the alkyl group.

5 of CC bond dehydrogenation of an unbranched alkyl group.

6 nzoxazoles with the selective cleavage of an alkyl group.

7 dily, alpha-protons must be available on the alkyl group.

8 rresponding roughly to the size of the alpha-alkyl group.

9 tal alpha-carbon, and (e) branching in the N-alkyl group.

10 the C-C bond to dithiane or to the tertiary alkyl group.

11 vase conformation with self-inclusion of one alkyl group.

12 primary amide group from a chemically inert alkyl group.

13 d activation of an amine with an unactivated alkyl group.

14 ne can be tuned by varying the length of the alkyl group.

15 the beta-carbon, such as an aryl or branched alkyl group.

16 n when the two substituents are both primary alkyl groups.

17 ading capacities and solubilizing oligoether/alkyl groups.

18 a prototypical substrate bearing two linear alkyl groups.

19 otency decreases with increasing size of the alkyl groups.

20 topology arises when the key atom bears two alkyl groups.

21 es contained significant amounts of nonpolar alkyl groups.

22 kyl substituent for both linear and branched alkyl groups.

23 wo TLS polymerases and the structures of the alkyl groups.

24 le W138 provides specificity for short-chain alkyl groups.

25 m polar cyano- and nitro- groups to nonpolar alkyl groups.

26 up while dimethylethylammonium only contains alkyl groups.

27 the 6-position can accommodate a variety of alkyl groups.

28 tive amounts of 1,2- and 1,4-addition of the alkyl groups.

29 hen polyamine length was shortened below six alkyl groups.

30 ed aromatic rings and a limited selection of alkyl groups.

31 -Ti(O-i-Pr)(3) was used as the source of the alkyl groups.

32 igher k(cat) values than those with branched alkyl groups.

33 action is undiminished by sterically bulky N-alkyl groups.

34 in sp(3) C-H bonds are replaced with sp(3) C-alkyl groups.

35 hexyl and octyl) and branched (2-ethylhexyl) alkyl groups.

36 that contain fluorinated and nonfluorinated alkyl groups.

37 alkyl groups; and (iv) steric demands of the alkyl groups.

38 her two aryl, one aryl and one alkyl, or two alkyl groups; 3-aminocyclohex-2-en-1-ones of this type a

39 uch is known about how the structures of the alkyl group affect the repair and replicative bypass of

40 me, that the size of the heteroatom-attached alkyl group affects the rate of conjugate addition.

41 ble with a host of sterically differentiated alkyl groups, alkenes, acidic protons alpha to carbonyl

42 of LDK1203 and LDK1222 are substituted by an alkyl group and a tosyl group, respectively.

43 imides containing a solubilizing swallowtail alkyl group and a variety of substituted aryl groups can

44 nactivation involves the removal of the O(6)-alkyl group and its transfer to the active-site cysteine

45 R-CH(OH)-(CH(2))(n)-CH(3), where R = H or an alkyl group and n >or= 6.

46 imizing steric interactions between the beta-alkyl group and one of the ligands on boron.

47 ion is selective toward the less-substituted alkyl group and shows moderate to excellent diastereosel

48 to the smaller steric repulsion between the alkyl group and the lithium surface.

49 in which the large substituent is a primary alkyl group and the medium substituent is a methyl group

50 ally friendly chiral racemic semifluorinated alkyl group and with AB3 minidendrons containing the sam

51 ich the carbomethoxy has been replaced by an alkyl group and with different phenyl substituents, have

52 regio- and chemoselective dehydrogenation of alkyl groups and alkanes.

53 g, at the beta'-position, linear or branched alkyl groups and aryl groups.

54 ituents were not tolerated; however, shorter alkyl groups and cyclic alkyls were acceptable.

55 osphate and monophosphonate groups by simple alkyl groups and evolved into the sophisticated ProTide

56 e relationship between the length of pendant alkyl groups and framework stability toward water vapor

57 m one another in the length and branching of alkyl groups and neutralized by different anions.

58 of complexes with chemical bonds between the alkyl groups and the copper complexes.

59 The alkyl groups and the heteroaromatic core play further co

60 mmetrical dendrons with alternating branched alkyl groups and triarylamine moieties at their peripher

61 ould be minimized with sterically hindered N-alkyl groups), and use of a novel "diamine switch" strat

62 n alkyl amine derivative with an unactivated alkyl group, and allows both primary and secondary alkyl

63 sions decreased with the chain length of the alkyl group, and these lesions directed promiscuous nucl

64 rporation of hydrophobic heterocyclic rings, alkyl groups, and halogens allowed a fine-tuning capabil

65 on current for SAMs terminated in nonpolar n-alkyl groups, and polar groups selected from common pola

66 ive migratory aptitude of phenyl groups over alkyl groups, and provides an efficient synthesis of (+)

67 R and R' are alkyl groups, and the terminal methylene is activated by

68 ) lateral van der Waals interactions between alkyl groups; and (iv) steric demands of the alkyl group

69 determining concerted N(2)-loss/shift of the alkyl group antiperiplanar to the N(2) leaving group.

70 etones with increasing steric demands of the alkyl group are evaluated as potential electrophiles for

71 )-alkyl-dG lesions in human cells, where the alkyl groups are ethyl, n-butyl (nBu), and, for O (6)-al

72 Fluorinated alkyl groups are important motifs in bioactive compounds

73 alpha values for both secondary and tertiary alkyl groups are in the range: alpha = 0.57-0.61.

74 correlation effects between electrons in 1,3-alkyl groups are largely responsible for the enhanced co

75 Poly(N-alkylacrylamide)s with larger N-alkyl groups are predominantly (C(6), 85%; C(7), 95%) or

76 In general, alkyl groups are readily contorted when their internal s

77 , but alkene reactions that form hydrophobic alkyl groups are substantially less favorable in water t

78 ugh U=O and U=NR double bonds (where R is an alkyl group) are well-known analogues to transition-meta

79 Unbranched alkyl groups assume fully extended conformations in the

80 prefers a pseudoequatorial position, and the alkyl group at C-4 has little influence on conformationa

81 Among 8-phenyl analogues, a larger alkyl group at the 1-position than at the 3-position fav

82 ents exist as equilibrating isomers with the alkyl group at the 7-11 or 12 halide positions of the CB

83 uction of a variety of primary and secondary alkyl groups at room temperature.

84 substituted silanes possessing both aryl and alkyl groups at silicon atom were efficiently prepared u

85 whereas analogs bearing smaller and branched alkyl groups at the 3 position of the oxopiperazine temp

86 A number of amines with three bulky alkyl groups at the nitrogen, which surpass the steric c

87 transferase (MGMT) is an enzyme that removes alkyl groups at the O(6)-position of guanine in DNA.

88 the metal-Calpha-Cbeta-R moiety, in which an alkyl group attached to the Cbeta atom is transferred to

89 Subtle changes in the alkyl groups attached to the thioether sulfur caused dra

90 roviding allylic alcohols bearing almost any alkyl group available using organoborane chemistry and i

91 (n = 5) are ordered and crystalline, and the alkyl groups become increasingly disordered and liquidli

92 rboring seven O(2)-alkyldT lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu or sBu, a

93 red how eight O(4)-alkyldT lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu, (R)-sBu

94 a series of O (6)-alkyl-dG lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu, or sBu,

95 ture both anancomeric structures, displaying alkyl groups bound to the cyclohexyl ring in equatorial

96 aromatic substitution and replacement of an alkyl group by the nucleophilic alpha-C atom of the phos

97 entation of the lithiation relative to the N-alkyl group, (c) the presence or absence of a potentiall

98 The position of the alkyl group (C1) was established by NMR spectroscopy and

99 s the introduction of a variety of perfluoro alkyl groups (C1-C10) and a CF2COOEt moiety.

100 In the resulting structures, long chain alkyl groups (C12 and C14) and phosphopantetheinate defi

101 Methyl, primary, and secondary alkyl groups can all be coupled in good yield (77% ave y

102 Primary and secondary alkyl groups can be installed.

103 ylides (i.e. those bearing only hydrogens or alkyl groups) can be generated from (2-azaallyl)stannane

104 electron-donating groups such as amides and alkyl groups cause a decrease.

105 to a weakening of the bonds to the bridging alkyl groups; CCG is thus usually more favored for steri

106 inyl, acyl, methyl, and other functionalized alkyl groups chemoselectively to a wide variety of unact

107 ex that isomerizes if necessary to place the alkyl group cis to the boryl group.

108 ue and reports that 3'-n-propyl and longer n-alkyl groups conferred RXR antagonism.

109 servation that ketones with sterically bulky alkyl groups could be reduced to the corresponding alcoh

110 otentially chelating methoxy moiety on the N-alkyl group, (d) the presence of a 2-methyl substituent

111 2-alkylimidazoline 24 is proposed, where the alkyl group derives from the substrate; this imidazoline

112 The size and shape of the N-alkyl group dramatically changed the potency of the tria

113 y to anti (17a and 17b) by introducing bulky alkyl groups (e.g., propyl groups) onto the hydroxy grou

114 pallidols) (both or one ring substituted by alkyl groups, e.g., 4,4'-dimethylstilbene); and those wh

115 ituted, tetracyclic indoline derivative with alkyl groups, employing a mild Negishi C-C bond forming

116 lic substituents (o-, m-, p-pyridyl) or four alkyl groups (ethyl, propyl, butyl, pentyl), in which ca

117 Alkyl groups favor equatorial positions in the oxocarben

118 We report that alkyl group fluorination (e.g., CB[7].1-AdNH2Et versus C

119 Coadsorption of hydrogen and alkyl groups, followed by heating of the surface, result

120 e substituents (i.e., chlorines for PCBs and alkyl groups for alkylated-PAHs) to the molecular struct

121 ltransferase (AGT), which transfers the O(6)-alkyl group from the damaged base to a cysteine residue

122 adducts of AChE that result from loss of one alkyl group from the inhibited enzyme (the aging reactio

123 AGT proteins remove methyl and other alkyl groups from an alkylated O(6) in guanine by transf

124 ough the inner-sphere attack of nucleophilic alkyl groups from magnesium to the reacting carbons via

125 The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and al

126 Rates of individual steps in the removal of alkyl groups from O6-methyl (Me) and -benzyl (Bz) guanin

127 ylguanine-DNA methyltransferases to transfer alkyl groups from other lesions onto a cysteine residue.

128 ant headgroups, counterions, water, and some alkyl groups from the hydrophobic tails.

129 sferase is effective in removing the smaller alkyl groups from the O (6) position of guanine, whereas

130 other O(6)-alkylguanine lesions by removing alkyl groups from the O(6)-position.

131 (AGT) is a DNA repair protein which removes alkyl groups from the O-6 position of guanine, thereby p

132 even when they contain stereocenters on the alkyl groups from their periphery.

133 ap that promotes exchange of an acyl with an alkyl group, generating the characteristic ether bond.

134 hydroxy-s-triazines, and those with linear N-alkyl groups had higher k(cat) values than those with br

135 l ketones, ArC(O)R, with a diverse number of alkyl groups have been achieved with an isolated carbony

136 ting copper-rich species have less polarized alkyl groups, i.e. gradually reduced reactivities.

137 dly, flips O6-alkylG residues, transfers the alkyl group in a chemical step that is rate-limiting in

138 effectively distinguish between a CF3 and an alkyl group in order to provide good ee.

139 migrate less effectively than other types of alkyl group in such reactions and that O-migration compe

140 han the hydrophobic interactions between the alkyl group in the thioether tail and surrounding protei

141 Positional disorder of the alkyl group in the X-ray structure of 4 corresponds to p

142 what are generally considered to be "remote" alkyl groups in -CbetaH=CalphaHS(O)n-alkyl systems and -

143 positely adjacent open metal sites and dense alkyl groups in a metal-organic framework (MOF).

144 e-tree columns that allow interdigitation of alkyl groups in adjacent columns regardless of their dir

145 aldehyde acetals with secondary and tertiary alkyl groups in contrast to specific hydrogen catalysis

146 ted pyridyl moieties in position 4 and small alkyl groups in position 2 provided the best profiles.

147 alkyl zincates and show the relevance of the alkyl groups in the efficiency of TMP-dialkyl zincate ba

148 polarizability substituent constants of the alkyl groups in the form of a linear free energy relatio

149 The alkyl groups in the study are ethyl, n-propyl, n-butyl,

150 s can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the s

151 Molecular modeling clearly shows that the alkyl groups in these Michael acceptors shield the beta-

152 rs does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for

153 rimary amine with an alpha-chiral tertiary N-alkyl group, in very good yields.

154 over 50% of the top-selling drugs contain N-alkyl groups, in which it is very challenging to selecti

155 ield and the polarizability constants of the alkyl groups increases the value of DeltaE(H)(double dag

156 occur with retention of configuration at the alkyl group, indicating that these reductive elimination

157 of the rotational isomers for the less bulky alkyl groups, indicating that the observed preference is

158 The alkyl groups introduced to carbohydrates by OH insertion

159 The cannabinoid alkyl group is a critical structural feature that govern

160 n of imide and amide bonds with a long-chain alkyl group is an attractive feature of this protocol.

161 Surprisingly, when the terminal end of the alkyl group is completely fluorinated, the balance tips

162 ter charge on the number-2 carbon unless the alkyl group is electron withdrawing.

163 athway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1 degree

164 2.0-7.4) and rabbit serum; furthermore, the alkyl group is possibly tuned to attain the desired phar

165 lsulfonyl-2'-biphenyl radicals, in which the alkyl group is primary, secondary, or tertiary, were gen

166 The alkyl group is the most common component of organic mole

167 der for N-alkyl aza-18-crown-6, in which the alkyl group is varied systematically from ethyl to n-dod

168 detailed structure of the attachment of the alkyl groups is not known, and it is proposed that it in

169 helicene inner rim and multiple solubilizing alkyl groups, is an attractive building block for long [

170 creased, the increased steric demands of the alkyl groups lead to liquidlike, disorganized alkyl laye

171 n of the R-group attached to the imide, with alkyl groups leading to low-spin diamagnetic (S=0) compl

172 The presence of electron-donating alkyl groups leads to isomerization of the corresponding

173 ility that, under appropriate circumstances, alkyl groups may undergo transfer from alkyl sulfate mon

174 e chain, combined with the presence of small alkyl groups (methyl or ethyl), bromine, or aryl moietie

175 ons and experimental evidence show that tert-alkyl groups migrate less effectively than other types o

176 g 3-alkoxy-2-halocyclohex-2-enones via a 1,4 alkyl group migration shown to be concerted and intramol

177 The second or alkyl group migration step has a much reduced activation

178 de both the addition step and the subsequent alkyl group migration step included ketones, acetone, t-

179 lex which breaks down in a rate-limiting 1,2-alkyl group migration with concomitant expulsion of a mo

180 opening, C-C bond rotation, and hydrogen or alkyl group migration) are required in any path.

181 e C-F bond to the OBF2 group and hydrogen or alkyl group migration, as first demonstrated in this wor

182 atures (solvent effects, concurrent hydrogen/alkyl group migration, carbocation substitution, benzyli

183 In reactions involving alkyl-group migration, intermolecular fluoride attack is

184 ene depends strongly on the structure of the alkyl group: n-alkyl approximately gamma-substituted >>

185 L1 was able to catalyze removal of different alkyl groups not only from N(6)-substituted purine or 2-

186 (wherein R could be methyl, ethyl, aryl, or alkyl group) obtained from synthetic procedures, and a s

187 lly slow migration of the beta-disubstituted alkyl group of 6 and not to differences in the equilibri

188 ing pantetheinate arm and the second for the alkyl group of one substrate.

189 bstituent of the substrate and the N-aryl or alkyl group of the ketone catalyst.

190 kylated species, arising by migration of the alkyl group of the N-alkyl moiety to the adjacent ring c

191 in the reaction with alkyl phosphite if the alkyl group of the selected substrates differ.

192 the halogenase SyrB2 that positioning of the alkyl group of the substrate away from the oxo/hydroxo l

193 t is suggested that the rearrangement of the alkyl group of thebaine is favored due to the formation

194 alpha-methylene carbon of 2-nitrobenzyl with alkyl groups of increasing size was discovered as a key

195 tution of the oxatriquinane ring system with alkyl groups of increasing steric demand pushes the C-O

196 e closely related area of dehydrogenation of alkyl groups of substrates containing heteroatoms.

197 Ion pairing, where the alkyl groups of the cation shield the meta C-H bonds in

198 enter that can be incorporated either in the alkyl groups of the dendron or in the triphenylene part

199 esents the number of methylenic units in the alkyl groups of the dendron, are reported.

200 imization of steric interactions between the alkyl groups of the diol on boron and the chiral phospho

201 that results from the interdigitation of the alkyl groups of the Janus dendrimer.

202 ity relationship study revealed that a small alkyl group on the alpha-position of the ether was requi

203 We report here the use of a 2-alkyl group on the imidazolo[1,2-a]pyrimidone core to ge

204 ion is slightly cationic with respect to the alkyl group on the Pt(111) surface, RC + H <--> {RC(delt

205 Alternatively, an alkyl group on the terminus of the allene undergoes cycl

206 The stabilizing and destabilizing effects of alkyl groups on an aromatic stacking interaction were ex

207 onstrates that, while the steric effect of o-alkyl groups on aryl substituents is highly localized to

208 ar columnar structure containing fluorinated alkyl groups on its periphery.

209 e strands by 29.5 to 37.4 kcal/mol; (2) that alkyl groups on the amino acid side chains favor helix f

210 of the transition state to hydrogenation of alkyl groups on the Pt(111) surface.

211 urther, we have correlated the effect of the alkyl groups on the structural order and orientation of

212 ibuted to nonbonded interactions between the alkyl groups on the substrates and the aryl groups of th

213 a larger cross-linking strategy, we appended alkyl groups onto the N2' position of 2'-amino-modified

214 intramolecular hydrogen abstraction from the alkyl group or addition to the solvent, benzene.

215 hydroxyethyl-guanine but does not remove the alkyl group or base and does not cleave the oligonucleot

216 using compounds bearing pyrenemethyl esters, alkyl groups, or a single pyrene substituent (3-6).

217 At higher concentrations, with longer N-alkyl groups, or in selected solvents, electronic excita

218 nsitivity, we installed an electron-donating alkyl group ortho to each phenol group.

219 selective functionalization of the tertiary alkyl group over primary and secondary C-H bonds.

220 ve differently, leading to detachment of the alkyl groups over the temperature range 180-500 degrees

221 s suggest that the highly electron-releasing alkyl group partially localizes the charge distribution

222 In a trialkylaluminum reagent, 1.1-1.4 alkyl groups per Al can be used to replace C-F bonds.

223 The bound alkyl groups point either into the back of the distal po

224 ger), which are dependent on the size of the alkyl group (polarizability) and the degree of fluorinat

225 in 78-98% yield depending on the halogen and alkyl group present.

226 y is ascribed to an inhibitory effect of the alkyl group projecting into the minor groove of double-s

227 lectivity of the reactions was high when the alkyl group R(2) was tertiary (tert-butyl), irrespective

228 , in which the steric difference between the alkyl groups R(1) and R(2) is sufficient.

229 d in one thiolate, transfer of the resulting alkyl group (R') to another thiolate, and subsequent eli

230 (independently) controlled by choice of the alkyl group (R).

231 a weaker, less specific interaction involves alkyl groups reaching into the broad prime-side protein

232 lts explain the overall patterns of rates of alkyl group removal versus AGT concentration and the eff

233 the benzo ring C, as well as H, methoxy, and alkyl groups replacing the hydroxyl group were synthesiz

234 F pretreatment was detected in soils where O-alkyl groups represented the major fraction of the soil

235 cs via attachment of a steroid or long chain alkyl group resulted in compounds with significantly imp

236 roperties of 1-methyladenine; removal of the alkyl group results in a >10-fold light-up signal.

237 more, the possibility of a [1,5] sigmatropic alkyl group shift of bicyclo[4.2.0]octa-2,4-diene system

238 iradical-mediated stepwise [1,5] sigmatropic alkyl group shift were shown to be comparable with the r

239 ese lesions is influenced by the size of the alkyl groups situated on the O (6) position of the guani

240 s were prepared to examine the effect of the alkyl group size, sulfur oxidation state, and phenyl rin

241 To probe the effect of minimizing the alkyl-group size on the chemistry of IPA/NO, we prepared

242 With a large alkyl group substituent, the vibrational energy of the a

243 Simple benzyl and other alkyl groups successfully activated the challenging pyri

244 However, the introduction of small alkyl groups, such as methyl, by this method has not bee

245 y was gained by replacing the ribose with an alkyl group that formed van der Waals interactions with

246 to an aromatic ring, a benzylic group, or an alkyl group that possesses a tertiary or quaternary carb

247 undertaken to determine the conformations of alkyl groups that are forced into small spaces.

248 e work is isonitriles bearing perfluorinated alkyl groups that enable the ready separation of such re

249 the size of the alkyl group, the smaller the alkyl group the greater the exothermicity.

250 hium surface is dependent on the size of the alkyl group, the smaller the alkyl group the greater the

251 Due to the presence of two alkyl groups, the metal-occupied d orbitals (particularl

252 Owing to the strong hydrophobicity of the alkyl groups, the resultant COFs show high crystallinity

253 This complex with cis boryl and alkyl groups then undergoes B-C bond formation by a seco

254 t dioxygenase superfamily, which removes the alkyl group through oxidation eliminating a methyl group

255 The rate of migration of an alkyl group to a coordinated alkene depends strongly on

256 alkyltransferases (MGMT) by transfer of the alkyl group to a cysteine residue in the active site.

257 ises from nucleophilic displacement at the O-alkyl group to afford the terminally functionalized N-su

258 ering from the circulation is removal of the alkyl group to generate an intermediate that can subsequ

259 he role of the dialkylzinc is not to add the alkyl group to the carbonyl but rather to transfer the a

260 ing of the epoxy bridge with transfer of one alkyl group to the intermediate cycloadduct.

261 nism involves transfer of hydrogen from an N-alkyl group to the keto oxygen to produce zwitterionic i

262 nism involves transfer of hydrogen from an N-alkyl group to the keto oxygen to produce zwitterionic i

263 p to the carbonyl but rather to transfer the alkyl group to titanium.

264 nsformations, including addition of aryl and alkyl groups to alpha,beta-unsaturated ketones and hydro

265 -1-ol (5), a Z-selective cuprate addition of alkyl groups to an alpha,beta-alkynyl ester intermediate

266 ine activators in the asymmetric addition of alkyl groups to benzaldehyde, we have observed enantiome

267 agent allows effective conjugate delivery of alkyl groups to cyclic and acyclic alkenenitriles.

268 the surface, results in hydrogenation of the alkyl groups to form alkanes, which then desorb into the

269 elopment of catalysts for dehydrogenation of alkyl groups to give the corresponding olefins could ope

270 challenge because of the propensity of these alkyl groups to isomerize under the reaction conditions.

271 mmetric addition of alkyl and functionalized alkyl groups to ketones under highly concentrated and so

272 cleophilic addition of propargylic and other alkyl groups to ketones, using easily accessible (poly)u

273 NA equilibrium binding molecules to transfer alkyl groups to specific positions on DNA is an approach

274 relationship studies revealed that attaching alkyl groups to the cyclohexyl ring significantly improv

275 Alkyllithium reagents may be used to attach alkyl groups to the sidewalls of fluoro nanotubes.

276 on, formally a 1,5 hydrogen shift from the N-alkyl groups to the vinyl position of a gold-coordinated

277 enabling technology for the mild transfer of alkyl groups to transition metal catalysts in cross-coup

278 rve as a competent replacement for Zn(II) in alkyl group transfer enzymes, turnover may be limited by

279 This method permits iterative alkyl group transfer from tertiary amines and demonstrat

280 ses a coordinated diisopropylzinc moiety for alkyl group transfer.

281 e studied, and CH-insertion into an adjacent alkyl group was found to be the dominant or exclusive pa

282 A selective transfer of alkyl groups was achieved in reactions with alkyl carbas

283 bstituted glycoluril subunits with different alkyl groups were designed, synthesized, and fully chara

284 tions of the small meta-alkyl and large para-alkyl groups were due to their similar distances and van

285 ms with different numbers of methyl and long alkyl groups were examined as positively charged heparin

286 trapeptides that possessed greater than nine alkyl groups were superior to alpha-MSH in terms of the

287 Balances with deuterated and non-deuterated alkyl groups were synthesized, and their intramolecular

288 ly, at the farther para-position, the larger alkyl groups were systematically more stabilizing with t

289 and tBu) and position (meta and para) of the alkyl groups were varied in a molecular balance model sy

290 d substrates, such as those bearing tertiary alkyl groups, were additions slower.

291 t (as well as an aldehyde derived from the O-alkyl group), whereas O-tert-butyl acetophenone oxime (4

292 r ion group can be prepared from halogenated alkyl groups which are also employed for the mass balanc

293 bonyl oxides with the syn-positioned methyl (alkyl) group, which is more favorable than isomerization

294 omain and show that the interaction of the N-alkyl group with a hydrophobic cage of the binding site

295 ing the H-transfer steps during reactions of alkyl groups with CO* to form longer-chain alkylidynes a

296 at the lipophilicities of perfluoroalkyl and alkyl groups with the same length are nearly identical a

297 e insensitive to the replacement of terminal alkyl groups with the terminal polar groups in this set.

298 ctra indicate slowed internal motions of the alkyl groups within the space.

299 ions, those forming a C-N bond at a tertiary alkyl group would be particularly valuable, because this

300 were examined using different sources of the alkyl group [ZnMe(2) or MeTi(O-i-Pr)(3)].