ライフサイエンスコーパス: alkylate

1 n-rich substituted benzenes are successfully alkylated.

2 diate catechol moiety that is subsequently O-alkylated.

3 zoic acids undergo a dearomatization to give alkylated 2,5-cyclohexadienyl ketoesters which are subje

4 utilizes 2-propargyloxypyridines to access N-alkylated 2-pyridone products derived from both 5-exo an

5 The same technology was used to alkylate a K18C mutant of histone H3.

6 KR12 alkylates adenine N3 at the target sequence, causing str

7 erapy with bortezomib, dexamethasone, and an alkylating agent (BDex+AA) is associated with improved b

8 t donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced

9 rgeting of KRAS mutant DNA using a synthetic alkylating agent (pyrrole-imidazole polyamide indole-sec

10 Compared with temozolomide, a clinical DNA-alkylating agent against glioma, 6OTD required lower con

11 alidomide, pomalidomide, daratumumab, and an alkylating agent and had disease refractory to at least

12 rate that ALX, through its dual action as an alkylating agent and topoisomerase inhibitor, represents

13 increase in mutations and sensitivity to an alkylating agent compared with the WT hMPG.

14 subsequent sarcoma among those who received alkylating agent doses in the third tertile (RR, 14.9; 9

15 rolidinone (NMP) established that the active alkylating agent is the azetidinium ion, 4, 4-azoniaspir

16 under basic conditions in the presence of an alkylating agent leads to atropselective O-alkylation wi

17 leotide resolution in yeast treated with the alkylating agent methyl methanesulfonate (MMS).

18 ild-type and Aag(-/-) cells treated with the alkylating agent methyl methanesulfonate (MMS).

19 e was enhanced upon DNA damage caused by the alkylating agent methyl methanesulfonate and that the re

20 s-link in vitro and in HeLa cells exposed to alkylating agent methylmethanesulfonate (MMS).

21 The trichloroacetimidate alkylating agent must be a stable cation precursor for t

22 man lymphoblastoid cell lines exposed to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (M

23 lowed by radiotherapy and treatment with the alkylating agent Temozolomide (TMZ), can extend patient

24 RvIII influences the sensitivity towards the alkylating agent temozolomide (TMZ).

25 nergistic cytotoxicity of treatment with the alkylating agent temozolomide in combination with the PA

26 y the proteasome inhibitor bortezomib or the alkylating agent temozolomide.

27 y radiotherapy and chemotherapy with the DNA alkylating agent temozolomide.

28 of the cobalt complex with 0.75 mol % of the alkylating agent to afford the desired products in up to

29 Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma

30 Temozolomide is a DNA-alkylating agent used to treat brain tumors, but resista

31 An isoxazole-based alkylating agent was developed to selectively alkylate c

32 TMZ is an alkylating agent which is water soluble.

33 le mice with melphalan (MLP), a bifunctional alkylating agent widely used in chemotherapy, induces DN

34 g with two alkylating agents (p=0.015 vs one alkylating agent) and last available pre-HSCT bilirubin

35 Moreover, the current generated by the alkylating agent, N-ethylmaleimide, occluded the effect

36 d after reduction of receptor reserve by the alkylating agent, phenoxybenzamine, as it reduced the ma

37 ent of polymers with methyl iodide (MeI), an alkylating agent, to convert polymer-bound tertiary amin

38 yl trifluoromethanesulfonate as a reversible alkylating agent.

39 verse nucleophiles using methylarenes as the alkylating agent.

40 icrotubule toxin and a duocarmycin-class DNA-alkylating agent.

41 ore as well as on the aromatic moiety of the alkylating agent.

42 ing regimen, with 73 also receiving a second alkylating agent.

43 The use of an alkene as the formal "alkylating" agent associated with the tolerance for nume

44 %) or in association with rituximab (21.1%), alkylating agents (36.8%) or a combination of cyclophosp

45 ies), including proteasome inhibitors (91%), alkylating agents (91%), autologous stem cell transplant

46 not significantly elevated after exposure to alkylating agents (hazard ratio, 1.27; 95% CI, 0.3 to 3.

47 multivariate analysis, conditioning with two alkylating agents (p=0.015 vs one alkylating agent) and

48 s been increasingly used in combination with alkylating agents and dexamethasone.

49 ive SCID suggest that minimizing exposure to alkylating agents and ionizing radiation is important fo

50 ne (1-MeA) is formed in DNA by reaction with alkylating agents and naturally occurring methyl halides

51 plausible cause-effect relationship between alkylating agents and PVOD.

52 ses and related quaternary ammonium salts as alkylating agents and singlet oxygen sensitizers.

53 5), and a dose response was observed between alkylating agents and SMN rate (RR, 1.2/5,000 mg/m(2); 9

54 Linear dose responses were seen between alkylating agents and SMN rates and between anthracyclin

55 specifically increases in response to S(N)2 alkylating agents and to a lower extent to S(N)1 alkylat

56 ng adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential expos

57 DNA-alkylating agents are commonly used to kill cancer cells

58 s in Diels-Alder reactions and electrophilic alkylating agents are described.

59 nt, testicular radiotherapy at any dose, and alkylating agents at cyclophosphamide equivalent doses o

60 N) or CB-839, hypersensitize cancer cells to alkylating agents both in vitro and in vivo.

61 te here that halogenated benzothiazine-based alkylating agents can be utilized to rapidly measure the

62 Alkylating agents can induce sustained drug-free remissi

63 rates for the activity of the major types of alkylating agents defined by their nucleophilic substitu

64 tissue extracts, and the efficiencies of the alkylating agents enable completion of all three labelin

65 Trichloroacetimidates are useful alkylating agents for aromatic amines, requiring only a

66 pated and unknown DNA adducts induced by DNA alkylating agents in biological samples.

67 Crick faces of nucleobases are accessible to alkylating agents in canonical dsDNA and that Hoogsteen

68 ), radiation dose-volume, anthracyclines and alkylating agents in non-chest irradiated survivors, and

69 ht alcohols such as ethanol could be used as alkylating agents in this methodology.

70 was observed among survivors not exposed to alkylating agents included in the CED (P > 0.29).

71 tidases and rapidly and selectively releases alkylating agents into tumor cells.

72 oselectivity of ambident nucleophiles toward alkylating agents is a fundamental problem in heterocycl

73 Exposure to high doses of alkylating agents is associated with increased risk of i

74 terocycles using allyl or benzyl alcohols as alkylating agents is presented.

75 DNA alkylating agents like nitrogen mustard (NM) are easily

76 itivity was not observed upon treatment with alkylating agents or UV irradiation.

77 Treatment with alkylating agents resulted in a hypermutator phenotype a

78 Monofunctional alkylating agents sensitize MGMT-deficient tumor cells t

79 Other alkylating agents such as cyclic alkanes, ethers, and al

80 ssion confers significant sensitivity to DNA alkylating agents such as temozolomide, providing a natu

81 red with different alcohols, and shown to be alkylating agents to a range of nucleophiles.

82 Here we show that the addition of common alkylating agents to growing cultures of Escherichia col

83 eloped a strategy to harness alkyl amines as alkylating agents via C-N bond activation.

84 Pre-BMT exposure to alkylating agents was associated with an increased risk

85 ge, testicular radiotherapy, and exposure to alkylating agents were associated with LCF, which was as

86 s to be employed as nonhazardous and greener alkylating agents with the formation of environmentally

87 no optimal approach that uses standard dose-alkylating agents without significant late effects.

88 s, a mild protocol using simple and abundant alkylating agents would have considerable use in the syn

89 an catalyze the hydrolysis of the potent DNA-alkylating agents yatakemycin (YTM) and CC-1065.

90 s-resistant drugs used for conditioning (eg, alkylating agents) could favor elimination of residual c

91 nerated by chain-terminating nucleosides and alkylating agents, and base oxidation both in the nuclea

92 r-stable and inexpensive nitroalkanes as the alkylating agents, and delivers synthetically versatile

93 s of mutations in yeast strains treated with alkylating agents, as well as in whole-exome and whole-g

94 repair kinetics and increases sensitivity to alkylating agents, but not other forms of DNA damage.

95 arious histologic subtypes more sensitive to alkylating agents, but they have no effect in wild-type

96 rimary tumor, therapeutic radiation, but not alkylating agents, confer an increased risk of SNs.

97 arly higher cumulative doses of platinum and alkylating agents, face increased SMN risk.

98 sm may not augment some regionally delivered alkylating agents, leading to a net increase in tumor si

99 agents in WM include monoclonal antibodies, alkylating agents, purine analogs, proteasome inhibitors

100 a young age, as well as pre-BMT exposure to alkylating agents, should inform breast cancer screening

101 proaches with alkyl halides or sulfonates as alkylating agents, the use of unactivated olefins for al

102 n histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series

103 oma cells to apoptosis following exposure to alkylating agents, while not affecting primary melanocyt

104 aggregates in the presence of oxidizing and alkylating agents.

105 reactive methyl donor, and by reaction with alkylating agents.

106 SCC foci formation and are hypersensitive to alkylating agents.

107 adaptive response to exogenous nucleic acid-alkylating agents.

108 ed upon exposure to endogenous and exogenous alkylating agents.

109 ation of ketones using simple alkenes as the alkylating agents.

110 foci specifically upon exposure of cells to alkylating agents.

111 nse of malignant melanoma cells treated with alkylating agents.

112 ator compound for many types of carcinogenic alkylating agents.

113 and can detect both gas- and solution-phase alkylating agents.

114 t severe, pulmonary vascular complication of alkylating agents.

115 s makes them significantly more sensitive to alkylating agents.

116 n spectra and signatures associated with DNA alkylating agents.

117 capacity to repair DNA damage induced by DNA alkylating agents.

118 primary aliphatic alcohols to be employed as alkylating agents.

119 protects cells from carcinogenic effects of alkylating agents; however, MGMT is silenced by promoter

120 The beta-alkylated alcohols, including cholesterol derivatives, a

121 asymmetric induction in the resulting alpha-alkylated aldehydes.

122 n air and odor qualities of guaiacol and its alkylated, alkenylated, and methoxylated derivatives wer

123 m boron to carbon to give the alpha-arylated/alkylated alkyl boronic esters.

124 leophilic addition to the N-C(O) moiety of N-alkylated amides, indicating the lack of n(N) to pi*(C=O

125 achieving controllable isotope-labeling in N-alkylated amines, we herein rationally design photocatal

126 rolysis to eliminate unmask redox reporter N-alkylated aminoferrocene (AAF) to monitor their response

127 able against protease degradation than its S-alkylated analog.

128 Compared with alkylated analogs of the same backbone, the triethylene

129 The enzyme can also alkylate and form all-carbon quaternary stereocenters on

130 ligand-free Tdp2 and Tdp2-DNA complexes with alkylated and abasic DNA that unveil a dynamic Tdp2 acti

131 rt in such transformations, with mixtures of alkylated and acylated products often being obtained, th

132 The -OH group was also alkylated and arylated through simple alkylation and Cha

133 Commercially available pyrazoles were alkylated and formylated in a regiocontrolled manner to

134 e/all-cis hydrogenation of a large series of alkylated and fused arene derivatives to the correspondi

135 silylmethyl-1,2-dihydropyridines can also be alkylated and subsequently desilylated to give endocycli

136 linked with increased susceptibility to DNA alkylating and inter-strand cross-linking agents.

137 lating agents and to a lower extent to S(N)1 alkylating and oxidative agents.

138 We extracted doses of 14 alkylating and similar DNA interstrand crosslinking drug

139 otein was then isolated, denatured, reduced, alkylated, and digested, and peptides were collected in

140 Purified ADAMTS13 was reduced, alkylated, and processed into peptides with either tryps

141 sfully applied in the preparation of various alkylated arene products with good to high yields.

142 s can directly react with NHP esters to form alkylated arenes.

143 is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent hel

144 nines are sulfoxides (aS4ox); a fully lysine-alkylated aS (acetyl-aS); and aS fibrils, testing their

145 thesis was the use of a Nicholas reaction to alkylate at C2, crafting a fused seven-membered ring tha

146 mo-3-methoxycyclohex-2-en-1-ones are readily alkylated at C-6 with reactive halides, and then treatme

147 thesis of a library of kanamycin B analogues alkylated at various hydroxyl groups.

148 nd Tpa1 has been proposed to directly repair alkylated bases as does the prototypical oxidative dealk

149 the base excision repair pathway by removing alkylated bases from DNA, and Tpa1 has been proposed to

150 cial nucleotides that specifically pair with alkylated bases offer a possible strategy for recognitio

151 pecificity of Mag1 and found that it excises alkylated bases that are known AlkB substrates.

152 nzyme that initiates base excision repair of alkylated bases, the flipped-out nucleotide is stabilize

153 the fuel-amended incubations confirmed that alkylated benzene hydrocarbons were metabolized via know

154 The process affords alkylated benzenesulfonamides poised for medicinal chemi

155 the synthesis of 46 tertiary amine-bearing N-alkylated benzo[d]imidazol-2(3H)-ones, imidazo[4,5-b]pyr

156 Alkylated benzosulfonamides are compounds of high import

157 anometallics containing beta-hydrogen afford alkylated benzosulfonamides in high to excellent yields.

158 p-free method that delivers C3-arylated and -alkylated benzothiophenes with complete regioselectivity

159 The more efficient N-alkylated BINAM-derived bisurea catalysts undergo urea i

160 Here, we show that boron-alkylated BODIPY photocages are capable of directly phot

161 , a known metabolite of diallyl monosulfide, alkylates both amines and thiols under physiologically r

162 primary aliphatic amines can be cleanly mono-alkylated by unactivated secondary alkyl iodides in the

163 ed into at least 24 isomer groups, including alkylated carbazoles, benzocarbazoles, and indenoquinoli

164 oward the mutagenic activity of the SN2-type alkylating carcinogens in cigarettes.

165 tary COMT mutants and can be used to prepare alkylated catechols, including ethyl vanillin.

166 Deuterium labeling studies suggest O-alkylated cation 16 does not directly isomerize to N-alk

167 d cation 16 does not directly isomerize to N-alkylated cation 18; instead, it reverts to vic-amidoest

168 lated with the number of carbons in the PFCA alkylated chain.

169 us agents such as reactive oxygen species or alkylating chemicals have the potential to profoundly af

170 DNA damage caused by alkylating chemicals induces an adaptive response in Esc

171 and tumors from patients exposed to SN2-type alkylating chemicals.

172 Alkylating chemotherapy is a central component of the ma

173 Despite therapy with surgery, radiation, and alkylating chemotherapy, most people have recurrence wit

174 ablish that TsrM and a triple-alanine mutant alkylate cob(II)alamin efficiently leading to the synthe

175 Alkylating commercial 2-pyridinesulfonylacetonitrile wit

176 Nitrogen mustards (NMs) are DNA-alkylating compounds that represent the earliest antican

177 xins, including UV-B and ionizing radiation, alkylating compounds, aristolochic acid, aflatoxin B1, a

178 xes with the Sierpinski triangular motif and alkylated corners undergo a second self-assembly event t

179 ived), several saturated and unsaturated C-4 alkylated coumarins were synthesized.

180 OA-NO(2) alkylated Cys-319 in RAD51, and this alkylation depended

181 g-resistant EGFR-L858R/T790M, and covalently alkylate Cys797.

182 lkylating agent was developed to selectively alkylate cysteine residues in situ.

183 To model endogenous alkylating damage, we determined the mutation spectrum c

184 s), alkylated PAHs, dibenzothiophene and its alkylated derivatives (DBTs).

185 ibuted in eight homologous series, including alkylated derivatives and two hitherto unknown series.

186 The ortho-alkylated derivatives of phenoxy products possessing the

187 lly controlled syntheses of their trans-mono-alkylated derivatives, subsequently enabling access to b

188 ehydes with diazo compounds leading to alpha-alkylated derivatives.

189 Although the photogenerated benzyl cations alkylated dG, dC, and dA, ICL assay with variation of DN

190 subjected to pronase treatment yielding the alkylated dipeptide hydroxyethylthioethyl-CysPro (HETE-C

191 The resultant alkylated disaccharides are quantifiable by LC-MS/MS.

192 hat colibactins form unsaturated imines that alkylate DNA by cyclopropane ring opening (2 --> 3).

193 This compound is believed to alkylate DNA on adenine residues(4,5) and induces double

194 corresponding pyridone derivatives, potently alkylate DNA.

195 egulating MGMT homeostasis and DNA repair of alkylated DNA adducts in cells.

196 otide and amino acid biosynthesis, repair of alkylated DNA and the synthesis of mechanosensitive ion

197 Our findings show that AAG-initiated BER at alkylated DNA bases induces sex-dependent RD primarily b

198 nsient kinetics of recognition and repair of alkylated DNA by AlkB.

199 s are among the most mutagenic and prevalent alkylated DNA lesions that are associated with cancer in

200 Among the alkylated DNA lesions, O(4)-alkylthymidine (O(4)-alkyldT

201 rified recombinant Tpa1 did not repair these alkylated DNA substrates, but it did exhibit the prolyl

202 g E. coli Our data establish that colibactin alkylates DNA with an unusual electrophilic cyclopropane

203 Although colibactin alkylates DNA, the molecular basis for cross-link format

204 Mechanistically, upon oxidative stress or alkylating DNA damage, PARP1 interacts with and attaches

205 rast, inhibition of PARP by PARPi attenuates alkylating DNA damage-induced EZH2 downregulation, there

206 oietic stem-cell transplantation, cumulative alkylating drug dose, and an interaction between age at

207 to these updated consensus recommendations, alkylating drugs (bendamustine, cyclophosphamide) and pr

208 Greater doses of contemporary alkylating drugs and cisplatin were associated with a de

209 g Rnf4 are hypersensitive to hyroxyurea, DNA alkylating drugs and DNA crosslinking agents, but this s

210 melanoma therapy with temozolomide and other alkylating drugs suggests a combination approach where c

211 contribute to resistance of melanomas to the alkylating drugs temozolomide, dacarbazine, and fotemust

212 gammaglobulinemia, conventional therapy with alkylating drugs, and recently, purine analogs and mAb-a

213 d with the sensitivity toward venetoclax and alkylating drugs.

214 sbauer spectroscopic studies reveal that the alkylated Fe has an unusually low isomer shift, which re

215 lusters undergo Fe-C bond homolysis when the alkylated Fe site has a suitable coordination number, th

216 lvement of Pol nu and Pol theta in bypassing alkylated guanine lesions in human cells.

217 nts, we present the discovery of a series of alkylating HDACi using a pharmacophore-linking strategy.

218 Application of the alkylated hepcidin assay to 70 clinical plasma samples (

219 sults represent the first application of the alkylated hepcidin assay to clinical samples and demonst

220 Regioselectively C5-alkylated imidazoheterocycles were synthesized in good y

221 ameliorating the efficacy of the most common alkylating immunomodulatory compound.

222 ar complex under mild conditions to afford N-alkylated indole derivatives in good yield (up to 86 %)

223 eductase domain, which chemoselectively C(3)-alkylates indoles with up to 470 turnovers per minute an

224 DNA crosslinking agent based on a novel DNA-alkylating moiety.

225 rial AlkC and AlkD are specific for cationic alkylated nucleobases and have a distinctive HEAT-like r

226 for the absence of oxidative dealkylation of alkylated nucleobases in budding yeast.

227 ent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and RNA as part of the adap

228 These foci associate with alkylated nucleotides, and coincide spatially with elong

229 (phenylselanyl)methyl]pyrrolidine, which was alkylated on nitrogen with 2-bromo-1-(4-methoxyphenyl)et

230 on of primary amines into their respective N-alkylated or N-arylated pyridinium salts.

231 tes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been i

232 s serve the dual role of oxidants as well as alkylating or arylating agents.

233 articularly at purines and various oxidized, alkylated, or otherwise damaged nucleobases.

234 d pyridinium moieties by the corresponding N-alkylated-ortho,para-pyrimidinium counterparts.

235 discriminate sources of naturally occurring alkylated PAHs (fossil and modern biomass).

236 The sum of 50 common PAHs and alkylated PAHs (tPAH50) measured by gas chromatography/t

237 ignificant exponential declines were for the alkylated PAHs and DBTs and attributed to their associat

238 Profiles of alkylated PAHs, and heteroatomic (N, O, S) PACs enabled

239 for polycyclic aromatic hydrocarbons (PAHs), alkylated PAHs, dibenzothiophene and its alkylated deriv

240 phase combined with sequencing of the fully alkylated peptide by tandem mass spectrometry.

241 ckbone with helicoidal conformation, and its alkylated peptide side chains are structurally identical

242 s in Ugi and Passerini reactions to afford N-alkylated peptides and depsipeptides, respectively, foll

243 y mixing one-dimensional assemblies of small alkylated peptides bearing opposite charge and varying i

244 Importantly, the nitro-alkylated peptides provide a new handle for site-selecti

245 The ortho-alkylated phenoxypyridine possessing ester functionality

246 , respectively, to investigate the effect of alkylated pi-spacer on dye aggregation on the TiO2 surfa

247 Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fu

248 activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill stud

249 e synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hyb

250 Although concentrations of alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs)

251 cruises and were measured for 50 parent and alkylated polycyclic aromatic hydrocarbons (PAHs).

252 Commonly monitored aromatics (parent and alkylated-polycyclic aromatic hydrocarbons and dibenzoth

253 Diversification of alkylated product and late-stage functionalization of ke

254 were converted into the corresponding alpha-alkylated products in good yields.

255 ctivity with good to excellent yields of the alkylated products under mild reaction conditions are im

256 th potent antimalarial activity were able to alkylate protein target(s) within the asexual erythrocyt

257 iazolo[5,4-d]thiazole heterocycle allows the alkylated pyridinium groups to remain planar, strongly a

258 ed through the replacement of conventional N-alkylated pyridinium moieties by the corresponding N-alk

259 ate scope encompasses a variety of N-H and N-alkylated pyridobenzazepine variants with yields up to 9

260 ated intermediates provides a variety of C-2 alkylated pyrrolidines.

261 cation from clinical samples that uses fully alkylated rather than intact hepcidin as the internal st

262 Addition of two equivalents of an alkylating reagent to UO2 X2 (L)2 (X=Cl, Br, I, OTf; L=t

263 The alkylating reagent, N-(phenylseleno)phthalimide (NPSP),

264 s polymerization (ROMP) for use as efficient alkylating reagents is reported.

265 suggests a kinetic anionic activation of the alkylating reagents occurs, favoring nucleophilic additi

266 ha-1 degrees and alpha-2 degrees amines into alkylating reagents via Katritzky pyridinium salts.

267 icable use of unactivated alcohols as latent alkylating reagents, achieved via the successful merger

268 y available uranyl salts, silyl halides, and alkylating reagents.

269 ass, such as lignocellulose, are employed as alkylating reagents.

270 pecific quantitative approach integrating an alkylating resin-assisted capture and mass spectrometry-

271 TMO alkylates RNA at high levels in seconds, and thereby ena

272 The reaction works with several O-alkylated salicylaldehydes and amino functionalized thia

273 omiscuity toward hydroxyanthraquinones and S-alkylated SAM analogues and catalyzes efficient installa

274 he rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated i

275 alyzed decarboxylation, provides access to N-alkylated secondary and tertiary anilines and N-heterocy

276 thesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) - (EtO

277 C bond and the localization of Fe(3+) at the alkylated site in the solid state.

278 the pathogen Brucella abortus does encounter alkylating stress during the first hours of macrophage i

279 ar pathogenic bacteria have to cope with DNA alkylating stress within host cells.

280 Herein 64 examples of beta-alkylated styrene derivatives, synthesized through the r

281 Perfluorinated alkylate substances (PFASs) are widely used and have res

282 Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower ser

283 Perfluorinated alkylated substances (PFASs) are today considered persis

284 genated benzothiazine probes to sequentially alkylate sulfenic acids and then free thiols and, finall

285 probes, we define an ART proteome that shows alkylated targets in the glycolytic, hemoglobin degradat

286 t diazo compounds can be used to selectively alkylate the 5'-phosphate of ribo(oligo)nucleotides to g

287 e designed to retain biological activity and alkylate the molecular target(s) of Plasmodium falciparu

288 ream inhibitor of NF-kappaB degradation, (b) alkylated the NF-kappaB RelA protein to prevent DNA bind

289 dification is removed through catalysis; and alkylating the cysteine blocks activity.

290 This allowed the alkylated thiol-containing and UV-reduced cysteine-conta

291 rise to alkylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be p

292 O(2)- and O(4)-alkylated thymidine lesions are known to be poorly repai

293 e the first structural characterization of N-alkylated twisted amides prepared directly by N-alkylati

294 RNA can also be alkylated upon exposure to endogenous and exogenous alky

295 Here we quantify interactions of urea, alkylated ureas, and other amides by osmometry and amide

296 [4]arene, prepared on a multigram scale, was alkylated using the reaction conditions well known from

297 The alkylating warhead of the pancreatic cancer drug strepto

298 Less nucleophilic C1 carbon was also alkylated when C3-substituted indolizines were employed

299 Specifically, N-arylpyrroles were alkylated with N-acryloyl-1H-pyrazole electrophiles in u

300 ers, can be efficiently and regioselectively alkylated with very hindered C-electrophiles, such as ne