ライフサイエンスコーパス: alkylation

1 folding these proteins through reduction and alkylation.

2 ptane core, followed by a subsequent nitrile alkylation.

3 iants to identify improved catalysts for C-H alkylation.

4 late geometry, while removing the issue of O-alkylation.

5 on followed by intramolecular Friedel-Crafts alkylation.

6 mical damage to RNA, including oxidation and alkylation.

7 excellent yield by a mild Fe-catalyzed thiol alkylation.

8 t extract (PE) was modified by reduction and alkylation.

9 h a lithium amide reagent directs asymmetric alkylation.

10 also applicable to secondary C(sp(3))-H bond alkylation.

11 d by a one-step denaturation, reduction, and alkylation.

12 atropisomeric biaryls by a cation-directed O-alkylation.

13 e, becoming more unfavorable with increasing alkylation.

14 es in the observed regioselectivity during N-alkylation.

15 quence, as we proposed in the case of indole alkylation.

16 a radical based mechanism for the selective alkylation.

17 e cooperative isothiourea/Pd catalyzed alpha-alkylation.

18 in the aggregate structure and intervening O-alkylations.

19 carbon bond formation reactions, i.e., alpha-alkylations.

20 is demonstrated for both linear and branched alkylations.

21 onalization of enaminone precursors, such as alkylation; 1,2- 1,3-, or 1,4-addition; and C-O bond for

22 ining heterocycles has been achieved through alkylation/acylation of 2-hydroxyphenyl-substituted para

23 However, whether alkylation affects cellular metabolism in the absence of

24 Indeed, the addition of alkylation agents was found to robustly activate the tra

25 of cyclic ketones with simple alkenes as the alkylation agents.

26 ar to the genetically encoded mutations, the alkylation also induces a conversion of methionine resid

27 This alkylation also occurs with neurotransmitters, suggestin

28 The alkylation also proceeds with other conjugated systems s

29 alladium(II) complexes, demonstrating that N-alkylation alters the metalation properties for these ca

30 in five steps via an enantioselective ketone alkylation and a diastereoselective pinacol cyclization.

31 r the surface modification of NCNDs, such as alkylation and amidation reactions.

32 n metalation to Ni complexes, regioselective alkylation and arylation of olefins is possible.

33 s also alkylated and arylated through simple alkylation and Chan-Lam reaction, respectively.

34 w how RNA Pol II copes with minor-groove DNA alkylation and establishes a mechanism for drug resistan

35 substituted oxindoles are produced via a C-H alkylation and intramolecular oxidative cyclization sequ

36 trol are activated in response to nucleobase alkylation and oxidation.

37 often are non-selective and suffer from over-alkylation and reduction of carbonyl compounds to the co

38 or the suppression of epimerization in the O-alkylation and reductive amination steps.

39 ctivating the primary amino functions toward alkylation and secondary amino function protection.

40 Other chemodivergent reactions such as alkylations and allylations under transition metal catal

41 n broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosyntheti

42 alyzed regioselective N(2)-methylation, N(2)-alkylation, and N(2)-arylation of tetrazoles have been a

43 ube, the steps of protein reduction, protein alkylation, and protein digestion of complex proteomes a

44 ew tensor with three new modes: aromaticity, alkylation, and sample.

45 omaticity, number of carbon atoms related to alkylation, and sample.

46 the impacts of amino acid configurations, N-alkylation, and steric bulk on both synthetic success an

47 he mechanisms of Ni-catalyzed C-H arylation, alkylation, and sulfenylation with N,N-bidentate directi

48 tical compounds, which varied in size, group alkylation, and/or polar substituents, demonstrated simi

49 s substrates in a Pd/NBE mediated sequential alkylation-arylation, commonly known as a Catellani reac

50 versions based on C-H activation, heteroatom alkylation/arylation and annulation processes, in which

51 of and challenges associated with selective alkylation at a sp(3) carbon(1,2).

52 This results in alkylation at the C-4 position of indole derivatives exc

53 top1top2 mutant plants using a differential alkylation-based enrichment technique coupled with label

54 or five different photoredox reactions (beta-alkylation, beta-aminoalkylation, dehalogenation, amine

55 Protein and DNA alkylation by endogenously produced electrophiles is ass

56 chemical modifications, arising from protein alkylation by iodoacetamide, which is commonly used in t

57 yne formation through 1,2-elimination, their alkylation by Schiff bases through 1,2-addition, 1,4-int

58 and guanine bases of DNA are susceptible to alkylation by the aldehyde products of lipid peroxidatio

59 The N-cyclization-alkylation cascade introduces a novel retrosynthetic dis

60 e an improved strategy based on differential alkylation coupled to MS, assisted by zinc probe monitor

61 air of methyl methanesulfonate (MMS)-induced alkylation damage in DNA involves Mag1 but not Tpa1.

62 erevisiae) have both been reported to repair alkylation damage in DNA.

63 DNA alkylation damage is repaired by base excision repair (B

64 licase that provides single-stranded DNA for alkylation damage repair by the alpha-ketoglutarate-depe

65 DNA, it is commonly assumed that deleterious alkylation damage to the Watson-Crick faces of nucleobas

66 ng the factors that regulate the response to alkylation damage, NF-kappaB acts to both promote and bl

67 an expanded role of yeast Mag1 in repair of alkylation damage.

68 ivity of Mag1-deficient S. cerevisiae toward alkylation damage.

69 the potential of the direct decarboxylative alkylation (DDA) reaction.

70 nated samples according to the hydrocarbons' alkylation degree, whereas our SFC method provided an el

71 A-NO(2) alkylated Cys-319 in RAD51, and this alkylation depended on the Michael acceptor properties o

72 serves as a powerful alternative to enolate alkylation, enabling the direct coupling of ketones with

73 including C(2)/ C(3) regioselective pyrrole alkylation, enantioselective indole alkylation with ethy

74 This NP-catalyzed electrochemical allylic alkylation expands the synthetic scope of cross-coupling

75 of diazo compounds proceeds via selective S-alkylation followed by intramolecular N-cyclization enab

76 (RNA-seq) method, SLAMseq (thiol (SH)-linked alkylation for the metabolic sequencing of RNA).

77 s were also accessed via glycine Schiff base alkylation, further increasing the scope of Calpha-subst

78 ity platform has been applied to deaminative alkylation (Giese), allylation, vinylation, alkynylation

79 Initial success on distal alkylation has also been achieved using MeI and methyl b

80 g agents, the use of unactivated olefins for alkylations has become attractive from both cost and sus

81 ewis base/transition-metal catalyzed allylic alkylation/Hofmann rearrangement strategy.

82 Here we show how different forms of DNA alkylation impair transcription by RNA Pol II in cells a

83 pha-Brook rearrangement and a Friedel-Crafts alkylation in a one-pot procedure.

84 ryl and alkyl sulfonamides undergoes mono- N-alkylation in excellent isolated yields (32 examples, 85

85 idative stress, nitrogen starvation, and DNA alkylation in Saccharomyces cerevisiae cells.

86 s of brazilin have involved a Friedel-Crafts alkylation in the key carbon-carbon bond forming events.

87 igned for catalyzing electrochemical allylic alkylation in water/isopropanol (1:1 v/v) and 0.2 m KHCO

88 Rate studies of alkylations indicate that the aging of the aggregates ca

89 ugh Aag(-/-) cells display similar levels of alkylation-induced DNA breaks as wild type, PARP-1 activ

90 genesis and indicate the pervasive nature of alkylation-induced mutagenesis in cancers.

91 itiating DNA glycosylase AAG did not exhibit alkylation-induced necroptosis or inflammation.

92 a-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis, but its function and substr

93 is assumed to be the main mechanism of this alkylation-induced photoreceptor (PR) cell death in RD.

94 Female mice were partially protected from alkylation-induced RD, showing reduced necroptosis and i

95 mmed cell death process) and inflammation in alkylation-induced RD.

96 The alkylation is accomplished using chiral lithium amides a

97 Regioselective alpha'-alkylation is achieved for substrates with existing alph

98 in the inner-sphere asymmetric Tsuji allylic alkylation is C-C bond formation through a seven-membere

99 The Friedel-Crafts alkylation is commonly used in organic synthesis to form

100 Alkylation is one of the most ubiquitous forms of DNA le

101 metal cooperative catalysis mode, the alpha-alkylation is realized in an atom- and step-economic man

102 -opening, vesidryl synthesis, Friedel-Crafts alkylation, jasminaldehyde synthesis, m-xylene isomeriza

103 igrone A has been achieved using an umpolung alkylation-lactonization to assemble an isochromanone fr

104 ed in palladium-catalyzed asymmetric allylic alkylations, leading to enantioselectivities from 91% (R

105 ent reaction pathways toward aromaticity and alkylation levels evolutions.

106 ular classes in polarity, glycosylation, and alkylation, manually annotated for substance classes, th

107 Rate studies show an alkylation mechanism involving an intervening tetramer-m

108 To further probe alkylation mechanisms, we directly monitored protein add

109 We also demonstrated that the selective O-alkylation method could significantly improve the effici

110 Herein, a counterion-mediated O-alkylation method for the generation of atropisomeric am

111 This new alkylation method is fast and straightforward and allows

112 This represents one of the mildest alkylation methods for the systematic modification of ca

113 ors identified signatures highly specific to alkylation mutagenesis and indicate the pervasive nature

114 Alkylation occurs at the carbon atom adjacent to boron,

115 tative strategy for determining how much DNA alkylation occurs in a sequence of interest.

116 lt alkyls occurred under an N(2) atmosphere, alkylation of (R,R)-((iPr) DuPhos)Co(CO)(2) Cl in the pr

117 Direct enantioselective alpha-alkylation of 2-alkylpyridines provides access to chiral

118 azoles analogues has been achieved involving alkylation of 2-bromo-1-(phenylsulfonylmethyl)arene/hete

119 Ru-catalyzed alkylation of 3-formylbenzofuran with acrylates and acry

120 with a 400-fold improvement in activity for alkylation of 3-substituted oxindoles and the ability to

121 of asymmetry-amplifying autocatalysis in the alkylation of 5-(trimethylsilylethynyl)pyridine-3-carbal

122 The cobalt(III)-catalyzed C(sp(3))-H bond alkylation of 8-methyl quinoline with maleimides is repo

123 The sp(3) C-H alkylation of 9H-fluorene using alcohol and a Ru catalys

124 l acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporat

125 Chemists have been interested in the N-alkylation of a peptide bond because such a modification

126 e synthesis of cediranib, AZD2171, 1, is the alkylation of a phenol with an alkyl halide to generate

127 yl phthalates was derived from the reductive alkylation of a phthalate diester with hindered halides

128 Alkylation of a steroid hormone can be achieved.

129 Specifically, we demonstrate alpha-alkylation of aldehydes with a turnover number (TON) of

130 t a directed enantio- and diastereoselective alkylation of aldehydes with simple olefins to selective

131 idation of arylboronic acids, and asymmetric alkylation of aldehydes, 8-mercaptoquinoline-Pt(II) comp

132 ic substitution reaction, the selective mono-alkylation of aliphatic amines by unactivated, hindered

133 cycle for asymmetric decarboxylative allylic alkylation of allyl beta-ketoesters.

134 rogen atom transfer) catalyzed arylation and alkylation of alpha-amino C(sp3)-H bonds developed by Ma

135 ckel cycle indicated that both arylation and alkylation of alpha-amino C(sp3)-H bonds occurs via the

136 catalyzed decarboxylative asymmetric allylic alkylation of alpha-nitro allyl esters to afford acyclic

137 The alkylation of amines by alcohols and related C-C couplin

138 for the synthesis of alpha-chiral amines by alkylation of amines with alcohols in the absence of any

139 The alkylation of amines with either alcohols or carboxylic

140 Although the alkylation of an amine by an alkyl halide serves as a "t

141 nging palladium-catalyzed asymmetric allylic alkylation of an N-alkyl-alpha,beta-unsaturated lactam.

142 The para-selective C-H alkylation of aniline derivatives furnished with a pyrim

143 Herein we report on the alkylation of archetypal ambident 1,2,4-triazole, 1,2,3-

144 A new protocol for the alkylation of aromatic amines has been described using a

145 y displays a broad substrate scope for the N-alkylation of aromatic and heteroaromatic amines using a

146 The C-H alkylation of arylacetamides with activated alkenes such

147 dimeric iridium(III) complex catalyzed alpha-alkylation of arylacetonitriles using secondary alcohols

148 t as recyclable catalysts in the reductive N-alkylation of arylamines under mild conditions and at ex

149 o be applicable to the C2-selective branched alkylation of azabenzimidazoles.

150 lladium(II)-catalyzed enantioselective alpha-alkylation of azlactones with nonconjugated alkenes is d

151 or the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors.

152 This is disclosed for the C-H bond alkylation of biologically relevant cyclic amides with m

153 Reductive alkylation of bis-tosyl-cystamine was integrated into th

154 e)](2)/[Cp*Rh(III)Cl(2)](2)-catalyzed direct alkylation of C(sp(3))-H bond of 8-methylquinolines with

155 Herein we present a Ni-catalyzed alkylation of C-SMe with alkyl bromides for the decorati

156 d for the site-selective and stereoselective alkylation of carbohydrate hydroxyl groups via Rh(II)-ca

157 ild, photoinduced decarboxylative 4-position alkylation of coumarins has been reported.

158 termolecular direct branched-selective alpha-alkylation of cyclic ketones with simple alkenes as the

159 ides and proteins through site-selective bis-alkylation of cysteine residues present as disulfides un

160 we present a dual catalytic system for the N-alkylation of diverse aromatic carbocyclic and heterocyc

161 a mode of RNA Pol II stalling that is due to alkylation of DNA in the minor groove.

162 alyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl

163 fers a versatile methodology for the radical alkylation of electron-deficient alkenes.

164 for achieving chemo- and enantioselective C-alkylation of electronically challenging benzylic nitron

165 Alkylation of guanine bases in DNA is detrimental to cel

166 A Mn(II)-catalyzed efficient C-H alkylation of imidazoheterocycles and N-heteroarenes wit

167 work, we present the first chemoselective N-alkylation of indoles in aqueous microdroplets via a thr

168 n the mechanistically related Friedel-Crafts alkylation of indoles, but to our surprise, almost null

169 nvestigate the kinetics and mechanism of the alkylation of indolphenol, 2, 4-[(4-fluoro-2-methyl-1 H-

170 Although the alpha-alkylation of ketones has already been established, the

171 logous pronucleophile in the allylic-allylic alkylation of Morita-Baylis-Hillman (MBH) carbonates is

172 A general and chemoselective catalytic alkylation of nitriles using a homogeneous nonprecious m

173 The alpha-alkylation of nitriles with primary alcohols to selectiv

174 A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is des

175 s, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodide

176 Oxidation and alkylation of nucleobases are known to disrupt their bas

177 orane amino acid derivatives was achieved by alkylation of phenylphosphine borane with gamma-iodo-alp

178 el asymmetric phase-transfer-catalyzed gamma-alkylation of phthalide 3-carboxylic esters has been dev

179 The results demonstrate that core alkylation of porphyrinoids greatly alters the reactivit

180 ased catalytic approach for chemoselective N-alkylation of primary and secondary aromatic amines and

181 The intermolecular alkylation of pyridine units with simple alkenes has bee

182 Diisopropylzinc alkylation of pyrimidine aldehydes-the Soai reaction, wi

183 Of note, OA-NO(2) alkylation of RAD51 inhibited its binding to ssDNA.

184 scribed for Ir(I)-catalyzed alpha-C(sp(3))-H alkylation of saturated azacycles using readily availabl

185 ylic wingtips efficiently catalyzed the beta-alkylation of secondary alcohols with primary alcohols a

186 trated turnover numbers of 940 000 (for beta-alkylation of secondary alcohols with primary alcohols b

187 of alpha,alpha-disubstituted ketones via the alkylation of secondary alcohols with primary alcohols i

188 enzymatic strategy to enhance the scope of C-alkylation of small molecules via the in situ formation

189 s for palladium-catalyzed beta-arylation and alkylation of sp(3) C-H bonds in carboxylic acid derivat

190 o-, regio- and chemoselective intermolecular alkylation of sp(3) C-H bonds through carbene C-H insert

191 An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed.

192 present an operationally simple catalytic N-alkylation of sulfonamides using commercially available

193 er pre-equilibrium followed by rate-limiting alkylation of tetrasolvated monomers.

194 stereospecific, biocatalytic Friedel-Crafts alkylation of the 2-position of resorcinol rings using t

195 By convenient alkylation of the 5-sulfanyl group, we synthesized 3-iso

196 in a [3 + 2] cycloaddition accompanied by an alkylation of the enoate substituent.

197 unable to catalyse subsequent Friedel-Crafts alkylation of the flavin C6, but can be rescued by addit

198 A synthases (HCSs) are responsible for beta-alkylation of the growing polyketide intermediates in AT

199 Upon O-alkylation of the H-bond donor, the barrier to rotation

200 e intermediates, but they could be caught by alkylation of the isomerization active thiol.

201 h the largely ignored experimental fact that alkylation of the N-H functionality within M/NH bifuncti

202 onalized by tin-lithium exchange followed by alkylation of the newly formed tertiary carbanion.

203 SH in the presence of InCl(3), followed by O-alkylation of the resulting alcohol.

204 rox (PPh(2)), to palladium catalyzed allylic alkylation of trans-1,3-diphenylallyl acetate revealed a

205 The direct, site-selective alkylation of unactivated C(sp(3))-H bonds in organic su

206 A catalytic deaminative alkylation of unactivated olefins is described.

207 An efficient ortho-C-alkylation of unprotected anilines with a variety of sty

208 odology for ambident control in the direct N-alkylation of unsubstituted triazole anions.

209 is able to catalyze chemoselective reductive alkylation of various functionalized amines with functio

210 Cesium carbonate-mediated anomeric O-alkylation of various protected 2-azido-2-deoxy-d-mannos

211 The synthesis takes advantage of sequential alkylations of an indole core to rapidly construct the p

212 chromium-catalyzed highly diastereoselective alkylations of arylmagnesium halides with cyclohexyl iod

213 Catalytic activities for Friedel-Crafts alkylations of indoles with trans-beta-nitrostyrenes wer

214 tants were determined for the Friedel-Crafts alkylations of N-methylindole with trans-beta-nitrostyre

215 ond formation, contrary to the already known alkylations of such ambident nucleophiles, is mostly tri

216 the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting

217 ated the effect of OA-NO(2)-mediated Cys-319 alkylation on ABL1 binding and found that OA-NO(2) inhib

218 ogate, which can be synthesized using robust alkylation or alkenylation reactions, and thus obviates

219 O(2)-alkylation or arylation of diazeniumdiolates form stable

220 attack by acetamide to form cation 16 via O-alkylation or by reversible ether formation.

221 ycles or cyclic alkenes to obtain C(sp(2))-H alkylation or cyclopropane products are valuable transfo

222 By combining an initial acylation, alkylation, or glycosylation step with an amine-mediated

223 as previous studies have shown that Heck or alkylation pathways are preferred when stronger-coordina

224 lopment of a Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) of acyclic alpha-hydroxyketones usin

225 atalytic, decarboxylative asymmetric allylic alkylation performed on an alpha-silylated substrate, to

226 N-monosubstituted acrylamides, the branched alkylation proceeded with intramolecular aldehyde-amide

227 The C-H alkylation proceeds efficiently using diverse hydrocarbo

228 he selectivity for a branched alpha-C(sp(3))-alkylation product is also observed for the first time w

229 h methyl acrylate, the intermediate branched alkylation product underwent cycloannulation with anothe

230 e ligand facilitate the formation of allylic alkylation products in high branch selectivity.

231 formation of allenyl electrophiles affords C-alkylation products in high regio-, diastereo-, and enan

232 or the generation of enantioenriched allylic alkylation products in the presence of catalytic copper

233 wever, in all of the cases, the intermediate alkylation products seem to undergo further reactions, e

234 onate, deformylation of the initially formed alkylation products was observed.

235 esence of Pd(0) and chiral ligands to afford alkylation products with regio- and enantioselectivity.

236 reagents with a catalyst yield exclusively C-alkylation products.

237 procedure consisting of an initial reductive alkylation promoted by alkaline metals, followed by a re

238 photoredox-catalyzed radical/polar crossover alkylation protocols with DELs.

239 the molecular determinants that influence C-alkylation provides the basis to develop a late-stage en

240 An intramolecular arene alkylation reaction has been developed using the organic

241 ped this concept by performing the reductive alkylation reaction in monolayer CVD graphene films.

242 This alkylation reaction uses naturally abundant alcohols and

243 This alkylation reaction was also performed without any preli

244 ophiles in a Pd-catalyzed asymmetric allylic alkylation reaction, furnishing phosphinates with high e

245 to beta-sulfonium ions via an intramolecular alkylation reaction, leading to highly alpha-selective g

246 It involves an S-alkylation reaction, promoted by activated molecular sie

247 ns of the decarboxylative asymmetric allylic alkylation reaction.

248 cocatalyst for site- and stereoselective C-H alkylation reactions of carbohydrates under photoredox c

249 UCs as catalysts for synthetically important alkylation reactions under phase-transfer conditions.

250 In addition, tandem semihydrogenation-alkylation reactions were demonstrated, with potential a

251 N-alkylation reactions were used as the test case due to t

252 /carboxylic acid reductase (CAR) to affect N-alkylation reactions.

253 tative monitoring of catalytic oxidation and alkylation reactions.

254 obes offer advantages over existing cysteine alkylation reagents, including accelerated reaction rate

255 eriments revealed that AlkB is a much faster alkylation repair enzyme than previously reported and th

256 This expanded role of Mag1, as compared with alkylation repair glycosylases in other organisms, could

257 f highly regioselective ion pairing, exhibit alkylation selectivities that are completely inverted (1

258 mutation loads associated with the SN2-type alkylation signature were higher in lung tumors from smo

259 oducts indicated that dGs were the preferred alkylation sites in DNA for the benzyl cations produced

260 kflow was easily implemented by adapting the alkylation step in a conventional workflow and was direc

261 OSDAs for EMM-17 are prepared in one simple alkylation step, making EMM-17 an easy to prepare, highl

262 nthesized via an aminocatalyzed annulation/O-alkylation strategy starting from simple substrates.

263 romoethylamine was applied as an alternative alkylation strategy to introduce artificial tryptic clea

264 d through pai-conjugation extension and an N-alkylation strategy.

265 ed positions in VcINDY using a site-specific alkylation strategy.

266 factor of these enzymes to mediate sp(3) C-H alkylation suggests that diverse haem proteins could ser

267 ier work on photoinduced enantioconvergent N-alkylation, supporting the premise that this important c

268 Complementary to classical alkylation techniques, this reaction utilizes Umpolung c

269 we describe a catalytic, intermolecular C-H alkylation that circumvents such reactive species via a

270 important role in the metabolic response to alkylation that could be exploited in the treatment of c

271 screening assay based on 1-methylindole C(3)-alkylation that enabled rapid analysis of thousands of P

272 Additional examples, including double alkylation, the installation of metabolically robust deu

273 e catalyst enables sequential one-pot double alkylation to bis-hetero aryl ketones using two differen

274 DNA adduct, advancing tools for linking DNA alkylation to mutagenesis and for detecting DNA adducts

275 this radical by a Ni catalyst allows distal alkylation to occur in good yield and excellent selectiv

276 We also confirmed that without alkylation, Trx-reduced interchain disulfide bonds reoxi

277 port a Cu-catalyzed enantioselective allylic alkylation using a gamma-butyrolactone-derived silyl ket

278 We subsequently used this optimized alkylation variant for parallel evolution toward more ch

279 st example of a ruthenium-catalyzed C-H bond alkylation via six-membered ruthenacycles is presented.

280 gh-valent iron oxos and nitrenes, C(sp(3))-H alkylations via isoelectronic iron carbene intermediates

281 e cooperative isothiourea/Ir catalyzed alpha-alkylation was overcome by appropriate substituent choic

282 iometrically generated metallacycles undergo alkylation, we report a catalytic, alkylative [3 + 2] cy

283 The alpha-alkylations were efficiently performed at 120 degrees C

284 rotecting N(1) encouraged evolution toward C-alkylation, which persisted when protection was removed.

285 rovides access to the benefits of backbone N-alkylation, while preserving the ability for on-demand d

286 tion of a simple ketone oxidant, followed by alkylation with a beta-ketoacid under mild conditions to

287 Alkylation with a sterically bulky cyclopropylmethyl-der

288 the mode of action of the iron-catalyzed C-H alkylation with allenes.

289 Rate and computational studies of an alkylation with allyl bromide implicate a bis-diamine-ch

290 y through catalytic asymmetric fluoroenolate alkylation with allylic acetates.

291 ed acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alcoh

292 pyrrole alkylation, enantioselective indole alkylation with ethyl 2-diazopropanoate, and cyclic inte

293 pared on multigram scale by double reductive alkylation with melamine acetaldehyde, resulting in a te

294 ed reaction rate decrease for benzyl alcohol alkylation with mesitylene, a reaction that cannot take

295 ursors by flow sequences featuring base-free alkylation with methyl bromoacetate in DMF, saponificati

296 Branched alkylation with N,N-dimethyl acrylamide was successfully

297 ion of Schiff-base followed by base mediated alkylation with phenacyl bromide/substituted phenacyl br

298 ne underwent selective and exclusive mono-C9-alkylation with primary alcohols in good to excellent is

299 enters that are inaccessible through enolate alkylation, with high enantioselectivity (up to 97% ee)

300 The N-alkylation yield is moderate in microdroplets, up to 53