ライフサイエンスコーパス: allele

1 fect of moderate alcohol consumption between alleles).

2 in sister clades with and without a specific allele.

3 is mutated to the nonphosphorylatable S129A allele.

4 ISPR)-Cas9 system and a transposon-disrupted allele.

5 403S strains expressing the more active GcpE allele.

6 iption-altering mutation was the responsible allele.

7 s compared to those with an inherited driver allele.

8 elic expression of GATA2 from the unaffected allele.

9 hibition of V(D)J recombination on the other allele.

10 at position +5 in leader exon of Igh (Ter5H) allele.

11 ation into a conditional NrasG12D "knock-in" allele.

12 inactive allele to levels >60% of the active allele.

13 guish the supergene allele from the standard allele.

14 ased livers of children homozygous for the Z allele.

15 dentified a 120 kb insertion in the wingless allele.

16 1-1 and HP2-1) and HP2-2 to evaluate the HP1 allele.

17 ve transcriptional silencing of one parental allele.

18 g mammalian development using targeted mouse alleles.

19 codons specifically within the mutant BEST1 alleles.

20 tically generates insertion mutations in all alleles.

21 eres, are elevated in TRIM32 disease-causing alleles.

22 iating precise MICs with specific resistance alleles.

23 onstrating intragenic complementation of SMN alleles.

24 urvival time for selectively neutral nuclear alleles.

25 sessed mixed PfRh2b deletion and full-length alleles.

26 nsistent with reported phenotypes for mutant alleles.

27 e with wild-type strains that lack resistant alleles.

28 ession, our analyses reveal distinct mimicry alleles.

29 are related to ExPEC-and 2,826 corresponding alleles.

30 o rescue the loss of Cdk8 and behave as null alleles.

31 ight melanoma patients for all their class I alleles.

32 ent pig breeds, including the breed specific alleles.

33 g that the mutations create loss-of-function alleles.

34 rtitioned between loss- and gain-of-function alleles.

35 sites using deep sequencing of SP-resistance alleles.

36 itope datasets covering a broad range of HLA alleles.

37 imed at efficient introgression of desirable alleles.

38 tes were positively associated with the risk allele (17-58% increase/allele copy, P = 0.046-0.002), i

39 id point-of-care genotyping of CYP2C19 major alleles (*2, *3, *17) via salivary swab (genotyped group

40 ly), while CC genotype (3.8% vs. 4.4%) and C allele (20.4% vs. 23.9%) carriers were the lowest.

41 The derived G allele became the major allele (60-90%) in the populations represented in the 10

42 ific Islanders/Hawaiians carried the ADH1B*2 allele (86%) than other racial groups (4%-13%).

43 The allele A (ADH1B*2) of the rs1229984: A>G variant in ADH1

44 Allele (A) was highly prevalent in CRC tissues represent

45 ion was predominantly restricted to a single allele across different cells, introducing the concept o

46 was generated by summing BMI-increasing risk alleles across the genome.

47 Finally, we use allele age estimates to power a rapid approach for infer

48 jointly estimating selection coefficient and allele age from time series data of allele frequencies.

49 , for both the selection coefficient and the allele age, to a one-dimensional search over the selecti

50 ant differences in the distribution of SLA-1 alleles among the different pig breeds, including the br

51 ility is not accounted for by common disease alleles analyzed by SNP array-based GWASs.

52 those carrying a hypomorphic mutation in one allele and a missense mutation in the other are the most

53 mouse model that harbors an ATPase-deficient allele and demonstrates that mutant CHD7 retains the abi

54 omplex relationship between the expanded Htt allele and Hdac2 with implications for targeting transcr

55 ch fluorescence is driven by a gene-tracking allele and ultimately with outputs of other means of spa

56 nerally considered as loss-of-function (LoF) alleles and classified as pathogenic.

57 en-presenting cells for 25 different class I alleles and greater than 800 peptides, we systematically

58 ective human leukocyte antigen (HLA) class I alleles and HIV progression is well defined, the interac

59 nship between 44 HLA class I and 28 class II alleles and percentages of activated CD8 (CD8+CD38+DR+)

60 on, greatly increasing the fractions of rare alleles and, enhancing the sensitivity of downstream det

61 OR, genetically mimicking the melon OR(His) allele, and found that it also constrains chromoplast nu

62 entification of human leukocyte antigen risk alleles, and drug-induced proliferation of lymphocytes i

63 This is because ctDNA is a mix of fragmented alleles, and the contribution of different cancer deposi

64 processing, we developed HLAthena, providing allele-and-length-specific and pan-allele-pan-length pre

65 Non-functional resistant alleles are eliminated via a dominantly-acting maternal

66 Our analyses indicate that ADHD-associated alleles are enriched in loss of function intolerant gene

67 w their distinctive combinations of adaptive alleles are maintained despite hybridization with non-ad

68 ultifactorial relationship in which HLA risk alleles are one factor.

69 n a piRNA cluster, indicating that repressor alleles are produced by de novo insertion at an exceptio

70 many animals including Drosophila, repressor alleles are produced by transpositional insertions into

71 Potential drive-resistant target-site alleles arise at a frequency <0.1, and five of the most

72 er found significantly less polymorphism (11 alleles), as was expected of a non-classical MHC gene.

73 d Arabidopsis Skp1-Like1 (ASK1) Ds insertion allele, ask1, in different Arabidopsis accessions.

74 The HP2 allele associated with a favourable long-term outcome af

75 The HP2 allele associated with lower CSF haemoglobin-haptoglobin

76 Interestingly, evidence links HLA alleles associated with high risk for autoimmune disease

77 We identified individuals with risk alleles associated with NASH-fibrosis: rs738409C>G in PN

78 Alleles at fungal allorecognition loci are highly polymo

79 r)-binding motifs, inferred from alternative alleles at the haQTLs, implied a surprising direct assoc

80 c acid treatment and by the presence of risk alleles at the Pitx2 locus.

81 Approximately 80% of the alleles at this locus were modified, with no evidence of

82 The derived G allele became the major allele (60-90%) in the populatio

83 te score (meta-analysis effect size of minor allele beta(meta) = -6.04; 95% CI: -8.13 to -3.94; P = 1

84 values < 0.05 comparing the frequency of the alleles between the isolates from subjects with gastriti

85 ic link or conduit for the passage of genes (alleles) between two others that rarely, if ever, hybrid

86 Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes b

87 additionally generated an RFX6(HA) reporter allele by gene targeting in wild-type H9 cells to precis

88 CKR2-V41A receptor compared to the wild type allele by measuring its ligand binding affinity, CCL2 sc

89 de mechanistic insights into how CHRNA3 risk alleles can increase the risk of tobacco dependence and

90 The HLA-DQA1*05 allele, carried by approximately 40% of Europeans, signi

91 Among rs1333049 risk-allele carriers (CC+GC), the incidence of MI was reduced

92 ), but not among the other 2 phenotypes (Hp1 allele carriers) (n = 3,673; aHR: 0.95; 95% CI: 0.79 to

93 sed transepidermal water loss (TEWL) in risk allele carriers.

94 higher for patients homozygous for the minor allele carrying higher ADA risk (mean: 2,693 pg/ml) than

95 Arabidopsis CGEP null mutant alleles (cgep) had no visible phenotype but showed stron

96 a dominant model, carriers of the rs2069705T allele compared with the rs2069705CC genotype showed a 5

97 he first documentation of a major resistance allele conferring high levels of Vip3Aa resistance in a

98 In addition to the conditional alleles, constitutive knockout alleles were also obtaine

99 ciated with the risk allele (17-58% increase/allele copy, P = 0.046-0.002), including five gamma-glut

100 of molecular matching for DQA(1) and DQB(1) alleles could also help to minimize de novo DSA formatio

101 that KIF3A SNP rs11740584 and rs2299007 risk alleles create cytosine-phosphate-guanine sites, which a

102 However, EPO or Tfr2 single-allele deletion alone, respectively, exacerbated or did

103 t the 1-3% of patient population with single-allele DHCR7 mutations might not be ideal candidates for

104 beta transcription factor (TF), while the T allele did not show any interaction with any TFs.

105 e this, many individuals expressing HLA risk alleles do not develop hypersensitivity when exposed to

106 ive selection, and rare functional resistant alleles do not prevent drive invasion.

107 se allele quantitation in loci where the RNA alleles do not scale with the genotype count.

108 n vivo, whereas the DeltaCEH and 1- and 2-bp alleles do not support telomerase function.

109 nalyse molecular marker data with or without allele dosage information, such as that from microarray

110 ortantly, isolation of independent insertion alleles enabled genetic confirmation of genotype-to-phen

111 HLA class II alleles encode MHC proteins on antigen-presenting cells,

112 fying specific cell types in which a disease allele exerts a pathogenic effect.

113 Patients with DAP1 risk allele exhibit significantly higher autoantibody titers

114 ered mouse harboring a conditional Halo-Ago2 allele expressed from the endogenous Ago2 locus.

115 ith nearly complete identity between the two alleles expressed in humans, HLA-E*01:01 and HLA-E*01:03

116 Allele expression (AE) analysis robustly measures cis-re

117 the field, using lines that contain variant alleles for the key photoperiod gene, Photoperiod-1 (Ppd

118 f TC through natural variation in GI and ZTL alleles found on the Cape Verde Islands.

119 ow researchers to easily compute and compare allele frequencies and LD statistics of dbSNP catalogued

120 We show that differences in allele frequencies and linkage disequilibrium between Eg

121 A genes were associated with large shifts in allele frequencies between catchments and in individual

122 The geographic mapping of each SNP's allele frequencies by population as well as visualizatio

123 We then used Pool-seq to compare nuclear allele frequencies for high- or low-fitness hybrids.

124 We measured SP-resistance allele frequencies in Malawian women participating in a

125 vors of WNS, and found significant shifts in allele frequencies of genes associated with regulating a

126 We measured the corresponding changes in the allele frequencies of genomic variants responding to art

127 Although the minor allele frequencies of TMEM40 rs11719526 were generally c

128 Minor allele frequencies of two fetal CD46 SNPs were significa

129 estimate specimen tumor purity based on the allele frequencies of variants detected in high-depth, t

130 framework by leveraging individual-specific allele frequencies projected from reference genotypes on

131 hnic groups, BAG3 rs17617337 was rare (minor allele frequencies<0.05) in Asian and African ancestry p

132 ient and allele age from time series data of allele frequencies.

133 [95% 1.10-1.68]; P=0.004; CHIP with variant allele frequency >0.1: odds ratio, 1.40 [95% CI, 1.10-1.

134 ts carry a very rare missense variant (minor allele frequency < 0.0001) in BRIP1.

135 ced for the identification of rare variants (allele frequency < 0.05) in 16.9 kB of SERPINA1.Measurem

136 ssociated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5

137 We estimate that at least 17 to 37% of allele frequency change is driven by selection in these

138 e genes and significant differences in their allele frequency distributions across breeds.

139 proteins, as did all other variants with an allele frequency greater than 0.001.

140 BigTop uses the z-axis to display minor allele frequency of each SNP, allowing for the identific

141 equencing read depth information and variant allele frequency patterns, to infer the true copy number

142 cy functional protein-coding variants (minor allele frequency, <=5%) measured by an exome array were

143 rved nucleotides, tended to have low derived allele frequency, and were depleted from promoters of es

144 While allele frequency-based approaches that do not detect seg

145 eatinine ratio (rs527493184 at ZBTB16, minor allele frequency=0.002, P=1.1x10(-8)).

146 ar filtration rate (rs58720902 at AQR, minor allele frequency=0.01, P=1.6x10(-8)) or urine albumin-to

147 Allele-frequency-based imputation of tumor (All-FIT) is

148 he broad-spectrum resistance-Digu 1 (bsr-d1) allele from rice Digu.

149 g changes that now distinguish the supergene allele from the standard allele.

150 omic variation from immigrants combined with alleles from the recipient population resulted in highly

151 abolizing activity compared to the ancestral allele G (ADH1B*1).

152 acterized several mutants of dcl5, including alleles generated by the clustered regularly interspaced

153 ing the imbalance in CpG methylation between alleles genome-wide have been described but their algori

154 interaction, with higher FPS in the CC vs G allele groups among those with higher violence exposure

155 ficities is hindered by the diversity of HLA alleles (>20,000) and the complexity of many pathogen ge

156 While the diversity of CRISPR alleles has been explored, the associated structure and

157 g any EBV-derived peptide in this common HLA allele have been found thus far.

158 lions of years ago, and we propose that both alleles have been maintained in the species, likely due

159 Children with mosaic alleles have fewer tumors per eye compared with those wi

160 ed nomenclature guidelines and acknowledging allele history in research publications; and consider ho

161 in Delhi on one of the most prevalent HLA-B alleles, HLA-B*52:01, present in 22.5% of infected indiv

162 Moreover, the A-allele homozygotes were protected against stress-induced

163 uired MGE-encoded genes, silencing recessive alleles if the recipient bacterium already carries a wil

164 ulatory factors that specifically bind in an allele-imbalanced manner to the fSNPs on the FGFR2 locus

165 Imprinted genes are expressed from only one allele in a parent of origin-specific manner.

166 ses significant reactivation of the inactive allele in combination with removal of methyl groups from

167 BD patient with a mosaic de novo, pathogenic allele in CYBB.

168 tabolic traits associated with the 1q25 risk allele in HUVECs, including impairments of the gamma-glu

169 -PAV SPE genes with expression of the silent allele in hybrids are more likely to exhibit above high

170 We identified alleles in 4 loci that were associated with the reproduc

171 Combining SE deletion and KO and wild-type alleles in a genotypic series, we determined the amount

172 , to assess the evolution of ADHD-associated alleles in European populations using archaic, ancient a

173 Risk alleles in PNPLA3 and HSD17B13 were both associated with

174 linkage between advantageous and deleterious alleles in the case of introgressions.

175 y improved the PPV when tested on five human alleles, including some with limited data for training.

176 ic mobility shift assay suggested that the G allele interacted with CCAAT/enhancer-binding protein be

177 Japonica OsSGR alleles introgressed into indica-type cultivars in Korea

178 tional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's d

179 isk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's de

180 (IgHR) from a nonproductively rearranged Igh allele is degraded by nonsense-mediated decay (NMD).

181 (still-water) habitats, where the low-plated allele is favoured.

182 tonomous manner, and for which the BALB/cByJ allele is recessive to that of BALB/cJ.

183 F) and show that tethering DCP1A to one Tsix allele is sufficient to drive monoallelic Xist expressio

184 The apolipoprotein E (APOE) epsilon4 allele is the most common genetic risk factor for AD and

185 The myb81-1 allele is transmitted normally through the female, but r

186 ubgroups dependent on the nature of the POLE allele, its expression level, and MMR status.

187 ups bearing bearing hypomorphic Keap1 floxed alleles (Keap1(f/f)) with increased levels of Nrf2 to te

188 than hybrids that do not express the silent allele, leading to non-additive expression.

189 As expected, the modal allele length increased over time, driven primarily by e

190 ubsequent recombination events between these allele lineages have increased the frequency of KLRA*02

191 to responses restricted by other HLA class I alleles longitudinally after control of peak viremia.

192 NAs) expressed from the maternally inherited allele ("maternally expressed") to explore the molecular

193 CoV-2, suggesting that individuals with this allele may be particularly vulnerable to COVID-19, as th

194 HLA alleles may be factors that influence phenotypes along t

195 These African ancestry-predominant alleles may help explain the increased frequency and sev

196 Dominant PD-associated LRRK2 alleles may suppress EPAC-1 activity, further restrictin

197 locus, and that evolutionary turnover of dsx alleles may underlie the wing pattern diversity of extan

198 In patients who carry the IFNL4-DeltaG allele, mean LDL increased during treatment, then decrea

199 rs per eye was fewer in patients with mosaic alleles (median, 1.0; range, 1-6) compared with patients

200 ; range, 1-6) compared with patients with HP alleles (median, 3.0; range, 1-8) (P < 0.0003).

201 y transcripts, indicating that the DAP1 risk allele mediates enhanced autophagy, leading to the survi

202 -0.17 to -0.07; P = 6.62 x 10(-8)) with each allele of African ancestry.

203 Retreatment was associated with T(risk) allele of ARMS2 A69S (P = 2.0 x 10(-4); hazard ratio: 2.

204 aseline BCVA and AMD subtype, A (protective) allele of C2-CFB-SKIV2L rs429608 was associated with vis

205 Remarkably, loss of a single allele of Cebpb prevented the pro-inflammatory phenotype

206 rd ratio: 2.18:95%CI: 1.47-3.24) and C(risk) allele of CFH rs1329428 (P = 2.0 x 10(-3); hazard ratio:

207 oduce a dual epitope tag into the endogenous allele of each of 11 known components of cohesin in huma

208 Genetic knockout of one allele of Eprs globally (Eprs(+/-)) using CRISPR-Cas9 te

209 Ablation of one allele of Fasl, Fadd, or Ripk1 prevented the pathology o

210 tio, 0.76; P=.0027); conversely, the minor C allele of HNRNPUL1:rs15052 was associated with an increa

211 n the phase 2 validation cohort, the minor A allele of MARC1:rs2642438 was associated with reduced ri

212 l and biochemical effects of eliminating one allele of Rom1 (Rom1+/-) in three different Prph2 models

213 n those individuals that carry the high-risk allele of rs1061170 (Y402H).

214 7%) and CG genotypes (33.1% vs. 38.9%) and G allele of rs755622 (79.6% vs. 76.1%, respectively), whil

215 A lipodystrophy allele of seip-1 resulted in embryonic lethality as well

216 Furthermore, the derived G allele of SNP rs12191876, in the inserted region, is ass

217 Our results thus show that the paternal allele of the Cdkn1c locus plays a key role in maintenan

218 Furthermore, we identify an allele of the GTPase obgE that is synthetically sick in

219 The G allele of the lead risk single nucleotide polymorphism (

220 e present robust evidence for the role of an allele of the major histocompatibility complex (MHC) I g

221 Critically, the protective allele of the strongest AMD-associated CFH locus variant

222 Using a gfp-tagged allele of tra-1, we reveal unanticipated dynamics of TRA

223 c resistance correlated with the presence of alleles of 23S rRNA (A2142G/A2143G) for clarithromycin (

224 cern the mechanistic links between different alleles of a single locus and their associated pathophys

225 In persons with the protective genetic alleles of complement factor H (CFH), the Mediterranean

226 ntrogression of the Cape Verde Islands (Cvi) alleles of GI and ZTL into the Landsberg erecta (Ler) ba

227 ines analyzed from this screen, including 13 alleles of the gene encoding the ARABIDOPSIS HIS KINASE4

228 , pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-Cas9 edit

229 s between different types of SLF and between alleles of the same type of SLF of different S-haplotype

230 es depends on the differential impact of the allele on ClC-6 function.

231 enIE), which assesses the effects of defined alleles on transcription or splicing when introduced in

232 populations because they captured coadapted alleles or by selfishly distorting the laws of Mendelian

233 No HLA alleles or C4 haplotypes were associated with depression

234 binants were constructed in which 6 of the 8 alleles or genotypes (GT) of gO were analyzed in the bac

235 core (tSDS), driven by the height-increasing alleles (p = 9.1 x 10(-4)).

236 providing allele-and-length-specific and pan-allele-pan-length prediction models for endogenous pepti

237 In humans, the gain-of-function allele PIEZO1 E756del is highly prevalent and enriched i

238 Finally, we show wild-type Tcrb alleles produce mature alphabeta T cells that express up

239 At the recombinant junction, the duplication allele produces a fusion gene derived from ATAD3A and AT

240 Thus, our newly generated allele provides novel biological insights into RGC type

241 ion (PV) of outer membrane components, multi-allele PV of restriction systems and recombination-drive

242 continuous measure which allows for precise allele quantitation in loci where the RNA alleles do not

243 onger predictor of MCM and that each derived allele reduces body size by about 1 inch and 5 pounds.

244 lele, while cells harboring the non-targeted allele remain intact.

245 han the frequency of all rare BRIP1 missense alleles reported in more than 60,000 individuals of the

246 on mutant while expression of the diminutive allele resulted in increased thermosensitivity.

247 , and cells expressing a Foxp3 reporter null allele revealed that the majority of Foxp3-dependent cha

248 eased in subjects with the 17q21 asthma-risk alleles rs7216389 and rs8076131.

249 Using a temperature-sensitive allele (Sac1(ts)), we show that Sac1 is required for str

250 ts the simple binding compound into a potent allele-selective cleaver of r(CUG)(exp).

251 ana (commercials, wild/exotic) using 423 SSR alleles showed an average gene diversity (h) at 0.208 am

252 We assessed CGG repeat allele size by Southern Blot and PCR analysis.

253 Introduction of this minor allele SNP by genome editing confirmed its functionality

254 These allele-specific CNAs affect genomic regions containing w

255 Allele-specific copy number and serial sampling analyses

256 xpression quantitative trait loci (eQTL) and allele-specific expression (ASE) signals.

257 an epigenetic phenomenon leading to parental allele-specific expression.

258 We further show that allele-specific inactivation of either of two essential

259 spora delbrueckii FBA1 efficiently and in an allele-specific manner, leading to DNA repair by gene co

260 nts can be derived from such data, important allele-specific mutations-such as copy-neutral loss of h

261 or the repressor Broad, driving differential allele-specific nutcracker expression.

262 ied thousands of genetic variants exhibiting allele-specific open chromatin (ASoC).

263 A multiplex allele-specific PCR targeting outbreak-specific single n

264 Using allele-specific single-cell RNA sequencing, we here esti

265 pt and model system for the potential use of allele-specific small interfering RNA in treating KID sy

266 Notably, allele-specific small interfering RNA treatment caused o

267 Allele-specific targeting of enCRISPRa to oncogenic TAL1

268 We encounter allele-specific TE methylation and demethylation of aber

269 We found that allele surfing from range expansion could explain the di

270 with EBV-CTLs restricted by a different HLA allele (switch therapy) can also induce remissions if in

271 Here, we developed a multicolor reporter allele system to genetically label and trace polyploid c

272 The risk allele ('T') is associated with higher expression of PCA

273 nted based on recovery of a crwn4-2 missense allele that disrupts a predicted NLS and lowers the abun

274 ajor obstacle in the formation of resistance alleles that prevent Cas9 cleavage.

275 d about how apolipoprotein E (APOE) epsilon4 allele, the best-known genetic risk for AD, affect brain

276 In contrast to a productively rearranged Igh allele, the Igh messenger RNA (mRNA) (IgHR) from a nonpr

277 For each TA-allele, the risk of cirrhosis and hepatocellular carcino

278 c effect on the reactivation of the inactive allele to levels >60% of the active allele.

279 The identification of disease alleles underlying human autoinflammatory diseases can p

280 nd is subject to accumulation of deleterious alleles via Muller's ratchet.

281 ndicating that each Native American ancestry allele was associated with a 0.15-L increase in lung fun

282 The (FSF)TGFbeta(CA) allele was created to generate this model, and functiona

283 Consistent with being loss-of-function alleles, we show using patients' primary fibroblasts and

284 RS) constructed as the sum of inherited risk alleles, weighted by allelic effects established in an i

285 Risk alleles were also associated with either increased or de

286 e conditional alleles, constitutive knockout alleles were also obtained as byproducts of these experi

287 and 38 imputed Human Leukocyte Antigen (HLA) alleles were analyzed through a genome-wide association

288 Significant biases for maternal alleles were detected on 5 (of 12) chromosomes in high-f

289 We found that both alleles were present prior to pea aphid biotype lineage

290 OSC8) reduces growth of cells harboring that allele, while cells harboring the non-targeted allele re

291 A, by crossing mice bearing a floxed Rapgef2 allele with a cre mouse line driven by calcium/calmoduli

292 (+/KD) mouse models, the latter harboring an allele with a kinase-dead (KD) mutation.

293 a natural null mutant carrying Rcr3 and Pip1 alleles with deleterious frame-shift mutations.

294 re, highly penetrant variants to common risk alleles with small effect sizes.

295 iance in in vitro functional data among star alleles with unknown function.

296 mozygous for the dominant P(C) Celtic POLLED allele, with horned cows (pp) and obtained six heterozyg

297 the assembly of a functional AgR gene on one allele, with subsequent feedback inhibition of V(D)J rec

298 Instead, two tt7 mutant alleles, with defects in a branchpoint enzyme blocking q

299 occurs stochastically on two competing Tcrb alleles, with suboptimal Vbeta recombination signal sequ

300 Our functional annotation of the risk alleles within 15q24.3 coupled with previously establish

301 Risk for childhood asthma is conferred by alleles within the 17q21 locus affecting ORMDL sphingoli