ライフサイエンスコーパス: allopregnanolone

1 xy-5alpha-pregnan-20-one (3alpha,5alpha-THP; allopregnanolone).

2 ely catalyzes the intracellular oxidation of allopregnanolone.

3 to synthesize 5alpha-dihydroprogesterone and allopregnanolone.

4 re observed for estradiol, progesterone, and allopregnanolone.

5 nol, t-butanol, pentobarbital, diazepam, and allopregnanolone.

6 e modulator DHEAS and the positive modulator allopregnanolone.

7 s were markedly prolonged in the presence of allopregnanolone.

8 mplicated in the etiology of PMDD, including allopregnanolone.

9 eous formulation of the neuroactive steroid, allopregnanolone.

10 tor finasteride, as well as progesterone and allopregnanolone.

11 ersion of progesterone into the neurosteroid allopregnanolone.

12 the presence of transmitter and the steroid allopregnanolone.

13 s including sensitivity to the neurosteroid, allopregnanolone.

14 with EC50 values similar to those found for allopregnanolone.

15 (2-minute) application of GABA or GABA plus allopregnanolone.

16 r a combination of clonazepam with exogenous allopregnanolone.

17 Finally, PPI deficits were exacerbated by allopregnanolone (10 mg/kg, IP) and attenuated by proges

18 rents were also enhanced by the neurosteroid allopregnanolone (10 nM).

19 um, cultures were exposed to DHEA, DHEAS, or allopregnanolone (10(-10), 10(-8), or 10(-6) M), or vehi

20 -(trifluoromethyl)-3H-diazirine-3-yl)benzoxy]allopregnanolone ([(3)H]21-pTFDBzox-AP), a potent GABA(A

21 roid 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone, 3 alpha, 5 alpha-TH PROG).

22 that the neuroactive progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one)

23 Of 20 NAS tested, allopregnanolone, (3alpha,5alpha,20E)-3-hydroxy-13,24-cy

24 Allopregnanolone (3alpha5alpha-P), pregnanolone, and the

25 e mutations could not confer potentiation by allopregnanolone (3alpha5alphaP) when expressed in recep

26 ceptor modulation by the endogenous steroids allopregnanolone (3alpha5alphaP), pregnenolone sulfate,

27 of (3alpha,5alpha)-3-hydroxypregnan-20-one (allopregnanolone, 3alpha5alphaP).

28 Among these steroids, however, only allopregnanolone (5-15 mg/kg, IP) dose-dependently exace

29 quantitative method for the determination of allopregnanolone (5alpha,3alpha-THP) and related neurost

30 Here we show that THP (allopregnanolone), a steroid that is released as a resul

31 ress) and induces peripheral biosynthesis of allopregnanolone, a gamma-aminobutyric acidergic neurost

32 ulates opioid production in the brainstem is allopregnanolone, a neurosteroid metabolite of progester

33 r levels of progesterone and lower levels of allopregnanolone, a neurosteroid metabolite of progester

34 47 injection), an intravenous formulation of allopregnanolone, a positive allosteric modulator of gam

35 yl-3-hydroxybutyryl-CoA and the oxidation of allopregnanolone, a positive modulator of the gamma-amin

36 d and unsulfated steroids, such as DHEAS and allopregnanolone, act at distinct sites implies that ste

37 This novel opioid-mediated mechanism of allopregnanolone action may alter regulation of other br

38 Allopregnanolone acts as a positive allosteric modulator

39 The neurosteroid allopregnanolone acts as a positive allosteric modulator

40 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulato

41 A single neonatal allopregnanolone administration (10 mg/kg, i.p.) was pre

42 We investigated whether neonatal allopregnanolone administration alters the neuronal popu

43 These findings suggest that neonatal allopregnanolone administration disrupts the normal deve

44 ct of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocamp

45 ult mice previously stressed during puberty, allopregnanolone administration was sufficient to reprod

46 decreased in the medial dorsal nucleus after allopregnanolone administration.

47 Interestingly, mice treated with allopregnanolone after MPTP lesion were able to perform

48 We show that the neurosteroid allopregnanolone (ALLO) and T0901317, a synthetic oxyste

49 Allopregnanolone (ALLO) and tetrahydrodeoxycorticosteron

50 gression associated with a decrease of brain allopregnanolone (Allo) content and a decrease (approxim

51 ard intruders and a down-regulation of brain allopregnanolone (Allo) content.

52 ctase type I (5alpha-RI) mRNA expression and allopregnanolone (Allo) levels in selected neurons of th

53 ated with a down-regulation of telencephalic allopregnanolone (Allo) levels.

54 ogesterone (P4), and the neuroactive steroid allopregnanolone (ALLO) may disrupt the molecular mechan

55 The progesterone derivative allopregnanolone (ALLO) rapidly potentiates gamma-aminob

56 systemic administration of the neurosteroid allopregnanolone (ALLO), a positive allosteric modulator

57 Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A r

58 (plKO), we investigate how reduced placental allopregnanolone (ALLO), an anti-inflammatory neurostero

59 Allopregnanolone (ALLO), is a brain endogenous neuroster

60 Allopregnanolone (ALLO), synthesized by pyramidal neuron

61 ments, such as the neuroactive steroid (NAS) allopregnanolone (AlloP, brexanolone), may induce autoph

62 Allopregnanolone also evoked dose-dependent anesthetic a

63 Treatment with the allopregnanolone analog SGE-516 protects mice from chron

64 -AP), a general anesthetic and photoreactive allopregnanolone analog that is a potent GABA(A)R PAM, t

65 Treatment with an exogenous allopregnanolone analog, SGE-516, was sufficient to incr

66 e Food and Drug Administration's approval of allopregnanolone analogs, which function as positive all

67 ssant effects of exogenous administration of allopregnanolone analogs; yet, the role of endogenous al

68 We hypothesized that serum allopregnanolone and 3alpha-androstanediol levels would

69 rosteroids can reduce HPA axis responses, so allopregnanolone and 3beta-androstanediol (3beta-diol; 5

70 d 5alpha-DHP reduction yielded two products, allopregnanolone and 5alpha,20alpha-tetrahydroprogestero

71 positive allosteric modulators of GABA(A)Rs allopregnanolone and DS2 also induced larger current shi

72 ntiomers (pregnanolone and ent-pregnanolone, allopregnanolone and ent-allopregnanolone) and show that

73 In contrast, both allopregnanolone and epi-allopregnanolone bind to intras

74 pregnenolone following a swim stress and for allopregnanolone and epiallopregnanolone following allop

75 sults further demonstrate similar effects of allopregnanolone and ethanol on hippocampal neurophysiol

76 [(3)H]flunitrazepam as radioligand in which allopregnanolone and its active analogues stimulated the

77 Allopregnanolone and its synthetic analog alphaxalone ar

78 d an increase in [Ca2+]i in response to both allopregnanolone and muscimol.

79 azepam had recognizable common features with allopregnanolone and pentobarbital but was also distinct

80 y and "endogenous tranquilizer" neurosteroid allopregnanolone and poor PPAR-alpha function.

81 001) were observed in the frontal cortex for allopregnanolone and pregnenolone following a swim stres

82 imol binding in the presence of the steroids allopregnanolone and pregnenolone sulfate, although the

83 We demonstrated that allopregnanolone and synthetic neuroactive steroid analo

84 e modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone.

85 ride, indicating a causal connection between allopregnanolone and the endogenous opioid mechanism.

86 uency and amplitude of sIPSCs, the action of allopregnanolone and the hypertrophy of oxytocin neurone

87 in the presence of the potentiating steroid allopregnanolone and the inhibitory steroid pregnenolone

88 While the mechanism of action of allopregnanolone and the physiological and pharmacologic

89 ures of a synaptic GABA(A) receptor bound to allopregnanolone and two inhibitory sulfated neurosteroi

90 of combinations of GABA, taurine, propofol, allopregnanolone and/or the inhibitory steroid pregnenol

91 d ent-pregnanolone, allopregnanolone and ent-allopregnanolone) and show that the ability to potentiat

92 one, a progesterone metabolite also known as allopregnanolone, and 5alpha-androstane-3alpha,17beta-di

93 ositive allosteric modulators clonazepam and allopregnanolone, and by the NMDA receptor antagonists d

94 ); the GABA(A) receptor modulators diazepam, allopregnanolone, and Ro15-4513; and the L-type Ca2+ cha

95 acement therapy, the progesterone derivative allopregnanolone, and testosterone.

96 BA, propofol, pentobarbital, and the steroid allopregnanolone, and the observed steady-state response

97 TS-associated responses via the neurosteroid allopregnanolone (AP) in an animal model of repetitive b

98 ated that the progesterone (PROG) metabolite allopregnanolone (AP) is more potent than PROG in the tr

99 Endogenous neurosteroids, such as allopregnanolone (AP), regulate neuronal excitability by

100 ncreased brain synthesis of the neurosteroid allopregnanolone (AP).

101 Neurosteroids, such as allopregnanolone (AP; 3alpha-hydroxy-5alpha-pregnan-20-o

102 Our previous analyses showed that allopregnanolone (APalpha) significantly increased proli

103 and postpartum depression (the neurosteroid allopregnanolone (APG)).

104 Decreased production of allopregnanolone apparently contributes to the pathology

105 IPSCs but enhanced the effect of subsequent allopregnanolone application.

106 Both PPAR-alpha and allopregnanolone are abundantly expressed in the colon,

107 Neuroactive steroids including allopregnanolone are implicated in the pathophysiology o

108 strogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, reshape compete

109 of GABA(A) receptor signaling, and identify allopregnanolone as a candidate therapeutic lead.

110 The therapeutic potential of allopregnanolone as a neurogenic molecule is discussed.

111 that a single injection of the neurosteroid allopregnanolone at postnatal day 7 significantly prolon

112 The addition of allopregnanolone, at levels comparable with those found

113 Allopregnanolone attenuated ACTH responses to IL-1beta (

114 increased in pregnant mice in the absence of allopregnanolone attributable to brain region-specific d

115 Further, these studies suggest that allopregnanolone-based treatments may directly target th

116 a clinical neurosteroid general anesthetic, allopregnanolone, believed to occupy the colchicine site

117 s of certain bacterial progestins, including allopregnanolone, better known as brexanolone, an FDA-ap

118 In contrast, both allopregnanolone and epi-allopregnanolone bind to intrasubunit sites in the beta(

119 Allopregnanolone binds at the receptor-bilayer interface

120 one, but not its inhibitory 3beta-epimer epi-allopregnanolone, binds to the canonical beta(3)(+)-alph

121 Furthermore, blockade of allopregnanolone biosynthesis by preadministration of fi

122 oprogesterone (5alpha-DHP), the last step in allopregnanolone biosynthesis, is catalyzed by 3alpha-hy

123 ion of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective f

124 m-effects meta-analysis of studies comparing allopregnanolone blood concentrations in women with vers

125 herapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) shows promise as the firs

126 We found that the potentiating neurosteroid, allopregnanolone, but not its inhibitory 3beta-epimer ep

127 conversion of 5alpha-dihydroprogesterone to allopregnanolone by human 3alpha-HSD type III 10- to 30-

128 For catalyzing the oxidation of allopregnanolone by NAD+ the Hill coefficient of the mut

129 so have membrane actions, and in particular, allopregnanolone can act at GABAA receptors to potentiat

130 ty of GABA(A) receptors of epileptic DGCs to allopregnanolone can increase susceptibility to seizures

131 These findings show that allopregnanolone can modulate hippocampal development an

132 Accordingly, allopregnanolone caused an increase in the slow decay ti

133 e more sensitive to the stimulant effects of allopregnanolone compared with SLOW mice.

134 Allopregnanolone concentrations assessed during pregnanc

135 Allopregnanolone concentrations did not differ between w

136 and certain other small molecules increased allopregnanolone concentrations in vivo by activating 3a

137 siological and pharmacological modulation of allopregnanolone concentrations in vivo have been extens

138 Subgroup analyses indicated higher allopregnanolone concentrations in women with versus wit

139 the mechanism by which fluoxetine increases allopregnanolone concentrations.

140 PDS were not associated with differences for allopregnanolone concentrations.

141 microbiota or metabolites influences central allopregnanolone content after trafficking to the brain,

142 lpha expression downregulation and decreased allopregnanolone content and ameliorates depressive-like

143 Neonatal administration of allopregnanolone delays the onset of neurological sympto

144 und that at comparable doses, the effects of allopregnanolone, despite purported selectivity for cert

145 The allopregnanolone effect on IPSCs was inhibited by a G-pr

146 Allopregnanolone enhanced GABA-evoked currents less pote

147 The steroids (allopregnanolone, epiallopregnanolone, pregnenolone, tes

148 eptors, we still do not fully understand how allopregnanolone exerts persistent antidepressant effect

149 we used 11beta-(p-azidotetrafluorobenzoyloxy)allopregnanolone (F(4)N(3)Bzoxy-AP), a general anestheti

150 teroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) facilitates GABA(A) receptor-mediated

151 ther support for the potential usefulness of allopregnanolone for treating NPC disease.

152 racterize the role of 3alpha-HSD type III in allopregnanolone formation and suggest that activation o

153 es to activate 3alpha-HSD type III catalyzed allopregnanolone formation.

154 f the kinetics of human 3alpha-HSD catalyzed allopregnanolone formation.

155 eparate a rapid antidepressant neurosteroid, allopregnanolone, from other GABA(A) positive modulators

156 ing baseline noise in DGCs were sensitive to allopregnanolone, furosemide, and loreclezole and insens

157 Allopregnanolone had modest effects on neuron survival t

158 Allopregnanolone had no effect on [Ca2+]i or on the rele

159 )3-hydroxypregnan-20-one (3alpha,5alpha-THP, allopregnanolone) has protective activity in animal mode

160 s of progesterone and its natural metabolite allopregnanolone have been synthesized and screened usin

161 However, the neural mechanism whereby allopregnanolone improves mood and reduces anxiety is un

162 Here we describe the use of allopregnanolone in 2 pediatric patients with super-refr

163 bitors (SSRIs) could alter concentrations of allopregnanolone in human cerebral spinal fluid and in r

164 The effects of allopregnanolone in MPTP-lesioned mice were more apparen

165 metabolites pregnenolone sulfate (PregS) and allopregnanolone in serum are inversely associated with

166 Allopregnanolone in the BLA enhances BLA high theta osci

167 Allopregnanolone in the BLA enhances BLA high theta osci

168 ine exhibited no distinguishing overlap with allopregnanolone in the parameters examined.

169 anolone analogs; yet, the role of endogenous allopregnanolone in the pathophysiology of depression re

170 progesterone to its neurosteroid metabolite allopregnanolone in women with premenstrual dysphoric di

171 ypothesis, the current data demonstrate that allopregnanolone, in a dose-dependent manner, induces a

172 ones and NASs, particularly progesterone and allopregnanolone, in preparing the brain for the transit

173 s derivatives 5alpha-dihydroprogesterone and allopregnanolone, in the prefrontal cortex (PFC) of D1CT

174 utic potential of a neurogenic neurosteroid, allopregnanolone, in the restoration of the components o

175 During the appraisal condition, allopregnanolone increased activity in the dorsal medial

176 CR and Western blot validation revealed that allopregnanolone increased the expression of genes that

177 Indeed, allopregnanolone induced opioid inhibition over HPA resp

178 om the isolated supraoptic nucleus, but only allopregnanolone induced significant release of vasopres

179 We hypothesized that allopregnanolone-induced neurite regression was a prelud

180 Surprisingly, in these very young rats, allopregnanolone-induced oxytocin release was inhibited

181 ntrast, in supraoptic nuclei from adult rats allopregnanolone-induced oxytocin release was much small

182 Allopregnanolone-induced proliferation was antagonized b

183 Allopregnanolone-induced proliferation was isomer and st

184 nifedipine, consistent with the finding that allopregnanolone induces a rapid increase in intracellul

185 Thus, in pregnancy, allopregnanolone induces opioid inhibition over HPA axis

186 that the neuroactive progesterone metabolite allopregnanolone induces these changes in HPA responsive

187 egnanolone and epiallopregnanolone following allopregnanolone injection (8 mg/kg, sc).

188 Allopregnanolone is a neuroactive steroid that, like eth

189 Allopregnanolone is a neurosteroid which exhibits anxiol

190 Allopregnanolone is a positive allosteric modulator of G

191 The neurosteroid allopregnanolone is a potent allosteric modulator of the

192 Allopregnanolone is an endogenous steroid, that positive

193 ions are associated with postpartum RSFC and allopregnanolone is associated with postpartum intra-DMP

194 Allopregnanolone is synthesized from progesterone by red

195 -hydroxypregnan-20-one (3alpha,5alpha-THP or allopregnanolone) is a positive modulator of GABAA recep

196 eroid 3alpha-hydroxy-5alpha-pregnane-20-one (allopregnanolone) is a potent endogenous modulator of GA

197 ositive allosteric modulators; one of these, allopregnanolone, is the only drug approved specifically

198 n non-classical progesterone actions through allopregnanolone, its neuroactive steroid metabolite, an

199 Stabilization of allopregnanolone levels from the follicular to the lutea

200 analog, SGE-516, was sufficient to increase allopregnanolone levels in the BLA following CUS.

201 e, symptom cyclicity maintained), and plasma allopregnanolone levels increased in women with PMDD fro

202 Allopregnanolone levels, but not progesterone levels, we

203 was highly correlated with increased plasma allopregnanolone levels.

204 pression, and normalization of corticolimbic allopregnanolone levels.

205 in socially isolated mice with reduced brain allopregnanolone levels.

206 Open,peak) = 0.4), or the endogenous steroid allopregnanolone (maximal P(Open,peak) = 0.2).

207 s provide initial neuroimaging evidence that allopregnanolone may be a target for pharmacologic inter

208 Neuroactive steroids such as allopregnanolone may be potential therapeutic targets fo

209 Furthermore, allopregnanolone may enhance activity in regions linked

210 ted by 5alpha-reductase, and by reduction to allopregnanolone, mediated by 3alpha-hydroxysteroid dehy

211 ntly, the acute addition of the neurosteroid allopregnanolone mitigated functional impairments observ

212 rosterone sulfate (DHEAS), pregnanolone, and allopregnanolone, modulate ionotropic amino acid neurotr

213 , larger in amplitude, and less sensitive to allopregnanolone modulation than those recorded from DGC

214 There was no effect of allopregnanolone on the asphyxia induced impairment of t

215 d subcutaneously (0.2 ml) with either 3mg/kg allopregnanolone or 20% w/v beta-cyclodextrin vehicle.

216 ssant, imipramine, was without any effect on allopregnanolone or androstanediol production.

217 ne) and show that the ability to potentiate (allopregnanolone) or inhibit (pregnanolone) the rho1 rec

218 ract with distinct sites and either enhance (allopregnanolone) or reduce (pregnenolone sulfate) recep

219 r association to the change in estradiol and allopregnanolone over the course of pregnancy, suggestin

220 ibition studies for 5alpha-DHP reduction and allopregnanolone oxidation indicated that 3alpha-HSD typ

221 The neurosteroid allopregnanolone partially mediates the anesthetic activ

222 Allopregnanolone partially prevented the decrease in lon

223 anol on hippocampal neurophysiology and that allopregnanolone plays a key role in producing ethanol-i

224 -3-hydroxypregnan-20-one (3alpha,5alpha-THP, allopregnanolone)-positive cells in the VTA, but did not

225 lone), and 5alpha-pregnane-3alpha-ol-20-one (allopregnanolone) potentiated the GABA-evoked currents f

226 ectrophysiology support a mechanism by which allopregnanolone potentiates channel activity and sugges

227 This study examined the effects of allopregnanolone, progesterone and 17beta-oestradiol on

228 ment with a negative allosteric modulator of allopregnanolone promoted avoidance behavior in control

229 These data demonstrate that allopregnanolone promotes the restoration of tyrosine hy

230 e HRSA correlated negatively with changes in allopregnanolone (r(22)=-0.43, p=0.036) and pregNANolone

231 Conversely, allopregnanolone reduced HPA responses in virgin rats.

232 trate that in response to emotional stimuli, allopregnanolone reduces activity in regions associated

233 Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone b

234 ABA site are potentiated by the neurosteroid allopregnanolone regardless of whether the steroid inter

235 ggerating allosteric actions of zolpidem and allopregnanolone, respectively.

236 ute treatment (once/week for two weeks) with allopregnanolone restored the number of tyrosine hydroxy

237 from pregnant mice compared with virgin, but allopregnanolone reverted the threshold for inducing epi

238 Diazepam, allopregnanolone, Ro15-4513, and nitrendipine had no eff

239 To investigate the brain basis of allopregnanolone's impact on emotion regulation, partici

240 ed sensitivity to Zn2+ indicate that loss of allopregnanolone sensitivity is likely to be due to alte

241 determine whether selection has also altered allopregnanolone sensitivity.

242 alogs with molecular pharmacology similar to allopregnanolone (SGE-516 [tool compound] and zuranolone

243 s suggest that altered vHIP progesterone and allopregnanolone signaling during diestrus increases avo

244 These data demonstrate that allopregnanolone significantly increased rat NPC and hNS

245 ahydroisoxazolo[5,4-c]pyridin-3(2H)-one, and allopregnanolone similar to group-housed mice.

246 rodeoxycorticosterone, pregnanolone sulfate, allopregnanolone sulfate, and beta-estradiol) and probed

247 ress may exacerbate TS symptoms by promoting allopregnanolone synthesis in the PFC, and corroborate p

248 ockdown of rate-limiting enzymes involved in allopregnanolone synthesis, 5alpha-reductase type 1 and

249 nhibitor of the main rate-limiting enzyme in allopregnanolone synthesis.

250 5alpha-reductase, a key enzyme required for allopregnanolone synthesis.

251 regnancy, inhibition of 5alpha-reductase (an allopregnanolone-synthesizing enzyme) with finasteride r

252 In late pregnancy, activity of the allopregnanolone-synthesizing enzymes (5alpha-reductase

253 rtle was probably mediated by its metabolite allopregnanolone [tetrahydroprogesterone (THP)], because

254 e, converting 3alpha-tetrahydroprogesterone (allopregnanolone) to dihydroprogesterone and 3alpha-andr

255 reated mutant mice, but was mostly absent in allopregnanolone-treated animals.

256 In control birth pups, maternal allopregnanolone treatment caused significant changes in

257 Furthermore, in virgin rats, allopregnanolone treatment increased, whereas in pregnan

258 aken together, our results clearly show that allopregnanolone treatment not only reduces cholesterol

259 Here, we further characterized the effect of allopregnanolone treatment on cholesterol accumulation,

260 Furthermore, allopregnanolone treatment significantly enhanced myelin

261 Both changes were significantly reduced by allopregnanolone treatment.

262 (mediated by neuroactive metabolites such as allopregnanolone), typified by irritability and hyperaro

263 lity that are restored by the high levels of allopregnanolone under normal conditions but under patho

264 endogenous oxytocin, and (ii) the effect of allopregnanolone upon oxytocin release changes with age,

265 This is the first report of allopregnanolone use to treat status epilepticus in chil

266 the adult, oxytocin effects are modulated by allopregnanolone via an interaction with inhibitory GABA

267 inactive mutant, increased significantly as allopregnanolone was added to culture media.

268 s also noted that MPTP treated mice to which allopregnanolone was administered had an increase in Brd

269 Sensitivity to allopregnanolone was also measured in FAST and SLOW mice

270 Compared with placebo, allopregnanolone was associated with reduced activity in

271 tivity to the locomotor stimulant effects of allopregnanolone was determined in 24 BXD recombinant in

272 Plasma allopregnanolone was higher in PPD (p = 0.03) and positi

273 Mean serum allopregnanolone was lower in AN and OW/OB than HC (AN 9

274 Brexanolone (allopregnanolone) was recently approved by the Food and

275 We hypothesized that the pregnancy hormone, allopregnanolone, was involved in presentation of the bl

276 5alpha-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA

277 g GABA(A) receptors and endogenous levels of allopregnanolone were reduced in the BLA following CUS.

278 anesthetic steroids such as alphaxalone and allopregnanolone, which have a 5alpha-configuration at t

279 amide, chlorthalidone, and the neurosteroid, allopregnanolone, which inhibits chloride transport, pro

280 s of the weight spectrum have low mean serum allopregnanolone, which is associated with increased dep

281 Cs is significantly longer in the absence of allopregnanolone, which now has no significant effect.

282 the combination of GABA and the neurosteroid allopregnanolone, which was intended to desensitize a fr