ライフサイエンスコーパス: alpha subunit

1 ding the T2DM-linked KCNQ1 potassium channel alpha subunit.

2 depends on the stabilization of their labile alpha subunit.

3 the skeletal muscle-expressed KCNC4 (Kv3.4) alpha subunit.

4 g phosphohistidine-containing segment of the alpha subunit.

5 ed region of rpoA, the gene encoding the PEP alpha subunit.

6 eletion of Scnn1a, encoding the ENaC channel alpha subunit.

7 units promote cell surface expression of the alpha subunit.

8 of changes in cell surface expression of the alpha-subunit.

9 s encircles the C-terminal segment of the IR alpha-subunit.

10 t T210 phosphorylation of the Snf1 catalytic alpha-subunit.

11 AGDV has very little contact with the alpha-subunit.

12 , but the suppression is much greater in the alpha-subunit.

13 bunit and an S6 point mutation in the second alpha-subunit.

14 s used as a stand-alone catalyst without the alpha-subunit.

15 and C-terminal domains of the RNA polymerase alpha-subunit.

16 nic receptors fused with the G(15) G-protein alpha-subunit.

17 t is a heteromeric receptor composed only of alpha subunits.

18 H and promoting lysosomal degradation of HIF-alpha subunits.

19 and binding pocket conferred by two adjacent alpha subunits.

20 in cells overexpressing either WT or 3M ENaC-alpha subunits.

21 h accelerate growth via stabilization of HIF-alpha subunits.

22 72, and retards ATP binding to the catalytic alpha subunits.

23 ological gating cooperativity between Nav1.5 alpha-subunits.

24 P) is blocked by the convergent N termini of alpha-subunits.

25 idual alpha-subunits and between neighboring alpha-subunits.

26 nd nearest-neighbor distances between Nav1.5 alpha-subunits.

27 ding Ral GTPase activating protein catalytic alpha subunit 1) in four unrelated individuals with prof

28 e allele of the gene encoding DNA polymerase alpha subunit 2 (pola2) that disrupts fin regeneration i

29 (Nfe2) and core-binding factor, runt domain, alpha subunit 2, translocated to, 3 homolog (Cbfa2t3h) b

30 -encoding gene, sodium voltage-gated channel alpha subunit 5 (SCN5A), often cause inherited arrhythmi

31 Conversely, GNAS (G-protein alpha subunit), a PKA activator that is genetically acti

32 signaling by binding to activated G-protein alpha-subunits, accelerating GTP hydrolysis.

33 hosphate ribosylation of the small G protein alpha-subunit activating CFTR with consequent secretory

34 echanism in which Ca(2+) binding to a single alpha-subunit affects all VSDs equally.

35 on of a new allosteric site on the catalytic alpha-subunit, along with first small molecule ligands b

36 h mutant mice harboring diazepam-insensitive alpha-subunits alpha1, alpha2, alpha3, or alpha5 have re

37 FSH is a heterodimer consisting of an alpha subunit, also present in luteinizing hormone, and

38 yclase (sGC) is a heterodimer composed of an alpha subunit and a heme-containing beta subunit.

39 lso identifies the gamma-binding site on the alpha subunit and demonstrates that in the majority of i

40 are transmembrane receptors composed of one alpha subunit and one beta subunit and are involved in c

41 pe and the switching function of a G-protein alpha subunit and the influence of a GPCR in that landsc

42 a protein complex comprising a pore-forming alpha subunit and two associated beta subunits.

43 orylation/dephosphorylation of the catalytic alpha subunit and/or associated proteins.

44 otassium (Kv) channels comprise pore-forming alpha subunits and a multiplicity of regulatory proteins

45 tailed analysis of a link between specific G-alpha subunits and beta-catenin using G-alpha subunit ge

46 erizes alphaIIbbeta3 is seen between various alpha subunits and beta1 TM/CTs.

47 erties and cell-surface localization of VGSC alpha subunits and participate in cell-cell and cell-mat

48 Genes encoding two putative alpha subunits and two putative beta subunits of Rab-GGT

49 ng increased expression of the IL-2 receptor alpha-subunit and activation of the transcriptional regu

50 bunit or an S4S5 point mutation in the first alpha-subunit and an S6 point mutation in the second alp

51 ther an S4S5/S6 double mutation in the first alpha-subunit and no mutation in the second (concatenate

52 ed sodium channels comprise an ion-selective alpha-subunit and one or more associated beta-subunits.

53 R decrease interactions between LuxR and the alpha-subunit and result in defects in transcription act

54 e corresponding clustering properties of the alpha-subunit and the effects upon these of the beta3-su

55 naptotagmin, unc-2/P/Q/N-type Ca(2+) channel alpha-subunit and unc-31/CAPS, in addition to unc-13/Mun

56 olves dynamic binding both within individual alpha-subunits and between neighboring alpha-subunits.

57 ntly occurring mutants of trimeric G-protein alpha-subunits and GPCRs.

58 It consists of four KCNQ1 alpha-subunits and up to four KCNE1 beta-subunits, which

59 voltage-activated K+ (BK) potassium channel alpha-subunit, and pathogenic gain-of-function variants

60 uced rearrangements of the voltage sensor in alpha-subunits, and (iii) the relative position of the b

61 A-positive signals generated by anti-(Nav1.5 alpha-subunit) antibodies, mainly at the plasma membrane

62 ed a new class of FP from an allophycocyanin alpha-subunit (APCalpha).

63 associated protein interaction domain of the alpha subunit are key components of this recognition pro

64 Unlike potassium channels, sodium channel alpha-subunits are believed to form functional monomers.

65 ghtly bound homodimer at the center, and two alpha-subunits are bound to each side of the beta(2) dim

66 We demonstrate that many of the GPCTRs and alpha-subunits are co-expressed in these tissues and tha

67 The contributions of specific alpha-subunits are further dissected using exogenously e

68 beta-subunit interactions with pore-forming alpha-subunits are long-thought to be obligatory for cha

69 homo- or heterotetramers of Kv7.4 and Kv7.5 alpha-subunits, are important regulators of vascular smo

70 in electrophysiological studies, the Nav1.5 alpha-subunit assembles on the plasma membrane of HEK293

71 ved parallel amino acid substitutions in the alpha-subunit (ATPalpha) of the sodium pump (Na(+)/K(+)-

72 in interacts with its platform formed by the alpha-subunit beta-propeller and beta-subunit betaI doma

73 The GABAA receptor alpha subunit beta1 strand runs anti-parallel to the bet

74 ction through the same mechanism: mimicry of alpha-subunit binding.

75 (+)(BK) channel consists of the pore-forming alpha subunits (BKalpha) and auxiliary subunits.

76 ecific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-bet

77 receptor TrkB and of P/Q-type Ca(2+) channel alpha-subunits, but did not detect expression changes of

78 the relative alignment of individual Nav1.5 alpha-subunits, but the clustering itself depends on oth

79 l constructs and relate it to other integrin alpha subunits by mutagenesis.

80 We observe the interaction of the Msm RNAP alpha-subunit C-terminal domain (alphaCTD) with DNA, and

81 ly defined as ancillary to the Na(+) channel alpha subunit, can be partly consequent to disrupted int

82 ly defined as ancillary to the Na(+) channel alpha subunit, can be partly consequent to disrupted int

83 itely on a single CaM preassociated with the alpha-subunit carboxyl tail.

84 ylation of conserved proline residues in its alpha-subunit, carried out by prolyl-hydroxylases, and s

85 oximately 200 times more rapidly than native alpha subunits, causing the oxygenated form of rHb Kirkl

86 The interleukin-3 receptor alpha subunit, CD123, is expressed in many hematologic m

87 t stimulate gene transcription of the common alpha-subunit (Cga) and the hormone-specific beta-subuni

88 Ciliary neurotrophic factor receptor alpha subunit (CNTFRalpha) and CNTF play important roles

89 Interleukin 6, interleukin 10 receptor alpha subunit, colony stimulating factor 3 receptor and

90 TSH is composed of a alpha-subunit common to gonadotropins, and a beta-subuni

91 eticulum (ER), but the glycan-free catalytic alpha subunit complexes with glycosylated beta subunit i

92 rs adopt the analogous beta-alpha-delta-beta-alpha subunit configuration remains controversial.

93 llection of Gram-negative bacteria, with the alpha subunit containing the BC and the beta subunit the

94 Mutant alpha subunits containing Leu-58(E7) autoxidize approxim

95 ar S0-S1 loop of the BK channel pore-forming alpha-subunit controls functional coupling to regulatory

96 ne gamma2-subunit, whereas the nature of the alpha-subunit critically determines the properties of th

97 G protein alpha subunits cycle between active and inactive conform

98 AMPK mice deficient for one of the catalytic alpha subunits displayed reduced endogenous tau phosphor

99 induction of eukaryotic initiation factor 2 alpha subunit (eIF2alpha) signaling and ER stress marker

100 ptide on the human epithelial sodium channel alpha-subunit (ENaC-alpha).

101 Vertebrate genomes contain three alpha subunits encoded by three different genes and CAPZ

102 Co-expression of the AP-2 alpha subunit enhanced the Nef.AP-2 sigma2 subunit BiFC

103 a heterotrimeric complex, and its catalytic alpha subunit exists in 2 isoforms: AMPKalpha1 and AMPKa

104 nctional effects on human cardiac Kv channel alpha subunits expressed in Xenopus laevis oocytes.

105 ation between miR-92 expression and integrin alpha subunit expression.

106 BKCa alpha-subunit expression was unchanged, BKCa beta1-subun

107 ndau tumor suppressor, which targets the HIF-alpha subunit for proteasomal degradation, led to rapid

108 s from investigations of the large G-protein alpha subunit from yeast (Gpa1) and the three RAS isotyp

109 stency with the traditional idea of a single alpha-subunit functioning as a monomer.

110 (G(T)) by catalyzing GDP-GTP exchange on its alpha subunit (Galpha(T)).

111 plex is composed of the GTP-bound transducin alpha subunit (Galpha(T).GTP) and the cyclic GMP (cGMP)

112 that guanine nucleotide-binding (G) protein alpha subunit (Galpha)-interacting vesicle-associated pr

113 GEF) that activates heterotrimeric G protein alpha subunits (Galpha) and serves as an essential Galph

114 ing (RGS) proteins that deactivate G protein alpha subunits (Galpha).

115 The inhibitory G protein alpha-subunit (Galpha(z)) is an important modulator of b

116 or (GPCR)-independent regulator of G protein alpha-subunits (Galpha), acting as a guanine nucleotide

117 ic8A) is an essential regulator of G protein alpha-subunits (Galpha), acting as a guanine nucleotide

118 G protein stimulatory alpha-subunit (Galphas)-coupled heptahelical receptors r

119 NA level of Scn5a (the cardiac Na(+) channel alpha subunit gene), as well as a 56% reduction (by Wnt3

120 , the P/Q-type voltage-gated calcium channel alpha subunit gene, expressed throughout the brain desta

121 was highly specific, involving just 3 of 69 alpha subunit genes probed: known KCNE3 partners KCNC4 a

122 ic G-alpha subunits and beta-catenin using G-alpha subunit genetic knockout and knockdown approaches.

123 histidine (R243H) mutation in the G-protein alpha subunit GNAO1 in breast carcinoma tissue.

124 ng the TSH receptor (TSHR) or the Gs protein alpha subunit (GNAS) are found in approximately 70% of A

125 third pathway is initiated by the G-protein alpha subunit Gpa1.

126 tor glycoprotein Ib (GPIb), specifically its alpha subunit (GPIbalpha), to signal as they tether and

127 lting in binding of the activated transducin alpha-subunit (Gt(alpha)) to PDE6, displacement of Pgamm

128 on upon addition of the activated transducin alpha-subunit (Gt(alpha)*-GTPgammaS).

129 Furthermore, we determined that the alpha subunit has a primary functional module consisting

130 At the same time, the mutant alpha subunit has an approximately 80,000-fold higher af

131 opsis (Arabidopsis thaliana) SnRK1 catalytic alpha-subunit has regulatory subunit-independent activit

132 ers, casting further doubt on thecal inhibin alpha subunit having a significant role in modulating an

133 the accumulation of hypoxia-inducible factor alpha-subunits (HIF-alpha) and their downstream targets.

134 arker RAM-11, and hypoxia-inducible factor-1 alpha subunit [HIF-1alpha]).

135 The hypoxia inducible factor 1 alpha subunit (HIF1A) directly repressed the MIR34A gene

136 ed the binding of hypoxia inducible factor 1 alpha subunit (HIF1A) in the VEGFA gene promoter.

137 -induced adult-onset ablation of P/Q channel alpha subunit (iKOp/q) display identical patterns of dys

138 epithelial anti-inflammatory IL-10 receptor alpha subunit (IL-10RA) is also important for barrier fo

139 Here, we identify the IL-11 receptor alpha subunit (IL-11Ralpha) as a cell surface marker of

140 studied the internal mobility of a G-protein alpha subunit in its apo and nucleotide-bound forms and

141 glycosylated and do not associate with VGSC alpha subunits in the brain.

142 several classes of heterotrimeric G protein alpha subunits in vertebrates.

143 The crystal structure of the alpha-subunit in the complex with an analog of glycyl ad

144 The oligomeric status of the Nav1.5 alpha-subunit in vivo, with or without the beta3-subunit

145 in three out of the four diazepam-sensitive alpha-subunits in mice with a 129X1/SvJ background, diaz

146 different components of the Kv7.4 and Kv7.5 alpha-subunits in vascular smooth muscle cells to determ

147 sults from a phylum-specific cleavage of the alpha subunit, in which the C-terminal alphaC fragments

148 ique post-translational modifications in its alpha subunit, including thioglycine, 1-N-methylhistidin

149 We identified one of four planarian integrin-alpha subunits inhibition of which phenocopied these eff

150 binding in the ion channel and to a gamma(+)-alpha(-) subunit interface site similar to its GABAAR in

151 ctivity relationship at the GABA(A)R beta(+)-alpha(-) subunit interface steroid-binding site and iden

152 cated at the base of a pocket in the beta(+)-alpha(-) subunit interface that extends to the level of

153 Nemolizumab targets the IL-31 receptor alpha subunit involved in atopic dermatitis (AD) pathoge

154 ed by Yme1p acting alone, while the released alpha subunit is degraded in parallel by an unidentified

155 eta2-subunit of the Na/K-ATPase, whereas the alpha-subunit is exchangeable.

156 dicating that loop C of the GABA(A) receptor alpha-subunit is the dominant molecular determinant of d

157 ns in the genes coding for Na(+),K(+)-ATPase alpha-subunit isoforms lead to severe human pathologies

158 does not contain homologs of bacterial RNAP alpha subunits, it contains, in addition to the beta and

159 e splice variants of the single pore-forming alpha subunit ( KCa1.1, Kcnma1, Slo1) gene, two families

160 ed pulmonary expression of potassium channel alpha subunits Kcnq1 and Kcnb1 but did not alter express

161 In the heart, KCNE1 associates with the alpha-subunit KCNQ1 to generate the slowly activating, v

162 Here, we show that the catalytic alpha-subunits KIN10 and KIN11 of the Arabidopsis (Arabi

163 We systematically mutated individual alpha subunit knuckle domain residues and assessed funct

164 ormed by the co-assembly of the pore-forming alpha-subunits, Kv4.2 and Kv4.3, together with the acces

165 expression of the epithelial sodium channel alpha-subunit, largely abolished basolateral potassium i

166 the activity of BK channels by decreasing BK-alpha subunit levels at the plasma membrane.

167 electrophysiology to examine the role of the alpha-subunit M4 (alphaM4) in the function of the adult

168 e)) with a podocyte-specific deletion of the alpha subunit (main catalytic subunit) of Ac.

169 CSF2RA (colony-stimulating factor 2 receptor alpha-subunit), MARS (methionyl aminoacyl-tRNA synthetas

170 s identify Galphai2 as the primary G protein alpha-subunit mediating the detection of volatile chemos

171 oreceptor IS PM: the sodium-potassium ATPase alpha-subunit (NKAalpha).

172 Here we demonstrate that sodium channel alpha-subunits not only physically interact with each ot

173 GNA13, the alpha subunit of a heterotrimeric G protein, mediates si

174 utations in Galphaq proteins, which form the alpha subunit of certain heterotrimeric G proteins, driv

175 ween the N-terminal residues of PsbP and the alpha subunit of Cytochrome (Cyt) b559 (PsbE).

176 l similar interactions between GPCRs and the alpha subunit of different G protein isoforms.

177 environmental stress, phosphorylation of the alpha subunit of eIF2 (eIF2alpha-P) represses global pro

178 3/PEK) results in the phosphorylation of the alpha subunit of eIF2 (eIF2alpha-P), which represses tra

179 s signals lead to the phosphorylation of the alpha subunit of eIF2 (Ser51), resulting in inhibition o

180 sponse (ISR) in which phosphorylation of the alpha subunit of eIF2 results in a coincident global red

181 ranslation is through phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2).

182 5 through mediating dephosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alp

183 ylation of the translation initiation factor alpha subunit of eukaryotic initiation factor 2 (eIF2alp

184 tion of a translation initiation factor, the alpha subunit of eukaryotic initiation factor 2 (eIF2alp

185 of translation initiation factor eIF2alpha (alpha subunit of eukaryotic initiation factor 2), ensuri

186 our stress-sensing kinases phosphorylate the alpha subunit of eukaryotic translation initiation facto

187 roteins was impaired, phosphorylation of the alpha subunit of eukaryotic translation initiation facto

188 ly for Pro-containing protein regions in the alpha subunit of Hb, revealing new protected Hb regions

189 The pntA gene encoding the alpha subunit of heteromultimeric PntAB in Synechocystis

190 ubiquitin ligase, which targets hydroxylated alpha subunit of hypoxia inducible factors (HIFs) for ub

191 butable to the extent of deregulation of the alpha subunit of hypoxia-inducible factor alpha, a well

192 toxin targets a cysteine residue within the alpha subunit of inhibitory trimeric G-proteins, we obse

193 Interestingly, the pore-forming alpha subunit of KCa1.1 coimmunoprecipitates with beta1

194 ppression of ICAM-1 or its binding site, the alpha subunit of lymphocyte function-associated antigen-

195 The alpha subunit of MCR (McrA) contains several unusual pos

196 In methanogenic archaea, the alpha subunit of MCR (McrA) typically contains four to s

197 The bellwether (blw) gene encodes the alpha subunit of mitochondrial ATP synthase.

198 rial matrix and phosphorylates the catalytic alpha subunit of PDHc (PDHA) on two residues S295 and S3

199 Additionally, the alpha subunit of the 11S alphabeta regulatory particle,

200 We used alpha subunit of the calcium/calmodulin-dependent kinase

201 ntroducing a (His)6-tag within a loop in the alpha subunit of the complex.

202 tion-triggered degranulation by cleaving the alpha subunit of the EGF-like module-containing mucin-li

203 Injection of inhibitory antibodies to the alpha subunit of the Gs heterodimeric protein (GalphaS)

204 ough the importance of the C terminus of the alpha subunit of the heterotrimeric G protein in G prote

205 n-containing protein 1 (EPAS1), a regulatory alpha subunit of the hypoxia-inducible factor complex, d

206 However, the role of CD103, the alpha subunit of the integrin alphaEbeta7 (also known as

207 , a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that signifi

208 e show that mycolactone directly targets the alpha subunit of the Sec61 translocon to block the produ

209 this stress response in the liver, including alpha subunit of translation initiation factor 2 (eIF2al

210 N-terminal helix bundle domains of delta and alpha subunits of eIF2B.

211 ons in GNAQ and GNA11, two highly homologous alpha subunits of Galphaq/11 heterotrimeric G proteins,

212 In this complex, the alpha subunits of Hb are refolded with the heme displace

213 on mutations of GNAQ and GNA11, which encode alpha subunits of heterotrimeric Galpha(q/11) proteins,

214 The oxygen-regulated alpha subunits of Hif-1 and Hif-2 (namely, Hif-1alpha an

215 EF) activity toward heterotrimeric G protein alpha subunits of the i, q, and 12/13 classes, catalyzin

216 ATP1A3 encodes the alpha-subunit of a neuron-specific ATP-dependent transme

217 Null mutants of numb or the alpha-subunit of Adaptor Protein complex-2 enhance domin

218 Ca(2+)-binding capacity to the pore-forming alpha-subunit of Ca(V)1.2, Ca(V)1.3, and Ca(V)2.1 and/or

219 Phosphorylation of the alpha-subunit of eIF2 (p-eIF2alpha), the central compone

220 er stress conditions, phosphorylation of the alpha-subunit of eIF2 downregulates cellular protein syn

221 t a postulated ligand entry/exit site in the alpha-subunit of hemoglobin, which, to the best of our k

222 the binding of an antibody (mAb 637) to the alpha-subunit of the AChR, suggesting that both antibodi

223 Here, we show that the alpha-subunit of the alpha2beta2 GlyRS from the bacteriu

224 Mutations in the gene KCNMA1, encoding the alpha-subunit of the BK channel have emerged as responsi

225 control mice and in adult mice in which the alpha-subunit of the epithelial sodium channel was condi

226 om the small GTPase K-Ras and the inhibitory alpha-subunit of the heterotrimeric G-protein Galphai sh

227 beta prodomain and through the beta- and not alpha-subunit of the integrin.

228 ns related to SCN5A (the gene coding for the alpha-subunit of the most abundant sodium channel in the

229 SEC61A1 encodes the alpha-subunit of the Sec61 complex, which governs endopl

230 SCN4A encodes the alpha-subunit of the skeletal muscle voltage-gated sodiu

231 n of the transcript of the gene encoding the alpha-subunit of the sodium channel ENaC in cell lines a

232 mutations in the SCN5A gene, coding for the alpha-subunit of the sodium channel NaV1.5.

233 by GNAS, XLalphas is partly identical to the alpha-subunit of the stimulatory G protein (Gsalpha), bu

234 the production of which is catalyzed by the alpha-subunit of the stimulatory G protein (Gsalpha), co

235 The hypoxic response is mediated by the alpha-subunit of the transcription factor HIF-1 (HIF-1al

236 IFNAR1-knockout mice that do not express the alpha-subunit of the type 1 IFNR did not prevent splenom

237 of stresses triggers phosphorylation of the alpha-subunit of translation initiation factor eIF2.

238 The alpha-subunits of hypoxia-inducible factors (HIF1alpha a

239 s and physiological function of pore-forming alpha-subunits of large conductance calcium- and voltage

240 MpeV showed no detectable activity on the alpha-subunits of PEI or PEII.

241 , T2R118, T2R138 and T2R104), as well as the alpha-subunits of the associated signalling complex (alp

242 e showed that the N-terminal residues of the alpha-subunits of the CP from the archaeon Thermoplasma

243 that noncovalently associates with the small alpha subunit on the intermembrane space side of the inn

244 etory cargos, such as interleukin 2 receptor alpha subunit or Tac, transferrin receptor, and cluster

245 and no mutation in the second (concatenated) alpha-subunit or an S4S5 point mutation in the first alp

246 mic S4S5/S6 binding occurs within individual alpha-subunits or between neighboring alpha-subunits, we

247 previously disordered N-terminal arm of the alpha-subunit over the beta-ATP.

248 tage-gated sodium channels, particularly the alpha subunits (p = 8.6 x 10(-4)).

249 n beta subunit p40 and the specific cytokine alpha subunit p35 and p19, respectively.

250 xclusive interactions that produce alternate alpha-subunit pairing, creating two integrins with disti

251 enzyme (GBE) and the phosphorylase b kinase alpha subunit (PhKalpha) protein, were significantly upr

252 ctive beta-catenin; however, PMT-activated G-alpha subunits positively regulate LiCl-induced beta-cat

253 First, alpha subunits possess intrinsic signals to segregate in

254 fluid (FF) which is also abundant in 'free' alpha subunit, presumed to be of granulosal origin, but

255 ex consisting of an orphan prenyltransferase alpha-subunit, PTAR1, and the catalytic beta-subunit of

256 Hence, G-alpha subunit regulation of beta-catenin is context depe

257 We find that the IL-23 alpha-subunit remains partially unstructured until assem

258 Gastrocnemius K(+) channel alpha subunit remodeling arising from Kcne3 deletion was

259 ains with self-reactivity but is occluded by alpha subunit replacement of pTalpha upon alphabetaTCR f

260 ion analysis of voltage-gated sodium channel alpha subunits revealed NaV 1.7 mRNA transcripts in near

261 The structure of the alpha subunit reveals that it is a haem-binding PAS doma

262 formed between putative Arabidopsis Rab-GGT alpha subunits RGTA1/RGTA2 and beta subunits RGTB1/RGTB2

263 are present within the regulatory (R) PKA RI alpha-subunit (RIalpha).

264 n this study, we targeted the RNA polymerase alpha subunit (rpoA) using a PNA that was covalently con

265 C and its derivatives should prove useful as alpha subunit-selective nAChR PAMs.

266 gnaling by accelerating deactivation of Gi/o alpha-subunits, several neurological phenotypes of R7-RG

267 copied silencing FNTA, the prenyltransferase alpha subunit shared by farnesyltransferase and geranylg

268 heterologous coexpression of LRRC52 with BK alpha subunits shifts BK current gating about -90 mV, to

269 es during development and in adults, whereas alpha subunits showed a structure- and age-characteristi

270 Importantly, ENaC beta-subunit or alpha-subunit silencing or kidney tubule-specific beta-E

271 al integrity of the labile C terminus of the alpha subunit (site A).

272 eptor with both IL-5 and GM-CSF but, through alpha-subunit-specific properties, uniquely influences e

273 terminal domain to a standard F-ATP synthase alpha subunit suppresses ATPase activity.

274 preferentially respond to signaling from the alpha-subunit-tethered CaM.

275 s that contain amino acid sequences from the alpha subunit that confer GM2 ganglioside-degrading acti

276 d KCNE4 functionally regulated Kv1.5 (the Kv alpha subunit that generates IKslow1 in mice).

277 haolf (Golf) are highly homologous G-protein alpha subunits that activate adenylate cyclase, thereby

278 X2 increased, and Kv1.4, a potassium channel alpha-subunit that can form A-type potassium (K(A) ) cha

279 ulated exon (STREX), a splice-variant of the alpha-subunit that displays altered channel regulation b

280 In HEK293 cells, alpha-subunits that cannot be S-acylated show attenuated

281 acellular TAAR1 couples to G(13) and to G(S) alpha-subunits to increase RhoA and PKA activity, respec

282 is to chaperone voltage-gated sodium channel alpha-subunits to the plasma membrane.

283 ety from the Ac-CoA binding site (within the alpha subunit) to the NDP-binding site (within the beta

284 he activity of BK channels by stimulating BK-alpha subunit trafficking.

285 e, but not in mice lacking the rod G-protein alpha subunit, transducin (Galphat), revealing these res

286 iate indole and the mutual activation of the alpha-subunit TrpA and the beta-subunit TrpB via a compl

287 ditional knock-out mouse in which the Cav1.2 alpha subunit was deleted in GFAP-positive astrocytes.

288 An nACh non-alpha subunit was expressed in a group of unidentified c

289 EIF2B1 (encoding the eIF2B complex alpha subunit) was the only gene with novel de novo vari

290 cs the activation afforded by binding of the alpha-subunit, was demonstrated to have a similar activa

291 vidual alpha-subunits or between neighboring alpha-subunits, we performed a double-mutant cycle analy

292 Specifically, NaV -alpha subunits were dispersed and NaV beta4 subunit was

293 g both alpha- and beta1-subunits, BK channel alpha-subunits were endogenously S-acylated.

294 no evidence for an involvement of any other alpha-subunit, whereas TP003, described as a selective m

295 GNAQ and GNA11 are heterotrimeric G protein alpha subunits, which are mutated in a mutually exclusiv

296 K(+) channels containing Kv1.1 alpha subunits, which become prevalent at internodes in

297 efold, thereby templating the folding of the alpha-subunits, which then chaperone the assembly of the

298 orebrain structures, and coassembly of these alpha subunits with the beta subunit appears to occur to

299 ecause of expression of the diphtheria toxin alpha subunit within developing DCs.

300 activity/levels of the extralarge G protein alpha-subunit (XLalphas) are implicated in various human