ライフサイエンスコーパス: alpha(2A) adrenergic receptor

1 eraction of the same alphai subunit with the alpha2A-adrenergic receptor.

2 a well-defined allosteric site on the human alpha2A-adrenergic receptor.

3 0, a PC12 cell line overexpressing the human alpha2A-adrenergic receptor.

4 receptor could be replaced by activation of alpha2A-adrenergic receptors.

5 rtion of the third intracellular loop of the alpha(2a) adrenergic receptor.

6 emonstrated noncompetitive inhibition of the alpha(2A)-adrenergic receptor.

7 is thus more complex than that found for the alpha(2A)-adrenergic receptor.

8 a well defined allosteric site on the human alpha(2A)-adrenergic receptor.

9 a well defined allosteric site on the human alpha(2A)-adrenergic receptor.

10 vation of either the P2T(AC) receptor or the alpha(2A)-adrenergic receptor.

11 er GPCRs, such as GABA(B), adenosine A1- and alpha(2A)-adrenergic receptors.

12 eurons, while POMC neurons are inhibited via alpha2A - adrenergic receptors.

13 both peptides disrupted Gbetagamma-mediated alpha(2A) adrenergic receptor activation of mitogen-acti

14 trengthen the dlPFC via pharmacological (the alpha(2A) adrenergic receptor agonist, guanfacine) or re

15 onded to both amphetamine and guanfacine, an alpha2A adrenergic receptor agonist.

16 is specifically stimulated by the selective alpha2A-adrenergic receptor agonist UK14304 and by lysop

17 undergo agonist-stimulated endocytosis, the alpha(2A) adrenergic receptor (alpha(2A) AR), with ERK a

18 in the third intracellular (3i) loop of the alpha(2A) adrenergic receptor (alpha(2A)-AR) can fully a

19 The alpha(2A) adrenergic receptor (alpha(2A)AR) is a clinica

20 nt stem cell-derived neurons, reveal a novel alpha(2A) adrenergic receptor (alpha(2A)AR)-spinophilin-

21 gulated by a G protein-coupled receptor, the alpha(2A) adrenergic receptor (alpha(2A)AR).

22 The alpha(2a)-adrenergic receptor (alpha(2a)-AR) agonist gua

23 alpha(2a)-adrenergic receptor (alpha(2a)-AR) agonists ar

24 that RGS14 functionally associates with the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in a Galpha

25 Genetic manipulation of the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in mice has

26 o-Golgi export kinetics of newly synthesized alpha(2A)-adrenergic receptor (alpha(2A)-AR), a prototyp

27 arly true for synaptic receptors such as the alpha(2A)-adrenergic receptor (alpha(2A)-AR).

28 at this D79(TM2)-N422(TM7) interface in the alpha(2A)-adrenergic receptor (alpha(2A)AR) affects not

29 beta(1)-adrenergic receptor (beta(1)AR) and alpha(2A)-adrenergic receptor (alpha(2A)AR) heterodimeri

30 sms regulating the surface t(1/2) of various alpha(2A)-adrenergic receptor (alpha(2A)AR) structures.

31 d the direct interaction between DMI and the alpha(2A)-adrenergic receptor (alpha(2A)AR), a key regul

32 lecules against a validated pain target, the alpha(2A)-adrenergic receptor (alpha(2A)AR), seeking new

33 alpha(2A)-Adrenergic receptors (alpha(2A)AR) are presyna

34 Alpha(2A)-adrenergic receptors (alpha(2A)AR) regulate mu

35 n vivo Gbetagamma specificity of presynaptic alpha(2a)-adrenergic receptors (alpha(2a)ARs) in both ad

36 monitor the recruitment of GRK2 to activated alpha(2A)-adrenergic receptors (alpha(2A)ARs) in living

37 nstrates that agonist-mediated activation of alpha2A adrenergic receptors (alpha(2A)AR) is voltage-de

38 Here, we used the alpha2A-adrenergic receptor (alpha(2A)AR) as a model to

39 intracellular (3i) loop of the heptahelical alpha2A-adrenergic receptor (alpha2A AR) is critical for

40 Previous studies have shown that alpha2A-adrenergic receptor (alpha2A-AR) retention at th

41 The alpha2A adrenergic receptor (alpha2AAR) is directly deli

42 ne expressing a point mutation (D79N) in the alpha2a adrenergic receptor (alpha2aAR) to investigate t

43 was tethered to the carboxyl terminus of the alpha2A adrenergic receptor (alpha2AAR-Galphai2YFP).

44 inent feature of long-term regulation of the alpha2A-adrenergic receptor (alpha2AAR) is a loss of cel

45 novel direct interaction between APP and the alpha2A-adrenergic receptor (alpha2AAR) that occurs at t

46 Truncations and chimeras of the alpha2A-adrenergic receptor (alpha2AAR) were evaluated t

47 C (PKC) to phosphorylate and desensitize the alpha2A-adrenergic receptor (alpha2AAR).

48 etween delta opioid receptors (deltaORs) and alpha2A adrenergic receptors (alpha2AARs) require protei

49 ype Galpha(z) with a specific agonist to the alpha(2A)-adrenergic receptor also attenuated cAMP-induc

50 s is regulated by postsynaptic noradrenergic alpha(2A) adrenergic receptor and mGluR3 (metabotropic g

51 ulate insulin secretion via the G(i)-coupled alpha(2A)-adrenergic receptor and the G(s)-coupled recep

52 competing at the one allosteric site on the alpha2A-adrenergic receptor and rules out the possibilit

53 alter subsequent radioligand binding to the alpha2a-adrenergic receptor and the dopaminergic D1 rece

54 which was further inhibited by yohimbine, an alpha(2A)-adrenergic receptor antagonist.

55 hich N-terminal hemagglutinin epitope-tagged alpha(2A)-adrenergic receptor (AR) expression was driven

56 The alpha(2A)-adrenergic receptor (AR) undergoes rapid agoni

57 For the alpha(2A)-adrenergic receptor (AR) we determine the rela

58 hips of the amilorides at the alpha(1A)- and alpha(2A)-adrenergic receptors are different.

59 ily member G(alpha)(z) (which couples to the alpha(2A) adrenergic receptor) are deficient in epinephr

60 We find that activation of alpha(2A)-adrenergic receptors (ARs) by the agonist guan

61 In COS-7 cells, alpha(2A)-adrenergic receptors (ARs) stimulate ERK phosp

62 293 cells, stimulation of either alpha1B- or alpha2A-adrenergic receptors (ARs) leads to rapid 5-10-f

63 drenergic receptor-encoding mRNA, alpha1 and alpha2A adrenergic receptor-encoding mRNA, and alpha1, a

64 The amyloid precursor protein modulates alpha2A-adrenergic receptor endocytosis and signaling th

65 ith fluorescent proteins and four GPCRs: the alpha2A-adrenergic receptor, GABAB, cannabinoid receptor

66 fluorescently labeled Galphai1 subunits and alpha2A-adrenergic receptor, GABAB, or dopamine receptor

67 receptor complexes between micro-opioid and alpha2A-adrenergic receptors has been demonstrated in tr

68 titution studies with the adenosine A(1) and alpha(2A) adrenergic receptors have reached a similar co

69 Stimulation of the Galpha(i)-linked alpha(2A)-adrenergic receptor induces a conformational c

70 e RVL, 59% of c-Fos-positive cells contained alpha2A-adrenergic receptor-like immunoreactivity in clo

71 uggest that the effects of the overexpressed alpha2A-adrenergic receptor on PLD activity are mediated

72 tion of Gi-coupled lysophosphatidic acid and alpha2A adrenergic receptors or overexpression of Gbeta1

73 We show that mu opioid and alpha2A adrenergic receptors reside in close proximity i

74 ctive stimulation of the P2Y(12) receptor or alpha(2A)-adrenergic receptor, respectively.

75 and 0.97) with the affinities for the human alpha2A adrenergic receptor subtype and poorly correlate

76 this inhibition is relieved by activation of alpha2A-adrenergic receptor, suggesting that the interac

77 R1 interacts with adenosine A1, GABA(B), and alpha(2A)-adrenergic receptors, through a mechanism invo

78 rtion of the third intracellular loop of the alpha(2A)-adrenergic receptor to dissect these aspects o

79 amilorides act via an allosteric site on the alpha(2A)-adrenergic receptor to strongly inhibit antago

80 ation of agonist binding and function at the alpha(2A)-adrenergic receptor was explored.

81 f9 cell membranes expressing the recombinant alpha2A-adrenergic receptor were used to assess the cont

82 couple to the inhibition of NHE1, but not in alpha(2A)-adrenergic receptors, which do not regulate NH

83 abeled agonist and antagonist binding to the alpha2a-adrenergic receptor with an IC50 value of 0.5 mi