ライフサイエンスコーパス: alpha-actinin

1 teins, including DEB-1 (vinculin) and ATN-1 (alpha-actinin).

2 , lamellipodia (fimbrin), and stress fibers (alpha-actinin).

3 toplasmic domain of ICAM-2 binds directly to alpha-actinin.

4 t 14-3-3 binding blocks its interaction with alpha-actinin.

5 ICAM-2 with the cytoskeletal linker protein alpha-actinin.

6 nt with observations of cells overexpressing alpha-actinin.

7 ated by staining for z-line proteins such as alpha-actinin.

8 actin networks crosslinked with palladin and alpha-actinin.

9 low tract expressed the cardiomyocyte marker alpha-actinin.

10 focal adhesions and binds to both actin and alpha-actinin.

11 d in a regular pattern mainly by the protein alpha-actinin.

12 the crystallographic structures of actin and alpha-actinin.

13 itin in the Z-disk is the actin cross-linker alpha-actinin.

14 a1 activation in the presence and absence of alpha-actinin.

15 signals accumulate in the caps together with alpha-actinin.

16 erconnected Z lines and were cross-linked by alpha-actinin.

17 nd an interaction with the actin crosslinker alpha-actinin.

18 ancestor of Entamoeba and higher eukaryotic alpha-actinins.

19 proteins of microbial pathogens or the human alpha-actinin 1 (HuACTN1) homolog.

20 We show that perturbations to formin and alpha-actinin 1 activity selectively inhibited stress fi

21 While Dyn2 binds directly to both alpha-actinin 1 and alpha-actinin 4, only the interactio

22 low levels of smn, cofilin 1, profilin 2 and alpha-actinin 1 did not affect smn morphant motor axon o

23 sponsive sister paralogs-myosin IIB (MYH10), alpha-actinin 1, and filamin A-had lower expression diff

24 CTN1, which encodes the cytoskeletal protein alpha-actinin 1, in 10 of 239 consecutive probands with

25 In this study, we assessed the role of alpha actinin-1 (ACTN1), one of the two alpha actinin is

26 CLP36 interacted with both alpha-actinin-1 and -4 in breast cancer cells.

27 Decreases in actin-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related pr

28 interacting with actin-cross-linking protein alpha-actinin-1 and increasing its affinity to filamento

29 the IQ motif (residues 1,646-1,664) bound to alpha-actinin-1 and to apo-calmodulin (apoCaM).

30 1662E mutations, which impair apoCaM but not alpha-actinin-1 binding, decreased single-channel open p

31 .2 K1647A and Y1649A mutations, which impair alpha-actinin-1 but not apoCaM binding, but not the F165

32 herin EC1 ectodomain, or alternatively of an alpha-actinin-1 mutant that inhibits F-actin bundling, i

33 Depletion of either alpha-actinin-1 or -4 inhibited breast cancer cell migra

34 Time-lapse imaging reveals that alpha-actinin-1 puncta within actomyosin bundles move mo

35 er leaflet of the plasma membrane, including alpha-actinin-1, moesin, 14-3-3 protein zeta/delta, anne

36 the expression and activation of moesin and alpha-actinin-1, which associate with actin filaments an

37 rk and rescued by the actin bundling protein alpha-actinin-1.

38 f cytoskeleton remodeling factors, including alpha-actinin-1.

39 in which a novel disease-causing variant in alpha-actinin 2 (ACTN2) was identified by next-generatio

40 mediated regulation of Entamoeba histolytica alpha-actinin-2 (EhActn2) with features expected for the

41 ional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences

42 ebrafish can be rescued by overexpression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from ze

43 We have further demonstrated that alpha-actinin-2 competes with calcineurin for binding to

44 n between actn2 and actn3, the phenotypes of alpha-actinin-2 deficient zebrafish can be rescued by ov

45 ete high-resolution structure of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore i

46 ounts of other sarcomeric proteins including alpha-actinin-2, alpha-sarcomeric actin and tropomyosin

47 alpha-Actinin-2, which is differentially expressed in al

48 ociated with dose-dependent up-regulation of alpha-actinin-2, z-band alternatively spliced PDZ-motif

49 A premature stop codon in ACTN3 resulting in alpha-actinin-3 deficiency (the ACTN3 577XX genotype) is

50 on null polymorphism (R577X) in ACTN3 causes alpha-actinin-3 deficiency in approximately 18% of the g

51 here is no associated disease phenotype, but alpha-actinin-3 deficiency is detrimental to sprint and

52 alpha-Actinin-3 deficiency occurs in approximately 16% o

53 This suggests that alpha-actinin-3 deficiency reduces muscle performance at

54 Here, we have shown that alpha-actinin-3 deficiency results in increased calcineu

55 Mechanistically, we show that alpha-actinin-3 deficiency triggers an increase in oxida

56 the primary sequences of alpha-actinin-2 and alpha-actinin-3 evolved differences to optimize their fu

57 Here, we investigate the effects of alpha-actinin-3 expression level by comparing the muscle

58 Loss of alpha-actinin-3 is associated with reduced power and enh

59 We show reduction in alpha-actinin-3 mRNA and protein in HET muscle compared

60 overexpression of alpha-actinin-2 but not by alpha-actinin-3 mRNAs from zebrafish or human.

61 X individuals, suggesting dose-dependency of alpha-actinin-3, while others have shown no difference b

62 inin-2, which is differentially expressed in alpha-actinin-3-deficient muscle, has higher binding aff

63 In this study, we demonstrated that alpha actinin 4 (ACTN4), an actin-cross-linking protein

64 Mutations in alpha-actinin 4 (ACTN4) are linked to familial forms of

65 t mutation (K255E) of the actin cross-linker alpha-actinin 4 (ACTN4) causes its binding kinetics to b

66 e binding affinity of the actin cross-linker alpha-actinin 4 (ACTN4) in cells modulates cytoplasmic m

67 Mutations in the actin-binding protein, alpha-actinin 4 (ACTN4), are linked to focal segmental g

68 y interacting with the actin-binding protein alpha-actinin 4 during tumor cell invasion.

69 Specific disruption of the Dyn2-alpha-actinin 4 interaction blocks the ability of PDAC c

70 d alpha-actinin 4, only the interaction with alpha-actinin 4 is required to promote tumor cell invasi

71 or tissue additionally reveals that elevated alpha-actinin 4 or Dyn2 expression are predictive of poo

72 nonmuscle myosin IIA (MYH9) and IIC (MYH14), alpha-actinin 4, and filamin B, were highly expressed in

73 hrough the C-terminal tails of both Dyn2 and alpha-actinin 4, and these proteins interact at invasive

74 2 binds directly to both alpha-actinin 1 and alpha-actinin 4, only the interaction with alpha-actinin

75 in, integrin-linked kinase, laminin-521, and alpha-actinin 4.

76 nd the actin-bundling protein alpha-actinin (alpha-actinin) 4 is critical for tumor cell migration an

77 n and mass spectrometric analysis identified alpha-actinin-4 (ACTN4) as an MTBP-interacting protein.

78 hat occur within the actin binding domain of alpha-actinin-4 (ACTN4) cause an autosomal dominant form

79 the homodimeric actin cross-linking protein alpha-actinin-4 (ACTN4) during cell migration involves s

80 alpha-Actinin-4 (ACTN4), a key regulator of the actin cy

81 lin further increased binding of MICAL-L2 to alpha-actinin-4 (ACTN4), a protein involved in GLUT4 tra

82 Genetic mutations in alpha-actinin-4 (ACTN4)-an important actin crosslinking

83 Furthermore, a point mutation of alpha-actinin-4 (K255E) associated with FSGS failed to s

84 ge of cortical mechanical tension, rendering alpha-actinin-4 a catch bond in physiological tension ra

85 Functional silencing of alpha-actinin-4 abolished spine elongation and turnover

86 We found that mechanical force induces alpha-actinin-4 and actin accumulation at the cell junct

87 n actin-binding proteins alpha-actinin-1 and alpha-actinin-4 and actin-related protein 2/3 complex su

88 Synaptopodin forms a complex containing alpha-actinin-4 and beta-catenin and interacts with myos

89 apply our approach to the actin cross-linker alpha-actinin-4 and show that the cross-linking time of

90 eling by metabotropic signaling and identify alpha-actinin-4 as a critical effector of structural pla

91 Our study identified alpha-actinin-4 as a novel NHERF1 interaction partner an

92 ed a tension-sensitive upstream regulator of alpha-actinin-4 as synaptopodin.

93 FSGS3/CD2AP colocalizes with E-cadherin and alpha-actinin-4 at the apical junction in polarized Madi

94 Degradation of the podocyte-specific protein alpha-actinin-4 by the UPS depended on oxidative modific

95 and coimmunoprecipitation studies showed the alpha-actinin-4 carboxyl-terminal region specifically in

96 Knockdown of alpha-actinin-4 decreased total junctional actin and inh

97 Knockdown of synaptopodin and alpha-actinin-4 decreases the strength of cell-cell adhe

98 have shown that actin cross-linkers such as alpha-actinin-4 exhibit mechanosensitive properties in t

99 ltured podocytes, treatment with C3a reduced alpha-actinin-4 expression and promoted ILK-dependent nu

100 podocyte loss and changes in ILK, Snail, and alpha-actinin-4 expression.

101 ence supporting mechanisms involving loss-of-alpha-actinin-4 function in human glomerular diseases re

102 Although a mechanism involving gain-of-alpha-actinin-4 function was well described and is respo

103 in-4 and show that the cross-linking time of alpha-actinin-4 homodimers increases approximately twofo

104 This function of alpha-actinin-4 in spine dynamics was underscored by gai

105 and found that silencing of either EWI-2 or alpha-actinin-4 increased cell infectivity.

106 Here alpha-actinin-4 induced spine head enlargement, a morpho

107 The NHERF1/alpha-actinin-4 interaction increased alpha-actinin-4 ub

108 nteraction with spinophilin, but not through alpha-actinin-4 or Arp3.

109 These findings demonstrate that alpha-actinin-4 plays an important role in coupling acti

110 alpha-Actinin-4 specifically localized to sites of actin

111 al change requiring the C-terminal domain of alpha-actinin-4 that binds to CaMKII, an interaction we

112 A point mutation at lysine 255 in human alpha-actinin-4 to glutamate increases the binding affin

113 NHERF1/alpha-actinin-4 interaction increased alpha-actinin-4 ubiquitination and decreased its express

114 alpha-Actinin-4, an actin cross-linking protein, was ide

115 d by NHERF3 and another ligand such as NHE3, alpha-actinin-4, and PKCalpha, promoting formation of NH

116 including those of podocin, nephrin, neph1, alpha-actinin-4, and vimentin.

117 TN4 gene, encoding the actin-binding protein alpha-actinin-4, are a rare cause of autosomal dominant

118 fy a Ca(2+)-sensitive actin-binding protein, alpha-actinin-4, as a novel group 1 mGluR-interacting pa

119 epletion prevents junctional accumulation of alpha-actinin-4, vinculin, and actin.

120 Intercellular tension also induces alpha-actinin-4-dependent recruitment of vinculin to the

121 n of Snail and downregulation of nephrin and alpha-actinin-4.

122 n vitro, including diminished proteolysis of alpha-actinin-4.

123 brane of infected cells and association with alpha-actinin-4.

124 the in vitro actin assembly assay identified alpha-actinin-4/focal segmental glomerulosclerosis 1 (FS

125 , we reported that an actin-binding protein, alpha-actinin (ACTN)4, was dysregulated in placentas fro

126 alpha-Actinins (ACTNs) are a family of proteins cross-li

127 rphology, and expressed the MEC markers SMA, alpha-actinin, adenylate cyclase II, and vimentin.

128 By mutating or titrating actin cross-linkers alpha-actinin Ain1 and fimbrin Fim1 in live cells, we re

129 Here, we identified alpha-actinin Ain1, a contractile ring ABP, as another F

130 between Dyn2 and the actin-bundling protein alpha-actinin (alpha-actinin) 4 is critical for tumor ce

131 The T. vaginalis alpha-actinin amino acid sequence and the sequences of t

132 ailed to detect any of the epitopes or other alpha-actinin amino acid sequences.

133 organized accumulation of actin, myosin, and alpha-actinin and a complete loss of myofibrillar organi

134 otion, PLM synaptogenesis was independent of alpha-actinin and ENA-VASP, both of which bind to the N-

135 alpha-Actinin and Ena/VASP proteins bind to the stress f

136 radation of key sarcomeric proteins, such as alpha-actinin and filamin C, and is essential for mainte

137 al substrates, including the z-disc proteins alpha-actinin and filamin C.

138 -132 markedly attenuated degradation of both alpha-actinin and filamin C.

139 integrin, other cytoplasmic proteins such as alpha-actinin and filamin can directly interfere with ta

140 molecular understanding of the mechanisms of alpha-actinin and filamin catch-bonding behavior.

141 g, we successfully predicted which mammalian alpha-actinin and filamin paralogs would be mechanoaccum

142 in II motors and actin cross-linkers such as alpha-actinin and filamin, accumulate in response to int

143 anism of actin association in both wild-type alpha-actinin and in the K225E mutant.

144 y regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FA

145 ghly seropositive in response to trichomonad alpha-actinin and its truncated protein (ACT-P2) (positi

146 IP6K1 physiologically associates with alpha-actinin and localizes to focal adhesions.

147 ative mislocalization of the Z-disk proteins alpha-Actinin and muscle LIM protein 84B.

148 Furthermore, alpha-actinin and myosin minifilaments turned over signi

149 ely controlled by zyxin and binding partners alpha-actinin and p130Cas, but not vasodilator-stimulate

150 ge-independent growth, co-precipitation with alpha-actinin and production of localized and disseminat

151 tes of Cas and two other adhesion molecules, alpha-actinin and talin, were also significantly slower

152 A single interaction of alpha-actinin and titin turns out to be surprisingly wea

153 ast-specific protein-1), and cardiomyocytes (alpha-actinin and troponin I).

154 t forms filaments with desmin and also binds alpha-actinin and vinculin.

155 a scaffold protein (actin), a cross-linker (alpha-actinin), and a motor (myosin).

156 proteins), adherens junctions (VE-cadherin, alpha-Actinin), and the basement membrane (Collagen IV),

157 s via its C-terminal SH3 domains in an ATN-1(alpha-actinin)- and ALP-1(ALP/Enigma)-dependent manner,

158 Here, we show that non-muscle myosin II, alpha-actinin, and filamin accumulate to mechanically st

159 ents separated by the actin bundling protein alpha-actinin, and is mechanically coupled to noncontrac

160 e and mutant ZASP interact with alpha-actin, alpha-actinin, and myotilin.

161 d by overexpression of the actin crosslinker alpha-actinin, and rheology measurements reveal that cha

162 by pulling VBS peptides derived from talin, alpha-actinin, and Shigella IpaA out of the vinculin hea

163 on simulations with the K237E mutant chicken alpha-actinin--and evaluate the mechanism of alpha-actin

164 adin also serves as a molecular scaffold for alpha-actinin, another key actin crosslinker.

165 Immunofluorescence staining with the anti-alpha-actinin antibody (a z-line marker) showed that nea

166 ArgBP2gamma binding to alpha-actinin appears to underlie its ability to localiz

167 orientation, and 3) surprisingly, actin and alpha-actinin are present in two discrete z-layers.

168 alpha-Actinins are actin-binding proteins that can be br

169 Although alpha-actinins are better known to cross-link actin fila

170 alpha-Actinins are major F-actin bundlers that are inhib

171 These findings identify epitopes of alpha-actinin as candidate serodiagnostic targets and su

172 in vitro experiments of motility assays with alpha-actinins as molecular force sensors.

173 afish embryos results in the accumulation of alpha-actinin associated with severely impaired contract

174 filaments and the muscle-specific isoform of alpha-actinin at the PM of differentiated myotubes.

175 anization, changing spacing and alignment of alpha-actinin bands due to increase in proteolytic activ

176 We map a small alpha-actinin binding region in ArgBP2 (residues 192-228

177 alpha-actinin--and evaluate the mechanism of alpha-actinin binding to actin.

178 presented here was to evaluate the impact of alpha-actinin binding to ICAM-2 on the phenotype of NB t

179 f pancreatic cancer, does not interfere with alpha-actinin binding.

180 Furthermore, mutations inhibiting the alpha-actinin-binding activity abolished the ability of

181 lls expressing ICAM-2 variants with modified alpha-actinin-binding domains differed from cells expres

182 en expressed variants of ICAM-2 with mutated alpha-actinin-binding domains, and compared the impact o

183 We show that the actin-binding protein alpha-actinin binds to the C-terminal surface targeting

184 The calmodulin-like domain of alpha-actinin binds to the Z-repeats of titin.

185 ting in the formation of distinct fascin- or alpha-actinin-bundled domains.

186 n bundles, with no enhancement on fimbrin or alpha-actinin bundles.

187 n was soluble and interacted with sarcomeric alpha-actinin by coimmunoprecipitation, while alpha-syne

188 Regulation of alpha-actinin by IP6K1 requires its kinase activity.

189 icant reduction of cardiac myocyte proteins (alpha-actinin, cardiac myosin-binding protein C, and car

190 Knockdown of alpha-actinin causes aberrant rigidity sensing, loss of

191 ids with high seeding density exhibited more alpha-actinin(+) cells and less nuclear YAP expression.

192 iations and higher length-to-width ratios of alpha-actinin(+) cells.

193 we show in an in vitro assay that talin and alpha-actinin compete for binding to beta3 integrins, bu

194 It has been shown that alpha-actinin competes with talin for binding to the cyt

195 to the actin cytoskeleton by talin, and then alpha-actinin competes with talin to bind beta3 integrin

196 epletion of CLP36 or disruption of the CLP36-alpha-actinin complex in breast cancer cells substantial

197 Our data suggest that the EWI-2-alpha-actinin complex is involved in the regulation of t

198 (actin, tropomyosin, troponins) and Z-band (alpha-actinin) components and promotes their degradation

199 g activity with robust expression of cardiac alpha-actinin, connexin 43, myosin light chain 2a, alpha

200 n adapter protein, ArgBP2, is a component of alpha-actinin containing stress fibers and inhibits migr

201 yosin network consisting of actin filaments, alpha-actinin cross-linking proteins, and non-muscle myo

202 of reconstituted actin networks formed with alpha-actinin crosslinks.

203 interactions with the actin cytoskeleton via alpha-actinin (DeltaABD) abrogated migratory responses t

204 The data suggest the presence of alpha-actinin-dependent and alpha-actinin-independent me

205 Consistently, we find opposite effects of alpha-actinin depletion and expression of mutants on sub

206 Surprisingly, only one-fourth of alpha-actinin dimers were bound to two actin filaments.

207 t fascin domains are densely packed, whereas alpha-actinin domains consist of widely spaced parallel

208 that depletion of the focal adhesion protein alpha-actinin enhances force generation in initial adhes

209 Finally, alpha-actinin enters NAs periodically and in clusters th

210 says, and the range of levels of identity of alpha-actinin epitopes with HuACTN1 was 0% to 50%.

211 Comparison of the T. vaginalis alpha-actinin epitopes with proteins in data banks, such

212 f actin cytoskeleton, bundle-like sarcomeric alpha-actinin expression, higher pacing beat rate at low

213 ed by disrupting nonfocal adhesion proteins (alpha-actinin, F-actin, and myosin II) and subcellular o

214 letal proteins, including beta-III-spectrin, alpha-actinin, filamin, and dystrophin.

215 , is the competition between tropomyosin and alpha-actinin for binding actin.

216 s initial adhesion and force generation) and alpha-actinin for integrin binding.

217 Expression of an alpha-actinin fragment containing the integrin binding d

218 We demonstrate that calmodulin displaces alpha-actinin from their shared binding site on alpha11.

219 Disruption of alpha-actinin function by dominant-negative or small hai

220 e, which contains orthologoues of each human alpha-actinin gene, including duplicated copies of actn3

221 lamin that shares actin-binding domains with alpha-actinin had a strong inhibitory effect on PC2(iv)

222 adjacent sarcomeres that are cross-linked by alpha-actinin homodimers.

223 ling activity and is more dynamic than human alpha-actinin HsACTN4.

224 Our results suggest that alpha-actinin impairs integrin signaling by both undermi

225 nor component of the Z-disc (about 1 per 400 alpha-actinin) important for myofibrillar development an

226 These results may shed light on the role of alpha-actinin in cellular mechanotransduction and focal

227 Palladin coexists with alpha-actinin in stress fibers and focal adhesions and b

228 ides a detailed understanding of the role of alpha-actinin in transmitting tension between actin fila

229 nsport was seen for alpha6beta1-integrin and alpha-actinin in U2OS.

230 alpha-actinins in particular are the major actin crossli

231 The actin-bundling protein alpha-actinin increased PC2(iv) channel function in the

232 the presence of alpha-actinin-dependent and alpha-actinin-independent mechanisms, and indicate that

233 king model for NA assembly whereby transient alpha-actinin-integrin complexes help nucleate NAs withi

234 Here we directly observe that fascin and alpha-actinin intrinsically segregate to discrete bundle

235 alpha-Actinin is an actin cross-linker and may act as a

236 alpha-Actinin is an essential actin cross-linker involve

237 The interaction with alpha-actinin is blocked by CaMKII autophosphorylation a

238 indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediat

239 The cytoskeletal protein alpha-actinin is shared between these two force-producin

240 lates with force generation, suggesting that alpha-actinin is the main link transmitting force betwee

241 e of alpha actinin-1 (ACTN1), one of the two alpha actinin isoforms expressed in keratinocytes, in sk

242 We have further validated alpha-actinin isoforms, phospholamban, dystrophin, alpha

243 ly, disordered actomyosin bundles induced by alpha-actinin knockdown led to higher than normal tensio

244 ises four to six layers of links, presumably alpha-actinin, linking antiparallel overlapping ends of

245 lex formation with the actin-binding protein alpha-actinin, linking membrane-bound CD13 to the cytosk

246 filaments within the Z-band is devoid of any alpha-actinin links and is likely to be the location of

247 The alpha-actinin links run diagonally between connected pai

248 When mixed, fascin and alpha-actinin mutually exclude each other by promoting t

249 taining protein (ZASP)/Cypher interacts with alpha-actinin, myotilin, and other Z-disc proteins via t

250 from women and men that were unreactive with alpha-actinin (negative control sera) failed to detect a

251 and caveolin, Rab5a in early endosomes, and alpha-actinin, often in relationship to cortical actin.

252 tituted with zyxin variants that lack either alpha-actinin or Ena/VASP-binding capacity display compr

253 ell polarization on soft substrates, whereas alpha-actinin overexpression prevented polarization on s

254 's canal cells with dexamethasone treatment, alpha-actinin overexpression, or RhoA overexpression cau

255 These results also suggest that the zyxin/alpha-actinin/p130Cas module may ensure that motile cell

256 udies also showed that composite networks of alpha-actinin/palladin/actin behave very similar to pure

257 on, we have demonstrated that the sarcomeric alpha-actinins play a role in the regulation of calcineu

258 Specifically, alpha-actinin plays distinct roles in regulating alphaII

259 Furthermore, we showed that alpha-actinin promote talin association with beta1-integ

260 Once adhesions have matured, alpha-actinin recruitment correlates with force generati

261 Thus, alpha-actinin recruits Ca(V) 1.2 to defined surface regi

262 othelial ABPs, such as cortactin, myosin, or alpha-actinin, regulate leukocyte extravasation by contr

263 showed that the interplay between talin and alpha-actinin regulates signal transmission via controll

264 alpha-Actinin regulates the immune synapse formation and

265 In contrast, alpha-actinin remained nearly unchanged in both samples.

266 n elicit distinct responses, with myosin and alpha-actinin responding to dilation, and filamin mainly

267 ightly curved and flattened structure of the alpha-actinin rod has a distinct fit into the map.

268 The molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its

269 IP6K1 deletion disrupts alpha-actinin's intracellular localization and function.

270 activation trajectory is generated in which alpha-actinin's vinculin-binding site swings out of the

271 CHC in myotubes induced a loss of actin and alpha-actinin sarcomeric organization, whereas CHC deple

272 In intact cells, alpha-actinin selectively stabilizes CaMKII association

273 tin binding proteins, including spectrin and alpha-actinin, serve as molecular linkages between the a

274 es pombe, in which the cross-linking protein alpha-actinin SpAin1 bundles the actin filament network.

275 actin filaments of mixed polarity like other alpha-actinins, SpAin1 has lower bundling activity and i

276 folding of a titin immunoglobulin domain and alpha-actinin spectrin repeats.

277 Cortexillins I-III are members of the alpha-actinin/spectrin subfamily of Dictyostelium calpon

278 embrane AMPAR regulatory protein) binding to alpha-actinin-stabilized PSD-95, and extracellular inter

279 We conclude that alpha-actinin stabilizes Ca(V)1.2 at the plasma membrane

280 ongly that a highly seropositive reaction to alpha-actinin suggests exposure to T. vaginalis.

281 However, we found evidence that palladin and alpha-actinin synergistically modify network viscoelasti

282 binding of vinculin and, to a lesser extent, alpha-actinin, talin, and filamin, to phosphomimetic Cav

283 ere we show that the F-actin-binding protein alpha-actinin targets CaMKIIalpha to F-actin in cells by

284 just forces on matrices, unveiling a role of alpha-actinin that is different from its well-studied fu

285 oleus muscles exhibit normal localization of alpha-actinin, the nebulin M1M2M3 domain, Tmod3, and cyt

286 Force transmitted through alpha-actinin then triggers adhesion maturation.

287 tion of EWI-2 with the actin-binding protein alpha-actinin; this association was regulated by PIP2.

288 influencing phosphorylation of both FAK and alpha-actinin through its product 5-IP7.

289 Thus, tropomyosin acts as a check on alpha-actinin to achieve intermediate levels of myosin s

290 data show that Ca(2+)-independent binding of alpha-actinin to CaMKII differentially modulates the pho

291 The binding of alpha-actinin to CaMKII is Ca(2+)-independent and activa

292 prominent actin-bundling proteins fascin and alpha-actinin to distinct networks is an intrinsic behav

293 ents interlace with perijunctional actin and alpha-actinin to form a continuous belt of muscle-like s

294 Binding of alpha-actinin to the IQ motif of Ca(V) 1.2 supports its

295 te a major mechanosensitive pathway in which alpha-actinin triggers adhesion maturation by linking in

296 Deletion of IP6K1 abolishes alpha-actinin tyrosine phosphorylation, which is known t

297 reducing myosin II activity or knocking down alpha-actinin, we found that both promoted cell polariza

298 n flow is correlated with a third component, alpha-actinin, which upon CRISPR knockout led to reduced

299 Specific 15-mer peptide epitopes of alpha-actinin with low to no identity with other protein

300 at Zasp52 is required for the association of alpha-actinin with the flight muscle Z-disc, and for nor

301 Our results suggest a model where multiple alpha-actinin/Z-repeat interactions cooperate to ensure