ライフサイエンスコーパス: alpha-catenin

1 volving multistate conformational changes of alpha-catenin.

2 a-catenin ubiquitylation requires binding to alpha-catenin.

3 of the N-cadherin complex in the absence of alpha-catenin.

4 and the N-terminal amino acids 117 to 161 of alpha-catenin.

5 vicinity to the amino-terminal VH1 domain of alpha-catenin.

6 n beta-catenin and the actin-binding protein alpha-catenin.

7 d beta-catenin through its interactions with alpha-catenin.

8 asmic domain of classical cadherins and with alpha-catenin.

9 termediate binding proteins beta-catenin and alpha-catenin.

10 x20 and the cytoskeletal remodeling protein, alpha-catenin.

11 1A mutant bound more vinculin than wild-type alpha-catenin.

12 h increased protein levels of E-cadherin and alpha-catenin.

13 least partly to be intrinsic to the loss of alpha-catenin.

14 siRNA increased the levels of E-cadherin and alpha-catenin.

15 nhancing the interactions between DE-Cad and alpha-Catenin.

16 association with vinculin's binding partner, alpha-catenin.

17 n the heart, is a constitutive actin-binding alpha-catenin.

18 force-dependent conformational activation of alpha-catenin.

19 d substrates reduced the levels of activated alpha-catenin.

20 ace of Tsc1-mutant cells with E-cadherin and alpha-catenin.

21 cal cadherins to the F-actin-binding protein alpha-catenin.

22 d to the activated state remains unknown for alpha-catenin.

23 anically regulates cellular adhesion through alpha-catenin.

24 een the actin-binding domain and the rest of alpha-catenin.

25 sense mutations in the CTNNA1 gene (encoding alpha-catenin 1) in three families with butterfly-shaped

26 ere we show that in the presence of F-actin, alpha-catenin, a cytoplasmic component of the cadherin a

27 n E-cadherin expression was not dependent on alpha-catenin, a DLC1-binding protein associated with E-

28 Here we show that the APC CID interacts with alpha-catenin, a Hippo signaling regulator and heterodim

29 Additionally, our studies reveal that alpha-catenin, a molecule previously implicated in tumor

30 ere, we report the identification of p100 as alpha-catenin, a vinculin-related protein involved in ad

31 ofiling and biochemical analyses reveal that alpha-catenin ablation is accompanied by activation of N

32 pling these clusters with F-actin through an alpha-catenin actin-binding domain (alphaABD) dramatical

33 .beta-catenin complex, and the effect of the alpha-catenin actin-binding domain on beta-catenin assoc

34 to actin and used them to probe the role of alpha-catenin-actin interactions in adherens junctions.

35 itching and vinculin recruitment reveal that alpha-catenin activation and vinculin recruitment occur

36 lt-bridge mutations R551A and D503N enhances alpha-catenin activation in live cells, but R551A has a

37 idges within the force-sensing core modulate alpha-catenin activation.

38 We show that reductions in alpha-catenin, activation of NF-kappaB, and inflammation

39 We find that a decrease in alpha-catenin activity causes the anterior fold to invag

40 The mechanosensitive junctional protein alpha-catenin acts through vinculin and Ena/VASP protein

41 Thus a VE-cadherin-PAR3-alpha-catenin adhesion complex regulates cPLA(2)alpha re

42 Biochemical data suggest that alpha-catenin adopts an autoinhibitory conformation, in

43 Activation of alpha-catenin allows it to interact with vinculin in add

44 These results suggest that the loss of alpha-catenin alone drastically reduces the adhesive for

45 alpha-Catenin (alpha-cat) is an actin-binding protein re

46 here the AJ components E-cadherin (E-cad) or alpha-catenin (alpha-cat) were knocked down.

47 The function of the actin-binding domain of alpha-catenin, alphaABD, including its possible role in

48 characterize the expression of two forms of alpha-catenin, alphaE-catenin and alphaN-catenin, in the

49 tified the adherens junction molecule neural alpha-catenin (alphaN-catenin) as a Snail2 target gene w

50 dynamics of GFP-tagged wild-type and mutated alpha-catenins, altered for their binding capability to

51 actin cytoskeleton through beta-catenin and alpha-catenin, although the quaternary complex has never

52 Interestingly, PC3 cells do not express alpha-catenin, an actin binding protein in the cadherin

53 TXBP4 assembles a protein complex comprising alpha-catenin and a group of Hippo PY motif-containing c

54 mmunoprecipitation studies further show that alpha-catenin and APC are recruited with beta-catenin to

55 beta-Catenin in turn binds alpha-catenin and connects the AJ complex with the actin

56 Of importance, reverse genetics shows that alpha-catenin and delta-catenin, but not beta-catenin, r

57 al borders, but was linked to recruitment of alpha-catenin and dephosphorylation of N-cadherin-linked

58 The hybrid junctions recruit alpha-catenin and exhibit remodeled cortical actin.

59 We show that simultaneous depletion of alpha-catenin and focal adhesion kinase or p21-activated

60 anotransmitter, allowing vinculin binding to alpha-catenin and formation of a secondary molecular bon

61 and p120ctn, as well as the dissociation of alpha-catenin and gamma-catenin from VE-cadherin.

62 rce-dependent binding of vinculin stabilizes alpha-catenin and is responsible for AJ adaptation to fo

63 n regulating the actin-binding ability of an alpha-catenin and its proper function during epithelial

64 veal that Merlin can associate directly with alpha-catenin and link it to Par3, thereby providing an

65 haken about the other two major AJ catenins, alpha-catenin and p120-catenin.

66 ms a flexible "tongue" that is inserted into alpha-catenin and participates in the assembly of the AB

67 of E-cadherin and increased the abundance of alpha-catenin and stabilizing proteins in adherens junct

68 ins, also increased levels of E-cadherin and alpha-catenin and stimulated formation of adherens junct

69 fines evolutionarily conserved properties of alpha-catenin and suggests that multiple mechanisms regu

70 evidence that EPLIN interacts directly with alpha-catenin and tethers the VE-cadherin.catenin comple

71 We further show that Jub associates with alpha-catenin and that its localization to adherens junc

72 lin must be in an activated state to bind to alpha-catenin and that this interaction is stabilized by

73 ntercellular Ecad/Ecad bond strength through alpha-catenin and the kinase activity of glycogen syntha

74 e human parental breast cancer cells lacking alpha-catenin and these cells where alpha-catenin is re-

75 t5a signaling stabilizes vinculin binding to alpha-catenin, and abrogation of vinculin in vivo and in

76 e tension-dependent recruitment of vinculin, alpha-catenin, and F-actin as a function of stiffness, a

77 -cadherin by two ways: direct recruitment of alpha-catenin, and linking its cytosolic tail to the tra

78 e requires beta-catenin, but not cadherin or alpha-catenin, and muscle-expressed beta-integrin is non

79 g fluorescent fusion proteins of beta-Actin, alpha-Catenin, and the ERM family member Moesin1 (Moesin

80 to p120-catenin nor beta-catenin binding to alpha-catenin, and thereby the actin cytoskeleton, is re

81 ect on the adherens junction, as deletion of alpha-catenin, another component of the complex, did not

82 , mechanical and force-sensing properties of alpha-catenin are critical to its proper function.

83 n to adherens junctions and association with alpha-catenin are promoted by cytoskeletal tension.

84 mobilities of E-cadherin, beta-catenin, and alpha-catenin are similar, regardless of the dynamic sta

85 These studies demonstrate that alpha-catenins are critical regulators of Yap, a transcr

86 alpha-Catenins are important mediators of cell-cell adhe

87 We identified alpha-catenin as a predominant miR-9 target.

88 atenin may serve as a link between AChRs and alpha-catenin-associated cytoskeleton, revealing a novel

89 rane domain (JMD) diminished the turnover of alpha-catenin at adherens junctions as measured by fluor

90 (Ecad) and binding partners beta-catenin and alpha-catenin at adherens junctions.

91 on via CK2alpha-dependent phosphorylation of alpha-catenin at S641.

92 th diminished localization of E-cadherin and alpha-catenin at the sites of adherens junctions.

93 Interestingly, tyrosine phosphorylation of alpha-catenin at Y177 disrupts binding to APC but not be

94 ention of beta-catenin from interacting with alpha-catenin attenuated agrin-induced AChR clustering.

95 wn magi-1 or afd-1 function in a hypomorphic alpha-catenin background leads to complete morphogenetic

96 n between normal and cancer cells as well as alpha-catenin-based intercellular adhesion of the normal

97 We show that alpha-catenin becomes Tyr phosphorylated in intercellula

98 ble conformation change further reveals that alpha-catenin behaves like an elastic spring in series w

99 the adherens junction complex formed by the alpha-catenin*beta-catenin*epithelial cadherin cytoplasm

100 We establish that the junctional components alpha-catenin, beta-catenin, and cadherin become highly

101 The expression pattern of alpha-catenin, beta-catenin, and IQGAP1 varied with cell

102 d suggests that multiple mechanisms regulate alpha-catenin binding to F-actin.

103 inding to BCL9 without affecting cadherin or alpha-catenin binding.

104 Monomeric alpha-catenin binds more strongly to E-cadherin-beta-cat

105 rmore, unlike all known vinculin activators, alpha-catenin binds to and activates vinculin independen

106 Although alpha-catenin binds to beta-catenin and to F-actin, beta

107 ltiple Wnt regulatory complexes reveals that alpha-catenin binds with beta-catenin to LEF-1/TCF DNA-b

108 The dogma according to which alpha-catenin bridges cadherin.beta-catenin complexes to

109 alpha-Catenin can bind beta-catenin and F-actin, but in

110 As a dimer, alpha-catenin can bind to actin filaments, affecting the

111 As a monomer, alpha-catenin can bind to beta-catenin, which localizes

112 his static model into question, showing that alpha-catenin can directly regulate actin dynamics.

113 It is currently thought that alpha-catenin cannot simultaneously bind beta-catenin an

114 ify the implicated mechanisms, which involve alpha-catenin capture at the nuclear envelope by nesprin

115 In contrast, depletion of alpha-catenin caused long-term disruption of junctions.

116 The absence of alpha-catenin causes a dominant negative effect on both

117 teins, we show that desmosomal cadherins and alpha-catenin compete directly for binding to plakoglobi

118 mensional model of the cadherin.beta-catenin.alpha-catenin complex based on these new structural data

119 The classical cadherin.beta-catenin.alpha-catenin complex mediates homophilic cell-cell adhe

120 The DLC1-alpha-catenin complex reduced the Rho GTP level at the p

121 es to regulate chemotactic response and ZO-1/alpha-catenin complexes to regulate endothelial barrier

122 t cell-cell junctions by using an engineered alpha-catenin conformation sensor based on fluorescence

123 cence resonance energy transfer (FRET)-based alpha-catenin conformation sensor demonstrated that each

124 cells, the relative rates of force-dependent alpha-catenin conformation switching and vinculin recrui

125 gested how the salt-bridge mutants alter the alpha-catenin conformation, and identified a novel load-

126 ference between the active and autoinhibited alpha-catenin conformers.

127 vidence that in the cadherin-catenin complex alpha-catenin contributes to the binding strength of ano

128 Precisely how alpha-catenin contributes to the formation and stabiliza

129 alpha-catenin controls Yap1 activity and phosphorylation

130 These multiple functions for alpha-catenin converge on the regulation of adhesion and

131 Examination of the alpha-catenin-deficient MDA-MB-468 cells and their deriv

132 by distinct activity states of Rap1 modulate alpha-catenin-dependent coupling between junctions and a

133 This sensor reconstitutes alpha-catenin-dependent functions in alpha-catenin-deple

134 icts invagination of both dorsal folds in an alpha-catenin-dependent manner.

135 genic genes in cooperation with MyoD; and an alpha-catenin-dependent membrane function that helps con

136 titutes alpha-catenin-dependent functions in alpha-catenin-depleted cells and recapitulates the behav

137 tudies question the conventional wisdom that alpha-catenin directly bridges the cadherin adhesion com

138 Significantly, alpha-catenin directly regulates actin-filament organiza

139 on, in the accompanying paper we report that alpha-catenin does not bind simultaneously to both E-cad

140 We test this hypothesis and find that alpha-catenin does not interact with actin filaments and

141 Fetal genes were increased in the alpha-catenin double knockout hearts indicating a less m

142 companied cardiomyocyte proliferation in the alpha-catenin double knockout hearts.

143 -deficient epidermal cells fail to undertake alpha-catenin-driven actin cytoskeletal reorganization a

144 Northern blotting for five of these genes (alpha-Catenin, DTR, FYN, GADD45a, and Zyxin) verified th

145 Using a mathematical model of alpha-catenin dynamics, I show that alpha-catenin must t

146 ependent recruitment of vinculin-a principal alpha-catenin effector-to junctions requires the vinculi

147 ind beta-catenin and F-actin, but in mammals alpha-catenin either binds beta-catenin as a monomer or

148 Collectively, these data suggest that alpha-catenin employs a novel mechanism to activate vinc

149 alpha-Catenin enhanced GTPgammaS binding by ARF6 in vitr

150 s also suggested that Tyr phosphorylation of alpha-catenin enhances its inhibitory role on cell trans

151 Tyr phosphorylation of alpha-catenin enhances its translocation to the plasma m

152 Here we demonstrate that alpha-catenin exists as a monomer or a homodimer with di

153 Recent data supports the classical view that alpha-catenin facilitates actin attachments at adherens

154 roperties are conserved across the mammalian alpha-catenin family.

155 le for Scribble in controlling clustering of alpha-catenin foci in dividing progenitors.

156 atenin significantly weakens the affinity of alpha-catenin for F-actin.

157 s of selective exclusion of beta-catenin and alpha-catenin from desmosomes.

158 relates with the loss of cytoplasmic protein alpha-catenin from E-cadherin-rich intercellular junctio

159 t Tmods protect actin filaments recruited by alpha-catenin from minus-end subunit loss, enabling them

160 ns, which was accompanied by dissociation of alpha-catenin from the beta-catenin/E-cadherin complex a

161 is is the first report showing regulation of alpha-catenin function by Tyr phosphorylation and its in

162 Thus, core properties of alpha-catenin function, F-actin and beta-catenin binding

163 ially rescued by expression of an E-cadherin-alpha-catenin fusion protein but not by E-cadherin-green

164 Consequent reduction in OB-cadherin, alpha-catenin, gamma-catenin, beta-catenin, vimentin and

165 ugh the C-terminal F-actin-binding domain of alpha-catenin has been shown to be crucial for its funct

166 The C-terminal actin-binding domain of alpha-catenin has no influence on the interactions with

167 cadherin HMR-1, its intracellular associates alpha-catenin (HMP-1) and beta-catenin (HMP-2), and the

168 eening using a weak allele of the C. elegans alpha-catenin, hmp-1, thereby identifying UNC-94/tropomo

169 The Caenorhabditis elegans alpha-catenin homolog HMP-1 is essential for actin-depen

170 force-dependent structural rearrangement of alpha-catenin in adherens junctions [10] and vinculin's

171 s completely abolished with the depletion of alpha-catenin in adipocytes.

172 st a functional cooperation between p120 and alpha-catenin in cadherin-based adhesion.

173 ells, and show that the forced expression of alpha-catenin in cancer cells can restore both higher in

174 cells are central to elucidating the role of alpha-catenin in cellular mechanics and tissue function.

175 ture of the vinculin binding domain (VBD) of alpha-catenin in complex with the vinculin head domain (

176 plakoglobin, consistent with the absence of alpha-catenin in desmosomes.

177 However, the potential role of alpha-catenin in directly modulating the adhesive functi

178 Knocking down alpha-catenin in DLC1-positive cells diminished DLC1 loc

179 Knockdown of alpha-catenin in hESCs prevents the switch-off of Wnt/be

180 These results indicate a new role for alpha-catenin in local regulation of actin assembly and

181 tained force is not required for maintaining alpha-catenin in the active state.

182 Our findings indicate a role for alpha-catenin in the APC destruction complex and at Wnt

183 p120 is positioned in proximity to alpha-catenin in the complex with cadherin.

184 Here, we show that ablation of alpha-catenin in the epidermis selectively induces apopt

185 identify a previously unappreciated role for alpha-catenin in these processes.

186 The role of alpha-catenin in this process has been vigorously debate

187 ify proteins that functionally interact with alpha-catenin in this process, we performed enhancer scr

188 Knockdown of alpha-catenins in neonatal rat cardiomyocytes also resul

189 Finally, inactivation of alpha-catenins in the adult heart using an inducible Cre

190 Perinatal depletion of alpha-catenins increased cardiomyocyte number in the pos

191 Here we demonstrate that alpha-catenin is a force-activatable mechanotransducer a

192 n human cells that the AJ-associated protein alpha-catenin is a new binding partner of DLC1.

193 The cytosolic protein alpha-catenin is a postulated force transducer at cadher

194 modulation of beta-catenin activity through alpha-catenin is a potentially attractive approach to at

195 ngineered alpha-catenin sensor revealed that alpha-catenin is a reversible, stretch-activatable senso

196 ion, and biophysical studies have shown that alpha-catenin is activated in a tension-dependent manner

197 alpha-Catenin is an actin- and vinculin-binding protein

198 se different binding states, indicating that alpha-catenin is an allosteric protein.

199 alpha-Catenin is an identified force transducer within c

200 alpha-catenin is central to recruitment of actin network

201 Wood et al. show that the junction component alpha-catenin is critical in freely moving cells to prom

202 terned membranes, we show that activation of alpha-catenin is dependent on E-cadherin clustering, and

203 ely dispensable in mature junctions, whereas alpha-catenin is essential for the maintenance of functi

204 As contact time between cells increases, alpha-catenin is essential for the strengthening of the

205 alpha-Catenin is essential in cadherin-mediated epitheli

206 t known if this conformational regulation of alpha-catenin is evolutionarily conserved.

207 The protein alpha-catenin is found as a monomer or homodimer.

208 At usual cytoplasmic concentrations, alpha-catenin is found predominantly in monomeric form.

209 This structure reveals that alpha-catenin is in a unique unfurled mode allowing dime

210 munocomplex phosphatse assays confirmed that alpha-catenin is in deed an SHP2 substrate.

211 lacking alpha-catenin and these cells where alpha-catenin is re-expressed.

212 alpha-Catenin is the primary link between the cadherin.c

213 hat when a single adherens junction protein, alpha-catenin, is removed by conditional targeting, the

214 he weakening of cell-cell interactions in an alpha-catenin knockdown monolayer reduces the defect siz

215 tical for this event because a point mutant (alpha-catenin L344P) lacking high affinity binding does

216 hway, which reduces levels of E-cadherin and alpha-catenin leading to disruption of adherens junction

217 casein kinase 2-mediated phosphorylation of alpha-catenin, leading to destabilization of the adheren

218 Binding of DLC1 to alpha-catenin led to their accumulation at the plasma me

219 alpha-Catenin links cell-cell adhesion complexes to the

220 Contrary to the idea that alpha-catenin links the adhesion protein E-cadherin thro

221 alpha-catenin links the cadherin-catenin complex (CCC) t

222 iR-9 in human SCC metastases correlated with alpha-catenin loss but not E-cadherin loss.

223 t adherens junctions, but also suggests that alpha-catenin may act as a force transducer, and may hav

224 At short contact times, alpha-catenin mediates a 30% stronger interaction betwee

225 we provide proof of concept that inhibiting alpha-catenins might be a useful strategy to promote myo

226 an AJ, are sufficient to locally accumulate alpha-catenin monomers and homodimers.

227 model of alpha-catenin dynamics, I show that alpha-catenin must transiently homodimerize while bound

228 thereby abrogating the inhibitory effect of alpha-catenin on beta-catenin transactivation via CK2alp

229 ectroscopy measurements in cells depleted of alpha-catenin or expressing the hereditary diffuse gastr

230 d VAB-9/claudin, but surprisingly, not HMP-1/alpha-catenin or HMP-2/beta-catenin.

231 ramework with other binding partners such as alpha-catenin or talin to induce vinculin head-tail diss

232 with a loss of interaction between actin and alpha-catenin or ZO-1.

233 esion components like focal adhesion kinase, alpha-catenin, or vinculin.

234 eum lacks a cadherin homolog, we identify an alpha-catenin ortholog that binds a beta-catenin-related

235 ction proteins E-cadherin, beta-catenin, and alpha-catenin, p120 catenin family members p0071, ARVCF,

236 The data suggest that alpha-catenin-p120 contact within the cadherin-catenin c

237 cyte model system, we show that depletion of alpha-catenin perturbs adherens junctions, enhances cell

238 sequently enhancing CK2alpha activity toward alpha-catenin phosphorylation.

239 dherin germ-line missense mutation show that alpha-catenin plays a critical role in cadherin-mediated

240 alpha-Catenin plays a crucial role in cadherin-mediated

241 Therefore, whether alpha-catenin plays a direct role in cadherin-dependent

242 ZO-1 and alpha-catenin polypeptides were colocalized in S1P-induc

243 ers of cadherin signaling, gamma-catenin and alpha-catenin predominate in the lateral motor column.

244 his EGFR-ERK-CK2-mediated phosphorylation of alpha-catenin promotes beta-catenin transactivation and

245 Importantly, alpha-catenin promotes beta-catenin ubiquitylation and p

246 Finally, depletion of either PAR3 or alpha-catenin promotes cPLA(2)alpha-dependent endothelia

247 the neural subtype of the adherens junction alpha-catenin protein, regulates cranial neural crest ce

248 Alpha (alpha) catenin proteins can regulate both cell adhesion

249 rnary complex of cadherin, beta-catenin, and alpha-catenin regulates actin-dependent cell-cell adhesi

250 domain (AMD) of Caenorhabditis elegans HMP-1/alpha-catenin regulates its F-actin-binding activity and

251 h alpha-catenin was reintroduced showed that alpha-catenin reinforces E-cadherin-p120 association.

252 cate that although the initial activation of alpha-catenin requires micron-scale clustering that may

253 Conversely, introduction of alpha-catenin restored the responsiveness of cells to JN

254 Truncating alpha-catenin's C-terminus eliminates force-activated F-

255 force-activated binding, demonstrating that alpha-catenin's C-terminus is a modular detector of F-ac

256 In addition, levels of alpha-catenin S641 phosphorylation correlate with levels

257 Moreover, alpha-catenin self-associates into homodimers that block

258 This engineered alpha-catenin sensor revealed that alpha-catenin is a re

259 ns requires the vinculin binding site of the alpha-catenin sensor.

260 Collectively, our findings reveal Ovol-Zeb1-alpha-catenin sequential repression and highlight Ovol1

261 ch as vinculin, connexin 43, N-cadherin, and alpha-catenin showed no significant change with the loss

262 ssing a Vinculin binding-deficient mutant of alpha-catenin, showing that Vinculin recruitment is not

263 em, we have characterized mutations in hmp-1/alpha-catenin that identify HMP-1 residues 687-742 and 8

264 t-bridge network within the core M region of alpha-catenin that may be the structural determinant of

265 y conserved amino acids in the C terminus of alpha-catenin that modulate F-actin binding in living em

266 elongated multidomain assembly of monomeric alpha-catenin that structurally and functionally couples

267 on hyperactive Wnt signaling is dependent on alpha-catenin; the rescue effect is completely abolished

268 isruption of the complex of beta-catenin and alpha-catenin, thereby abrogating the inhibitory effect

269 main deletion mutants showed that binding of alpha-catenin to beta-catenin was required for transport

270 sely, activation of JNK increased binding of alpha-catenin to beta-catenin, which was blocked by the

271 , force-induced conformational transition of alpha-catenin to the activated conformation.

272 Direct binding of alpha-catenin to vinculin is critical for this event bec

273 adherin-11 cytoplasmic JMD as a regulator of alpha-catenin turnover at adherens junctions and actin-c

274 complex composition varied, showing enriched alpha-catenin under the cell-type-specific conditions in

275 ells expressing the sensor demonstrated that alpha-catenin undergoes immediate, reversible conformati

276 The two alpha-catenin variants differ in their self-association

277 , and induced vinculin dissociation from the alpha-catenin-VE-cadherin complex.

278 ts intracellular partners, such as beta- and alpha-catenins, vinculin, and actin filaments.

279 We propose a feed-forward model whereby alpha-catenin-vinculin interactions promote their bindin

280 is stabilized by the formation of a ternary alpha-catenin-vinculin-F-actin complex, which can be for

281 se data demonstrate that the force-dependent alpha-catenin/vinculin interaction, manipulated here by

282 o adherens junction formation in cells where alpha-catenin was absent or knocked down.

283 Interaction of p100 with alpha-catenin was confirmed by coimmunoprecipitation of

284 showed that interaction of beta-catenin with alpha-catenin was important for efficient differentiatio

285 ly with the peripheral assemblies, activated alpha-catenin was present in both peripheral and central

286 When the full-length alpha-catenin was re-introduced, the phenotype of PC3 ce

287 DA-MB-468 cells and their derivates in which alpha-catenin was reintroduced showed that alpha-catenin

288 tingly, we found that the N-terminal half of alpha-catenin was sufficient to suppress invasive phenot

289 ty during epidermal morphogenesis depends on alpha-catenin, which connects the cadherin complex to F-

290 A key regulator of this stability is alpha-catenin, which connects the cadherin-catenin compl

291 Depletion of alpha-catenin, which couples E-cadherin to the actin cyt

292 in complex binds to the cytoskeletal protein alpha-catenin, which is essential for both the formation

293 0 as bait revealed specific interaction with alpha-catenin, which is known as a regulator of adherens

294 residue abolishes binding of beta-catenin to alpha-catenin, which links to cytoskeleton, suggesting t

295 s are disconnected from the cytoskeleton and alpha-catenin, which links VE-cadherin to the cytoskelet

296 ough cytoplasmic interactions with beta- and alpha-catenin, which serve to increase adhesive strength

297 erin junctions led to reduced association of alpha-catenin with N-cadherin, prevented organization of

298 suggest that JNK affects the association of alpha-catenin with the adherens junction complex and reg

299 adherin complex and increased association of alpha-catenin with the cytoskeleton.

300 tributed to inhibition of the association of alpha-catenin with the DeltaEXD-beta-catenin complex.