ライフサイエンスコーパス: alpha-catulin

1 (q) protein, suggesting cooperation with Lbc/alpha-catulin.

2 ting protein of relatively unknown function, alpha-catulin.

3 ans genetic study, we demonstrate that CTN-1/alpha-catulin, a cytoskeletal protein, physically intera

4 Mechanistic investigations revealed that alpha-catulin activated Akt-NF-kappaB signaling downstre

5 Here, we report that alpha-catulin also drives malignant invasion and metasta

6 dy demonstrates that the interaction between alpha-catulin and alpha-dystrobrevin is evolutionarily c

7 Clinically, high levels of expression of alpha-catulin and ILK were associated with poor overall

8 These results suggest a novel function for alpha-catulin and imply that alpha-catenin and alpha-cat

9 d endogenous alpha-catulin product, document alpha-catulin and Lbc co-expression in multiple human ce

10 ssion in multiple human cell lines, and show alpha-catulin and Lbc subcellular co-fractionation and i

11 exin, alpha-Liprin, SYDE, ELKS/CAST, RIM-BP, alpha-Catulin, and MAGI1.

12 Alpha-catulin appears to inhibit Ras-mediated signals to

13 Taken together, our study implicates alpha-catulin as a unique regulator of GPCR signaling an

14 Thus, the Lbc/alpha-catulin axis participates in 5-HT-induced PASMC mi

15 hment for LT-HSCs and sixfold enrichment for alpha-catulin+c-kit+ HSCs, and yielded HSCs with superio

16 Furthermore, alpha-catulin co-expression enhances Lbc-induced GTP-Rho

17 Functionally, alpha-catulin co-expression leads to increased Lbc-induc

18 Interestingly, alpha-catulin expression attenuates the activation of th

19 itutively upregulated Wnt signaling, whereas alpha-catulin expression had no effect.

20 The human alpha-catulin gene (CTNNAL1) maps to 9q31-32.

21 ted as alpha-catulin(GFP)), we discover that alpha-catulin(GFP) is expressed by only 0.02% of bone ma

22 e gene Ctnnal1 in mice (hereafter denoted as alpha-catulin(GFP)), we discover that alpha-catulin(GFP)

23 l imaging, allowing us to image thousands of alpha-catulin-GFP(+)c-kit(+) cells and to digitally reco

24 titution of irradiated mice, indicating that alpha-catulin-GFP(+)c-kit(+) cells are comparable in HSC

25 We find that approximately 30% of alpha-catulin-GFP(+)c-kit(+) cells give long-term multil

26 The distribution of alpha-catulin-GFP(+)c-kit(+) cells indicated that HSCs w

27 ifferences in femurs and sterna, their adult alpha-catulin-GFP+ HSCs had similar distributions.

28 both had indistinguishable localization from alpha-catulin-GFP+ HSCs.

29 We found adult femoral alpha-catulin-GFP+ or Mds1GFP/+Flt3Cre HSCs proximal to

30 pha-catulin and imply that alpha-catenin and alpha-catulin have distinct activities that downregulate

31 increased, suggesting a compensatory role of alpha-catulin in dystrophic muscle.

32 apped, and complex formation between Lbc and alpha-catulin in mammalian cells was detected.

33 paB or alphavbeta3 was sufficient to inhibit alpha-catulin-induced cell migration and invasion.

34 alpha-Catulin interacted with integrin-linked kinase (IL

35 The required regions for Lbc and alpha-catulin interaction were mapped, and complex forma

36 alpha-Catulin is an oncoprotein that helps sustain proli

37 tation and blot overlay assays indicate that alpha-catulin is directly recruited to the alpha(1D)-AR

38 strophin, we discover that the expression of alpha-catulin is increased, suggesting a compensatory ro

39 We further show that in mouse alpha-catulin is localized at the sarcolemma and neuromu

40 ith alpha-dystrobrevin and that the level of alpha-catulin is reduced in alpha-dystrobrevin-deficient

41 we show that CTN-1, a homologue of mammalian alpha-catulin, is required for subcellular localization

42 Furthermore, alpha-catulin knockdown attenuated 5-HT-induced PASMC th

43 Here, based on evidence suggesting that alpha-catulin may associate with a beta-catenin fraction

44 Taken together, our study shows that alpha-catulin plays a critical role in cancer metastasis

45 Here we identify the predicted endogenous alpha-catulin product, document alpha-catulin and Lbc co

46 ort the concept that the recently identified alpha-catulin protein may modulate Rho pathway signaling

47 t and is identical to the alpha-catenin-like alpha-catulin protein of unknown function.

48 Attenuation of ILK or alpha-catulin reciprocally blocked cell migration and in

49 eased association between Lbc, RhoA, and the alpha-catulin scaffold.

50 eomic and biochemical analysis revealed that alpha-catulin supersensitizes alpha(1D)-AR functional re

51 alpha-Catulin was upregulated in highly invasive non-sma

52 identified an alpha-catenin-related protein, alpha-catulin, whose function is poorly understood, as p