ライフサイエンスコーパス: alpha-chain

1 nsthyretin, serum amyloid A4, and fibrinogen alpha chain.

2 ion of CD25, the high affinity IL-2 receptor alpha chain.

3 arding the role of the similarly polymorphic alpha chain.

4 is a preferred cleavage site in the protein alpha chain.

5 rains share a lacto-N-neotetraose (nLc4) LOS alpha chain.

6 rminant in the optimal expression of the TCR-alpha chain.

7 oded portions of CDR3 of the T cell receptor alpha chain.

8 -3, both of which are thought to bind to HGF alpha chain.

9 xis in mice expressing the human FcepsilonRI alpha-chain.

10 3epsilondelta ECDs to sit underneath the TCR alpha-chain.

11 reased expression of Stat6 and IL-4 receptor alpha-chain.

12 lation, and proteolytic processing of the Hp alpha-chain.

13 xpression correlating with mRNA level of its alpha-chain.

14 promoted by, expression of an endogenous TCR alpha-chain.

15 ition, with little contribution from the TCR alpha-chain.

16 f Il4ra, the gene encoding the IL-4 receptor alpha-chain.

17 nition with no contribution from the HLA-DP2 alpha-chain.

18 )14J(alpha)18) T cell antigen receptor (TCR) alpha-chain.

19 ed by a self-peptide derived from the HLA-DR alpha-chain.

20 proximately 38% of BMCPs expressed the IL-3R alpha-chain.

21 r upregulate expression of the IL-7 receptor alpha-chain.

22 ouse recognize a peptide from the H/K-ATPase alpha-chain.

23 pecific receptor chain (TSLPR) and the IL-7R alpha-chain.

24 ein (CCP) domain 1/CCP2 and CCP8 of the C4BP alpha-chains.

25 R Vbeta5.1 chains coupled with different TCR alpha-chains.

26 beta- and gamma(c)-chains, but have distinct alpha-chains.

27 d by the ability to coexpress additional TCR alpha-chains.

28 lding is intermolecular shearing of collagen alpha-chains.

29 n the collagen domain of COL4A2 (collagen IV alpha chain 2) in a family displaying porencephaly with

30 includes Il2ra (for interleukin 2 receptor, alpha chain), a gene that is known to be associated with

31 Variants of fibrinogen A alpha-chain (AFib) cause the most common type of heredit

32 ained peptide sequences from type I collagen alpha chain, albumin, and LDL receptor-related protein.

33 red to consist of three genetically distinct alpha chains (alpha1, alpha2, and alpha3).

34 entification of three novel long collagen VI alpha chains, alpha4, alpha5, and alpha6, led to the que

35 he protein and mRNA levels of the receptor's alpha-chain, analyzed by flow cytometry and quantitative

36 ntrols, including human leukocyte antigen DM alpha chain and chemokine (C-C motif) ligand 20 (CCL20),

37 d and myeloid fates, expressed IL-6 receptor-alpha chain and responded to IL-6 by phosphorylation of

38 olutionary conservation of the invariant TCR-alpha chain and restricting molecule MR1, this populatio

39 e binds to the subunit centers of both nAChR alpha chains and one of the GLIC chains, in a site that

40 ing protein) is a polymer of seven identical alpha chains and one unique beta chain synthesized in li

41 Namely, the iT(reg) TCR alpha-chain and beta-chain are overlaid with the alpha-c

42 QA1 and DQB1 genes into two groups where any alpha-chain and beta-chain belonging to the same group a

43 a-chain and beta-chain are overlaid with the alpha-chain and beta-chain of MHC class II, respectively

44 Previous work has shown that both alpha-chain and beta-chain phosphorylations of CD11a/CD1

45 s encoding the T cell antigen receptor (TCR) alpha-chain and delta-chain (Tcra-Tcrd) undergoes recomb

46 MHC class II molecules are composed of one alpha-chain and one beta-chain whose membrane distal int

47 on CD8(+) T cell responses, mAbs to the TCR alpha-chain and T cells expressing two TCR species were

48 ma subunits were situated underneath the TCR alpha-chain and TCR beta-chain, respectively.

49 onsisting of the extracellular IL-2 receptor alpha-chain and the cytoplasmic ADAM15 domain were IL-2-

50 Three alpha-chain and three beta-chain public TCR sequences we

51 Both TCR alpha-chains and TCR beta-chains made contact with the C

52 ammed death-1 (PD-1) and CD25 (IL-2 receptor alpha chain), and led to antigen-specific tumor cell kil

53 Further, CD25, an IL-2R alpha chain, and lytic granules of NK cells in social mi

54 uFeHis evolution is faster for beta than for alpha chains, and pump-probe rR spectroscopy in solution

55 determining region 3 (CDR3) sequences on the alpha-chain, and displayed restricted V-beta use.

56 and soluble forms of CD25, the IL-2 receptor alpha-chain, and quenching T-cell-derived IL-2.

57 of the pyrrolidine ring, manipulation of the alpha-chain, and the N-substituent) under mild, metal-fr

58 kinase CbetaII (PKCbetaII), GM-CSF receptor alpha-chain, and two actin-associated proteins, paxilin

59 loss-of-function studies, anti-IL-7 receptor alpha-chain (anti-IL-7Ralpha) antibody or its isotype co

60 h AD is available for the anti-IL-4 receptor alpha-chain antibody dupilumab, but a number of studies

61 We found that 19 of 22 collagen-alpha chains are significantly up-regulated (p < 0.05) i

62 , a monoclonal antibody to the IL-5 receptor alpha-chain, are comparatively limited, especially for b

63 o californica acetylcholine receptor (TAChR) alpha-chain as a neo-self Ag.

64 of exogenous TCR-beta chains, but not of TCR-alpha chains, assembly and functional cell surface expre

65 thesized and secreted as a 290-kDa mutant C7 alpha chain at levels similar to wild type C7.

66 ed, mycolyl lipid-reactive (GEM) TCRs had an alpha-chain bearing the variable (V) region TRAV1-2 rear

67 well as an unconventional GA-binding protein alpha chain binding motif.

68 ith the associated peptide in favor of MHCII alpha-chain binding.

69 For the TCR alpha chain, both complete ER import and subunit assembl

70 en structure that has a nearly identical TCR alpha chain but a different beta chain, highlighting the

71 us, several other isotypes that use the same alpha chain but have beta chains encoded by other genes.

72 nartuzumab acts specifically by blocking HGF alpha-chain (but not beta-chain) binding to MET.

73 invariant Valpha14-Jalpha18 T cell receptor-alpha chain, but is rescued by overexpression of a rec-V

74 triple helical and NC1 domain of individual alpha-chains, but in vivo evidence is lacking.

75 Here we show that the human FcepsilonRI alpha-chain can efficiently reach the cell surface by it

76 beta2 (CD18) integrins with alpha-chains CD11a, -b, -c, and -d are important adhesio

77 n primary patient samples, the IL-3 receptor alpha chain CD123 was highly expressed on leukemia-initi

78 The interleukin-3 receptor alpha chain (CD123) has been identified as a potential i

79 ansient down-regulation of the IL-7 receptor alpha chain (CD127) in both CD4(+) and CD8(+) T cells.

80 cells to recycle IL-7 is dependent on IL-7R alpha-chain (CD127) and endocytosis, consistent with a m

81 erized by a high expression of IL-2 receptor alpha chain (CD25) and of forkhead box P3 (FOXP3), the l

82 2 (IL-2) signaling through the IL-2 receptor alpha chain (CD25) facilitates HIV replication in vitro

83 xpression of the high affinity IL-2 receptor alpha chain (CD25) on virus-specific CD4 T cells, which

84 itions predominant (GARP), the IL-2 receptor alpha chain (CD25), and programmed cell death 1 ligand 1

85 ) T cells express the interleukin 2 receptor alpha-chain (CD25) at lower levels.

86 lls (Tregs) constitutively express the IL-2R alpha-chain (CD25) on their surface.

87 cells (hDCs) produce IL-2 and express IL-2R alpha-chain (CD25), but the role of IL-2 in DC functions

88 mes damaged by apoptosis and glycoprotein Ib alpha chain (CD42b) shedding.

89 sregulation, including soluble IL-2 receptor alpha chain, CD45RO(+)CD4(+) effector T cells, and autoa

90 d the sigma-moiety is a triatomic alpha-beta-alpha chain composed of C, Si, or Ge atoms.

91 for generating trimeric NC1 domains of other alpha-chain compositions to investigate the alpha121, al

92 I, whereas rs7192 was predicted to influence alpha-chain conformation.

93 We found that the nLc4 alpha chain conforms at least four different antigens.

94 We found that folding of the TCR alpha chain constant domain Calpha is dependent on alpha

95 ion with MR1, whereas the invariant MAIT TCR alpha chain controlled specificity through a small numbe

96 wide frequency range (<0.00001-1.62%) of TCR alpha-chains corresponding to GAD65-specific T cells.

97 novel structural details with respect to the alpha chain cross-linking compared with earlier efforts.

98 osslinking sites, but not in clots that lack alpha-chain crosslinking sites.

99 ntion of RBCs in clots is mediated by fibrin alpha-chain crosslinking.

100 colony-stimulating factor (GM-CSF) receptor alpha-chain (CSF2RA) deficiency is a rare, life-threaten

101 h IL-10 deficiency and 1 patient with IL-10R alpha chain deficiency and proved to be an effective the

102 po-form and in complex with human K10 and Fg alpha-chain-derived peptides, respectively.

103 e lacking ST2 (ST2(-/-)), the IL-33 receptor alpha-chain, developed attenuated AIA and reduced expres

104 Mice lacking ST2, the IL-33 receptor alpha-chain, developed attenuated collagen-induced arthr

105 position of group 14 atoms in the alpha-beta-alpha chain dictates whether electronic communication be

106 sidue present in the cytoplasmic tail of the alpha chain, DMalpha.

107 s had higher expression of the IL-2 receptor alpha chain, DN Ikaros-transduced cells achieved their c

108 ha1(VI), alpha2(VI), and alpha3(VI) collagen alpha chains encoded by the COL6A1, COL6A2, and COL6A3 g

109 cific, clonally diverse VB19 T cells express alpha-chains encoded by multiple AV genes with different

110 ult from a genetic deficiency of the GM-CSFR alpha chain, encoded in the X-chromosome pseudoautosomal

111 aining (pseudo)halide functionalities at the alpha-chain end but, depending on the termination mechan

112 nto the side chain of linear polymers or the alpha-chain end of star polymers.

113 ossessing a pentavalent arsenic acid (As(V)) alpha-chain end was transformed into trivalent As(III) p

114 in surface expression of IFN-gamma receptor alpha-chain even in the absence of IFN-alpha/beta signal

115 in LOS with a complete lacto-N-neotetraosyl alpha-chain even though previous reports suggested that

116 ruct the structural models of the fibrinogen alpha-chain (excluding two highly flexible regions) and

117 urther investigate this we evaluated laminin alpha-chain expression in the cerebral cortex and eye of

118 The C-terminal portion of the fibrin alpha chain extends into the alphaC region (210-610).

119 trally above CD1b, whereby the conserved TCR alpha-chain extensively contacts CD1b and GMM.

120 2, as well as to other epitopes of the TAChR alpha-chain extracellular domain, was maintained in old

121 ild-type mice versus those deficient in FcRn alpha-chain, FcgammaIIb, and FcgammaRI/FcgammaRIII, foll

122 ts resulted from heme distortion and, in the alpha chain, Fe-His bond tilting.

123 , the MAIT-TCR contacts are dominated by the alpha-chain, focused on the MR1 alpha2 helix.

124 hat the ability of AHSP to stabilize nascent alpha chain folding intermediates prior to hemin reducti

125 ry complexes of 1:1:1 stoichiometry with all alpha chain fragments.

126 ls are identified by their expression of the alpha-chain from the integrin alpha(E)(CD103)beta(7), an

127 e localization of proximal constraint in the alpha chains, geminate recombination was found to be equ

128 n deficiency [via knockout of the fibrinogen alpha chain gene (Fbg(-/-))] affected APAP-induced liver

129 e soluble form of the interleukin-7 receptor alpha chain gene (sIL7R) produced by alternative splicin

130 ession of a rearranged Valpha14-Jalpha18 TCR-alpha chain gene into the Nur77(tg) (Nur77(tg);Valpha14(

131 n accumulation of unresolved T cell receptor alpha-chain gene (Tcra) breaks.

132 Mutations in the fibrinogen A alpha-chain gene are the most common cause of hereditary

133 , we show that the conserved T cell receptor alpha-chain generates insulin autoantibodies when transg

134 d the disruption of endogenous TCR beta- and alpha-chain genes.

135 The alpha3(VI) collagen alpha chain has much larger N- and C-globular domains th

136 s contain a mixture of functionally distinct alpha-chain hemoglobin isoforms that are predicted to ha

137 s suggested that the presence of an extended alpha-chain hinders C3 PEA substitution of Hep II.

138 In alpha chains, however, the respective lysine and glutami

139 ciency of the Interferon alpha/beta receptor alpha chain (IFNAR1) in a child with fatal systemic hype

140 ing aptamers against Interleukin 10 receptor alpha chain (IL-10RA) and experimentally confirmed our p

141 Polymorphisms in the interleukin-4 receptor alpha chain (IL-4R alpha) have been linked to asthma inc

142 and vascular endothelial (VE) IL-4 receptor alpha chain (IL-4Ralpha) signaling in histamine-abelson

143 onal antibody that targets the IL-4 receptor alpha chain (IL-4Ralpha), common to both IL-4R complexes

144 ing on their expression of the IL-4 receptor alpha chain (IL-4Ralpha/CD124).

145 ceptor (IL-5R), composed of a ligand binding alpha chain (IL-5Ralpha), and a common beta chain, betac

146 cell-specific deletion of the IL-6 receptor alpha chain (IL-6Ralpha) results in impaired Th1 and Th1

147 he gene expression of interleukin-7 receptor alpha chain (IL-7Ralpha) and postulated to be critical i

148 Interleukin-7 receptor alpha chain (IL-7Ralpha) is induced upon T cell positive

149 levels of CD127, the interleukin 7 receptor alpha chain (IL-7Ralpha).

150 MEF cells from mice deficient in the IL-18R alpha-chain (IL-18Ralpha) compared with wild type MEF.

151 phil surface expression of the IL-4 receptor alpha-chain (IL-4Ralpha), essential for IL-4- and IL-13-

152 the Il4ra locus, which encodes IL-4 receptor alpha-chain (IL-4Ralpha), was essential for inducing and

153 IL-6 binds to the IL-6R alpha-chain (IL-6Ralpha) and signals via the signal tran

154 Using their IL-6 receptor alpha-chain (IL-6Ralpha), Sirpalpha(+) DCs trans-present

155 p1 repressed expression of the IL-7 receptor alpha-chain (IL-7Ralpha) by antagonizing Foxo1 and negat

156 in a severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expression associated with its

157 naive and memory T cells, and IL-7 receptor alpha-chain (IL-7Ralpha) expression is dynamically regul

158 LCs) that express the interleukin 7 receptor alpha-chain (IL-7Ralpha).

159 ene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced

160 in-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) and wild-type (WT) control anima

161 in-of-function mutation in the IL-4 receptor alpha chain (Il4raF709) were orally sensitized with food

162 sion of the genes encoding the IL-6 receptor alpha-chain (Il6ra) and the IL-6 signal transducer gp130

163 ghting the likely dominance of the conserved alpha chain in MR1-antigen recognition.

164 e C-terminal vSAG segment binds to the MHCII alpha-chain in a conformation-sensitive manner, the memb

165 alanine to threonine at position 118 of the alpha-chain in the CDR3 region of the TCR improved its f

166 r the 3-hydroxylation of the A3 site of both alpha-chains in bone but not in tendon.

167 However, the importance of these alpha-chains in disease pathogenesis and the paired TCRb

168 ked disturbance in the deposition of laminin alpha-chains including alpha1, alpha2, alpha4, and alpha

169 The band intensity of beta-chain and alpha-chains increased as the extraction temperature inc

170 CD4 T cells that express CD25 (IL-2 receptor alpha-chain) increases with age on subsets of both CD31(

171 ated cross-linking of IgE-loaded FcepsilonRI alpha-chains induces cell activation via immunoreceptor

172 Daclizumab (Dac), an Ab against the IL-2R alpha-chain, inhibits brain inflammation in patients wit

173 ller T (NKT) cells with an invariant (i) TCR alpha chain (iNKT cells) recognize glycolipids from B. b

174 natural killer T cells with an invariant TCR alpha-chain (iNKT cells) are a conserved population of T

175 In a cis heterodimer, the alpha-chain interacts with the beta-chain coded by the s

176 ld assembly begins with the trimerization of alpha-chains into protomers inside the cell, which then

177 e complement control protein-6 domain of the alpha-chain is necessary for the tolerogenic activity of

178 bsets bearing alphabeta TCRs using invariant alpha-chains is indicative of unique and important funct

179 high-affinity interleukin-2 (IL-2) receptor alpha chain, is rapidly upregulated by antigen-specific

180 of Fg (FgalphaCC; amino acids 392-644 in Fg alpha chain; isothermal titration calorimetry, K(D) = 0.

181 an invariant alpha-chain variable region 14-alpha-chain joining region 18 (V(alpha)14J(alpha)18) T c

182 IgG that bound the internal nLc3 alpha chain killed both L3,7 and L2,4 strains, whereas I

183 Serum soluble IL-2 receptor alpha chain levels and in vitro immunoglobulin productio

184 -phosphatase 1 and interferon-gamma receptor alpha-chain levels in activated CD4(+) T cells in the ly

185 rall architecture similar to that of laminin alpha chain LN domains but includes significant differen

186 g, we showed that the A allele alters IL-23R alpha-chain mRNA splicing and favors exon 9 skipping by

187 with disruptions in Muc1 and T-cell receptor alpha chain (Muc/TCR double knockout mice).

188 We found that the three alpha-chain mutations (alpha+53G, alpha+53R, or alphaY22

189 t/Jalpha-segment, but no conservation of the alpha-chain N region and no conservation of the Vbeta-ch

190 blood GAD65-specific CD4(+) T cells, and TCR alpha-chain next-generation sequencing to bulk memory CD

191 s: a structure-based design study on the TCR alpha chain (nine mutations) and an in vitro selection s

192 In the alpha chain nuFeHis dropped sharply at 20 mus, the final

193 tion mutations in COL13A1, which encodes the alpha chain of an atypical non-fibrillar collagen with a

194 y allergen cross-linking of IgE bound to the alpha chain of FcepsilonRI, the mast cell/basophil high

195 We previously showed that the alpha chain of fibrinogen is a preferred substrate of mM

196 It has been proposed that mutations in the alpha chain of HexA can impair folding, enzyme assembly,

197 n-coupled receptor GPR35 interacted with the alpha chain of Na/K-ATPase and promotes its ion transpor

198 ions in the gene encoding the ligand-binding alpha chain of the GM-CSF receptor.

199 ation by cells expressing IL-15 bound to the alpha chain of the IL-15 receptor (IL-15Ralpha).

200 Overexpression of IL2RA, which encodes the alpha chain of the IL2 receptor, is associated with chem

201 the homodimeric transmembrane dimer from the alpha chain of the integrin alpha(IIb)beta(3).

202 ined the turnover of a model PM protein, the alpha chain of the interleukin-2 receptor (Tac).

203 CD25, the alpha chain of the interleukin-2 receptor, is expressed

204 CD123, the transmembrane alpha chain of the interleukin-3 receptor, is expressed

205 IT TCR-MR1 docking that was dominated by the alpha chain of the MAIT TCR.

206 563)-Lys(539), and Gln(563)-Lys(601)) on the alpha chains of fibrin were newly identified.

207 These crosslinks involve both the gamma and alpha chains of fibrin.

208 cognized laminin LG domains from the subunit alpha chains of laminin-111 and -332, the latter isoform

209 e 1 modifies a single proline residue in the alpha chains of type I, II, and III collagens to (3S)-hy

210 Here we show that the extracellular (alpha) chain of LRP1 mediates TGFbeta-induced enhancemen

211 In contrast, incubation with the monomeric alpha-chain of C4BP was less effective.

212 encies of both T cells that express only the alpha-chain of CD8 and double-negative T cells.

213 m of hybrid cytokine containing IL-7 and the alpha-chain of HGF (HGFalpha) (hrIL-7/HGFalpha).

214 presence of a transdimer formed between the alpha-chain of HLA-DQ2 (DQA1*05:01) and the beta-chain o

215 RB(high) T cells from mice deficient for the alpha-chain of IL-27 receptor failed to induce colitis i

216 associated with diminished expression of the alpha-chain of IL-33 receptor on choriodecidual B cells

217 Because conservation of the TCR alpha-chain of invariant T cells is much higher than the

218 hese results support the hypothesis that the alpha-chain of MSPalphabeta mediates RON dimerization.

219 TCR, allowing for an interaction between the alpha-chain of TCR and MHC.

220 buted to autoantibodies directed against the alpha-chain of the high-affinity IgE receptor (Fcepsilon

221 The gene encoding the alpha-chain of the IL-2 receptor, IL2RA, harbors alleles

222 ells as well as the proper expression of the alpha-chain of the IL-7 receptor (CD127) and Ebf1.

223 moval of a C-terminal RKRR motif(2) from the alpha-chain of the insulin-like growth factor 1 receptor

224 s specific for the autoallergen Hom s 2, the alpha-chain of the nascent polypeptide-associated comple

225 While the alpha-chain of the NKTcr is invariant, the beta-chain is

226 M2) activation of macrophages driven via the alpha-chain of the receptor for interleukin 4 (IL-4Ralph

227 hich a large number of the T(EM) express the alpha-chain of VLA-2, CD49b.

228 n, type IV collagen contained macromolecular alpha-chains of 225 and 250 kDa.

229 domain (CY) sequences of the ligand-binding alpha-chains of gamma-chain-associated receptors.

230 Electrophoretic study revealed that alpha-chains of gelatin in films became lowered with inc

231 allosteric effectors and isolated beta- and alpha-chains of hemoglobin, it appears that NO reacts wi

232 tendon and bone, but absent in skin in both alpha-chains of the wild type animals.

233 rally accepted that LH2 modifies procollagen alpha chains on the endoplasmic reticulum before the for

234 vs low expression of the AI4 clonotypic TCR alpha-chain on developing thymocytes in B6.H2g7 and NOD

235 ugh downregulation of the IFN-gamma receptor alpha-chain on macrophages and dendritic cells.

236 ata suggest a likely binding site of the HGF alpha-chain on MET, which when dimerized leads to MET si

237 ssion of CD25 (interleukin-2 [IL-2] receptor alpha chain) on Ad5-elicited CD4 T cells, and administra

238 ased on the disruption of the endogenous TCR alpha chain only, followed by the transfer of genes enco

239 Deletion of ST2, the IL-33 receptor alpha chain, or treatment with a soluble IL-33 decoy rec

240 et complementation is shorter in the ClfB.Fg alpha-chain peptide complex.

241 shown to be tolerant to p146-162, the TAChR alpha-chain peptide that dominated young nontransgenic T

242 was implemented to characterize cross-linked alpha chain peptides originating from native fibrin.

243 ingle, unique TCR-beta chain and diverse TCR-alpha chains, pinpointing malignant transformation to a

244 detected T cells with highly stereotyped TCR alpha-chains present among genetically unrelated patient

245 The migration of collagen type I alpha chains produced by these fibroblasts was mildly de

246 the extracellular domains of the functional alpha chain protein.

247 substrates, such as the pre-T-cell receptor alpha chain (pTalpha) and has also been shown to cleave

248 Once the FcepsilonRI alpha-chain reached the cell surface by itself, it forme

249 s express an invariant T-cell receptor (TCR) alpha chain rearrangement (Valpha14 Jalpha18 in mice; Va

250 are innate-like T cells with a conserved TCR alpha-chain recognizing bacterial metabolites presented

251 Genetic ablation of the HLA-DR alpha-chain rendered cells resistant to infection by bat

252 ls that express an invariant T-cell receptor alpha-chain restricted by the nonclassical MHC class I m

253 absence of the gammaC-dodecapeptide and the alpha-chain RGD sequences suggests that the alphaIIbbeta

254 and non allergic donors, TCRs expressing the alpha-chain segment TRAV9-2 or a histidine in their alph

255 of the active enzyme to cleave the collagen alpha chains sequentially, at Gly(775)-Leu(776) in colla

256 mbrane ER retention signals, the FcepsilonRI alpha-chain signal peptide contains a negative regulator

257 Circulating IL-7 and soluble IL-7 receptor alpha-chain (soluble CD127) concentrations were measured

258 llows: HbA (the major adult Hb isoform, with alpha-chain subunits encoded by the alpha(A)-globin gene

259 e) and HbD (the minor adult Hb isoform, with alpha-chain subunits encoded by the alpha(D)-globin gene

260 to mice deficient in the alpha1(VI) collagen alpha chain, suggesting that the cleavage product of the

261 of a primary insulin peptide by a conserved alpha chain T cell receptor.

262 te expression of the T-cell antigen receptor alpha chain (TCR-alpha) in developing thymocytes.

263 he gene encoding the T cell antigen receptor alpha-chain (Tcra) and had a profound, intrinsic block i

264 ch then rearrange the locus encoding the TCR alpha-chain (Tcra).

265 The T-cell antigen receptor (TCR) alpha-chain (TCRalpha) is a type I integral membrane pro

266 l C-terminal segment of the insulin receptor alpha-chain (termed alphaCT).

267 inding and IgG that bound the truncated nLc3 alpha chain that lacks this Gal residue.

268 would result in synthesis of polylactosamine alpha chains that could be sialylated.

269 mas, we identified key residues on the MHCII alpha-chain that are differentially recognized by the CD

270 e employed next-generation sequencing of TCR alpha-chains that contain the TRAV1-2 gene segment to id

271 ar details like the C-terminal domain of the alpha-chain, the heparin-binding domain on the beta-chai

272 uccessive saccharide deletions from the nLc4 alpha chain to characterize further the binding and bact

273 assign cross-linked peptide pairs of fibrin alpha chains to the monoisotopic masses relying on accur

274 kine trans-presented with the IL-15 receptor alpha-chain to the shared IL-2/IL-15Rbeta and common gam

275 etry, and in vivo by using human FcepsilonRI alpha-chain transgenic mice in a functional passive cuta

276 ed an insulin-reactive T-cell receptor (TCR) alpha-chain transgenic NOD mouse on a TCRCalpha and proi

277 s express an invariant T cell receptor (TCR) alpha-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12

278 press a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitami

279 nvariant owing to their mostly invariant TCR alpha-chain usage (Valpha14-Jalpha18 in mice, Valpha24-J

280 ing, we systematically studied the impact of alpha-chain usage in the formation of T cell memory and

281 her than the beta-chain, and because the TCR alpha-chain V gene segment TRAV1-2 is used by two of the

282 eir use of the T cell antigen receptor (TCR) alpha-chain variable region (Valpha) and beta-chain vari

283 racterized by the expression of an invariant alpha-chain variable region 14-alpha-chain joining regio

284 We report here a new hemoglobin alpha chain variant in a female patient with mild anemia

285 This reporter gene was excised during TCR alpha-chain VJ-recombination, and the retained H2BeGFP s

286 f both regulators, further degradation of C3 alpha' chain was observed.

287 uction of insulin autoantibodies by TRAV5D-4 alpha-chains was abrogated by the mutation of insulin pe

288 oresis after data collection, two species of alpha chain were present, indicating that some proteolys

289 At least four collagen-alpha chains were absent or had low expression in health

290 ents within the niche and found that laminin alpha chains were expressed by nonstem tumor cells and t

291 tion, single amino acid variants of the CDR3 alpha-chain were generated.

292 control protein (CCP) domains 8 and 2 of the alpha-chain were responsible for the strong, hydrophobic

293 on in 3-hydroxylation of the A3 site in both alpha-chains, whereas type I collagen extracted from ten

294 ntation that prevents interaction of the TCR-alpha chain with the MHC class II beta chain helix.

295 itro, the P30W AHSP variant bound oxygenated alpha chains with 30-fold increased affinity.

296 antigen, coprecipitation of the FcepsilonRI alpha-chain with the gamma-chain and beta-chain was mark

297 y studying retrogenic mouse lines expressing alpha-chains with different Valpha TRAV genes.

298 genic NOD strains expressing Valpha TRAV5D-4 alpha-chains with many different complementarity determi

299 P was found to lower nuFeHis selectively for alpha chains within the R state, and a binding site in t

300 Polylactosamine alpha chains would enhance virulence, and their sialylat