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1 P=.01 for alkaline phosphatase, P<.0001 for alpha-fetoprotein).
2 to a clinical diagnosis and was superior to alpha-fetoprotein.
3 respective of tumor burden or serum level of alpha-fetoprotein.
4 (KO) tumors that express increased levels of alpha-fetoprotein.
5 ted by MELD score, HCC size, HCC number, and alpha-fetoprotein.
6 lar invasion, metastasis, serum albumin, and alpha-fetoprotein.
7 ed expression of fetal liver genes including alpha-fetoprotein.
8 d concomitantly with increased expression of alpha-fetoprotein.
9 arly hepatic neoplasia and increase in serum alpha-fetoprotein.
10 per cm increase [1.04-1.11]; p<0.0001), log alpha-fetoprotein (1.10 per unit increase [1.02-1.20]; p
11 Of patients with an elevated pretreatment alpha-fetoprotein, 85% were found to have declining alph
12 to the homogeneous liquid-phase detection of alpha-fetoprotein, a common tumor marker, the system sho
13 calization of beta-catenin and expression of alpha-fetoprotein, a prognostic marker of hepatocellular
14 alpha-fetoprotein (MSAFP) or amniotic fluid alpha-fetoprotein (AFAFP) levels or abnormalities visual
16 an 3 years, 3-7 years, and 8 years or older; alpha fetoprotein (AFP) concentration of 100 ng/mL or lo
17 aximal tumor diameter of 3 to 5 cm and serum alpha fetoprotein (AFP) greater than 100 ng/mL at transp
20 A technique serum levels of IL-6, IL-10, and alpha fetoprotein (AFP) were evaluated in all groups.
21 s carcinoembryonic antigen (CEA), bilirubin, alpha fetoprotein (AFP), and c-reactive protein (CRP) we
22 immunodominant and subdominant epitopes from alpha fetoprotein (AFP), restricted by HLA-A*0201, which
25 (hazard ratio [HR], 3.1; P = 0.005) and with alpha-fetoprotein (AFP) >= 100 ng/mL at LT (HR, 2.4; P =
30 motherapy levels of serum tumor markers were alpha-fetoprotein (AFP) 2.0 ng/mL, human chorionic gonad
33 of this study was to compare the accuracy of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombi
34 her levels of alkaline phosphatase (ALP) and alpha-fetoprotein (AFP) and lower level of alanine amino
36 ce recommendation through the examination of alpha-fetoprotein (AFP) and ultrasound for patients at r
41 after accounting for etiology of cirrhosis, alpha-fetoprotein (AFP) at liver transplant, tumor diame
42 ter Transplant (RETREAT), which incorporates alpha-fetoprotein (AFP) at liver transplantation (LT), m
43 accurate quantitation of biomarkers such as alpha-fetoprotein (AFP) can be a key aspect of early sta
44 her the HCC-associated self/tumor antigen of alpha-fetoprotein (AFP) could be engineered to create an
46 pression under the control of an albumin and alpha-fetoprotein (AFP) enhancer and promoter (AFP-Notch
51 analyzed methylation of the rat albumin and alpha-fetoprotein (AFP) genes by hydridizing labeled cDN
53 ng the neutrophil-lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) have been associated with recurr
54 formance status, Child-Pugh score (CPS), and alpha-fetoprotein (AFP) in predicting individual surviva
55 orted to be more sensitive and specific than Alpha-fetoprotein (AFP) in the diagnosis of HCC among th
63 for sensitive detection of cancer biomarker alpha-fetoprotein (AFP) is described that uses a graphen
68 noma (HCC), because the sensitivity of serum alpha-fetoprotein (AFP) is too low for this purpose.
70 identified substantial necrosis, high serum alpha-fetoprotein (AFP) level (>100 ng/mL), and Barcelon
71 ent cohort of 721 patients (542 men), median alpha-fetoprotein (AFP) level at the time of LT was 8.3
72 (BCLC) staging system, tumor size, and serum alpha-fetoprotein (AFP) level were investigated using Co
75 (ADI) in terms of toxicity, tumor response, alpha-fetoprotein (AFP) levels, and serum arginine level
77 marker testing disclosed a slightly elevated alpha-fetoprotein (AFP) of 12.3 ug/L (upper limit of nor
78 s to identify a biomarker that could improve alpha-fetoprotein (AFP) performance in hepatocellular ca
80 Our group has shown that a rising natural alpha-fetoprotein (AFP) slope (NAS) correlates with tumo
85 To use the device under optimal conditions, alpha-fetoprotein (AFP) was detected at a limit of detec
88 the hepatitis B surface antigen (HBsAg) and alpha-fetoprotein (AFP) with the lowest concentration of
89 adhesion molecule (EpCAM)(+) HCC cells from alpha-fetoprotein (AFP)(+) tumors with cancer stem/proge
90 ls with activated Wnt signaling occupying an alpha-fetoprotein (AFP)+/cytokeratin-19 (CK-19)-positive
92 reased hepatic associated gene expression of alpha-fetoprotein (AFP), Albumin (Alb), Glucose-6-phosph
93 , with some potential advantages compared to alpha-fetoprotein (AFP), but its role in the context of
94 biomarkers: carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), cancer antigen 125 (CA125), and
95 kers carbohydrate antigen 19-9 (CA 19-9) and alpha-fetoprotein (AFP), commonly used to help in the di
97 sed overlapping peptides spanning the entire alpha-fetoprotein (AFP), glypican-3 (GPC-3), melanoma-as
100 , a factor required for HSC homing, and also alpha-fetoprotein (AFP), indicating that they are fetal
101 ed hepatocellular carcinoma (HCC) biomarkers alpha-fetoprotein (Afp), insulin-like growth factor 2 (I
103 trongly associated with elevated circulating alpha-fetoprotein (AFP), low rate of necrosis/fibrosis a
105 10 mRNA expression was associated with serum alpha-fetoprotein (AFP), tumor-node-metastasis (TNM) sta
106 With this approach, an aptamer specific to alpha-fetoprotein (AFP), which is a biomarker for liver
107 ted polymer (MIP) for trace level sensing of alpha-fetoprotein (AFP), which is a well know cancer bio
108 sodium (MELD-Na), tumour burden score (TBS), alpha-fetoprotein (AFP), year of transplantation, underl
116 protein biomarker panel [APOH, ORM2, C3, and alpha-fetoprotein (AFP)] has proven to outperform AFP, t
118 occurrence as well as patients with negative alpha-fetoprotein (AFP; n = 1), resulting in 24 patients
119 2 recently identified HCC subtypes (EpCAM(+) alpha-fetoprotein [AFP(+)] HCC and EpCAM(-) AFP(-) HCC).
121 of antibodies specific for epithelial cells (alpha-fetoprotein [AFP], albumin [ALB], pancytokeratin [
122 e Panel recommended measuring three markers (alpha-fetoprotein [AFP], human chorionic gonadotropin [h
124 erum alpha-fetoprotein and ferritin or serum alpha-fetoprotein alone, including four with coagulopath
125 albumin gene family is comprised of albumin, alpha-fetoprotein, alpha-albumin (afamin), and the more
126 encode the serum transport proteins albumin, alpha-fetoprotein, alpha-albumin, and vitamin D-binding
127 fibrinogen, fibronectin, transthyretin, and alpha-fetoprotein, an essential feature for functional H
128 te that this enhancer region is required for alpha-fetoprotein and albumin activation early in liver
129 lls were analyzed by immunocitochemistry for alpha-fetoprotein and albumin expression, qPCR for hepat
130 strate that RNA polymerase II loading on the alpha-fetoprotein and albumin promoters is reduced in th
133 f these genes, particularly that of albumin, alpha-fetoprotein and alpha-albumin, and their liver-spe
135 erum and cerebrospinal fluid (CSF) levels of alpha-fetoprotein and beta-subunit of human chorionic go
137 d higher than normal concentrations of serum alpha-fetoprotein and ferritin or serum alpha-fetoprotei
140 , 134-142 mEq/L [134-142 mmol/L]), and serum alpha-fetoprotein and human chorionic gonadotropin level
142 logistic regression selected combined serum alpha-fetoprotein and portal flow (F (p) ) skewness (are
145 lutamyl transferase activity, elevated serum alpha-fetoprotein and undetectable liver bile salt expor
146 tients with slow serum tumor marker decline (alpha-fetoprotein and/or human chorionic gonadotrophin)
147 nd-stage liver disease scores, pretransplant alpha fetoprotein, and cumulative tumor diameters; were
148 , secreted hepatic proteins such as Albumin, Alpha Fetoprotein, and Fibrinogen, metabolized ammonia,
153 tion expressed both donor marker (DPPIV) and alpha-fetoprotein, and some differentiated into hepatocy
154 igh level expression of active beta-catenin, alpha-fetoprotein, and SOX9, suggesting that DCLK1 overe
155 total bilirubin, albumin, prothrombin time, alpha-fetoprotein, and tumor number, which were incorpor
156 tribution; levels of bilirubin, albumin, and alpha-fetoprotein; and WHO/EASL response rate predicted
157 leaved K18, glutathione S-transferase alpha, alpha-fetoprotein, arginase-1, osteopontin (OPN), sorbit
158 gical stage, tumour histology, and levels of alpha-fetoprotein at diagnosis to receive risk-adapted t
160 tients with HBV had larger tumors and higher alpha-fetoprotein but less satellites and macrovascular
161 ibiting cytoplasmic/nuclear beta-catenin and alpha-fetoprotein but not CK19, HNF1beta, or Trop-2.
162 4, cytokeratin 19 (CK19), transthyretin, and alpha-fetoprotein by day 7, and expressed CK18, HNF-4, a
165 ed according to randomising centre and serum alpha-fetoprotein concentration (<400 ng/mL and >/=400 n
167 anced hepatocellular carcinoma and increased alpha-fetoprotein concentrations have poor prognosis.
168 Group (ECOG) performance statuses of 0 or 1, alpha-fetoprotein concentrations of 400 ng/mL or greater
169 a from REACH (NCT01140347) for patients with alpha-fetoprotein concentrations of 400 ng/mL or greater
170 s with advanced hepatocellular carcinoma and alpha-fetoprotein concentrations of 400 ng/mL or higher.
171 n patients with hepatocellular carcinoma and alpha-fetoprotein concentrations of at least 400 ng/mL w
172 ction was assessed by expression of albumin, alpha-fetoprotein, cytochrome P4502E1, cytokeratin-18, t
174 re alpha-fetoprotein(+)/cytokeratin-19(+) or alpha-fetoprotein(+)/cytokeratin-19(-) and contain all o
176 d CaM kinase-like-1 (DCAMKL-1), Lgr5, CD133, alpha-fetoprotein, cytokeratin-19 (CK19), Lin28, and c-M
177 heral zones were simultaneously positive for alpha-fetoprotein, cytokeratin-19, and c-kit, indicating
178 lls express the classical oval cell markers (alpha-fetoprotein, cytokeratin-19, OV-1 antigen, a6 inte
179 ever, when the values of known serum markers alpha fetoprotein, des-gamma carboxyprothrombin, and GP7
180 leukemia (n = 1), and 1 patient treated with alpha-fetoprotein-directed CAR T cells for hepatocellula
185 nder the control of the albumin promoter and alpha-fetoprotein enhancer to ablate Jag1 in hepatoblast
186 he expression of vimentin, beta-III tubulin, alpha-fetoprotein, eomesodermin, HEB, ARNT, and FoxD3 as
189 oval cell proliferation and a lower level of alpha-fetoprotein expression as compared with control an
190 ogs induced albumin expression and decreased alpha-fetoprotein expression in HepG2 cells, which sugge
191 e basis of the similarities between Gpc3 and alpha-fetoprotein expression in the liver, we reasoned t
192 F-1 expression caused a dramatic decrease in alpha-fetoprotein expression, implying impaired oval cel
194 ok 2, spalt-like transcription factor 4, and alpha-fetoprotein expression; and high coordinated expre
196 ts (HR, 0.3; 95% CI, 0.2-0.7; P = 0.003) and alpha-fetoprotein > 100 ng/mL (HR, 2.5; 95% CI, 1.1-5.0,
197 the downstaging group included pretreatment alpha-fetoprotein >/=1,000 ng/mL (multivariate hazard ra
199 r disease (HR, 1.66; 95% CI, 1.02-2.71), and alpha-fetoprotein >1000 ng/mL (HR, 1.86; 95% CI, 1.22-2.
200 alyses identified age <65 years (P = 0.038), alpha-fetoprotein >200 ng/mL (P = 0.04), and vascular in
201 sorafenib, or ramucirumab (for patients with alpha-fetoprotein >= 400 ng/mL), or atezo + bev where pa
203 ize of tumors, presence of metastases, serum alpha-Fetoprotein, hepatitis serologies, severity of hep
205 ted clinical diagnostic application, such as alpha-fetoprotein in liver carcinoma, and kallikreins 6
206 evaluate the prognostic usefulness of serum alpha-fetoprotein in patients with well-compensated cirr
207 cificity of des-gamma-carboxyprothrombin and alpha-fetoprotein in the diagnosis of hepatocellular car
208 ted on a clinically relevant assay to detect alpha-fetoprotein, in which a 42-fold enhancement to sen
209 The proposed Time-Radiological-response-Alpha-fetoprotein-INflammation (TRAIN) score was the bes
210 (AST)/alanine aminotransferase (ALT) ratio, alpha-fetoprotein, insulin, and homeostatic model assess
213 zard ratio, 1.61; 95% CI: 1.3-2.1) and serum alpha-fetoprotein level >/=455 ng/mL (hazard ratio, 2.15
214 Patients with larger (3-5 cm) tumors, serum alpha-fetoprotein level >/=455 ng/mL, or a MELD score >/
215 a cirrhotic liver in the presence of a serum alpha-fetoprotein level >400 ng/mL also is diagnostic.
217 l undifferentiated histology; elevated serum alpha-fetoprotein level (>100 ng/mL); a complete resecti
218 s showed significant effects of pretreatment alpha-fetoprotein level (P = .03) and ADC ratio (P < .00
219 rnational normalized ratio greater than 1.1, alpha-fetoprotein level greater than 20 ng/mL, multiple
221 priate candidates for liver transplantation; alpha-fetoprotein level limitations should be incorporat
222 mal range, 13-60 U/L [0.21-1.0 mukat/L]), an alpha-fetoprotein level of 3.81 ng/ mL (normal range, 0-
223 ory studies were significant for an elevated alpha-fetoprotein level of 7051 ng/ml and mild anemia.
224 vascular invasion, extrahepatic disease, and alpha-fetoprotein level to best supportive care plus ora
226 was achieved in 10 patients (83.3%), and the alpha-fetoprotein level was also decreased to normal in
227 erum markers for ovarian cancer were normal (alpha-fetoprotein level, 1.6 microg/L; Ca-125 level, 15
228 clinical factors (age, gender, preoperative alpha-fetoprotein level, hepatitis serology, number of t
229 tingly, the two most recent models combining alpha-fetoprotein level, number of nodules, and size of
230 for study site, age, sex, Child-Pugh score, alpha-fetoprotein level, tumor burden, and HCC treatment
232 oenvironment also correlated with high serum alpha-fetoprotein levels (P < 0.001), macrovascular inva
233 -Pugh scores (P = .003), higher pretreatment alpha-fetoprotein levels (P = .04), and a greater number
235 tion between second-trimester maternal serum alpha-fetoprotein levels and the risk of SIDS, which may
236 Patients were followed with CT scan and alpha-fetoprotein levels every 3 months for 2 years post
237 etoprotein, 85% were found to have declining alpha-fetoprotein levels from a pretreatment mean of 140
239 ence, 2.7 per 10,000 births among women with alpha-fetoprotein levels in the lowest quintile and 7.5
240 and increased aspartate aminotransferase and alpha-fetoprotein levels were associated with HCC (p < 0
241 otransferase/alanine aminotransferase ratio, alpha-fetoprotein levels, and IL28B single-nucleotide po
242 talian Program components, Child-Pugh class, alpha-fetoprotein levels, and percentage of tumor replac
243 markers of tumor aggressiveness (high serum alpha-fetoprotein levels, P = 0.038; satellite nodules,
249 95% confidence interval [CI], 1.03-1.30) and alpha-fetoprotein < 20 ng/mL (OR, 1.90; 95% CI, 1.12-3.2
252 ariables (Model for End-Stage Liver Disease, alpha-fetoprotein, Milan-Criteria status, and radiologic
253 logical response to loco-regional therapies, alpha-fetoprotein modification, inflammatory markers, an
254 eal patients, and follow-up, including serum alpha-fetoprotein monitoring for early detection of mali
255 d time from primary resection to recurrence, alpha-fetoprotein more than 100 ng/mL at recurrence, rec
256 ellite nodules, albumin less than 3.5 gm/dL, alpha-fetoprotein more than 100 ng/mL, and any vascular
258 FGF19 transgenic mice had elevated hepatic alpha-fetoprotein mRNA as early as 2 months of age, and
259 er RNA (mRNA) levels and reduced Albumin and Alpha-fetoprotein mRNA levels, indicating that they are
260 eatures were greatly elevated maternal serum alpha-fetoprotein (MSAFP) or amniotic fluid alpha-fetopr
261 ype (albumin-positive, transferrin-positive, alpha-fetoprotein-negative) and are able to proliferate
262 n of neuronal cellular adhesion molecule and alpha-fetoprotein, neuroectodermal, and endodermal marke
264 inal nonseminoma (group A) and elevations of alpha-fetoprotein of 100 ng/mL or greater or of human ch
266 ction of either one liver cancer marker, the alpha-fetoprotein, or the detection of Hepatitis C Virus
267 dent of BCLC ( P < .0001), CTP ( P < .0001), alpha-fetoprotein ( P < .0001), geographical origin ( P
270 eterogeneous recurrence risk, dependent upon alpha-fetoprotein (P = 0.026) and tumor number (P = 0.02
271 almitic acid, suggesting that the high serum alpha-fetoprotein phenotype of G1, associated with the k
273 striking increase in the number of c-kit and alpha-fetoprotein-positive progenitors, without altering
276 under age 40; p < 0.001), with greater serum alpha-Fetoprotein production (median level: HBV-1000 ng/
277 in activation early in liver development and alpha-fetoprotein reactivation during liver regeneration
280 f the albumin gene family that we have named Alpha-fetoprotein Related Gene (ARG) since it exhibits g
281 sful down-staging is predicted by wait time, alpha-fetoprotein response to LRT, and tumor burden and
282 ivariate predictors of down-staging included alpha-fetoprotein response to LRT, pathologic tumor numb
284 accessing the brain, therefore, to overcome alpha-fetoprotein sequestration of E2, estrogen replacem
289 factors of posttransplant survival included alpha-fetoprotein, size of the largest tumor, number of
290 apid loss of expression of the tumour marker alpha-fetoprotein, the increase in expression of liver c
292 rimester quadruple screening (measurement of alpha-fetoprotein, total human chorionic gonadotropin, u
293 erm has recently been shown to interact with alpha-fetoprotein transcription factor and repress chole
294 cPR included a favorable post-LRT radiologic/alpha fetoprotein tumor response, longer time interval f
295 ity of California at San Francisco criteria, alpha-fetoprotein, up-to-7 criteria, TTV, and platelet c
298 An 8-mer peptide (EMTOVNOG) derived from alpha-fetoprotein was compared with tamoxifen for activi