ライフサイエンスコーパス: alpha-helical conformation

1 tabilizing that portion of the S4 segment in alpha-helical conformation).

2 tein, which we reveal adopts a predominantly alpha-helical conformation.

3 G alpha s protein) of the peptide adopted an alpha-helical conformation.

4 active mutations suggested that IL2 is in an alpha-helical conformation.

5 and acceptors at neutral pH and disrupt the alpha-helical conformation.

6 that MEM-265 may recognize the epitope in an alpha-helical conformation.

7 hat the apoE CT domain adopts an amphipathic alpha-helical conformation.

8 cent reports have suggested a propensity for alpha-helical conformation.

9 al mesophases in which the peptides adopt an alpha-helical conformation.

10 e previous predictions, this region is in an alpha-helical conformation.

11 binding of Zn(2+) in a pi-helical but not an alpha-helical conformation.

12 a very strong preference for a transmembrane alpha-helical conformation.

13 of transmembrane domains IV and V is in the alpha-helical conformation.

14 The pattern of accessibility suggests an alpha-helical conformation.

15 acid peptides bound GroEL in an amphipathic alpha-helical conformation.

16 he role of Gla4 in stabilizing the apo-con-T alpha-helical conformation.

17 ing a significant role in maintenance of the alpha-helical conformation.

18 a beta-turn from residues Arg6 to Arg9 or an alpha-helical conformation.

19 FE3 and is predicted to adopt an amphipathic alpha-helical conformation.

20 pha-subunits of Gi and Go in a predominantly alpha-helical conformation.

21 i + 4 positions have been shown to stabilize alpha-helical conformation.

22 trate that transmembrane domain XII is in an alpha-helical conformation.

23 provided additional evidence for a conserved alpha-helical conformation.

24 hown by peptide models to be specific to the alpha-helical conformation.

25 to the 1-28 peptide region when folded in an alpha-helical conformation.

26 constraining short peptides typically in an alpha-helical conformation.

27 eas membrane-bound alpha-synuclein adopts an alpha-helical conformation.

28 to the ER based on their ability to adopt an alpha-helical conformation.

29 ly charged lipid membranes while adopting an alpha-helical conformation.

30 inhibit beta conformations and stabilize the alpha-helical conformation.

31 rom sequences that do not spontaneously form alpha-helical conformations.

32 does not discriminate between the 3(10)- or alpha-helical conformations.

33 roove-binding peptidic motifs known to adopt alpha-helical conformations.

34 f polypeptides under conditions that produce alpha-helical conformations.

35 sordered proteins with a propensity to adopt alpha-helical conformations.

36 c-containing M2 and correspond to more ideal alpha-helical conformations.

37 ut GdnHCl, the combined data are well fit by alpha-helical conformations.

38 by stabilizing alpha-synuclein in an active (alpha-helical) conformation.

39 mphiphilic in the pi-helical, but not in the alpha-helical, conformation.

40 olution, the 6-10 residue peptides adopt the alpha-helical conformation; (3) there might be two inter

41 by stabilizing a region of the S4 segment in alpha-helical conformation, a closed (resting or interme

42 pH-dependent manner between a transmembrane alpha-helical conformation, a peripherally bound nonheli

43 accessibilities to molecular O(2) reveal an alpha-helical conformation along the sequence.

44 ucture shows that the ATG16L1 W2IR adopts an alpha helical conformation and binds in an electropositi

45 ontains approximately 50% of its residues in alpha-helical conformation and <10% in beta-structure.

46 simulations on the Abeta(42) monomer at its alpha-helical conformation and a pentamer fibril fragmen

47 EBP (residues 117-137) adopts a well defined alpha-helical conformation and binds 14-3-3 in a phospho

48 The Rev peptide has an alpha-helical conformation and binds in the major groove

49 Interestingly, HCDR1 of MAb 3.1 adopts an alpha-helical conformation and engages in hydrophobic in

50 mplex revealed that EGL-1 adopts an extended alpha-helical conformation and induces substantial struc

51 ntion that transmembrane domain XII is in an alpha-helical conformation and on the periphery of the 1

52 several molecules of monomeric alphaS in an alpha-helical conformation and that such channels may ha

53 NBD consensus sequence is consistent with an alpha-helical conformation and that these residues maint

54 tion-based circular dichroism to confirm its alpha-helical conformation and transmembrane alignment.

55 s show that W41F M2 retains the pH-dependent alpha-helical conformations and tetrameric structure of

56 a broader conformational sampling, favoring alpha-helical conformations and, to a lesser extent, ran

57 hauser enhancement buildup points to a large alpha-helical conformation, and a distinct increase in f

58 the residues in them are found to be in the alpha-helical conformation, and another 10% in the 3(10)

59 ormation is the most stable, followed by the alpha-helical conformation, and then the unstructured co

60 ng PS revealed features characteristic of an alpha-helical conformation approximately approximately 1

61 Ac-(Aib)(4)-NH(2) constrained to 3(10)- and alpha-helical conformations are presented.

62 The peptide agonist retains an alpha-helical conformation as it sits deep within the re

63 h from a beta-turn/coil to an extended quasi-alpha-helical conformation as the actin-contacts are bro

64 h formation of a predominantly transmembrane alpha-helical conformation, as determined from the trans

65 ctivity of exon 4 may require adoption of an alpha-helical conformation, as mutations that disrupt al

66 w-concentration Con A transforms to a highly alpha-helical conformation at both neutral and low pH.

67 ordered state at low [TFE] and with a highly alpha-helical conformation at high [TFE].

68 E), or because of the appearance of a highly alpha-helical conformation at high TFE and hexafluoro-2-

69 ly disordered melittin monomers at low pH to alpha-helical conformations at neutral pH occurs on near

70 that extended conformations are favored over alpha-helical conformations at the dipeptide level at an

71 formation of a H(+)-stabilized intermediate alpha-helical conformation before aggregation develops.

72 NS4A revealed that this region can adopt an alpha-helical conformation, but that this folding requir

73 of Abeta(42) peptide (residues 17-21) to its alpha-helical conformation by interacting specifically i

74 y binding to the HAP being stabilized in the alpha-helical conformation by the presence of water.

75 y labeled Ac-A(24)-NHCH(3) constrained to an alpha-helical conformation by use of property tensor tra

76 ta42 is predominantly disordered but samples alpha-helical conformations covering residues 15-24 and

77 inserted segment in the S1 domain adopts an alpha-helical conformation, despite being predicted to b

78 cular dichroism data showed that Hsn-5 in an alpha-helical conformation does not aggregate in a hydro

79 Conantokin-Pr3 adopts an alpha-helical conformation even in the absence of divale

80 ains important residues which, in a putative alpha-helical conformation, exert inhibitory control on

81 the three MPER peptides each adopt symmetric alpha-helical conformations exposing the amino acid side

82 ary structure modeling algorithms predict an alpha-helical conformation for one of the gelsolin PPI-b

83 acts or may support the proper transmembrane alpha-helical conformation for optimal positioning of th

84 th the Bcl-2 family member Bcl-xL reveals an alpha-helical conformation for the BH3-like motif, sugge

85 mbrane interior, which is consistent with an alpha-helical conformation for the four transmembrane do

86 a also indicate a possible minor increase in alpha-helical conformation for the receptor in the compl

87 the middle of the exon 9 peptide and a loose alpha-helical conformation for the rest of the peptide.

88 me time to maximize the active mdm-2 binding alpha-helical conformation for these peptides, each was

89 Assuming the likely alpha-helical conformation for this area of the b subuni

90 attern of accessibility is consistent with a alpha-helical conformation for this segment of TMH6.

91 A novel strategy to replicate diverse alpha-helical conformations found at the interfaces of p

92 We found that SLN adopts a highly defined alpha-helical conformation from F9 through R27, with a b

93 n 1-17 upon membrane-association result in a alpha-helical conformation from K6 to F17, i.e., up to t

94 oth detergent systems, the peptide adopts an alpha-helical conformation from residue 4 through 18.

95 of helix 12, which can result in an extended alpha-helical conformation, further accelerates lipid-mi

96 e with incubation in a solvent that promotes alpha-helical conformation, further suggesting that conf

97 residues predisposing the peptide toward the alpha helical conformation in an effort to enhance the r

98 nt alpha-helical region and induces a unique alpha-helical conformation in Abeta.

99 nformation in neutral and basic media and an alpha-helical conformation in acidic media, the helical

100 21 are also embedded but deviate from linear alpha-helical conformation in contrast to I693-K716, whi

101 ane interaction and the novel membrane-bound alpha-helical conformation in IAPP aggregation are discu

102 d polypeptide chains, adopts a predominantly alpha-helical conformation in its native state.

103 BM2 adopts an alpha-helical conformation in lipid membranes.

104 Moreover, N34(L6)C28 adopts a highly alpha-helical conformation in lipid vesicles.

105 Here we show that helices 6-8 maintain an alpha-helical conformation in membranes with a lipid com

106 t potent stapled peptide, DD5-o, revealed an alpha-helical conformation in methanol, stabilized by an

107 tions were on the hydrophilic face showed an alpha-helical conformation in mild buffer.

108 nd to have a strong tendency for adopting an alpha-helical conformation in solution.

109 peptide, prove that the peptide is in an all alpha-helical conformation in the bilayers of multilamel

110 energy conformation was found to exhibit an alpha-helical conformation in the cyclized address seque

111 It was suggested that an alpha-helical conformation in the cyclized address seque

112 inal transmembrane domain of CYPOR adopts an alpha-helical conformation in the lipid membrane environ

113 that the MSD peptide assumes a stable tilted alpha-helical conformation in the membrane.

114 of RGS4 revealed that the peptide adopted an alpha-helical conformation in the presence of anionic ph

115 impairment of the nitrated protein to adopt alpha-helical conformation in the presence of liposomes.

116 ructured in solution and only folded into an alpha-helical conformation in the presence of liposomes.

117 ve residues has the propensity to take on an alpha-helical conformation in the presence of SDS micell

118 eous solution at neutral pH but can adopt an alpha-helical conformation in the presence of the hydrop

119 aggregation and displayed approximately 70% alpha-helical conformation in the presence of urea and S

120 ical conformation in CDCl(3) solution and an alpha-helical conformation in the solid state.

121 no acids 21-45 and 139-164 tended towards an alpha-helical conformation in trifluoroethanol buffer, i

122 all proteins have a strong tendency to adopt alpha-helical conformation in trifluoroethanol.

123 tions, B169L transmembrane sequences adopted alpha-helical conformations in lipid bilayers.

124 pt flexible conformations that transition to alpha-helical conformations in membrane-mimicking enviro

125 length; both peptides adopt nearly identical alpha-helical conformations in the complexes, where the

126 Conantokins-Pr1 and -Pr2 adopt alpha-helical conformations in the presence of divalent

127 PrP(89-143) form a mixture of beta-sheet and alpha-helical conformations in the randomly aggregated s

128 t bZIP-bRs have quantifiable preferences for alpha-helical conformations in their unbound monomeric f

129 Many host-defense peptides adopt alpha-helical conformations in which cationic side chain

130 d that when kafirin was dissolved in GAA its alpha-helical conformation increased substantially.

131 ecular association, whereas stabilization of alpha-helical conformation inhibits beta-sheet formation

132 smaller binding affinity and thus stabilizes alpha-helical conformations intermediately between NaClO

133 ransition of the F198S variant from a normal alpha-helical conformation into an oligomeric beta-sheet

134 t occur from cellular allowed random coil or alpha-helical conformation into insoluble cell-deleterio

135 In SDS, an increase in alpha-helical conformation is indicated by the predomina

136 osphorylation, suggesting that the predicted alpha-helical conformation is involved in the inhibition

137 he other helical polyamino acids in that its alpha-helical conformation is most stable in the left-ha

138 Previously, we have shown that the alpha-helical conformation is one of the important struc

139 of the kafirin molecules in GAA, assuming a alpha-helical conformation may have enhanced water bindi

140 and conformation and the previously reported alpha-helical conformation may underlie the multiple fun

141 e that conditions that promote weakly stable alpha-helical conformations may promote IAPP aggregation

142 e Trp to Phe(CN) mutation alters neither the alpha-helical conformation nor the 4-helix bundle struct

143 ues 176-227), retaining the disulfide-linked alpha-helical conformation observed in the normal cellul

144 The alpha-helical conformation occurred only after the forma

145 show for the first time that MOZ DPF induces alpha-helical conformation of H3K4-T11, revealing a uniq

146 ce loop (V63-N72) appear to be flexible; the alpha-helical conformation of helix B (E17-F22) is absen

147 is presented that stabilizes a pre-amyloid, alpha-helical conformation of IAPP.

148 An alpha-helical conformation of PAP(248-286), lying parall

149 the chemical chaperones act to stabilize the alpha-helical conformation of PrP(C) and thereby prevent

150 conformational change from the predominantly alpha-helical conformation of PrP(C) to the PrP(Sc) stat

151 A fully alpha-helical conformation of the bound agonist may be s

152 Salmonella typhimurium indicates a generally alpha-helical conformation of the linker region, and a c

153 te that phosphorylation at T3 stabilizes the alpha-helical conformation of the N-terminal 17 amino ac

154 ), which promotes shell assembly, the highly alpha-helical conformation of the P8 subunit is stabiliz

155 The predominantly alpha-helical conformation of the peptide alone at pH5-6

156 The propensity to alpha-helical conformation of the peptides in amphipathi

157 an engineered metal ion site, stabilizing an alpha-helical conformation of this loop segment.

158 bridge is believed to stabilize an extended alpha-helical conformation of this peptide while in solu

159 hypotheses for the high thermal stability of alpha-helical conformations of alanine-based peptides by

160 We conclude that the non-alpha-helical conformations of these peptides are domina

161 f the region, which is predicted to adopt an alpha-helical conformation on membrane contact.

162 ther phage proteins to nucleate pVIII in the alpha-helical conformation on the DNA.

163 mmonly assumed model where alphaS lies in an alpha-helical conformation on the membrane surface and i

164 -TM region systematically prefers a straight alpha-helical conformation once embedded in a membrane b

165 binds as a dimer to the dodecapeptide in an alpha-helical conformation, predicated on a substantial

166 cally strained VBS and stabilizes its folded alpha-helical conformation, providing resistance against

167 a transition of prion protein (PrP) from an alpha-helical conformation, PrP(C), to a beta-sheet-rich

168 nd Glu30-Lys33 lactam rings were favoring an alpha-helical conformation rather than a turn, we introd

169 ated that residues 306-314 were in a regular alpha-helical conformation representing the end of helix

170 segments 3 and 4, stabilizing the loop in an alpha-helical conformation required to engage the G prot

171 tion capability (up to 5-fold) by fixing the alpha-helical conformations required for optimal recepto

172 ody and base primarily in beta-structure and alpha-helical conformations, respectively.

173 i + 4 and i, i + 7 pairs, to favor 3(10)- or alpha-helical conformations, respectively.

174 The dipole moments associated with alpha-helical conformations show the best alignment with

175 o side-chain lactam rings would stabilize an alpha-helical conformation shown to be important for the

176 o-side-chain lactam rings would stabilize an alpha-helical conformation shown to be important for the

177 ocidin is predicted to assume an amphipathic alpha-helical conformation similar to many other linear

178 e TNFalpha-derived sequence was induced into alpha-helical conformation, suggesting that conformation

179 backbone of TRH inside the receptor is in an alpha-helical conformation, suggesting that the receptor

180 tions had similar FTIR spectra, with greater alpha-helical conformation, than the kafirin preparation

181 bacterial surface, where this peptide adopts alpha-helical conformations, than cholesterol-enriched L

182 lar, the peptides assume a membrane-spanning alpha-helical conformation that does not disrupt bilayer

183 The arrested NC adopts a compact alpha-helical conformation that induces 28 S rRNA nucleo

184 into eukaryotic cells adopts a well-ordered, alpha-helical conformation that packs tightly against th

185 s a delicate balance to maintain pVIII in an alpha-helical conformation that requires either an orien

186 ore likely than the false positives to adopt alpha-helical conformations that transition to loops at

187 re pHLIP adopts a well-defined transmembrane alpha-helical conformation the peptide still exhibits he

188 gment of the peptide takes on a well-defined alpha-helical conformation; the center segment of the pe

189 cate that the transmembrane segment is in an alpha-helical conformation throughout, with an average h

190 0-204 and 215-223) undergo a transition from alpha-helical conformation to a beta and/or random coil

191 ulted in a time-dependent transition from an alpha-helical conformation to a beta-sheet structure and

192 led the binding of a C-terminal extension in alpha-helical conformation to a pocket next to the activ

193 gether, our data indicates that S4 undergoes alpha-helical conformation to a short-lived different se

194 present direct evidence of a conversion from alpha-helical conformation to beta-sheet fibrils in the

195 DAXX uses an extended alpha-helical conformation to compete with major inter-h

196 bind CD4, but the constructs must display an alpha-helical conformation to do so.

197 somer (PrPSc), shifting from a predominantly alpha-helical conformation to one dominated by beta-shee

198 Complexin binds in an antiparallel alpha-helical conformation to the groove between the syn

199 nomenclature) of Cgb adopts a highly ordered alpha-helical conformation unlike any previously charact

200 olution is largely unstructured, acquires an alpha-helical conformation upon association with lipid m

201 which transitioned from a random coil to an alpha-helical conformation upon BicD2 binding and formed

202 t up to six additional residues may adopt an alpha-helical conformation upon binding actin.

203 It folds into an alpha-helical conformation upon binding to anionic (but

204 coil conformation in solution and adopts an alpha-helical conformation upon binding to lipid membran

205 inear cationic peptides adopt an amphipathic alpha-helical conformation upon binding to lipids as an

206 lein is natively unstructured but assumes an alpha-helical conformation upon binding to phospholipid

207 f the c-region of the signal peptide form an alpha-helical conformation upon binding to SecA.

208 peptides, most of which adopt an amphipathic alpha-helical conformation upon binding to the lipids.

209 The peptide adopts an alpha-helical conformation upon binding to the minichape

210 e N-terminus of the protein, which adopts an alpha-helical conformation upon lipid binding, is essent

211 abilization of linear diazido peptides in an alpha-helical conformation upon reaction with dialkynyl

212 y and confirmed that 2 bound to copper in an alpha-helical conformation via its two histidine side ch

213 with thioflavin T, while with SDS, a partial alpha-helical conformation was adopted that gave no fluo

214 ilization and reconstitution an ~10% loss of alpha-helical conformation was observed, which may refle

215 ogy for stabilizing a peptide in a bioactive alpha-helical conformation, we report the discovery of a

216 d (StpA2-17) and stitched (StchA2-17), whose alpha-helical conformations were stabilized by chemical

217 Our results show that SNa15 adopts an alpha-helical conformation when adsorbed to HAP and TiO(

218 y revealed that the signal peptide adopted a alpha-helical conformation when bound by NapD, and subst

219 de is unstructured in solution, it adopts an alpha-helical conformation when bound to the ECD.

220 IAPP(1-19) is conformationally stable in an alpha-helical conformation when bound to the membrane.

221 members (urotensins and sauvagine) assume an alpha-helical conformation when interacting with CRF rec

222 30),Lys(33),Nle(38)]hCRF((12-41))] assume an alpha-helical conformation when interacting with their r

223 sition, adopting an L-shaped, extended chain/alpha-helical conformation when it interacts with a phyl

224 solution, but strongly adopts an amphipathic alpha-helical conformation when partitioned into membran

225 ratin bound to the membrane interface in the alpha-helical conformation when the peptide/lipid (P/L)

226 ution but undergoes a concerted change to an alpha-helical conformation when the polarity of the envi

227 However, wt-alphaSyn(2SS) adopts an alpha-helical conformation, whereas A30P-alphaSyn(2SS) a

228 Lowering the pH favors the monomeric alpha-helical conformation, whereas increasing the ionic

229 insert into the bilayers in a predominantly alpha-helical conformation, whereas self-associated fusi

230 Folding of this peptide into an alpha helical conformation, which occurs upon binding to

231 Interestingly, the peptide adopts an alpha-helical conformation, which orients the motif resi

232 remodeling preserved the dynamic adoption of alpha-helical conformations, which are essential for phy

233 mplex formation, the CaMKI peptide adopts an alpha-helical conformation, while changes in the CaM dom

234 arting at the N-terminus of alphaS adopts an alpha-helical conformation, while succeeding residues re

235 s of both peptides were observed to be in an alpha-helical conformation, while the N-terminal halves

236 ttern of accessibility is consistent with an alpha-helical conformation with a wide angle of accessib

237 istent with the notion that the TMs 6 are in alpha-helical conformations with a narrow strip of acces

238 ater solution into thermodynamically stable, alpha-helical conformations with well-defined tertiary s

239 elles, alphaS adopts an extended amphipathic alpha-helical conformation, with its long axis aligned w

240 opy showed that the channel exists mostly in alpha-helical conformation, with more than 50% alpha-hel

241 ured in an aqueous environment but adopts an alpha-helical conformation within a localized region on

242 21, an interaction necessary for stabilizing alpha-helical conformation within the transactivation do

243 sulfone groups resulted in disruption of the alpha-helical conformations without loss of water solubi

244 on cross-linking strategy to reinforce their alpha-helical conformation, yielding improved protease r