ライフサイエンスコーパス: alpha-ketoglutarate dehydrogenase

1 ctivity of a rate-limiting TCA cycle enzyme, alpha-ketoglutarate dehydrogenase.

2 ion and inhibition of the Krebs cycle enzyme alpha-ketoglutarate dehydrogenase.

3 piration: the bc1 center and, more recently, alpha-ketoglutarate dehydrogenase.

4 CA cycle enzymes, pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.

5 A cycle enzymes isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase.

6 fects on intact mitochondria by inactivating alpha-ketoglutarate dehydrogenase.

7 rs histone methylation in plants via nuclear alpha-ketoglutarate dehydrogenase.

8 LSG184 is devoid of alpha-ketoglutarate dehydrogenase activity, indicating t

9 hough Nitrosomonas europaea lacks measurable alpha-ketoglutarate dehydrogenase activity, the recent c

10 Despite the absence of alpha-ketoglutarate dehydrogenase activity, whole cells

11 Here we show that the alpha-ketoglutarate dehydrogenase (alpha-KGDH) complex i

12 and, between phosphotransacetylase (PTA) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) for their

13 ase that maintains the catalytic function of alpha-ketoglutarate dehydrogenase (alpha-KGDH), and its

14 and organization of the multienzyme complex alpha-ketoglutarate dehydrogenase (alpha-KGDH).

15 ansferase, and the E2 and E3 subunits of the alpha-ketoglutarate dehydrogenase (alphaKGDH) complex as

16 , we found an increase in phosphorylation of alpha-ketoglutarate dehydrogenase (alphaKGDH) in female

17 chondrial LipDH is part of the mitochondrial alpha-ketoglutarate dehydrogenase and branched chain alp

18 acid cofactor of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase and other mitochondria

19 citrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and succinyl-CoA ligas

20 ributions of regulation of the activities of alpha-ketoglutarate dehydrogenase and the aspartate-glut

21 ltiple proteins, including the E2 subunit of alpha-ketoglutarate dehydrogenase and the glutathione S-

22 complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the glycine cleava

23 complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and branched-chain ke

24 ve E2 subunits of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, and Gcv3, the H prote

25 se components of the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and glycine reductase

26 se components of the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and glycine reductase

27 cardiac sarcoplasmic reticulum Ca2+-ATPase, alpha-ketoglutarate dehydrogenase, and the mitochondrial

28 lines in mitochondrial function and identify alpha-ketoglutarate dehydrogenase as a likely site of fr

29 id is a coenzyme for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, branched chain-ketoac

30 ltienzyme complexes: pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, branched-chain alpha-

31 Glutathionylation of alpha-ketoglutarate dehydrogenase can therefore be viewe

32 %), isocitrate dehydrogenase (-27%), and the alpha-ketoglutarate dehydrogenase complex (-57%).

33 hydrolipoamide dehydrogenase subunits of the alpha-ketoglutarate dehydrogenase complex (alphaKGDH), a

34 succinyltransferase, the E2 component of the alpha-ketoglutarate dehydrogenase complex (KDC).

35 m for 24 h, resulted in a pronounced loss of alpha-ketoglutarate dehydrogenase complex (KGDHC) activi

36 The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC) declin

37 The mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is def

38 Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mit

39 The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), an ar

40 The activity of alpha-ketoglutarate dehydrogenase complex (KGDHC), an im

41 activity of a key mitochondrial enzyme, the alpha-ketoglutarate dehydrogenase complex (KGDHC), decli

42 a striking reduction in the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC).

43 Purified alpha-ketoglutarate dehydrogenase complex also is inacti

44 Lipoamide dehydrogenase, a component of the alpha-ketoglutarate dehydrogenase complex and two other

45 sferase to supply alpha-ketoglutarate to the alpha-ketoglutarate dehydrogenase complex and would, in

46 oxymethyl transferase, and components of the alpha-ketoglutarate dehydrogenase complex in conjunction

47 Zn(2+) inhibition of alpha-ketoglutarate dehydrogenase complex required enzym

48 Purified pig heart alpha-ketoglutarate dehydrogenase complex was strongly i

49 drogenase complex (OGHDC) (also known as the alpha-ketoglutarate dehydrogenase complex) is a rate-lim

50 d its target DLST-the E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, a rate-contro

51 ion of ThPP levels causes dysfunction of the alpha-ketoglutarate dehydrogenase complex, which explain

52 ced CoA to the reduction of NAD(+) using the alpha-ketoglutarate dehydrogenase complex.

53 This was attributed to inhibition of the alpha-ketoglutarate dehydrogenase complex.

54 notransferase, alanine aminotransferase, and alpha-ketoglutarate dehydrogenase complex.

55 respiration by reversible inhibition of the alpha-ketoglutarate dehydrogenase complex.

56 oteins, we demonstrate that the pyruvate and alpha-ketoglutarate dehydrogenase complexes directly cat

57 osttranslational lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes, resulting i

58 component of the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes.

59 ymes of central metabolism, the pyruvate and alpha-ketoglutarate dehydrogenase complexes.

60 d restored full activity to the pyruvate and alpha-ketoglutarate dehydrogenase complexes.

61 complex I during ischemia and complex IV and alpha-ketoglutarate dehydrogenase during reperfusion.

62 uld potentially compensate for inhibition of alpha-ketoglutarate dehydrogenase during symbiotic nitro

63 SLP-signaling pathways, and are dependent on alpha-ketoglutarate dehydrogenase for their activity, wh

64 Using a purified alpha-ketoglutarate dehydrogenase from pig hearts, the e

65 ken to identify the site and consequences of alpha-ketoglutarate dehydrogenase glutathionylation.

66 zobium japonicum sucA mutant that is missing alpha-ketoglutarate dehydrogenase is able to grow on mal

67 alpha-Ketoglutarate dehydrogenase is highly susceptible

68 It was determined that inactivation of alpha-ketoglutarate dehydrogenase is responsible, in lar

69 xylic acid cycle, but we recently found that alpha-ketoglutarate dehydrogenase (KDH) activity is lack

70 ic semialdehyde dehydrogenase (gabD1/gabD2), alpha-ketoglutarate dehydrogenase (kdh), and 2-oxoglutar

71 ed chain amino acid dehydrogenase (BCDH) and alpha-ketoglutarate dehydrogenase (KDH).

72 d lipoamide dehydrogenase (E3) components of alpha-ketoglutarate dehydrogenase (KDH).

73 peroxide (mH(2)O(2)) generating capacity of alpha-ketoglutarate dehydrogenase (KGDH) and compared it

74 e activities of specific Krebs cycle enzymes alpha-ketoglutarate dehydrogenase (KGDH) and succinate d

75 Pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KGDH) are vital entry

76 hydrogen peroxide (mtH(2)O(2)) production by alpha-ketoglutarate dehydrogenase (KGDH) can be inhibite

77 d mitochondria, we identified alterations in alpha-ketoglutarate dehydrogenase (KGDH) pathway upon lo

78 fects on the tricarboxylic acid cycle enzyme alpha-ketoglutarate dehydrogenase (KGDH) which provides

79 lexes, such as pyruvate dehydrogenase (PDH), alpha-ketoglutarate dehydrogenase (KGDH), and the glycin

80 plexes and Krebs cycle enzymes revealed that alpha-ketoglutarate dehydrogenase (KGDH), succinate dehy

81 ich inhibit pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KGDH), we hypothesize

82 rts its effects on respiration by inhibiting alpha-ketoglutarate dehydrogenase (KGDH).

83 Isolated mitochondrial alpha-ketoglutarate dehydrogenase (KGDHC) and pyruvate d

84 n of hypoxic/anaerobic genes was elevated in alpha-ketoglutarate dehydrogenase mutants, whereas expre

85 IM), and demonstrate its specific binding to alpha-ketoglutarate dehydrogenase (OGDH), a key rate-lim

86 ial chaperones and assists in the folding of alpha-ketoglutarate dehydrogenase (OGDH), a rate-limitin

87 by using a coupled enzyme system with either alpha-ketoglutarate dehydrogenase or pyruvate dehydrogen

88 d) in association with peptides derived from alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrog

89 utamine synthetase, glutamate dehydrogenase, alpha-ketoglutarate dehydrogenase, phosphate-activated g

90 Glutathionylation of alpha-ketoglutarate dehydrogenase protected lipoic acid

91 l aspartate aminotransferase followed by the alpha-ketoglutarate dehydrogenase reaction.

92 zymes of the tricarboxylic acid (TCA) cycle, alpha-ketoglutarate dehydrogenase (sucAB) and succinyl c

93 lot analysis revealed that the E2 subunit of alpha-ketoglutarate dehydrogenase was reversibly glutath

94 The sucA gene, encoding the E1 component of alpha-ketoglutarate dehydrogenase, was cloned from Brady