ライフサイエンスコーパス: alpha-lipoic acid

1 in the two diabetic groups (with and without alpha-lipoic acid).

2 s produced by the oxidative stress scavenger alpha-lipoic acid.

3 le vitamins biotin and pantothenic acid, and alpha-lipoic acid.

4 inistration, a high-fat diet with or without alpha-lipoic acid (1.65 g/kg) was given to the mice and

5 s (4-benzoic acid) porphyrin (10 mg/kg), and alpha-lipoic acid (100 mg/kg).

6 decreased by preincubation with NAC (1 h) or alpha-lipoic acid (24 h) but not vitamin E.

7 receiving diets supplemented with or without alpha-lipoic acid (400 mg/kg) for 11 months of diabetes.

8 this deficit is dose-dependently reversed by alpha-lipoic acid, a change associated with an improveme

9 ar weights, and molar-mass dispersities from alpha-lipoic acid, a commercially available and renewabl

10 culture medium with 100, 200, or 500 microM alpha-lipoic acid, a metabolic antioxidant, after inocul

11 (R)-alpha-Lipoic acid, a mitochondrial coenzyme, is a powerf

12 melatonin, a naturally occurring indole, and alpha-lipoic acid, a naturally occurring dithiol, were a

13 To examine the effect of alpha-lipoic acid, a potent natural antioxidant, on athe

14 alpha-Lipoic acid, a thiol antioxidant, has been shown t

15 OxPhos deficit in cINs could be reversed by Alpha Lipoic Acid/Acetyl-L-Carnitine (ALA/ALC) but not b

16 alpha-Lipoic acid administration for the entire duration

17 fold and 70%, respectively, in diabetes, and alpha-lipoic acid administration inhibited these increas

18 The effect of alpha-lipoic acid administration on retinal 8-hydroxy-2'

19 Alpha lipoic acid (ALA) and vitamin C (Vit-C) are very i

20 Alpha lipoic acid (ALA) is a nutraceutical and potent an

21 Treating A-T cells with the antioxidant, alpha lipoic acid (ALA), restored mitochondrial respirat

22 Male SD rats were pretreated with alpha-lipoic acid (ALA) and dihydrolipoic acid (DHLA) or

23 to synthesize a new UV active derivative of alpha-lipoic acid (ALA) by its esterification with 4-met

24 ts with a racemic mixture of the antioxidant alpha-lipoic acid (ALA) could improve glucose metabolism

25 alpha-lipoic acid (ALA) is a potent antioxidant that is

26 onditions at a much lower concentration than alpha-lipoic acid (ALA).

27 ination of mixed tocopherols (666 IU/d) plus alpha-lipoic acid (ALA; 600 mg/d) or matching placebos f

28 A nutraceutical, namely, alpha-lipoic acid (alpha-LA), is known for its potent an

29 f several antioxidant agents (ascorbic acid, alpha-lipoic acid, alpha-tocopherol, Mn(III)-tetrakis(4-

30 Polymers of alpha-lipoic acid (alphaLA) have the potential to fulfil

31 alpha-Lipoic acid (alphaLA) is an attractive building bl

32 mitochondria, lipoic acid synthase produces alpha-lipoic acid, an antioxidant and an essential cofac

33 dduct formation in human liver microsomes by alpha-lipoic acid, an inhibitor of NADPH: p450 reductase

34 l function and arborization were reversed by alpha lipoic acid and acetyl-L-carnitine treatments, whi

35 entation with the mitochondrial antioxidants alpha-lipoic acid and coenzyme Q(10) also suppresses Bak

36 ut normalized by treatment with antioxidants alpha-lipoic acid and D-alpha-tocopherol and, surprising

37 d, metformin, the combination treatment of R-alpha-lipoic acid and metformin, and niacin.

38 l derivatives of potent antioxidant vitamin, alpha-lipoic acid, and related analogues were designed,

39 Alpha-lipoic acid appears to be effective as well.

40 Polylipoates (PLp), derived from alpha-lipoic acid, are promising polymers for developing

41 under aqueous miniemulsion conditions using alpha-lipoic acid as a cheap and scalable building block

42 Diabetic rats were treated with 0.5% alpha-lipoic acid as a diet supplement or with hydroxyet

43 Treating diabetic rats with alpha-lipoic acid but not HES-DFO partially improved sci

44 Remarkably, alpha-lipoic acid completely prevented the increase in p

45 systemic treatment with either HC-030031 or alpha-lipoic acid could completely prevent hypersensitiv

46 aining vitamin C, vitamin E, zinc, selenium, alpha-lipoic-acid, cranberry extract, grapeseed extract,

47 Treatment with 500 microM alpha-lipoic acid decreased by 50% both the number and s

48 tration of either insulin or the antioxidant alpha-lipoic acid decreased proteinuria and oxidative st

49 The presence of 100 or 200 microM alpha-lipoic acid did not influence rickettsial growth i

50 Since alpha-lipoic acid does not seem to exhibit direct antiri

51 Alpha-lipoic acid dose- and time-dependently prevented t

52 Pretreatment with R-alpha-lipoic acid effectively protected ARPE-19 cells fr

53 n of the cell culture medium with 100 microM alpha-lipoic acid for 72 h after infection prevented the

54 -doped carbon dots (Tb@N-CDs), combined with alpha-lipoic acid-functionalized copper nanoclusters (LA

55 Alpha-lipoic acid had a biphasic effect: it dose-depende

56 Alpha-lipoic acid had no significant effect on either en

57 The metabolic thiol antioxidant alpha-lipoic acid has been suggested to be of therapeuti

58 nstrate that the long-term administration of alpha-lipoic acid has beneficial effects on the developm

59 supplements studied, N-acetyl-L-cysteine and alpha-lipoic acid hold the most promise.

60 rovide further evidence for the potential of alpha-lipoic acid in treatment of diseases related to ox

61 We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in th

62 Alpha-lipoic acid is a potent antioxidant that prevents

63 Our results suggest that dietary alpha-lipoic acid is a promising protective agent for re

64 r 0.2% (wt/vol) in drinking water], and/or R-alpha-lipoic acid (LA) [0.2% or 0.1% (wt/wt) in diet].

65 e shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects b

66 alpha-Lipoic acid (LA) has been found to attenuate diabe

67 alpha-Lipoic acid (LA) has been shown to improve memory

68 alpha-Lipoic acid (LA) has recently emerged as an attrac

69 In diabetic patients, alpha-lipoic acid (LA) improves skeletal muscle glucose

70 d with the antioxidants vitamin E (VE) and R-alpha-lipoic acid (LA) in streptozotocin-induced diabeti

71 alpha-Lipoic acid (LA) is a cofactor for mitochondrial a

72 alpha-lipoic acid (LA) is an essential cofactor for mito

73 hombencephalic neurons and co-treatment with alpha-lipoic acid (LA) or one of several other antioxida

74 ed that 2 mo of dietary supplementation with alpha-lipoic acid (LA) prevented early glomerular injury

75 ects of administration of the antioxidant DL-alpha-lipoic acid (LA) to streptozotocin-injected diabet

76 statistical and block copolymers containing alpha-lipoic acid (LA) using reversible addition-fragmen

77 We investigated the role of (R)-alpha-lipoic acid (LA) vs. glutathione and ascorbic acid

78 ate whether dietary supplementation with (R)-alpha-lipoic acid (LA) was effective at reducing oxidati

79 rter (hSMVT) has been suggested to transport alpha-lipoic acid (LA), a potent antioxidant and anti-in

80 on the "grafting-through" polymerization of alpha-lipoic acid (LA)-functionalized macromonomers.

81 or the mitochondrial antioxidant precursor R-alpha-lipoic acid (LA).

82 ranslocation, old rats were treated with (R)-alpha-lipoic acid (LA; 40 mg/kg i.p. up to 48 h), a disu

83 % (wt/vol) in the drinking water] and/or (R)-alpha-lipoic acid [LA, 0.5% (wt/wt) in the chow] improve

84 yielding 600 g of poly(n-butyl acrylate-stat-alpha-lipoic acid) latexes that degrade under reducing c

85 ants regulated Ang II receptors differently: alpha-Lipoic acid lowered Ang II binding after 24 h, and

86 e retina is impaired and may be corrected by alpha-lipoic acid (LPA), a drug that inhibits vascular h

87 s for immediate testing in progressive MS: R-alpha-lipoic acid, metformin, the combination treatment

88 tioxidants ascorbate, ascorbate 2-phosphate, alpha-lipoic acid, N-acetyl-L-cysteine and glutathione i

89 iabetic rats, treatment with the antioxidant alpha-lipoic acid normalized the amount of leukostasis b

90 e of this study was to examine the effect of alpha-lipoic acid on retinal capillary cell apoptosis an

91 ls was not improved by treatment with either alpha-lipoic acid or HES-DFO.

92 acid, Trolox, Resveratrol, Alpha tocopherol, Alpha lipoic acid, Orotic acid, Ginsenoside RB1, and Xan

93 of drugs, choline (CHO), idebenone (IDB), R-alpha-lipoic acid plus acetyl-L-carnitine (LCLA), was fo

94 Application of the antioxidant alpha-lipoic acid potently prevents glucose-induced oxid

95 Treating diabetic rats with alpha-lipoic acid prevented the diabetes-induced increas

96 Alpha-lipoic acid prevented the reduction in SCG creatin

97 supplementation of old animals with 0.5% (R)-alpha-lipoic acid prior to cell isolation almost complet

98 he antioxidants epigallocatechin gallate and alpha-lipoic acid reduces polyglutamine aggregation.

99 % or greater responder rate, flunarizine and alpha-lipoic acid (risk ratio [RR], 8.73; 95% CI, 2.44-3

100 ncubation with the AMPK activators AICAR and alpha-lipoic acid substantially prevented all of those c

101 nd their nondiabetic apoE(-/-) controls with alpha-lipoic acid supplement than in those without it.

102 Alpha-lipoic acid supplementation had no effect on gluco

103 alpha-Lipoic acid supplementation represents an achievab

104 Conversely, the antioxidant alpha-lipoic acid, that protected against the loss of gl

105 Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-

106 Simple formulations of alpha-lipoic acid (up to 10 mol %), n-butyl acrylate, a

107 treatment regardless of the concentration of alpha-lipoic acid used.

108 Duration of diabetes was 1 month, and alpha-lipoic acid was administered intraperitoneally 5 t

109 These protective effects of alpha-lipoic acid were accompanied by a reduction of pla

110 of acrolein and the protective effects of R-alpha-lipoic acid were examined with a variety of previo

111 Dihydrolipoic acid (the reduced form of alpha-lipoic acid), which contains free sulfhydryl group

112 receptor binding in cell membranes, whereas alpha-lipoic acid, which does not contain free sulfhydry

113 Substitution of alpha-lipoic acid with ethyl lipoate further improves th