ライフサイエンスコーパス: alpha-neurotoxin

1 gnate peptide and alpha-bungarotoxin, a long alpha-neurotoxin.

2 or interactions and the orientation of bound alpha-neurotoxin.

3 he binding and functional activity of a long alpha-neurotoxin.

4 omplex with ScNtx, a recombinant short-chain alpha-neurotoxin.

5 on of human neuromuscular signaling by snake alpha-neurotoxins.

6 which permitted the evolution of snake venom alpha-neurotoxins.

7 re with the biological action of short-chain alpha-neurotoxins.

8 sociation of agonists and slow rates for the alpha-neurotoxins.

9 forms a major determinant for the binding of alpha-neurotoxins.

10 Arg36, a residue that is invariant among all alpha-neurotoxins.

11 ariant in kappa-neurotoxins and not found in alpha-neurotoxins.

12 inhibition mechanism by snake-venom-derived alpha-neurotoxins.

13 neuronal membrane molecule related to snake alpha-neurotoxins able to modulate nAChRs.

14 ing for alpha-bungarotoxin and similar snake alpha-neurotoxins also targeting alpha7 nAChR.

15 ription of the contacts between a prototypic alpha-neurotoxin and its cognate recognition sequence.

16 olved in the binding interaction on both the alpha-neurotoxin and the receptor interface.

17 proteins to bind short-chain and long-chain alpha-neurotoxins and cytotoxins from the 3FTx family.

18 ding subtype-specific actions of short-chain alpha-neurotoxins and inspire strategies for design of n

19 While the alpha-neurotoxins are monomeric, the kappa-neurotoxins o

20 alpha-Neurotoxins are potent inhibitors of the nicotinic

21 The alpha-neurotoxins are three-fingered peptide toxins that

22 igate whether the alpha18-mer can bind other alpha-neurotoxins besides alpha-bungarotoxin, we designe

23 alpha-Neurotoxins bind with high affinity to alpha-gamma

24 ica mossambica (NmmI) that, similar to other alpha-neurotoxins, binds with high affinity to alphagamm

25 interaction, we examined the flexibility of alpha-neurotoxin bound to the acetylcholine-binding prot

26 alpha-Neurotoxins constitute a large family of polypepti

27 Like the kappa-neurotoxins, the long alpha-neurotoxins contain the same five conserved disulf

28 otoxins readily dimerize in solution and the alpha-neurotoxins do not and also suggest that there is

29 domain and tested the effect of short-chain alpha-neurotoxin erabutoxin-a (ETX-a) from the Erabu sea

30 luding two residues conserved throughout the alpha-neurotoxin family (K27 and R33), resulted in subst

31 Amino acid variants of alpha-neurotoxin from N. mossambica mossambica at positi

32 genesis had identified three residues on the alpha-neurotoxin from Naja mossambica mossambica (Lys27,

33 We report here on a short alpha-neurotoxin from Naja mossambica mossambica (NmmI)

34 Because the alpha-neurotoxin from Naja mossambica mossambica I shows

35 tro and in vivo against different long-chain alpha-neurotoxins from elapid snakes.

36 The three-fingered alpha-neurotoxins have played a pivotal role in elucidat

37 al resistance against conspecific long-chain alpha-neurotoxins in Elapidae snakes also interfere with

38 pha-conotoxin ImI and a chimeric Naja oxiana alpha-neurotoxin indicating that the major role in alpha

39 that only one face of the second loop of the alpha-neurotoxin is immobilized significantly by its bin

40 The results indicate that bound alpha-neurotoxin is not rigidly oriented on the surface

41 ited by some other three-finger toxins, long alpha-neurotoxin Ls III and nonconventional toxin WTX.

42 g occurs in millisecond time frames, and the alpha-neurotoxins may induce a distinct conformational s

43 To advance our understanding of the alpha-neurotoxin-nAChR interaction, we examined the flex

44 Using a recombinant DNA-derived alpha-neurotoxin (Naja mossambica mossambica, NmmI) and

45 e conserved disulfide bonds, while the short alpha-neurotoxins only contain four of the five.

46 ody that neutralizes long-chain three-finger alpha-neurotoxins produced by numerous medically relevan

47 A model describing alpha-neurotoxin resistance in Elapidae snakes is presen

48 Phylogenetic analysis of alpha-neurotoxin resistance suggests that alpha-neurotox

49 of alpha-neurotoxin resistance suggests that alpha-neurotoxin-resistant nAChR evolved first, which pe

50 his effect correlates with the variations in alpha-neurotoxin sensitivity of different species and, i

51 -Bungarotoxin is structurally related to the alpha-neurotoxins, such as alpha-bungarotoxin derived fr

52 uorescent conjugate of fasciculin 2, a snake alpha-neurotoxin that tightly binds to the catalytic sub

53 neofunctionalization occurred in snake venom alpha-neurotoxins upon loss of another pair of the plesi