ライフサイエンスコーパス: alpha-position

1 increased upon CH(3)/CF(2)H exchange at the alpha position.

2 substantial amounts of epimerization at the alpha position.

3 sidues with a variety of substituents at the alpha position.

4 ith or followed by uptake of a proton at the alpha-position.

5 ng OR or equivalent functional groups at the alpha-position.

6 h the nucleophilic amino group is not in the alpha-position.

7 ketones containing a thiophene moiety in the alpha-position.

8 high regioselectivity for the less-hindered alpha-position.

9 ketones containing quaternary carbons in the alpha-position.

10 ce the acidity as well as one located at the alpha-position.

11 such as diastereoselective alkylation of the alpha-position.

12 and amines having a quaternary carbon at the alpha-position.

13 , N)-centred nucleophiles exclusively at the alpha-position.

14 tion of the carbocation by a pi-donor in the alpha-position.

15 tonation by H2O is mostly at the naphthalene alpha-position.

16 Wittig-Horner reaction after chlorination in alpha-position.

17 tics such as 2-pyrrole or 2-indole favor the alpha-position.

18 ce by installing a second substituent in the alpha'-position.

19 tope effect of 1.010 was observed at the C2 (alpha) position.

20 template for catalytic activation of ketone alpha-positions.

21 on of substituents at the pyrrole alpha- and alpha'-positions (2- and 5-, respectively).

22 oketone substrate has a hydrogen atom at the alpha position a peroxyvinylsulfenic acid intermediate c

23 the conjugated system of the Bodipy core at alpha-position, a red-emitting rBBB.

24 by the presence of an aromatic group at the alpha-position adjacent to the ketone, which stabilizes

25 Linkage at the alpha-position allows both inter- and intramolecular N..

26 ents the need for redundant chirality at the alpha-position allylic alcohol, while simultaneously pro

27 were k(12C)/k(13C) = 1.041 +/- 0.005 at the alpha position and 1.013 +/- 0.006 at the beta position.

28 KIEs were k(H)/k(D) = 1.076 +/- 0.005 at the alpha position and 1.017 +/- 0.005 at the beta position.

29 When the dimer (I) was deuterated at the alpha position and subsequently oxidized by MnP in the p

30 izes two antiparallel bases focused at the C(alpha) position and oriented perpendicular to the PLP ri

31 Addition of carbonyl oxygen at the alpha-position and formation of C-O bond at the beta-pos

32 hange of substituted toluenes labeled in the alpha-position and relative equilibrium acidities comput

33 vinylsulfenic acid can also rearrange to the alpha position, and by reaction with the starting thioke

34 d possess trimethylsilyl substituents in the alpha-positions, and the ancillary Cp2, Me2C(eta(5)-C5H4

35 on in directing the Grignard addition to the alpha position as opposed to 1,4-addition on the ene-lac

36 pecificity and included not only the natural alpha position but also the adjoining carbon atom in the

37 g partners are exclusively arylated at their alpha-position by an asynchronous [3,3]-sigmatropic rear

38 Varying the lipophilicity of the alpha-position by replacing the isopropyl group of 11c w

39 roup was readily introduced into the pyrrole alpha-position by the reaction of 2-thiocyanatopyrrole (

40 The alpha-position can be readily substituted with a range o

41 root-mean-square (r.m.s) deviation for 210 C alpha positions considered equivalent is 2.28 angstroms

42 nylene dyad with primary amines in the alpha,alpha'-positions could be prepared and isolated.

43 nalization of amines at C-H bonds beyond the alpha-position could generate valuable difunctional prod

44 to study the dynamics of deuterated backbone alpha-positions, D(alpha), are developed.

45 Placing heavy atoms at the alpha-position decreases conductance, whereas placing th

46 ophene, was arylated regioselectively at the alpha-position directly with iodoarenes.

47 ctly at the beta position rather than at the alpha position followed by isomerization of a reaction i

48 ow-up reactions involve deprotonation at the alpha-position followed by beta-scission to form the ben

49 um introduction at the less-hindered pyrrole alpha-position, followed by distal attack of an oxygen n

50 A tetrahedral adduct at the C2 alpha-position formed between the enamine and D,L-S-meth

51 as oriented by different substituents on the alpha-position (H, methyl/aryl) of oxime acetates.

52 Substitution in the alpha position has the strongest effect.

53 However, SiH3 substitution at the alpha-position has a similar, if smaller, effect.

54 s where the carboxyl functional group at the alpha-position has been replaced by an ester or by a hyd

55 nctionalization of carbonyl compounds in the alpha-position has gathered much attention as a syntheti

56 this trend, whereas such substitution at the alpha-position has negligible effect.

57 ssion of WT macrophage ABCA1 migrated to the alpha position in a two-dimensional gel electrophoresis.

58 alpha-amino acids undergo arylation at their alpha position in an enantioselective manner on treatmen

59 hylene group in methylenecyclohexane and the alpha positions in the 8-tungstabicyclo[4.3.0]nonane com

60 ean-squared differences between comparable C-alpha positions in the X-ray structures and the NMR stru

61 istence of deactivating polar effects at the alpha-position in Cl(*) abstractions is likely also to b

62 idines are selectively functionalized at the alpha-position in good isolated yields.

63 e products are prone to epimerization at the alpha-position in the presence of the B-promoter system.

64 methyl substituents at the C2, C3, C4, or C(alpha) positions, including the unsubstituted parent, wa

65 forms, it facilitates racemization at the C(alpha)-position, incorporating a deuteron from a D(2)O s

66 ed mitogenic effect of steric bulk in the 11 alpha-position is also evident.

67 Whereas the coupling of the alpha position of a carbonyl compound with an alkenyl el

68 by regioselective azide substitution at the alpha position of alpha,beta-dihydroxyesters 6a-c via a

69 Addition of a carboxyl group at the alpha position of carbocyclic nucleoside phosphonate ana

70 ective migration of the N'-aryl group to the alpha position of the amino acid, followed by ring closu

71 y studies in this series by branching at the alpha position of the C-2 benzyl side chain and through

72 with either an ether or an alcohol at the C2 alpha position of the enamine.

73 red with linker chains extending from the 17 alpha position of the estradiol to N-2 (compound 3), N-6

74 "peptoids") containing chiral centers at the alpha position of their side chains can form stable stru

75 of two bromine atoms occurs at the alpha and alpha' positions of the cyclopentenyl scaffold via succe

76 enables carbon-carbon bond formation at the alpha'-position of silylenol ethers by using catalytic a

77 ce substituents appended to the biphenyl and alpha-position of 5 with structurally diverse functional

78 de and one cysteine thioether bridged to the alpha-position of a methionine, a posttranslational modi

79 incorporating them as leaving groups at the alpha-position of alpha,beta-unsaturated ester-based lip

80 Herein we show that, by rendering the alpha-position of amides electrophilic through a mild an

81 yl compound containing a phenyl group at the alpha-position of an aldehyde group reacts more readily

82 Functionalization at the alpha-position of carbonyl compounds has classically rel

83 tive coupling of electron-rich arenes to the alpha-position of carbonyl functionality of in situ gene

84 a-enoates and syn-selective azidation at the alpha-position of ester enolates.

85 thyl groups increase the reactivities of the alpha-position of hydrazines, they decrease the reactivi

86 carboxylic functionality at the pTyr mimetic alpha-position of macrocyclic ligands.

87 he rates of deuterium incorporation into the alpha-position of mandelate and the racemization of (R)-

88 alpha-nitrogen of pTyr residues or from the alpha-position of P0 pTyr mimetics not only increases bi

89 introduces acyclic and cyclic amines to the alpha-position of phosphonates in one step.

90 losure process: (i) condensation between the alpha-position of pyrrole ring A and the alpha-acetal un

91 No addition to the alpha-position of the alkynyl sulfide is observed, and r

92 Alkylation at the alpha-position of the amide (hook) is followed by highly

93 pivotal role of the alkyl substituent at the alpha-position of the amino acid (TDG) in altering enant

94 In contrast, modification at the alpha-position of the beta-alanyl carboxylate group resu

95 of lactones possessing a sulfur atom in the alpha-position of the butyrolactone group, whereas carbo

96 at is, products derived from coupling at the alpha-position of the enone.

97 udy revealed that a small alkyl group on the alpha-position of the ether was required, with the (R)-e

98 owed that 1, which has a chiral amine at the alpha-position of the gamma-aminobutyric acid turn (gamm

99 icoid agonists than those linked through the alpha-position of the lactone.

100 additional electron-withdrawing group at the alpha-position of the Michael acceptor can result in roo

101 up is installed at the gamma- instead of the alpha-position of the N-(2-aminoethyl)glycine backbone u

102 The configuration at the alpha-position of the new generated alpha-amino acid can

103 ective introduction of substituents into the alpha-position of the resulting gamma-amino acids.

104 The highly reactive alpha-position of the terminal thiophenes can allow for

105 od is that when a hydrogen is present in the alpha-position of the thioamide the initially formed thi

106 , and isotopic labeling established that the alpha-position of the three-membered ring is the favored

107 of introducing different substituents at the alpha-position of the tryptophan containing neurokinin-1

108 Introduction of methyl groups at the alpha-position of the vinyl group or the ortho positions

109 The selective oxidation of the alpha-position of two heme-Fe(III) tetraarylporphryinate

110 ees alkyl substituents were generated in the alpha-position of various ketones via synthesis of enami

111 ation of bulky mesityl (Mes) groups into the alpha-positions of a phenanthrene-appended zirconacyclop

112 erance is observed at the keto-, ester-, and alpha-positions of the nucleophile.

113 ons of thiophenes and annelation between the alpha-positions of thiophenes.

114 red with double bonds tethered either to the alpha-position or the gamma-position of the allene.

115 )-C(alpha)-Y, bearing a leaving-group at the alpha-position, proceed either via a direct attack at th

116 undergo diastereoselective alkylation at the alpha position, proceeding with either retention or inve

117 The 3-(dimethylamino)phenyl groups at the alpha position prove to be important to the efficiency o

118 phamycins which contain substitutions at the alpha-position proximal to the carbonyl group that norma

119 New C-C bonds in the alpha position relative to the nitrogen atom were formed

120 (E)-stereoisomers with the -OCH3 group in an alpha- position relative to the double bond had the grea

121 dine, C-H functionalization at the important alpha-position remains challenging.

122 nating carbon sites and deuteration at the C alpha position to overcome these difficulties.

123 ereochemistry of a methyl-substituent at the alpha position to the ester, resembling amino acid side

124 onamides bearing an asymmetric center at the alpha position to the sulfur atom is described.

125 eaturing trimethylsilyl substituents in both alpha positions to boron, by means of a 1,1-hydroboratio

126 ar recognition, where deprotonation at the C(alpha) position to form a putative ketene intermediate o

127 ring-contract thermally at a substituted WC(alpha) position to form a tungstacyclobutane and therefo

128 ating agent for introducing a CH(3) group in alpha-position to a carbonyl group.

129 which bear a benzylic methylene group in the alpha-position to a stereogenic center (-CHMeX), and wit

130 the functionalization of C(sp(3))-H bonds in alpha-position to an amine but also benzylic substrates.

131 (cat) of 48 +/- 1 min(-1), via attack at the alpha-position to exclusively generate the (R)-phenyl vi

132 cleavage of the carbon-hydrogen bond at the alpha-position to nitrogen.

133 his reaction, acting as a nucleophile at the alpha-position to provide fully substituted glycolic est

134 branched tryptamines with aryl groups in the alpha-position to the amino group, while (2-methylcyclop

135 omatic nitrogen heterocycle with nitrogen at alpha-position to the carbon of carboximidamide group si

136 pro-9R hydrogen atom of biotin, which is in alpha-position to the CO(2)(-) group, might be changed t

137 to occur between the triarylamino C atoms in alpha-position to the naphthalene linker because the res

138 by introduction of a heteroatom (N or O) in alpha-position to the phosphonate and using the resultan

139 rapped with Ellman imines selectively at the alpha-position to yield enantiopure 3-pyrroline products

140 s, while the azacyclic ketones with nitrogen alpha-positioned to carbonyl were univocally transformed

141 ubstituent groups in the meso (8)- and/or 3 (alpha)-positions was investigated.

142 with a stereogenic center (-C*HXR(2)) in the alpha position were generated by ionization of the respe

143 ortho-carborane groups at the 8(meso) or 3/5(alpha) position were synthesized and characterized by NM

144 oids with a 3-hydroxyl group oriented in the alpha position, whereas the beta-isoform acts on steroid

145 ining a diverse array of substituents at the alpha position with a single catalyst.

146 nds bearing a quaternary stereocenter at the alpha position with applications in peptidomimetic and m

147 a lambda(5)-phosphorus functionality at the alpha-position with respect to the diazo moiety, here re

148 Carbonylation at the alpha-position with respect to the N atom attached to th

149 bsequently hydroxylates fatty acids at their alpha-position with S-enantioselectivity.

150 the M-C bond more than anticipated if in the alpha-position, with the effect on bond strength diminis