ライフサイエンスコーパス: alpha-receptor

1 A(3) is about equipotent to TxA(2) at the TP alpha receptor.

2 ownstream to the tumor necrosis factor (TNF) alpha receptor.

3 quirement for pre-complexation to a specific alpha-receptor.

4 or necrosis factor alpha (TNF-alpha), or TNF-alpha receptors.

5 s is a consequence of the activation of PPAR-alpha receptors.

6 CD47 to macrophage signal regulatory protein alpha receptors.

7 ically act on 5-HT3, cholecystokinin, or TNF-alpha receptors.

8 gnaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors.

9 eak inducer of apoptosis (TWEAK) but not TNF-alpha receptors.

10 -agonist that has full efficacy at all brain alpha-receptors.

11 CI, 1.13-1.42]), TNF (tumor necrosis factor)-alpha receptor 1 (hazard ratio, 1.09 [95% CI, 1.08-1.11]

12 on, we introduced a deficiency of interferon alpha receptor 1 (Ifnar1) into B6.Aec1Aec2 mice, which a

13 Like TLR3(-/-) mice, IFN-alpha receptor 1 (IFNAR1)(-/-) mice exhibited reduced tu

14 = 0.009), and soluble tumor necrosis factor alpha receptor 1 (P = 0.007) than did no weight-loss tre

15 uble A8 indicated specific cleavage of a TNF-alpha receptor 1 (p55 TNF-R1) but not a TNF-R2 peptide.

16 and the 55-kDa soluble tumor necrosis factor-alpha receptor 1 (sTNF-R1).

17 d nearly completely in tumor necrosis factor alpha receptor 1 (TNF-R1) knockout mice.

18 alizing antibodies against TNF-alpha and TNF-alpha receptor 1 (TNF-R1), suggesting that TNF-alpha pla

19 dent manner following the stimulation of TNF-alpha receptor 1 (TNF-R1).

20 ransgenic AD mice (3xTg-AD) lacking both TNF-alpha receptor 1 (TNF-RI) and 2 (TNF-RII), 3xTg-ADxTNF-R

21 Tumour necrosis factor alpha receptor 1 (TNFR1) activation is known to induce c

22 We show that tumor necrosis factor alpha receptor 1 (TNFR1) in the paraventricular hypothal

23 The examination of IFN-alpha receptor 1 and 2 (IFNAR1 and IFNAR2) levels reveal

24 pared with the well-characterized type 1 IFN-alpha receptor 1 and 2 in mediating innate immune and au

25 Tumor necrosis factor-alpha receptor 1 and Fas recruit overlapping signaling p

26 ng cancer by enhancing tumor necrosis factor-alpha receptor 1 and nuclear factor-kappaB activation an

27 ent correlation was found between plasma TNF-alpha receptor 1 and SHBG levels in obese patients.

28 or necrosis factor alpha (TNF-alpha) and TNF-alpha receptor 1 block rSV5DeltaSH-induced apoptosis, su

29 Changes in soluble tumor necrosis factor alpha receptor 1 but not in C-reactive protein or interl

30 sTNF-alpha) promotes the shedding of the TNF-alpha receptor 1 ectodomain via increased mitochondrial

31 Moreover, blockade of IFN-alpha receptor 1 in NOD mice by a neutralizing antibody

32 hesion molecule 1, and tumor necrosis factor alpha receptor 1 in stored baseline blood samples.

33 ing monoclonal antibody directed against TNF-alpha receptor 1 inhibited FHA-associated apoptosis by 4

34 een baseline VCAM-1 or tumor necrosis factor alpha receptor 1 levels and risk of any of the DR end po

35 is essential for tumor necrosis factor (TNF) alpha receptor 1 regulation of intestinal epithelial cel

36 markers examined, only tumor necrosis factor alpha receptor 1 showed a significantly greater increase

37 Tumor necrosis factor-alpha receptor 1 signaling is vital for blood-brain barr

38 nsaminase, and soluble tumor necrosis factor alpha receptor 1 were lower after treatment with UDCA th

39 osomal degradation of the IFNAR1 (interferon alpha receptor 1) subunit of the type I interferon (IFN)

40 Moreover, TNF-alpha receptor 1, an important membrane death receptor t

41 tibodies to Fas, tumor necrosis factor (TNF)-alpha receptor 1, or TNF-related apoptosis-inducing liga

42 eria toxin receptor (DTR) transgenic and IFN-alpha receptor 1-deficient mice, as well as purified pri

43 y and reparative process, mainly through TNF-alpha receptor 1.

44 otein-1 but did not affect expression of TNF-alpha receptor 1.

45 control livers, expression of IFN-beta, IFN-alpha receptor 1/2, Jak1, and Tyk2 remained unchanged in

46 centrations of soluble tumor necrosis factor alpha receptors 1 and 2 (sTNF-R1, sTNF-R2), interleukin

47 Activated tumor necrosis factor alpha (TNF-alpha) receptor 1 (TNFR1) recruits TNFR1-associated deat

48 ctivator of tumor necrosis factor alpha (TNF-alpha) receptor 1 (TNFR1) signaling, inducing both chemo

49 proteinase-2 (MMP-2), MMP-13, and interferon alpha-receptors 1 and 2.

50 asma levels of soluble tumor necrosis factor-alpha receptor-1 (sTNFR-1) and brain natriuretic peptide

51 tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor-1 (TNF-alphaR1), TNF-alphaR2, and interle

52 comitantly, the proinflammatory receptor TNF-alpha receptor-1 (TNFR1) was shed from the endothelial s

53 sgenic mice, and tumor necrosis factor (TNF) alpha receptor-1 (TNFR1)(-)(/-) mice underwent nonreperf

54 electively down-regulated the functional IFN-alpha receptor-1 chain of type I, but not type II (IFN-g

55 of tumor necrosis factor (TNF)-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatou

56 Down-regulation of IFN-alpha receptor-1 resulted in defective JAK-STAT signalin

57 glial cells, whereas immunostaining for TNF-alpha receptor-1 was mainly positive in the retinal gang

58 Both protein and mRNA of TNF-alpha or TNF-alpha receptor-1 were predominantly localized to the inn

59 howed that mRNA signals for TNF-alpha or TNF-alpha receptor-1 were similarly more intense in glaucoma

60 ession and localization of TNF-alpha and TNF-alpha receptor-1 were studied in retina sections from 20

61 eutralizing Ab or to an inhibitor of the TNF-alpha receptor-1, increases proliferative potential, del

62 tile, 2.18; P = .005), tumor necrosis factor-alpha receptor 2 (odds ratio, 1.78; P = .04), and interl

63 ukin 6 (IL-6), soluble tumor necrosis factor alpha receptor 2 (sTNF-R2), E-selectin, soluble intercel

64 tween interleukin 6 or tumor necrosis factor alpha receptor 2 and risk in the NHS/NHS II.

65 seline levels of tumor necrosis factor (TNF)-alpha receptor 2, interleukin (IL)-6, and C-reactive pro

66 ty C-reactive protein, tumor necrosis factor-alpha receptor 2, interleukin-6, and soluble vascular ce

67 ty C-reactive protein, tumor necrosis factor-alpha receptor 2, interleukin-6, and white blood cell co

68 P), interleukin 6, and tumor necrosis factor alpha receptor 2-and risk of invasive epithelial ovarian

69 tation of the RACK-1 binding site in the IFN-alpha receptor 2/beta subunit of the type I IFN receptor

70 a multiprotein complex that includes the IFN-alpha receptor 2/beta-chain of the receptor, STAT1, Janu

71 ers, including soluble tumor necrosis factor-alpha receptor-2 (P<0.001), interleukin-6 (P=0.04), and

72 type peroxisome proliferator-activated (PPAR-alpha) receptors; (2) shifted nicotine self-administrati

73 Tumor necrosis factor alpha receptor 3 interacting protein 1 (Traf3ip1), also

74 By sorting for the PDGF-alpha receptor, a marker of paraxial mesoderm, and for t

75 gh affinity interaction between IL-2 and its alpha receptor, a moderately entropically favorable low

76 TNFR2-/- epidermis, suggesting that the TNF-alpha receptors act independently via different AP-1 com

77 predict that when EGFR is activated with TGF-alpha, receptor activation is biased toward the cell sur

78 ll-interfering RNA significantly reduced TNF-alpha, receptor activator for nuclear factor kB ligand,

79 .v. treatment prevented the elevation of TNF-alpha, receptor activator of NF-kappaB, and other inflam

80 autoubiquitination of tumor necrosis factor (alpha) receptor adaptor protein 6 (TRAF6), a protein inv

81 dy, the authors hypothesized that either the alpha-receptor agonist phenylephrine or the nitric oxide

82 o generate point mutations in the human PDGF alpha receptor (alphaPDGFR) cDNA, which resulted in sing

83 at the platelet-derived growth factor (PDGF)-alpha receptor (alphaPDGFR) is required for experimental

84 ndicated that platelet-derived growth factor alpha receptor (alphaPDGFR) plays an important role in a

85 e binds to the same site that binds the IL-2 alpha receptor and buries into a groove not seen in the

86 volved the recruitment of PKCbeta to the IFN-alpha receptor and interaction with protein tyrosine pho

87 ed IFN-alpha receptor expression, though IFN-alpha receptor and NKP30 expression was closely associat

88 his report we show, using mice lacking PGF(2)alpha receptor and pregnant rats, that PGF(2)alpha is re

89 ated following stimulation of the interferon-alpha receptor and the TCR in T cells by two different e

90 tabilize a similar complex of the interferon-alpha receptor and TYK2.

91 erleukins, leptin, and tumor necrosis factor-alpha receptors and their downstream molecular adaptors

92 ions of haematopoietic cells on MSCs via TNF-alpha receptors and then activating NF-kappaB signaling

93 ng antibodies, soluble tumor necrosis factor-alpha receptors, and hemin by abolishing both sEng and s

94 lated in response to LPS challenge in an IFN-alpha receptor- and IFN regulatory factor (Irf)9-depende

95 aracterizing pharmaceutical agents including alpha receptor antagonists as medical expulsive agents.

96 to monotherapy with antimuscarinic agents or alpha-receptor antagonists.

97 ressin antagonists and tumor necrosis factor-alpha receptor antibody are in phase II and III clinical

98 CV replicon expression, whereas the anti-IFN-alpha receptor antibody could partially block IRF-7-medi

99 e blockade of IFN-alpha receptor by anti-IFN-alpha receptor antibody on the replicon cells increased

100 e p55 TNF-alpha receptor whereas the p75 TNF-alpha receptor appeared to augment this response.

101 deficiency of NO synthesis and (2) both TNF-alpha receptors are necessary for TNF-alpha's prothrombo

102 s work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry i

103 ghts the role of Netrin-1 and a specific TNF-alpha receptor as candidate targets to prevent or treat

104 e p55 (p55 TNFR-/-) or p75 (p75 TNFR-/-) TNF-alpha receptors as donors in well-defined bone marrow tr

105 wn to act both as a ligand by binding to TNF-alpha receptors, as well as a receptor that transmits ou

106 he abundance of tyrosine-phosphorylated PDGF alpha receptors; as a result, STAT5 does not become acti

107 nt-negative mutants of tumor necrosis factor-alpha receptor-associated factor (TRAF) 6, TRAF2, and NF

108 tion-dependent manner: tumor necrosis factor-alpha receptor-associated factor 2 (TRAF2) and C-termina

109 The TNF-alpha receptor-associated factor 2 (TRAF2) and its downs

110 -containing adaptor protein, Tollip, and TNF-alpha receptor-associated factor 6 expression.

111 iated kinase 4 and 1, but independent of TNF-alpha receptor-associated factor 6.

112 or the MyD88-dependent ubiquitination of TNF-alpha receptor-associated factor 6; activation of TGF-be

113 Tumor necrosis factor alpha (TNF-alpha) receptor-associated factor 2 (TRAF2) regulates ac

114 tors, including beta-alpha-gamma/delta-alpha-alpha receptors at lower levels of gamma2/delta expressi

115 failure could be effectively rescued by IFN-alpha receptor blockade.

116 otein kinase A with KT5720, but not with the alpha receptor blockers prazosin (alpha1) and/or yohimbi

117 In addition, the blockade of IFN-alpha receptor by anti-IFN-alpha receptor antibody on th

118 Inhibition of the stromal cell-derived 1 alpha receptor (C-X-C receptor type 4 or CXCR4) using AM

119 results show for the first time that the IFN-alpha receptor can crosscommunicate with ErbB3.

120 Ligation of the tumor necrosis factor alpha receptor CD120a initiates responses as diverse as

121 The TNF-alpha receptor, CD120a, has recently been shown to be lo

122 specificity of action is conferred by their alpha receptor chains, IL-2Ralpha and IL-15Ralpha.

123 Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTF-Ralpha).

124 The ciliary neurotrophic factor alpha-receptor (CNTFRalpha) is required for motoneuron s

125 Although CNTF alpha-receptor (CNTFRalpha) mRNA and protein are localiz

126 have found that TAK1 is recruited to the TNF-alpha receptor complex in a RIP-dependent manner followi

127 as the forced recruitment of NEMO to the TNF-alpha receptor complex is insufficient for TNF-alpha-ind

128 can activate STAT4 by recruitment to the IFN-alpha receptor complex specifically via the carboxy-term

129 is to specifically recruit MEKK3 to the TNF-alpha receptor complex, whereas the forced recruitment o

130 domains of either of the subunits of the IFN-alpha receptor complex.

131 erized by increased expression of the T-cell alpha receptor constant chain and changes in T helper ce

132 NF-alpha monoclonal antibody (MAb) and a TNF-alpha receptor construct (p75-Fc) were compared with tha

133 ody to platelet-derived growth factor (PDGF) alpha receptors coprecipitated STAT5 from extracts of un

134 d to interact with the tumor necrosis factor alpha receptor [corrected].We have identified a locus co

135 es, opioid-mediated down-regulation of MIP-1 alpha receptors could be blocked by the general PKC inhi

136 ly affect FE, nor does FE depend on Fas, TNF-alpha receptor, cytotoxic T-lymphocyte antigen-4, IL-2,

137 Conversely, IFN-alpha receptor-deficient AGMs (Ifnalphar1(-/-)), had sig

138 Using TNF-alpha receptor-deficient mice, we identify TNF-alpha sig

139 ockout mice with either single or double TNF-alpha receptor deletion.

140 The recovery may reflect alpha-receptor desensitization.

141 Serum TNF-alpha receptors did not differ between unused (4.3+/-0.8

142 ed progesterone, glucocorticoid, or estrogen alpha receptors did not translocate FLAG-beta-catenin to

143 e cytokine subunit p28 and the non-signaling alpha-receptor EBI3.

144 dipose TNF-alpha mRNA when compared with TNF-alpha receptor-expressing ob/ob mice.

145 TNF-alpha receptor expression and function, along with combi

146 pendency of DCs and Ly6C(+) monocytes on IFN-alpha receptor expression for EmGFP/IL-15 upregulation a

147 efect was not attributable to diminished IFN-alpha receptor expression, though IFN-alpha receptor and

148 e response of the alveolar epithelium to TNF-alpha receptor family signaling.

149 eptor, a member of the tumor necrosis factor alpha receptor family.

150 the effects of etanercept, a soluble p75 TNF alpha receptor-Fc fusion protein, in 2 patients with HID

151 r a soluble tumor necrosis factor alpha (TNF-alpha) receptor/Fc construct (TNFR-Fc, etanercept).

152 ls that express the NG2 proteoglycan and the alpha receptor for PDGF (NG2 cells, polydendrocytes) mak

153 such as the use of a nonstandard sushi-type alpha receptors for IL-2 and IL-15 in assembling quatern

154 tingly, prostate cancer cells expressing the alpha-receptor for platelet-derived growth factor (PDGFR

155 t, and that these events are mediated by the alpha-receptor for platelet-derived growth factor (PDGFR

156 llebrand factor nor platelet glycoprotein Ib-alpha receptor (GPIb-alpha) is required for RBCs to adhe

157 inflammation (soluble tumor necrosis factor alpha receptor I [sTNF-RI], interleukin 6 [IL-6], and hi

158 etion of TNF-alpha and the expression of TNF-alpha receptor I in HM.

159 interleukin (IL)-8 and tumor necrosis factor-alpha receptor I, were significantly elevated in the cas

160 or-necrosis factor (TNF)-alpha; soluble TNF- alpha receptor I; and C-reactive protein (CRP) were meas

161 sis factor alpha (TNF-alpha) and soluble TNF-alpha receptors I and II; interleukin 1 beta (IL-1 beta)

162 ds to 2 distinct cell-surface receptors: TNF-alpha receptor-I (TNFR-I: p55) and TNF-alpha receptor-II

163 cytes deficient in the interferon-alpha (IFN-alpha) receptor IFN-alphaR showed reduced expression of

164 (NK) cells from mice lacking the type I IFN-alpha receptor (Ifnar(-/-)) or STAT1 (which signals down

165 er, in both CD4 competent, wild-type and IFN-alpha receptor (IFNAR) KO mice, Pneumocystis infection l

166 s an important inhibitory role in interferon-alpha receptor (IFNAR) signaling in mice.

167 ties through an evolutionarily conserved IFN-alpha receptor (IFNAR), consisting of IFNAR1 and IFNAR2.

168 amazonensisinfectivity in an IFN1-alpha receptor (IFNAR)-dependent manner.

169 increasedL.amazonensisinfectivity in an IFN1-alpha receptor (IFNAR)-dependent manner.

170 by the signaling via a single receptor, IFN-alpha receptor (IFNAR).

171 tion factor signaling through the interferon-alpha receptor (Ifnar1), resulting in the antigen-indepe

172 n (B = 0.27, p < .05), tumor necrosis factor alpha receptor II (B = 0.07, p < .01), and intercellular

173 d decreased HLA-DR and Tumor necrosis factor-alpha receptor II (CD120b) expression compared with cont

174 s included solubilized tumor necrosis factor-alpha receptor II (sTNF-alphaRII), vascular cell adhesio

175 erleukin-6 (IL-6), and tumor necrosis factor-alpha receptor II (TNF-alpha RII) in the atorvastatin gr

176 TNF-alpha receptor II (TNF-RII) was localized in the cytopla

177 10 [IL-10]), placental (TNF-alpha, IL-6, TNF-alpha receptor II [RII], and IL-1beta), and cord (IL-1be

178 TSD had higher average tumor necrosis factor alpha receptor II levels (B = 0.05, p < .05).

179 C-reactive protein and tumor necrosis factor alpha receptor II) and endothelial function (intercellul

180 n the AHEI and soluble tumor necrosis factor-alpha receptor II, interleukin-6, soluble intercellular

181 rotein, interleukin-6, tumor necrosis factor-alpha receptor II, pro-brain natriuretic peptide (pro-BN

182 V and caspase 8, and >80% expressed the TNF-alpha receptor II, while Fas, TNFR-I, and CD27 expressio

183 e precursor, as well as sequestration of TNF-alpha receptors II and I, is performed by the zinc-depen

184 : TNF-alpha receptor-I (TNFR-I: p55) and TNF-alpha receptor-II (TNFR-II: p75).

185 of the unliganded form of the interleukin-7 alpha receptor (IL-7Ralpha) extracellular domain (ECD) a

186 ct via the non-signaling membrane-bound IL-6 alpha-receptor (IL-6R) as an agonistic cytokine but also

187 lex, the viral cytokine can engage the human alpha-receptor (IL-6Ralpha) to form a hexameric vIL-6/IL

188 ignaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling re

189 ical studies of interleukin-7 (IL-7) and its alpha-receptor (IL-7Ralpha) and comparisons with other g

190 ences in plasma immunological profiles (TNF- alpha receptor, IL-6, IFN-gamma, IL-12, IL-17, IL-22, an

191 s by forming a complex with its cell surface alpha-receptor, IL-11Ralpha, and the beta-subunit recept

192 raction between interleukin-7 (IL-7) and its alpha-receptor, IL-7Ralpha, plays fundamental roles in t

193 Interleukin 7 (IL-7) and its alpha-receptor, IL-7Ralpha, serving as essential mediato

194 ransduction pathways generating from the TNF-alpha receptor in cardiomyocytes and leading preferentia

195 th receptor Fas or the tumor necrosis factor alpha receptor in peripheral T cells.

196 To evaluate the role played by each TNF-alpha receptor in the pathogenesis of this syndrome, mic

197 ions, estradiol up-regulates the level of ER-alpha receptors in keratinocytes and induces keratinocyt

198 scence was performed to localize PAF and TNF-alpha receptors in those cells.

199 tralized by abrogating signaling through TNF-alpha receptors in vivo in a mouse model of aging.

200 ion to canonical beta-alpha-gamma/delta-beta-alpha receptors, including beta-alpha-gamma/delta-alpha-

201 rotective, whereas signaling through the TNF-alpha receptor increases the severity of 1918 virus infe

202 We find that, in addition to the "alpha-receptor-independent" tetrameric vIL-6/gp130 compl

203 jected into lean mice lacking individual TNF-alpha receptors indicated that TNF-alpha autoamplificati

204 exercise with microspheres before and after alpha-receptor inhibition (phentolamine) and then NPY Y1

205 sin, rauwolscine) or combined (phentolamine) alpha-receptor inhibition.

206 pathways, such as hypoxia-inducing factor-1-alpha, receptor-interacting protein 1, and apoptosis-ind

207 ibitory effects of roscovitine on STAT5/PDGF alpha receptor interaction, STAT5 activity, and cell sur

208 necrosis factor-alpha, tumor necrosis factor-alpha receptor, interleukin-6 receptor, or L-selectin.

209 licit a calcium flux, failed to induce MIP-1 alpha receptors internalization, and mediated a less pot

210 examined the paradoxical hypothesis that the alpha-receptor inverse agonist doxazosin might produce b

211 e studies thus provide insights into the TNF-alpha receptors involved in mediating and modulating the

212 The level of interferon alpha receptor is also reduced, albeit less drastically

213 The interferon alpha receptor is composed of two subunits: IFNaR1 and I

214 The TNF-alpha receptor is demonstrated to signal through IkappaB

215 Comparing CD4 T cell-depleted IFN-alpha receptor knockout (KO) mice to wild-type mice, we

216 Tumour necrosis factor-alpha receptor knockout (KO) mice, including TNFR1KO, TN

217 pression of both genes was not seen in PGF(2)alpha receptor knockout mice.

218 f NO synthesis and selective blockade of TNF-alpha receptors may provide unique therapeutic approache

219 These findings suggest that alpha receptors mediate the effect of TH on the timing o

220 showed that tumor necrosis factor-alpha (TNF-alpha) receptors mediated cytoprotective signaling again

221 Furthermore, TNF-alpha receptor mutants lacking a functional death domain

222 uced NK cell activity and not to altered IFN-alpha receptor, NKP30, NKP44, NKP46, or NKG2D expression

223 erations are mediated through an endothelial alpha-receptor-NOS-signalling pathway.

224 receptor, Stat4 activation by the human IFN-alpha receptor occurs through indirect recruitment by in

225 s infection, but the broad expression of IFN-alpha receptors often leads to adverse reactions in many

226 e, a process that required expression of IFN-alpha receptor on the T cells and IL-15 in the host.

227 icant reduction in surface expression of TNF-alpha receptors on Fancc(-/-) HSC/P.

228 of TNF-alpha, which, acting through the TNF-alpha receptor p55, augments macrophage colony-stimulati

229 ng a probe to platelet-derived growth factor-alpha receptor (PDGF alpha R), an OPC-expressed mRNA.

230 of the mouse platelet-derived growth factor alpha receptor (PDGFalphaR) is fused to the cytosolic do

231 we show that platelet-derived growth factor-alpha receptor (PDGFR-alpha) is specifically phosphoryla

232 ects are mediated through activation of PDGF-alpha receptors (PDGFR-alpha) on perivascular astrocytes

233 Platelet-derived growth factor alpha receptor (PDGFRA)/NG2-expressing glia are distribu

234 brain express platelet-derived growth factor alpha-receptors (PDGFRA), as they do in more caudal regi

235 utside of the PDGF family activated the PDGF alpha receptor (PDGFRalpha) and promoted disease progres

236 disease, the platelet-derived growth factor alpha receptor (PDGFRalpha) is dramatically more capable

237 locked PDGF-dependent activation of the PDGF alpha receptor (PDGFRalpha).

238 The platelet-derived growth factor alpha-receptor (PDGFRalpha) plays a vital role in the de

239 It may be that cardiac alpha receptors play a primary role in elevating HR and

240 Therefore, we evaluated the role that PPAR-alpha receptors play in the heart.

241 alpha (TNF-alpha), acting via the type 1 TNF-alpha receptor, promotes fibrin deposition, while gamma

242 eukin-6 must first complex with its specific alpha-receptor (Ralpha) in order to bind and activate gp

243 s contain one of five chimeric retinoic acid alpha-receptor (RAR alpha) genes (X-RAR alpha) created b

244 ption factors CCAAT/enhancer binding protein-alpha, receptor retinoid X receptor-alpha, and peroxisom

245 olabeling for androgen (AR) and estrogen (ER alpha) receptors revealed no colocalization of hcrt/orx

246 a converting enzyme (TACE) prevented the TNF-alpha receptor shedding response, which suggests that ex

247 Ob/ob male but not female mice lacking TNF-alpha receptors showed significantly lower levels of adi

248 These data demonstrate that IFN-alpha receptor signaling in nonhematopoietic cells is im

249 cytosis activity, indicating that intact TNF-alpha receptor signaling is critical for microglial-medi

250 TNF-alpha receptor signaling regulates epithelial cell secre

251 To dissect TNF-alpha receptor signaling requirements in AD, we generate

252 (IFNAR1*557Gluext*46), which encodes the IFN-alpha receptor signaling subunit.

253 body response requires B cell-autonomous IFN-alpha receptor signaling, it is independent of B cell-in

254 The role of TNF-alpha receptor subtypes in mediating glutamate receptor

255 RY produced "classic" inverse agonism at all alpha receptor subtypes; thus, a neutral efficacy was no

256 nities comparable to that of the IL-15-IL-15 alpha receptor subunit (IL-15Ralpha) interaction.

257 to construct IL-2 mutants that bind the IL-2 alpha receptor subunit (IL-2Ralpha, CD25) with affinitie

258 indicate that reduced expression of the RXR-alpha receptor subunit may represent a mechanism for res

259 of the cytokine subunit p19 and the soluble alpha receptor subunit p40, binds to a receptor complex

260 in that it does not require the nonsignaling alpha-receptor subunit for the formation of gp130-based

261 IL-12 and IL-23 share p40 as an alpha-receptor subunit, yet show only 15% sequence homol

262 -fold differing affinities for their private alpha receptor subunits.

263 Inhibition of TGF-alpha receptor suppressed the G1-induced increase in GLT

264 The TNF-alpha receptor system is expressed in the cornea, and NF

265 Phosphorylation of the TNF-alpha receptor TNF-R1 has been shown to differentially r

266 t not by the antibody against the type I TNF-alpha receptor (TNF-RI).

267 Cs with the antibody against the type II TNF-alpha receptor (TNF-RII), but not by the antibody agains

268 are primarily mediated through the major TNF-alpha receptor, TNF-R1, which is constitutively expresse

269 lacking either of the tumor necrosis factor-alpha receptor (TNFR) genes were also studied; the induc

270 in a subset of peripheral glia, and the TNF-alpha receptor (TNFR), Wengen, is expressed in motoneuro

271 mpared delivery of the tumor necrosis factor alpha receptor (TNFR)-immunoglobulin G1 (IgG1) Fc fusion

272 cluding the tumor necrosis factor alpha (TNF-alpha) receptor (TNFR), Fas, and death domain receptors

273 The tumor necrosis factor alpha receptor (TNFR1) activates downstream effectors th

274 e of functional type I tumor necrosis factor alpha receptor (TNFR1) and interferon gamma.

275 Activation of the p55 TNF-alpha receptor (TNFR1) with an agonist antibody is suffi

276 Little is known about the role of TNF-alpha receptors (TNFR1/p55 and TNFR2/p75) in angiogenic

277 b/ob mice, p55 and p75 tumor necrosis factor-alpha receptors (TNFRs) act cooperatively to induce PAI-

278 seases; however, the precise role of the TNF-alpha receptors (TNFRs) has not been well defined using

279 t in TTP and either or both of the known TNF-alpha receptors (TNFRs), type 1 (TNFR1) and type 2 (TNFR

280 ce deficient in TNFR-I, TNFR-II, or both TNF-alpha receptors (TNFRs), we determined that AQARSAASKVKV

281 we observed increased expression of the TNF-alpha receptor Tnfrsf1b and Netrin-1.

282 s, including the redistribution of the SDF-1 alpha receptor, to the basal surface and leading edge of

283 ceptor complex composed of an IL-15-specific alpha receptor, together with beta and gammac receptors

284 s of type 1 tumor necrosis factor alpha (TNF-alpha) receptor transcription in gastrointestinal cells

285 hain of the tumor necrosis factor alpha (TNF-alpha) receptor transcripts with IFN-gamma activation.

286 ptosis, because macrophages deficient in IFN-alpha receptor type I (IFNAR1) are highly resistant to n

287 ith adenoviral vector expressing soluble TNF-alpha receptor type I attenuated both MMP-2 and MMP-9 ac

288 , resistin and soluble tumor necrosis factor alpha receptor type II) in peripheral blood were measure

289 of soluble tumor necrosis factor alpha (TNF-alpha) receptors types 1 and 2 (sTNF-R1 and sTNF-R2), C-

290 T or platelet-derived growth factor receptor alpha receptor tyrosine kinase genes.

291 studies demonstrate that activation of PPAR-alpha receptors using a selective PPAR-alpha ligand resu

292 th factor, soluble p75 tumor necrosis factor alpha receptor, vascular cell adhesion molecule 1, and m

293 Consistent with this observation, the IFN-alpha receptor was essential for the ability of MNV to c

294 The expression of TNF-alpha receptors was confirmed by RT-PCR.

295 rotoxin (CIRL or latrophilin) and neurexin 1 alpha receptors were found to be functionally present.

296 otein, fibrinogen, and tumor necrosis factor-alpha receptors were not related to the risk.

297 th sexes, whereas high levels of soluble TNF-alpha receptors were significant only among women.

298 genetically deficient in the p55 and p75 TNF-alpha receptors were used to study the roles of these re

299 ssues was mediated primarily via the p55 TNF-alpha receptor whereas the p75 TNF-alpha receptor appear

300 of the cytokine growth factor, IL-6, and its alpha receptor, would elicit growth of injured spinal co