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1 sm that differs from but synergizes with the alpha2beta1 integrin.
2 orylation events that are independent of the alpha2beta1 integrin.
3 in situ is the alpha1beta1 integrin, not the alpha2beta1 integrin.
4 ing of collagen to one of its receptors, the alpha2beta1 integrin.
5 equired for the internalisation of ECM-bound alpha2beta1 integrin.
6 e identified flavocetin-A as an inhibitor of alpha2beta1 integrin.
7 h calpain-1, and calpain enzymes can degrade alpha2beta1 integrin.
8  express elevated levels of MMP-1, AP-1, and alpha2beta1 integrin.
9 were largely nonfunctional in the absence of alpha2beta1 integrin.
10 stream of DDR1, whereas FAK is downstream of alpha2beta1 integrin.
11 L-7 increases their adhesion to collagen via alpha2beta1 integrin.
12  the functional endorepellin receptor is the alpha2beta1 integrin.
13 ir, fibroblasts first attach to collagen via alpha2beta1 integrin.
14 tivating antibodies against beta1, beta3, or alpha2beta1 integrins.
15                                          The alpha2beta1 integrin, a collagen receptor on platelets a
16                                          The alpha2beta1 integrin, a collagen/laminin receptor, is ex
17                                          The alpha2beta1 integrin, a collagen/laminin receptor, is ex
18                                          The alpha2beta1 integrin, a receptor for collagens, laminins
19  from several investigators suggest that the alpha2beta1 integrin, a receptor for collagens, laminins
20                       Moreover we found that alpha2beta1 integrin acquired core3 O-glycans in cells e
21 n, and may be due to cellular differences in alpha2beta1-integrin activation/ligand affinity state.
22 oth signaling through IGF-IR and influencing alpha2beta1 integrin activity.
23                     However, ligation of the alpha2beta1 integrin alone was insufficient to activate
24 1 integrin alone or both the alpha1beta1 and alpha2beta1 integrins, along with Chinese hamster ovary
25                                         Anti-alpha2beta1 integrin and anti-GP VI antibodies inhibited
26                                  The role of alpha2beta1 integrin and CD44/CSPG receptor binding on h
27  the signal requires two collagen receptors, alpha2beta1 integrin and discoidin domain receptor (DDR)
28              These results suggest that both alpha2beta1 integrin and GP VI are involved in inside-ou
29 l analyses proved that flavocetin-A binds to alpha2beta1 integrin and its alpha2A domain with high af
30                                     Finally, alpha2beta1 integrin and MAP3K1 expression were signific
31                            We also show that alpha2beta1 integrin and Src tyrosine kinase, which have
32                                   Binding of alpha2beta1 integrin and stretch-activated channels medi
33       DDR-2 signaling was independent of the alpha2beta1 integrin and the interleukin-1-induced signa
34 ngiogenesis by simultaneously binding to the alpha2beta1 integrin and the vascular endothelial growth
35 own as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced pl
36 ntagonism, through concurrent binding to the alpha2beta1 integrin and vascular endothelial growth fac
37 onstrate that endorepellin requires both the alpha2beta1 integrin and VEGFR2 for its angiostatic acti
38 vokes a physical down-regulation of both the alpha2beta1 integrin and VEGFR2, with concurrent activat
39  major cell surface receptor for collagen I, alpha2beta1 integrin, and provide an initial investigati
40 the sequence GDE(A) recognized by the VLA-2 (alpha2beta1) integrin, and to test if VLA-2 is involved
41 lso induced CLANs, whereas adsorbed beta3 or alpha2beta1 integrin antibodies did not.
42 nt to C-68 was inhibited by EDTA and by anti-alpha2beta1 integrin antibodies.
43 ities on p176 that can be blocked by an anti-alpha2beta1 integrin antibody.
44 ion whereas no effect was observed with anti-alpha2beta1 integrin antibody.
45 telet spreading was markedly reduced by anti-alpha2beta1 integrin antibody.
46                   Thus, our study identifies alpha2beta1 integrin as an important survival pathway in
47   Accordingly, C2C12 cells stably expressing alpha2beta1 integrin as the only collagen-binding integr
48 ent of C2C12-alpha2+myoblasts expressing the alpha2beta1 integrin as the sole collagen receptor.
49  collagen I was dependent on alpha1beta1 and alpha2beta1 integrins, as shown with function blocking a
50  that in squamous epithelial cells, collagen-alpha2beta1 integrin binding activates RhoA, slowing cel
51 evealed the presence of an Asp-Gly-Glu (DGE) alpha2beta1 integrin-binding motif in the N-terminal dom
52 ain, as bait for affinity purification of an alpha2beta1 integrin-binding toxin from the crude venom.
53                                          The alpha2beta1 integrin binds collagen in a Mg2+-dependent
54                           In a search for an alpha2beta1 integrin-blocking component from the venom o
55 ngs suggest that the separation of GPIb- and alpha2beta1 integrin-blocking members within the C-type
56               Endothelial cells that express alpha2beta1 integrin but lack VEGFR2, do not respond to
57  cells genetically engineered to express the alpha2beta1 integrin, but not in cells either lacking th
58 tudies demonstrated that reexpression of the alpha2beta1 integrin by a poorly differentiated breast c
59                              Ligation of the alpha2beta1 integrin by C1q contained in immune complexe
60 ely--alphaVbeta3 integrin by nearly 65%, and alpha2beta1 integrin by nearly 95%.
61 ported that the nonactivated conformation of alpha2beta1 integrin can also bind to large ligands, suc
62      Thus, the cooperation between IL-7R and alpha2beta1 integrin can represent an important pathogen
63 ) and collagen (via its interaction with the alpha2beta1 integrin), caused Vav to become phosphorylat
64                                              alpha2beta1 integrin, CD36, and GP VI have all been impl
65 ently reduced cell surface expression of the alpha2beta1 integrin collagen receptor and impaired sign
66 on lead to an accelerated down-regulation of alpha2beta1 integrin compared to the slow turnover of un
67 integrin, leading to decreased levels of the alpha2beta1 integrin complex, decreased activation of fo
68 esent in alpha2-MVBs, internalized clustered alpha2beta1 integrin coprecipitates with calpain-1, and
69                   In addition, the impact of alpha2beta1 integrin-deficiency on the function of prima
70                                          The alpha2beta1 integrin-dependent difference in angiogenesi
71                    In contrast, there was no alpha2beta1 integrin-dependent difference in the angioge
72 In this study, we show that decorin promotes alpha2beta1 integrin-dependent endothelial cell adhesion
73 ngs demonstrate that genetic deletion of the alpha2beta1 integrin does not significantly alter the ra
74 nvasion, restores cell surface expression of alpha2beta1 integrin, downstream FAK autophosphorylation
75 capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I colla
76 on collagen stimulation or clustering of the alpha2beta1 integrin, even in the absence of increased l
77 ged with B16F10 melanoma cells, mice lacking alpha2beta1 integrin ex-pression exhibit increased tumor
78  response to Listeria monocytogenes required alpha2beta1 integrin expression by peritoneal mast cells
79                Peritoneal mast cells require alpha2beta1 integrin expression for activation in respon
80 en I binding, collagen I-driven motility, or alpha2beta1-integrin expression.
81 on formation and altered localization of the alpha2beta1 integrin from cell-cell to cell-matrix adhes
82 and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traff
83 S16, a potent and selective inhibitor of the alpha2beta1 integrin, from Echis multisquamatus venom.
84 nhanced the collagen-inhibitory effect of an alpha2beta1-integrin function-blocking antibody.
85                                    Thus, the alpha2beta1 integrin functionally inhibits breast tumor
86                      The interaction between alpha2beta1 integrin (GPIa/IIa, VLA-2) and vascular coll
87 uction of MMP-1 occurs by signaling from the alpha2beta1 integrin in contact with dermal fibrillar ty
88 l and genetic evidence of a central role for alpha2beta1 integrin in experimental and developmental a
89 evious studies indicating high expression of alpha2beta1 integrin in normal breast epithelium and los
90                    To define the role of the alpha2beta1 integrin in pathologic angiogenesis, we inve
91  protein (IAP/CD47) augments the function of alpha2beta1 integrin in smooth muscle cells (SMC), resul
92       In this study, we examined the role of alpha2beta1 integrin in Th17-mediated destructive arthri
93         These results suggest a role for the alpha2beta1 integrin in the control of homeostasis of im
94            Numerous data have implicated the alpha2beta1 integrin in various cell types as the primar
95 that suggests an antiangiogenic role for the alpha2beta1 integrin in vivo.
96                    To define the role of the alpha2beta1 integrin in wound healing, wound repair was
97 r mechanisms that regulate expression of the alpha2beta1, integrin in cells with megakaryocytic diffe
98 ing autophagy through a VEGFR2-dependent but alpha2beta1 integrin-independent pathway.
99 ligand and molecular mechanisms by which the alpha2beta1 integrin induces activation and cytokine sec
100  protein separation protocols and tested for alpha2beta1 integrin-inhibiting capabilities by ELISA.
101                            Engagement of the alpha2beta1 integrin initiated a HAEC response similar t
102 galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393
103 ely, these results suggest that endorepellin/alpha2beta1-integrin interaction and effects are specifi
104                     Our results suggest that alpha2beta1 integrin interacts with two different ligand
105 The functional cooperation between IL-7R and alpha2beta1 integrin involves activation of the JAK/PI3K
106                                          The alpha2beta1 integrin is a major collagen receptor on pla
107                       We now report that the alpha2beta1 integrin is a novel receptor for multiple co
108 s study indicates that the collagen receptor alpha2beta1 integrin is a regulator of cell fate in huma
109                                          The alpha2beta1 integrin is abundantly expressed by basal ke
110 e the first evidence, to our knowledge, that alpha2beta1 integrin is an important pathway in Th17 cel
111 gent-stable, physical association of IAP and alpha2beta1 integrin is detected by coimmunoprecipitatio
112                         We further show that alpha2beta1 integrin is expressed on synovial Th17 cells
113                                We found that alpha2beta1 integrin is expressed on synovial Th17 cells
114               This finding suggests that the alpha2beta1 integrin is not only important for innate im
115 a signaling pathway whereby occupancy of the alpha2beta1 integrin is required, but not sufficient, fo
116 -positive HCC cells displayed high levels of alpha2beta1 integrin (ITG) receptor, both in vitro and i
117                                  Blockade of alpha2beta1 integrin led to a decrease in the number of
118 reaggregation of cells plated on collagen I (alpha2beta1 integrin ligand).
119                          We demonstrate that alpha2beta1 integrin-ligation negatively regulates expre
120 suggest that crosstalk between c-met and the alpha2beta1 integrin may contribute to mast-cell activat
121     We hypothesized that reexpression of the alpha2beta1 integrin may regulate expression of other ge
122           Moreover, flavocetin-A antagonized alpha2beta1 integrin-mediated adhesion and migration of
123 ng of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction as shown in ce
124 tocrine TNC increased BTIC growth through an alpha2beta1 integrin-mediated mechanism that elevated NO
125                         Thus, IAP stimulates alpha2beta1 integrin-mediated SMC migration via Gi-media
126 platelet aggregation, was blocked by an anti-alpha2beta1 integrin monoclonal antibody (P1E6), demonst
127 e C-terminal domain V of perlecan) binds the alpha2beta1 integrin on endothelial cells and triggers a
128 are associated with expression levels of the alpha2beta1 integrin on the platelet surface.
129    ADAM9-S binds directly to alpha6beta4 and alpha2beta1 integrins on the surface of colon carcinoma
130 ss spectroscopy as the alpha2 subunit of the alpha2beta1 integrin, one of the major type I collagen-b
131 potentials based on engagement of either the alpha2beta1 integrin or CD44/CSPG.
132 olysis in the NOTCH pathway, or silencing of alpha2beta1 integrin or JAG1, reduced the proliferative
133            However, forced overexpression of alpha2beta1 integrin or MMP1 in smooth muscle cells expr
134                   Our results identified the alpha2beta1 integrin/p38 signalling axis as a novel regu
135          The addition of an antibody against alpha2beta1 integrin partially reversed the inhibitory e
136                 Our findings reveal that the alpha2beta1 integrin plays an important role in angiogen
137                    Activated and neutralized alpha2beta1 integrin polyclonal antibodies, interleukin-
138 ogels presenting GFOGER, a peptide targeting alpha2beta1 integrin, prolong hMSC survival and engraftm
139                      We demonstrate that the alpha2beta1 integrin provides a costimulatory function r
140                   We propose, therefore that alpha2beta1 integrin receptor levels in dermal fibroblas
141                                          The alpha2beta1 integrin receptor plays a key role in angiog
142 pecific interaction of endorepellin with the alpha2beta1 integrin receptor.
143 ycan perlecan, inhibits angiogenesis via the alpha2beta1-integrin receptor.
144 milarities in wound healing, deletion of the alpha2beta1 integrin resulted in a dramatic increase in
145 hesion to collagen mediated primarily by the alpha2beta1 integrin resulted in a strong dephosphorylat
146 requires Mg2+ and is exclusively mediated by alpha2beta1 integrin, resulted in partial activation of
147         We now show that reexpression of the alpha2beta1 integrin results in up-regulation of both th
148                                          The alpha2beta1 integrin specific triple helical peptide lig
149 ate that signaling via the collagen receptor alpha2beta1 integrin specifically inhibits AICD by inhib
150 t and either C1q or type I collagen bound to alpha2beta1 integrin stimulates PMC activation.
151           Here we have demonstrated that the alpha2beta1 integrin suppresses metastasis in a clinical
152 lycystin-1 forms multiprotein complexes with alpha2beta1-integrin, talin, vinculin, paxillin, p130cas
153 s NF-kappaB-dependent expression of MMP1 and alpha2beta1 integrin, that are required for smooth muscl
154 ypic changes elicited by reexpression of the alpha2beta1 integrin, the alpha6 or beta4 integrin subun
155                  We have recently shown that alpha2beta1 integrin, the receptor of type I collagen, i
156 f two collagen receptors-the alpha1beta1 and alpha2beta1 integrins-through induction of mRNAs encodin
157     The interaction between endorepellin and alpha2beta1 integrin triggers a unique signaling pathway
158                     In the current study, an alpha2beta1 integrin triple helical peptide ligand deriv
159 recognized the non-activated conformation of alpha2beta1 integrin under shear stress conditions effec
160 ain, the portion responsible for binding the alpha2beta1 integrin, was ineffective.
161 s, recognition sites for the alpha1beta1 and alpha2beta1 integrins were identified in the short arms
162 ation of p125(FAK) of C2C12 cells expressing alpha2beta1 integrin, whereas parental cells do not.
163                Transcription factor AP-1 and alpha2beta1 integrin, which are key regulators of MMP-1
164 new, potent viper venom-derived inhibitor of alpha2beta1 integrin, which does not belong to the disin
165 or effect on the function of alpha1beta1 and alpha2beta1 integrins, which have been reported to play
166                        Moreover, blockade of alpha2beta1 integrin with a neutralizing mAb inhibited I
167                      The combination of anti-alpha2beta1 integrin with anti-GP VI antibody completely
168                   In contrast, clustering of alpha2beta1 integrin with antibodies or the human pathog
169           We propose that interaction of the alpha2beta1 integrin with dermal collagen mediates induc
170 lines and primary blasts, that engagement of alpha2beta1 integrin with its ligand collagen I (ColI),
171                            Engagement of the alpha2beta1 integrin with monoclonal antibodies or with
172                         Cross-linking of the alpha2beta1 integrin with stimulatory monoclonal antibod

 
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