ライフサイエンスコーパス: alteration

1 on the miRNA structural stability and target alteration.

2 ectable morphologic or functional glomerular alterations.

3 ied to other polyester systems without major alterations.

4 lume relationships and myocardial structural alterations.

5 c potential and the functional role of these alterations.

6 ancreatic cancer were mostly associated gene alterations.

7 ota and metabolites, we observed significant alterations.

8 mall-cell lung cancer (NSCLC) without driver alterations.

9 induces addiction to NRF2 in cells with NRF2 alterations.

10 g infection, in parallel with TCR repertoire alterations.

11 ion, that is, those with severe haemodynamic alterations.

12 h carcinoma cells harboring defined ARHGAP35 alterations.

13 then collected and analyzed for metabolomic alterations.

14 result from a set of genetic and epigenetic alterations.

15 link between parkin deficiency and lysosomal alterations.

16 as linked to the severity of monocyte subset alterations.

17 wenty-seven (87%) PSCs had component-private alterations.

18 mplications for MPNST patients harboring NF1 alterations.

19 ltiple chromosomes and additional structural alterations.

20 and the chronology of glioma-causing somatic alterations.

21 FR alterations, or patients with no FGF/FGFR alterations.

22 strategies do not provide localization of pH alterations.

23 d activity across tumors with activating RET alterations.

24 tumor cell's ability to acquire chromosomal alterations, a mechanism by which tumor cells evolve, ad

25 d protein kinase (MAPK) signaling or genetic alteration across human cancer.

26 ate functional significance of their genetic alterations across samples, genes, and pathways.

27 tigated the hypothesis that these epigenetic alterations act in a feed-forward fashion to promote abe

28 ounding prior observations of gut microbiota alterations among persons with HIV (PWH).

29 Identifying the cancer-driver alterations amongst the vast swathes of "passenger" chan

30 oxicant exposure in producing gut microbiota alteration and neurotoxicity.

31 ly, tested for treatment-determining genetic alterations and are considered to reflect the genetic co

32 ink between inflammation and somatic genomic alterations and are thus key targets for cancer chemopre

33 We characterize mutations, karyotype alterations and gene expression changes, and dissect the

34 resulting in more widespread transcriptional alterations and severe neurological dysfunction than MeC

35 LINC complex prevented RAC1-induced nuclear alterations and the invasive properties of melanoma cell

36 BRAF mutations, any RAS pathway alterations, and co-altered RAS/RAF-TP53 mutations were

37 NA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms.

38 d HCC harbored potentially druggable genetic alterations, and MET amplification was associated with c

39 Overall, we show that Hippo pathway alterations are a feature of sRCC, and enable the explor

40 UPR and DDR alterations are associated with aging and with pathologi

41 A majority of ELF3 alterations are frame-shift mutations that result in sev

42 These phenotypic alterations are initiated by HDAC1 in GBM core cells whi

43 rstanding of AD, single cell-based molecular alterations are largely unknown.

44 cer, but the functional implications of such alterations are not known.

45 As compared with SCZ, these alterations are present in SIB to a lesser extent and ar

46 posure, but it is unclear whether epigenetic alterations are required to achieve and maintain ground

47 These alterations are reverted when membrane fluidity is resto

48 These alterations are specific to dietary fat but not carbohyd

49 Notably, these alterations arise from disrupted functional interactions

50 stress and an abundance of focal copy-number alterations associated with activation of the stimulator

51 of Ccr2 in cancer cells resulted in multiple alterations associated with better immune control: incre

52 f our current understanding of the 3D genome alterations associated with cancers.

53 cued cognitive impairment and transcriptomic alterations associated with chronic epilepsy.

54 d a methodology to quantify microcirculatory alterations associated with disease and the success of c

55 response, we discovered numerous chromosomal alterations associated with response or resistance to PD

56 tly after birth leads to predictable pattern alterations at all levels of the system.

57 E expands the range of possible DNA sequence alterations, broadening the research applications of CRI

58 sion through nucleus accumbens (NAcc) volume alteration, but not through the amygdala and hippocampal

59 ated hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unc

60 have significant hyperuricemia and metabolic alterations, but only subtle alterations of renal urate

61 rial and marine systems and their modern-day alteration by N inputs from human activities.

62 mmunologic configurations based on treatment alterations can also be applied to other cancer types in

63 becomes vulnerable and multiple chromosomal alterations can form over a narrow time window.

64 MET tyrosine kinase inhibitors varies by MET alteration category.

65 POT1 alterations cause rapid telomere elongation, ATR kinase

66 s without perinatal sentinel events, genomic alterations contributed substantively to the diagnosis o

67 These alterations correlate with changes in the location and d

68 Gut microbiome alterations correlated with model for end-stage liver di

69 mplications; instead, other diabetes-related alterations could be causative.

70 dentified a set of cohorts for which somatic alterations could not predict prognosis.

71 ve analysis suggests that when using somatic alterations data for cancer prognosis prediction, pathwa

72 MET exon 14 alteration defines a molecular subgroup of NSCLCs for wh

73 We hypothesize that purine alterations detected in LND fibroblasts may also occur i

74 vated Wnt signaling due to recurrent genetic alterations drives several human cancers.

75 ylase ALKBH5 is regulated by chromatin state alteration during leukemogenesis of human acute myeloid

76 with key protein (GPX4 and ACSL4) expression alteration during reperfusion.

77 stance have been reported, including somatic alterations, epigenetic changes, and changes in the tumo

78 le, site-specific, disease-associated glycan alterations for clinical applications, we have adapted t

79 ool to distinguish immediate transcriptional alterations from those induced by persistent infection a

80 This alteration generated a nonfunctional CD56(bright) NK cel

81 miRNA alterations have a significant impact on the formation a

82 Driver gene alterations have been comprehensively charted, but the i

83 ignatures, intratumor heterogeneity, pathway alterations, histology, and overall survival.

84 py and those without an actionable molecular alteration (HR 0.82 [95% CI 0.64-1.04], p=0.10).

85 obic glycolysis, a near ubiquitous metabolic alteration in cancer.

86 Further analysis indicated that alteration in cellular energy metabolism was associated

87 papaya diminutive phenotype is caused by an alteration in gene function rather than a loss-of-functi

88 Our results revealed an overall alteration in gut microbiome and metabolites in associat

89 Overall, we find limited support for alteration in HPA axis functioning as a general mechanis

90 ules and tumor suppressing phosphatases, and alteration in immune modulators.

91 proved cognition in prediabetic rats without alteration in insulin sensitivity.

92 ood in the context of a mutationally induced alteration in protein motions that becomes manifest alon

93 gen-induced maternal autoantibodies produced alterations in a constellation of ASD-relevant behaviors

94 We first quantified shared working memory alterations in a delayed-response task.

95 enitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis.

96 tor (TF) signalling has been associated with alterations in Akt activity influencing cellular surviva

97 Whether these alterations in ART-treated HIV subjects occur in vitro i

98 unction mutations in RB1 and TP53 (88% carry alterations in at least one gene; 60% carry alterations

99 DX models and human clinical samples, due to alterations in BCL-2 family proteins that vary among cas

100 ary lipid secretion, which is independent of alterations in bile salt output, biliary bile salt hydro

101 s of sex hormone changes, as well as adverse alterations in body composition, lipids and lipoproteins

102 In contrast, alterations in both pathways led to ACC with pulmonary m

103 alterations in at least one gene; 60% carry alterations in both).

104 the hypothesis that mood- and sex-dependent alterations in brain circuitry implicated in the regulat

105 brain injury (TBI) is often characterized by alterations in brain connectivity.

106 se functional changes were followed by rapid alterations in brain microstructure in the order of minu

107 in hyperactivity reminiscent of human mania, alterations in brain pathways that have been implicated

108 Alterations in calcium signaling in pancreatic acinar ce

109 Metabolic alterations in cancer represent convergent effects of on

110 ns of E-selectin and ICAM-1 with subclinical alterations in cardiac function.

111 in large patient cohorts to identify protein alterations in cerebrospinal fluid (CSF), a proximal sit

112 The underlying alterations in CNS complement cascade proteins (C1q, C3)

113 es can not only cause genetic and epigenetic alterations in colorectal epithelial cells but also affe

114 ll lines have identified a high frequency of alterations in components of the mammalian switch/sucros

115 e rapid and modular approaches to screen for alterations in CT organization across widely available H

116 (DMF), for rapid determination of individual alterations in CYP activity from human-derived liver sam

117 ed by lamin-chromatin and lamin-cytoskeletal alterations in determining nuclear shape morphology and

118 ht us terabytes of information about genetic alterations in different types of human tumors.

119 But alterations in each of the five CFHR genes in the contex

120 as a degenerative disease, characterized by alterations in extracellular matrix and loss of smooth m

121 ular structure and function, so much so that alterations in FA are often associated with cell malfunc

122 Understanding the mechanisms responsible for alterations in gene and chromatin structure within skin

123 riptomics analyses also revealed significant alterations in gene expression levels of key enzymatic r

124 maging studies have found evidence of robust alterations in glutamate and dopamine receptors within b

125 Diet modulates the mucous barrier via alterations in gut microbiota, resulting in either disea

126 ompared to mice fed control bacteria and had alterations in hepatic lipids, including oxylipins.

127 nalyses of tumour extracts revealed specific alterations in Hippo pathway core components, as a funct

128 In conclusion, our data show alterations in hormone levels and SWLS in response to OC

129 To define the functional impact of alterations in huwentoxin-IV sequence, we produced a lib

130 We characterized age-associated alterations in immune cells across multiple mouse organs

131 he PI3K/GSK3 pathway, SGK1 and GSK3, induced alterations in levels of neurite markers betaIII tubulin

132 male's presence by itself leads to lifelong alterations in life history in female mice.

133 lecular and physiological changes that cause alterations in lung function, diminished pulmonary remod

134 yelin from peripheral nerves, resulting from alterations in melanocyte survival and differentiation o

135 Here, we investigate alterations in metabolism and volume using [(18)F]fluoro

136 l cells, which display invasive features and alterations in metastatic tropism when xenografted into

137 ic syndrome generally cause pro-inflammatory alterations in microbiota communities in the intestine.

138 triggers robust mitochondrial fragmentation, alterations in mitochondrial polarization, and blocks th

139 y, and stroke patients experience widespread alterations in neural activity after sensory loss.

140 is describes the prevalence of tumor-related alterations in normal appearing tissues.

141 ecruitment to the infected tongue but not to alterations in oral antimicrobial peptide expression.

142 o stressed wild-type plants, suggesting that alterations in PA levels are not likely the cause for th

143 RNA-seq analysis revealed alterations in pathways and genes associated with astroc

144 owever, such as periods of hyperactivity and alterations in place preference, are not phenocopied by

145 Continued fat alterations in PLWH will have an important effect on lif

146 relevant for psychiatric research, given the alterations in PNNs, PV+ interneurons and their physiolo

147 The alterations in polyamine metabolism in response to chemo

148 Furthermore, we observed minor alterations in protein levels, 2 hours after drug admini

149 FTIR studies revealed alterations in protein secondary structure induced by pl

150 d their physiological link, as well as their alterations in psychiatric disorders.

151 mised phosphodiesterase activity, as well as alterations in receptor-coupled G-protein activation.

152 te whether NM-MRI signal was associated with alterations in reward processing.

153 nt insights into the mechanisms of cognitive alterations in SCA1, we tested cognition in several mous

154 ddition, a substantial portion of epigenetic alterations in schizophrenia and related disorders may b

155 nical and preclinical findings of epigenetic alterations in schizophrenia and relevant disease models

156 ntify significant cell-specific gene network alterations in SCZ, these studies support a role for dis

157 it influence nitric oxide signalling through alterations in shear stress stimuli and haemoglobin scav

158 golipid synthesis inhibitor, suggesting that alterations in sphingolipid metabolism contribute to cel

159 d synaptic transmission phenotypes, specific alterations in spontaneous neurotransmitter release are

160 l days 7, 9, and 11] results in long-lasting alterations in synaptic transmission and reduced PV expr

161 clinical results demonstrate that MI induces alterations in systemic homeostasis, triggering cross-di

162 These data argue that diet-dependent alterations in taste weaken satiation by impairing the c

163 methylation changes, we observed no profound alterations in the blood transcriptome of individuals wi

164 Host gene expression indicates alterations in the cytokine expression that could be rel

165 do not appear to share similar mitochondrial alterations in the DLPFC.

166 Alterations in the expression level of alpha2delta subun

167 However, alterations in the expression of the corresponding wild-

168 The accumulation of alterations in the genetic and epigenetic spaces has bee

169 ation Group to Investigate Cancer Associated Alterations in the Genome consortium (OR 0.90; 95% CI 0.

170 sised that these phenomena were derived from alterations in the grafted cardiomyocyte characteristics

171 he wild type, suggesting that this is due to alterations in the initial invasion of the tissue.

172 It is not clear whether alterations in the intestinal microbiota of children wit

173 Alterations in the intrinsic function of these channels

174 The genetic defects lead to alterations in the ionic currents that determine the mor

175 ng in mgR mice was responsible for structure alterations in the lungs, mice were treated with N-[N-(3

176 Importantly, genetic alterations in the most extensively rewired PPIN nodes o

177 for chloride changes resulted in substantial alterations in the neuronal input-output function.

178 ng the uncleaved gp160(JR-FL) precursor with alterations in the protease cleavage site (R508S/R511S)

179 Alterations in the RAS-ERK1/2 pathway are associated wit

180 ce staining and confocal microscopy revealed alterations in the structure and composition of the airw

181 drug induced more pronounced and/or distinct alterations in the structure of the DMPC bilayer than th

182 s treated with TM also exhibited concomitant alterations in their electrical activity and cytosolic f

183 cipants, and found that 26 of them (81%) had alterations in their heart rate, number of daily steps o

184 ast, only a minority of sporadic tumors show alterations in these genes.

185 We identify significantly recurrent somatic alterations in these gliomas including mutant EGFR ampli

186 nd synchronization of cortical circuitry and alterations in these inhibitory neurons, especially in t

187 Alterations in this groove decrease the ability of BMF a

188 n appears to map our interpersonal ties, and alterations in this map may help explain why lonely indi

189 n the maintenance of calcium homeostasis and alterations in this mechanism are responsible for severa

190 Causal variants were also enriched for alterations in transcription factor binding sites.

191 se results demonstrate that mutation-induced alterations in tropomyosin-thin filament interactions un

192 Here, we aimed to uncover genome-wide alterations in uracil pattern upon drug treatments in hu

193 ing a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic devel

194 Alterations in white matter (WM) microstructure have bee

195 es suggest that young autistic children have alterations in white matter structure that differ from o

196 se changes in power output were reflected in alterations in work loop shapes.

197 Morphological alterations included cytoplasm vacuolization and partial

198 Such deleterious alterations, including epigenetic drift, irreversibly ac

199 n from TAC-induced cellular Ca(2+) signaling alterations (increased SOCE, decreased [Ca(2+)](i) trans

200 These alterations indicate improved energy metabolism through

201 mouse model to understand the transcriptomic alterations induced by VCP under the cardiac stress caus

202 obiome is linked to metabolic health and its alteration is associated with many diseases, including o

203 The prognostic power of somatic alterations is highly variable across different cancer t

204 A pathophysiological link between these two alterations is suggested by theoretical models based on

205 enetrance than Nectin1 loss, suggesting this alteration may drive CP via a dominant interfering mecha

206 Understanding early preclinical perfusion alterations may improve understanding of AD pathogenesis

207 uring fruit juice powdering process numerous alterations may occur as a result of interactions of nat

208 or the presence of MDS-associated phenotypic alterations (MDS-PA) in the bone marrow of 285 patients

209 he HLA-DR heterodimer, suggesting that these alterations might account for the association at HLA-DRB

210 urden, frequency of mutations or copy number alterations, mutation signatures, intratumor heterogenei

211 ints, genome-wide frequencies of copy number alterations, mutational signatures in whole exome, and t

212 larly, CH with additional, non-PIGA, somatic alterations occurs in the majority of patients with PNH.

213 , there is no evidence of success in genetic alteration of Ag-experienced memory CD8 T cells.

214 in chromatin accessibility and the strongest alteration of cell-cell interactions in SSc lesions.

215 Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular

216 polymer and peptide synthesis results in the alteration of DNA helical structure or reduced thermal s

217 Thus, persistent alteration of eCB signaling after repeated seizures may

218 Genetic alteration of ENaC-alpha causes aldosterone dysregulatio

219 nical studies have consistently demonstrated alteration of excitation/inhibition (E/I) balance and ab

220 These mutations would trigger an alteration of exon usage during RNA splicing, causing th

221 An early and persistent alteration of glial cell activity takes place at the neu

222 Alteration of membrane mechanical properties represents

223 The metabolic kinetic changes revealed the alteration of metabolism and neurotransmission in differ

224 The alteration of modified amino acid (MAA) profiles in biol

225 The gradual alteration of mortality risk after ICU admission was ass

226 Alteration of normal ploidy (aneuploidy) can have a numb

227 of underlying interaction potentials and the alteration of reaction rates using quantum statistics.

228 Here we show that seafloor alteration of serpentinites is a source of Si to the oce

229 No detected alteration of SFPR1 gene and SFRP1 expression in ampulla

230 rked by myolysis, glycogen accumulation, and alteration of structural proteins.

231 e and easily scalable strategy, which avoids alteration of the core sequence of the microprotein.

232 e tested in vitro and in vivo, demonstrating alteration of the E2 antigenic profile in several cases,

233 e insect was primarily zeolitized during the alteration of the host rocks and later sealed in opal de

234 ucocorticoid exposure resulted in persistent alteration of the hypothalamic-pituitary-adrenal (HPA) a

235 This is reflected by the strong alteration of the SubPz electronic properties produced b

236 Alterations of excitatory synaptic function are the stro

237 d (AUC = 0.92, p-value = 3.16E-8) MP-induced alterations of immune cell signaling trajectories, parti

238 l embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor ne

239 ficantly extends Drosophila lifespan, causes alterations of metabolites associated with increased lif

240 ed during this study demonstrates the subtle alterations of morphology characterized by reduced vesse

241 a and metabolic alterations, but only subtle alterations of renal urate excretion and ABCG2 abundance

242 , profiling of miRs from CAF exosomes showed alterations of several exosomal miRs in FAK-null CAFs, a

243 activities on physiology and transcriptional alterations of steroid-specific target genes at 96 and 1

244 t synapses, a phenotype that paralleled with alterations of synaptic morphology, transmission, and pl

245 -implant marginal mucosa defects (PMMDs) are alterations of the peri-implant soft tissue architecture

246 The alterations of the viscoelastic properties caused by glu

247 The alterations of those properties were dependent upon epig

248 Alterations of Young's modulus (YM) and Poisson's ratio

249 matin and associates with massive epigenetic alterations on the DNA methylation, chromatin accessibil

250 ECD) had higher Chlamydia loads, more tissue alterations or lesions, and lower fertility rate associa

251 rearrangements, patients with other FGF/FGFR alterations, or patients with no FGF/FGFR alterations.

252 ted with colorectal cancer (CRC), but causal alterations preceding CRC have not been elucidated.

253 uronal damage, investigating microstructural alterations provides information regarding brain organis

254 These alterations rapidly induced bacterial death.

255 estoration of muscle activity reverses these alterations, restoring oxygen supply to the tissue and e

256 ary adenomas showed that somatic copy number alteration (SCNA) rather than mutation is a hallmark of

257 e, we investigate ITH of somatic copy number alterations (SCNAs), DNA methylation, and point mutation

258 an explanation for site-specific epigenomic alterations seen in ICF syndrome with DNMT3B mutations.

259 on sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such

260 4 prostate tumours revealed that the genomic alteration signatures in Chinese patients were markedly

261 gene regulation, while architecture related alterations, such as translocations and gene fusions, ar

262 This review focuses on tumor cell-intrinsic alterations that blunt productive anti-tumor immune resp

263 variability comes from wide-spread molecular alterations that can be summarized by omic integration.

264 Identifying brain alterations that contribute to suicidal thoughts and beh

265 ead, burn injury leads to long-term profound alterations that must be addressed to optimize quality o

266 Of the 23 unique pairs of genetic alterations that we interrogated, 9 were able to induce

267 In addition, with precipitation alteration, the magnitude of root responses was greater

268 n in the mantle wedge and shallow serpentine alteration to authigenic clays by seawater.

269 Alteration to BDNF expression is associated with major d

270 Prime editing enables diverse genomic alterations to be written into target sites without requ

271 ting paranoia could be accounted by specific alterations to cognitive parameters characterising harmf

272 ehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour t

273 It is becoming clear that alterations to HEV network density and/or morphology can

274 this is due to increasing oxidative stress, alterations to interactions with the microbiota, and def

275 uence the selection of secondary concomitant alterations to promote oncogenic signaling during tumor

276 2q11DS to date, the authors found widespread alterations to subcortical brain structures, which were

277 Broad-ranging alterations to the DNA methylome were observed at both t

278 Alterations to the epigenome of uterine cells may theref

279 kine/cytokine adjuvants effected significant alterations to the recruitment of B and T cells to the s

280 SC with lower proportion of component-shared alterations (trunk-ratio) had a prolonged disease-free s

281 and workflows for the detection of different alteration types, including single-nucleotide variants (

282 nd their binary mixture (Cd/As(mix)) include alteration under varying dietary and media phosphorus (P

283 These alterations were accompanied by a Kv1.1-induced increase

284 These FD alterations were associated with both the degree of prem

285 These alterations were concomitant with a significant reductio

286 Actionable somatic alterations were identified.

287 Cardiovascular alterations were monitored by advanced speckle tracking

288 nces in bloodstream infections or laboratory alterations were registered.

289 CIN) related genes, including AURKA and TP53 alterations, were the most frequently acquired events.

290 ne P/LP variants have at least one druggable alteration, while more than half of them are from our ca

291 a crucial link that bridges cytosolic Ca(2+) alteration with JNK activation and Hippo-mediated tumor

292 to depict the potentially small oxygenation alterations with current noninvasive cardiac MRI blood o

293 study reveals associations of specific gene alterations with different TIME types.

294 , which is crucial to understand homeostatic alterations with disease.

295 ata, we associated several categories of RNA alterations with germline and somatic DNA alterations, a

296 ility of mouse models that integrate genomic alterations with relevant exposures and highlight the im

297 and DYNC1I1 show the highest frequencies of alterations, with multiple mutations overlapping transcr

298 ignificant transcriptional and translational alterations, with the number of virus-induced differenti

299 cterized by spatially confined mitochondrial alterations within postsynaptic spines in the pre-BotC n

300 recognition processes allow for dynamic self-alteration, yielding complex polymer systems with extrao