ライフサイエンスコーパス: alternative splicing

1 nd may exhibit significant function-altering alternative splicing.

2 tial association between gene expression and alternative splicing.

3 ptome of prostate cancer cells by modulating alternative splicing.

4 LAV-mediated alternative polyadenylation and alternative splicing.

5 PTPN5), with several isoforms resulting from alternative splicing.

6 ysis detects the effects of rare variants on alternative splicing.

7 al APX (tAPX) and stromal APX (sAPX) through alternative splicing.

8 Human MR1 undergoes alternative splicing.

9 ation, while loss of m(6)A in CIRBP promotes alternative splicing.

10 h multiple isoforms (45-65 kDa) generated by alternative splicing.

11 th the insertion, c.844_845ins68, because of alternative splicing.

12 nctional relevance of these modifications to alternative splicing.

13 ma-interacting domain in TRPM3 is subject to alternative splicing.

14 length and composition because of extensive alternative splicing.

15 higher organisms can be accomplished through alternative splicing.

16 arities as a result of a gene duplication or alternative splicing.

17 th scRNA-seq is a major obstacle to studying alternative splicing.

18 nt pre-mRNA to modulate RNAPII occupancy and alternative splicing.

19 mediated changes to transcript abundance and alternative splicing.

20 ting in inhibition of G-quadruplex-dependent alternative splicing.

21 nd retinal disease genes, as well as in mRNA alternative splicing.

22 synapses that are independently regulated by alternative splicing.

23 mechanism behind the SNP-genotype dependent alternative splicing.

24 total of 44 exons, 5 of which are subject to alternative splicing.

25 re we examine expression levels and identify alternative splicing.

26 tially therapeutically actionable changes to alternative splicing.

27 lling expression of a single protein through alternative splicing.

28 st molecular diversity by mutually exclusive alternative splicing.

29 dependence on pre-mRNA splicing and accurate alternative splicing.

30 n domain, allowing small molecule control of alternative splicing.

31 ystem contains some of the highest levels of alternative splicing.

32 insoluble aggregates, resulting in aberrant alternative splicing.

33 hylation may contribute to the efficiency of alternative splicing.

34 cancer drug-target interactions affected by alternative splicing.

35 in the nucleus to regulate light-responsive alternative splicing.

36 This review focuses on alternative splicing, 3' end processing, miRNA-mediated

37 ly been characterized as highly dependent on alternative splicing, a critical driver of tumor heterog

38 Alternative splicing, a widespread mechanism in eukaryot

39 Alternative splicing allows expression of mRNA isoforms

40 ed pro-survival signaling through regulating alternative splicing alterations of mitochondrial genes.

41 udies led to the surprising observation that alternative splicing among single cells is highly variab

42 However, their application for alternative splicing analysis has been hampered due to t

43 Alternative splicing analysis uncovered a total of 2323

44 Pre-mRNA processing events such as alternative splicing and alternative polyadenylation res

45 osttranscriptional regulation by influencing alternative splicing and alternative polyadenylation.

46 A response to cocaine and instead results in alternative splicing and chromatin accessibility events,

47 RBM10 also regulates alternative splicing and controls cancer cell proliferat

48 evil pgrp-lb generates three transcripts via alternative splicing and differential regulation.

49 We conclude that changes in alternative splicing and gene expression are observable

50 ique among invertebrate PVs, using extensive alternative splicing and incorporating transcription ele

51 Our findings indicate that alternative splicing and interactions between different

52 st-transcriptional regulatory events such as alternative splicing and mRNA translation.

53 litate a deeper understanding of the role of alternative splicing and polyadenylation in cell migrati

54 ise from molecular processing events such as alternative splicing and post-translational modification

55 reventing naturally occurring non-productive alternative splicing and promoting generation of product

56 avage and termination, elongation, splicing, alternative splicing and R-loop formation.

57 DAF-2B arises via alternative splicing and retains the extracellular ligan

58 Our data shed light on the relevance of p73 alternative splicing and show that the full-length C ter

59 ork illustrates a role of stwintrons in both alternative splicing and the evolution of intron structu

60 Alternative splicing and the non-constitutive exons toge

61 At the physiological level, we show that alternative splicing and the premature stop codon alter

62 olecular mechanisms including transcription, alternative splicing, and class switch recombination are

63 to the associations between gene expression, alternative splicing, and DNA methylation that may shape

64 proteoforms arising from combinatorial PTMs, alternative splicing, and genetic variation in HCM.

65 te to this phenotype are observed, including alternative splicing, and mRNA expression levels of prot

66 it is accomplished by alternative promoters, alternative splicing, and multiple transcriptional start

67 NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous del

68 and is associated with cis-acting elements, alternative splicing, and RNA-binding factors.

69 erms and analyzed their duplication history, alternative splicing, and subcellular targeting patterns

70 s 70 and 80 to quantify how gene expression, alternative splicing, and their genetic regulation are a

71 ons, isomerization of a critical proline, or alternative splicing are all sufficient to destabilize t

72 The mechanisms governing alternative splicing are known for relatively few genes

73 althy individuals-especially with regards to alternative splicing-are lacking for most primary cell t

74 anscriptome and suggest U2AF1a-driven 5'-UTR alternative splicing as a molecular mechanism of mTOR-re

75 Alternative splicing (AS) and alternative polyadenylatio

76 IFNalpha induces changes in alternative splicing (AS) and first exon usage, increasi

77 Alternative splicing (AS) creates proteomic diversity fr

78 We also examined 28 DEGs known as alternative splicing (AS) factors that regulate AS proce

79 The role of dysregulation of mRNA alternative splicing (AS) in the development and progres

80 Alternative splicing (AS) is a major gene regulatory mec

81 Alternative splicing (AS) is frequent during early mouse

82 Alternative splicing (AS) is involved in cell fate decis

83 Although alternative splicing (AS) is involved in virtually every

84 Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulato

85 Alternative splicing (AS) of pre-mRNAs increases transcr

86 Alternative splicing (AS) of pre-mRNAs, a process that g

87 Alternative splicing (AS) programs are primarily control

88 Alternative splicing (AS) promotes transcriptome and pro

89 cleus, CELF1 regulates networks of postnatal alternative splicing (AS) transitions, while in the cyto

90 Besides analyses of specific alternative splicing (AS) variants, little is known abou

91 on (ATI), alternative polyadenylation (APA), alternative splicing (AS), and fusion transcripts.

92 Notably, BdFTL1 is subject to alternative splicing (AS), and its transcriptional level

93 is a major factor regulating neuron-specific alternative splicing (AS), previously associated with an

94 MicroRNA (miRNA) and alternative splicing (AS)-mediated post-transcriptional

95 tion has an important role in the control of alternative splicing (AS); however, the in vivo conseque

96 at two major posttranscriptional mechanisms, alternative splicing (AS; especially intron retention) a

97 nts), a method for detecting allele-specific alternative splicing (ASAS) from RNA-seq data.

98 d subject to additional temporal control via alternative splicing at a conserved microexon.

99 himaerin is a truncated variant generated by alternative splicing at a cryptic splice site in exon 7.

100 domain (LNS2) of neurexin-1 and examined how alternative splicing at splice site #2 (SS2) regulates t

101 Thus, in C. elegans alternative splicing at the daf-2 locus generates a trun

102 s into large-scale detection and analysis of alternative splicing at the transcriptional level.

103 Twenty six alternative splicing biomarker peptides with one single

104 eloped a bioinformatics workflow to discover alternative splicing biomarkers from LC-MS/MS using RNA-

105 low for using RNA-seq data to discover novel alternative splicing biomarkers from the breast cancer p

106 First, we retrieved high confident, novel alternative splicing biomarkers from the breast cancer R

107 pathways, which are consistent with the 256 alternative splicing biomarkers from the RNA-Seq.

108 g differential gene expression, differential alternative splicing, both, or neither.

109 s, are believed to regulate light-responsive alternative splicing, but little is known about the unde

110 ding RNAs produced by a noncanonical form of alternative splicing called back-splicing.

111 Alternative splicing can generate p120 isoforms 1 and 3

112 Alternative splicing contributes to the functional diver

113 SR proteins controlling their expression via alternative splicing coupled to nonsense-mediated decay.

114 Alternative splicing creates three C-terminal isoforms p

115 id receptor gene, OPRM1, undergoes extensive alternative splicing, creating an array of splice varian

116 Junction Peptides, and created a customized alternative splicing database for MS searching.

117 As a complement to synthetic alternative splicing database technique for alternative

118 etry Search Algorithm against the customized alternative splicing database with breast cancer plasma

119 onents of the spliceosome likewise influence alternative splicing decisions.

120 ll motifs to GCAUG or GCACG permits accurate alternative splicing, demonstrating efficacy of both mot

121 that adopts CCD-dependent autoinhibition and alternative splicing-dependent actin interaction.

122 mor microenvironment in the expression of an alternative splicing-dependent tumor invasion program.

123 he Rbfox family of splicing factors regulate alternative splicing during animal development and in di

124 pping (ES) is reported to be the most common alternative splicing event due to loss of functional dom

125 able exons that undergo a mutually exclusive alternative splicing event to generate multiple function

126 ase of rMAPS focused only on the most common alternative splicing event, skipped exon or exon skippin

127 pecified genomic region, corresponding to an alternative splicing event, VALERIE generates an ensembl

128 ession and exon skipping, a readily measured alternative splicing event.

129 A discrete set of alternative splicing events (ASEs) are shared between MB

130 g experiments), an R package for visualising alternative splicing events at single-cell resolution.

131 Alternative splicing events differentially regulated bet

132 We present VALERIE (Visualising alternative splicing events from single-cell ribonucleic

133 uncovered a total of 2323 genes that undergo alternative splicing events in at least one nodule devel

134 appropriate for label-free quantification of alternative splicing events in complex samples.

135 RNA-seq datasets show a preponderance of 3' alternative splicing events in fam50a KO, suggesting a r

136 tantly, U2AF1a-driven transcriptomes feature alternative splicing events in the 5'-untranslated regio

137 may also involve the distinct alteration of alternative splicing events of specific transcription fa

138 ll-length transcript analysis links multiple alternative splicing events together and allows for bett

139 study, we profiled gene expression changes, alternative splicing events, and DNA methylation pattern

140 er, by systematically targeting thousands of alternative splicing events, CHyMErA identifies exons un

141 and for the analysis of other major types of alternative splicing events, especially for retained int

142 (but not downstream) of the introns regulate alternative splicing events, likely through modulating a

143 different cancer driver pathways with these alternative splicing events.

144 ilitate analyses for all five major types of alternative splicing events: skipped exon, mutually excl

145 cated in transcriptional gene regulation and alternative splicing, events that are restricted to the

146 Here we demonstrate that the RNA alternative splicing factor MBNL1, which is sequestered

147 ely low sequencing coverage, detect multiple alternative splicing forms in the same genomic location

148 expression, allele-specific expression, and alternative splicing from multitissue RNA-sequencing dat

149 istical problem for identifying differential alternative splicing from RNA-seq data with paired repli

150 CACTIN, SDE2, and NKAP-factors implicated in alternative splicing-further stabilize the catalytic con

151 Alternative splicing generates multiple isoforms from a

152 Alternative splicing has been shown to causally contribu

153 form of RNA (circular RNA), produced through alternative splicing, has become the focus of scientific

154 sian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously c

155 s of age and genetics on gene expression and alternative splicing; however, there has been no long-te

156 alternative splicing database technique for alternative splicing identification, this method combine

157 Our results establish a role for pre-mRNA alternative splicing in beta-cell function across the sl

158 sue-specific gene regulation at the level of alternative splicing in C. elegans that parallels the ev

159 rding the causes and functional relevance of alternative splicing in cancer.

160 riptome-wide distribution of RNA binding and alternative splicing in cells harboring the ROS1 translo

161 We analyze alternative splicing in human and mouse single-cell RNA-

162 However, the broader implications of ERBB2 alternative splicing in human cancers have not been expl

163 pment that modulates basal transcription and alternative splicing in neural cells with consequences f

164 events since this is the most common type of alternative splicing in plants, such as Arabidopsis thal

165 etic variation and phenotypic association of alternative splicing in populations.

166 of SR and SR-like proteins undergo extensive alternative splicing in response to diverse stresses and

167 We used fluorescent reporters to visualize alternative splicing in single Caenorhabditis elegans ne

168 increased awareness of the potential role of alternative splicing in the etiology of cancer.

169 untranslated regions and is characterized by alternative splicing in the nucleotide-binding domain.

170 r, the scope of splicing factors that govern alternative splicing in these processes remains largely

171 ysis reveals that emetine globally regulates alternative splicing, including splicing of variable exo

172 9, and rs373655596) promotes allele-specific alternative splicing, increasing mRNA levels of P2RX7L a

173 We propose that chimeric mRNAs produced by alternative splicing into polymorphic transposons, rathe

174 Alternative splicing is a key regulatory mechanism in eu

175 Alternative splicing is a key step in eukaryotic gene ex

176 highlighted in recent publications, aberrant alternative splicing is a major contributor to disease p

177 Genetic variation of alternative splicing is a prevalent source of transcript

178 f distinct splicing mechanisms, we show that alternative splicing is based in RON on a so-called "exo

179 Alternative splicing is emerging as an oncogenic mechani

180 This means that alternative splicing is involved in the selection of the

181 tion of RNA sequencing (RNA-seq) analysis of alternative splicing is its reliance on high sequencing

182 try, but how such plasticity might depend on alternative splicing is not known.

183 Alternative splicing is primarily regulated by transacti

184 We observed that FXR1 alternative splicing is pronounced in the serine- and ar

185 MBNL1, a protein involved in alternative splicing, is consistently overexpressed in M

186 identify potentially highly sample-specific alternative splicing isoform biomarkers at early-stage o

187 Alternative splicing isoforms have been reported as a ne

188 e the key cell-cycle factors and their known alternative splicing isoforms.

189 jective of this study was to investigate the alternative splicing landscape at the FMR1 locus in conj

190 BRCA1 alternative splicing may serve as an alternative regulat

191 MOCS1 protein maturation provides a novel alternative splicing mechanism that ensures the coordina

192 Our work elucidates an alternative-splicing mechanism that drives tumor dediffe

193 s in the study of the emerging complexity of alternative splicing mechanisms in neurons, and how thes

194 Alternative splicing mediated by mutant U1 snRNA inactiv

195 with the strongest expression level or where alternative splicing might be occurring.

196 Cell-specific alternative splicing modulates myriad cell functions and

197 Rbfox proteins regulate alternative splicing, mRNA stability and translation.

198 has enabled comprehensive quantification of alternative splicing, no correspondingly high-throughput

199 s well represent the diversity of NRXN1alpha alternative splicing observed in the human brain, catalo

200 ne the molecular mechanisms of cell-specific alternative splicing of a functionally validated exon in

201 s17134155 was a significant cis-sQTL for the alternative splicing of a non-coding transcript of EPB41

202 Because of alternative splicing of a single exon within the N-termi

203 Drosophila generates the same diversity by alternative splicing of a single gene.

204 In Arabidopsis, alternative splicing of a single Rca gene results in two

205 f mice colonized with ASD microbiota display alternative splicing of ASD-relevant genes.

206 reases action potential duration by changing alternative splicing of BK channels; this requires nucle

207 Moreover, AKAP8 expression and the alternative splicing of CLSTN1 predict breast cancer pat

208 RQ synthesis principally via changes in the alternative splicing of coq-2.

209 BB2 In some contexts, notably breast cancer, alternative splicing of ERBB2 causes skipping of exon 16

210 experiments, we found that depending on the alternative splicing of exon 1, type I splice variants (

211 nknown types of CCK+INs and demonstrate that alternative splicing of few genes, which may be viewed a

212 This process may be partially regulated by alternative splicing of full-length P2RX7A pre-mRNA, pro

213 When alternative splicing of gene products leads to protein p

214 virus (IAV) also induces a broad program of alternative splicing of host genes.

215 PTBP1 controls mRNA abundance and alternative splicing of important cell cycle regulators

216 ed with a novel analysis approach to compare alternative splicing of large, repetitive structural gen

217 main, recognition of the 3' splice site, and alternative splicing of many mRNAs.

218 Alternative splicing of Mena and CD44, which play import

219 Alternative splicing of MOCS1 within exons 1 and 9 produ

220 Our results suggest alternative splicing of MR1 represents a means of regula

221 Alternative splicing of mRNA precursors is a key process

222 at one explanation for this paradox involves alternative splicing of mRNA, which allows exons of a ge

223 An emerging role of PARPs in alternative splicing of mRNAs, as well as direct ADPRyla

224 5 and that loss of PRMT5 leads to changes in alternative splicing of multiple essential genes.

225 We conclude that alternative splicing of MyD88 may provide a sensitive me

226 Alternative splicing of pre-mRNA increases genetic diver

227 Alternative splicing of pre-mRNA of Arabidopsis SR45, wh

228 RNA-seq analysis revealed that alternative splicing of pre-mRNAs of 558 genes, includin

229 drives cancer metabolism by ensuring correct alternative splicing of pre-mRNAs of critical glycolytic

230 pliceosome interference, as well as specific alternative splicing of protein homeostasis machinery co

231 1 ensures the efficiency of constitutive and alternative splicing of selected pre-mRNAs.

232 Alternative splicing of Shtn1 at the C terminus and down

233 This leads to alternative splicing of target exons due to the RNA heli

234 clear receptor expressed in the brain, where alternative splicing of the 3' end of the pre-mRNA leads

235 ructure, including alternative promoters and alternative splicing of the 3' UTR.

236 f BMPRII impairs apoptosis by modulating the alternative splicing of the apoptotic regulator, B-cell

237 distinct combinations of Ca(v) subunits and alternative splicing of the encoding transcripts.

238 In vertebrates, alternative splicing of the MYO1C gene leads to the prod

239 In sensory neurons, cell-specific alternative splicing of the presynaptic Ca(V) channel Ca

240 PSI regulates the thermosensitive alternative splicing of timeless (tim), promoting splici

241 In addition, loss of m(5)C dysregulates the alternative splicing of viral RNAs.

242 rMAPS2 analyzes differential alternative splicing or CLIP peak data obtained from hig

243 ment to other expression analyses, including alternative splicing or differential gene expression ana

244 isoform, p73alpha, with a shorter product of alternative splicing, p73beta.

245 ntly when O-GlcNAc levels are low, yet other alternative splicing pathways change minimally.

246 prp-8 mutant C. elegans reveals that overall alternative splicing patterns are relatively unchanged.

247 ity and have a particular impact on pre-mRNA alternative splicing patterns.

248 pathway enrichment-guided activity study of alternative splicing (PEGASAS), to correlate transcripti

249 Alternative splicing plays a major role in shaping tissu

250 al process in mammalian gene expression, and alternative splicing plays an extensive role in generati

251 d of RNA polymerase elongation and extent of alternative splicing positioned at varying distances fro

252 show that in leukemic cells, MBNL1 regulates alternative splicing (predominantly intron exclusion) of

253 The FXR1 gene undergoes alternative splicing, producing multiple protein isoform

254 s to visualise cell-to-cell heterogeneity of alternative splicing profiles across single cells and pe

255 age, which is more suitable for representing alternative splicing profiles for a large number of samp

256 We conclude that PTBP2-orchestrated alternative splicing programming is required for robust

257 Posttranslational modifications (PTMs) and alternative splicing regulate the function of sarcomeric

258 Alternative splicing regulates ECR conformation and rece

259 A1 isoforms, providing novel insights of how alternative splicing regulates nociception.

260 Alternative splicing regulates the prototypical synaptic

261 How alternative-splicing regulates TEN-LPHN interaction rema

262 Alternative-splicing regulates the TEN2-LPHN3 interactio

263 , understanding the underlying mechanisms of alternative splicing regulation and identifying function

264 Interestingly, alternative splicing regulation was also dampened.

265 sical and direct involvement of NF-kappaB in alternative splicing regulation, which significantly rev

266 partially spliced retention products during alternative splicing regulation.

267 (CCD) and the autoinhibition is overcome by alternative splicing regulation.

268 NA-seq has been used to study alterations in alternative splicing related to several diseases.

269 es the generation of a short mTOR isoform by alternative splicing, resulting in reduced 4E-BP1 phosph

270 s of this developmental divergence including alternative splicing, RNA editing, nuclear pore composit

271 een shown to regulate RNA processing through alternative splicing, RNA stability, and translation.

272 -null plants revealed genome-wide changes in alternative splicing, suggesting that UPF1 functions in

273 opied the loss of ZMAT3 with respect to CD44 alternative splicing, suggesting that ZMAT3-mediated reg

274 fy A1CF as a key regulator of liver-specific alternative splicing, supporting this finding with subse

275 les, suggesting a sex-dependent delay of the alternative splicing switch from SNAP-25a to SNAP-25b.

276 esearchers have discovered a special form of alternative splicing that produces a circular form of RN

277 AR-V7 is generated by alternative splicing that results in inclusion of crypti

278 ed in the IAV-induced modulation of the TP53 alternative splicing that was associated with a strong m

279 tem for general studies of the regulation of alternative splicing, the inputs that determine the effi

280 ed a role for Musashi proteins in regulating alternative splicing, the loss of MSI1 and MSI2 prevente

281 Despite the critical role of alternative splicing, the mechanisms that drive the choi

282 propose that PpPHY4 and PphnRNP-F1 regulate alternative splicing through an exonic splicing silencer

283 mu-opioid receptor gene undergoes extensive alternative splicing to generate an array of splice vari

284 a single primary transcript, which undergoes alternative splicing to produce diverse protein products

285 sponses in GBM might also include MBNL-based alternative splicing to promote tumor progression.

286 The targeting of natural non-productive alternative splicing to upregulate expression from wild-

287 nactivation of MBNL causes an adult-to-fetal alternative splicing transition, resulting in the develo

288 also resulted in evidence of adult-to-fetal alternative splicing transitions.

289 ~3.5 min for the analysis of all five major alternative splicing types at once.

290 factor RELA to intragenic regions regulates alternative splicing upon NF-kappaB activation by the vi

291 o ask to what extent it is possible to study alternative splicing using scRNA-seq.

292 reveal potential causal variants that affect alternative splicing via allele-specific protein-RNA int

293 ate and adaptive immunity, proteostasis, and alternative splicing were overrepresented.

294 r data demonstrated a link between hPTMs and alternative splicing which will drive further experiment

295 at accounts for the modulation of binding by alternative splicing, which in turn regulates the compet

296 , differential expression of isoforms due to alternative splicing, while the second major mechanism-R

297 To accurately study alternative splicing with single-cell RNA-seq, a better

298 Further investigation revealed evidence of alternative splicing with the presence of two alternate

299 f AR activity demonstrates that AR regulates alternative splicing within cancer-relevant genes.

300 te preferences of O-glycosyltransferases via alternative splicing within specific subregions of funct