ライフサイエンスコーパス: alternatively activated macrophage

1 (ArgI, Retnla, and Chi3l3) characteristic of alternatively activated macrophages.

2 se-type C-type lectin 1 (MGL-1), a marker of alternatively activated macrophages.

3 pe C-type lectin 1 (MGL1/CD301), a marker of alternatively activated macrophages.

4 3, and -4 to interferon-gamma ratio), and 4) alternatively activated macrophages.

5 hile intestinal inflammation is regulated by alternatively activated macrophages.

6 ages assume a distinct phenotype, designated alternatively activated macrophages.

7 h a mechanism that involves the induction of alternatively activated macrophages.

8 that PPARgamma is required for maturation of alternatively activated macrophages.

9 a of F4/80+ cells that have the phenotype of alternatively activated macrophages.

10 duced IL-4 receptor(hi) (IL-4R(hi)) CD206(+) alternatively activated macrophages.

11 pe 2 innate lymphoid cells, eosinophils, and alternatively activated macrophages.

12 nt activation of HIPPO signaling, generating alternatively activated macrophages.

13 on of eosinophils as well as polarization of alternatively activated macrophages.

14 diated rejection gene sets and prominence of alternatively activated macrophages.

15 to the inflammatory axis of classically and alternatively activated macrophages.

16 facilitating accumulation of tumor-promoting alternatively activated macrophages.

17 lassical monocytes are biased progenitors of alternatively activated macrophages.

18 ibrosis and displayed a diminished number of alternatively activated macrophages.

19 mponents of the HA system and no clusters of alternatively activated macrophages.

20 macrophages and an increase in the number of alternatively activated macrophages.

21 ctivity in infected lungs, characteristic of alternatively activated macrophages.

22 her highlights EGR2 as a conserved marker of alternatively activated macrophages.

23 oxidase activity, which is characteristic of alternatively activated macrophages.

24 uced fibrotic gene expression, and increased alternatively activated macrophages.

25 ung neutropenia and enhanced accumulation of alternatively activated macrophages.

26 d with an altered cytokine profile and fewer alternatively activated macrophages.

27 type 2 cytokines interleukin (IL)-4/13, and alternatively activated macrophages.

28 crophages and is widely used as a marker for alternatively activated macrophages.

29 rognosis, markers of T cell dysfunction, and alternatively activated macrophages.

30 consistent with non-classical monocytes and alternatively-activated macrophages.

31 characterized by pulmonary eosinophilia and alternatively activated macrophages(3-8).

32 on of phenotypic markers for classically and alternatively activated macrophages, a state previously

33 on with Ft LVS also resulted in induction of alternatively activated macrophages (AA-Mphi).

34 n endotoxin tolerance and differentiation of alternatively activated macrophages (AA-MPhis or M2), we

35 ced lung myeloid cell infiltration, abnormal alternatively activated macrophage (AAM) function, and i

36 ted macrophages (CAM s) and the IL-4-derived alternatively activated macrophages (AAM s).

37 In the lung, alternatively activated macrophages (AAM) form the first

38 mice with worms resulted in the induction of alternatively activated macrophages (AAM) within the per

39 Although alternatively-activated macrophages (AAM) have been impl

40 Differentiation and recruitment of alternatively activated macrophages (AAMacs) are hallmar

41 at favors the production of higher levels of alternatively activated macrophages (AAMacs) compared wi

42 In turn, these alternatively activated macrophages (AAMacs) functioned

43 Alternatively activated macrophages (AAMPhi) are found i

44 vious studies, we found that IL-33 polarized alternatively activated macrophages (AAMPhi) in vivo.

45 t generated in immunocompromised hosts whose alternatively activated macrophages (AAMphi) predominate

46 was not required for the differentiation of alternatively activated macrophages (AAMPhi) that expres

47 e SIRS mice exhibited typical properties for alternatively activated macrophages (AAMphi).

48 nonuclear cells results in the generation of alternatively activated macrophages (AAMphi).

49 These macrophages are referred to as alternatively activated macrophages (AAMPhis) as they ex

50 oduced the protein Ym1, which is a marker of alternatively activated macrophages (aaMphis), in an IL-

51 Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant

52 une regulation of helminth infections and as alternatively activated macrophages (AAMs) are thought t

53 Markers of alternatively activated macrophages (AAMs) are upregulat

54 Alternatively activated macrophages (AAMs) contribute to

55 Additionally, alternatively activated macrophages (AAMs) expressing AD

56 YM1, FIZZ1, and Arg1, indicating a role for alternatively activated macrophages (AAMs) in pulmonary

57 environment resulted in the accumulation of alternatively activated macrophages (AAMs) in the lung.

58 us survives and replicates preferentially in alternatively activated macrophages (AAMs), which are mo

59 n, caspase-6 promoted the differentiation of alternatively activated macrophages (AAMs).

60 unity and allergy, often in conjunction with alternatively activated macrophages (AAMs).

61 ecessary for accumulation of eosinophils and alternatively activated macrophages (AAMs).

62 metabolic homeostasis and the maintenance of alternatively activated macrophages (AAMs).

63 The balance between alternatively activated macrophages (AAMs)/M2 cells and

64 rive the differentiation of macrophages into alternatively activated macrophages (aaMs, also referred

65 Alternatively, activated macrophages (AAMs) contribute t

66 Alternatively activated macrophages (AAMvarphi) are a ma

67 Alternatively activated macrophages (AAMvarphis) have be

68 e data demonstrate that both classically and alternatively activated macrophages accumulate in the li

69 y, Il5 (Tg) /Cd300f (-/-) mice had increased alternatively activated macrophage accumulation in the a

70 s, characterized by a decrease in protumoral alternatively activated macrophages and an increase in a

71 HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to p

72 ages secrete more TNFalpha and IL-1beta than alternatively activated macrophages and dramatically acc

73 ress and Wnt signaling, the contributions of alternatively activated macrophages and efferocytosis, t

74 M-2 is expressed on newly differentiated and alternatively activated macrophages and functions to res

75 e induced by Th2 cytokines, is a hallmark of alternatively activated macrophages and is responsible f

76 mans, as measured by survival, but had fewer alternatively activated macrophages and less inflammatio

77 Fusion of alternatively activated macrophages and osteoclasts is a

78 oducing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages and prevented the ap

79 described innate lymphoid cells, as well as alternatively activated macrophages and pulmonary stem c

80 ltrating the ICH brain, where they generated alternatively activated macrophages and suppressed neuro

81 t associated with increases in the levels of alternatively activated macrophages and T regulatory cel

82 Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of

83 T and NK cells, regulatory T cells (Tregs), alternatively activated macrophages and tolerogenic dend

84 he understanding of IL-4- and IL-13-mediated alternatively activated macrophages and type 2 immune re

85 5ac, Clca3, and RELMbeta, differentiation of alternatively activated macrophages, and airway hyperrea

86 mphocytes, myeloid-derived suppressor cells, alternatively activated macrophages, and dendritic cells

87 -12p40, TNF, and IFN-gamma, fail to generate alternatively activated macrophages, and develop endotox

88 ransforming growth factor-B, accumulation of alternatively activated macrophages, and enhanced peribr

89 sforming growth factor-beta, accumulation of alternatively activated macrophages, and enhanced peribr

90 dent immunoregulatory CD4(+) helper T cells, alternatively activated macrophages, and impaired bacter

91 ssociated with Th2-type cytokine production, alternatively activated macrophages, and inability of th

92 E production, basophilia, differentiation of alternatively activated macrophages, and protection agai

93 ocyte recruitment, inhibited polarization of alternatively activated macrophages, and suppressed T ce

94 Alternatively, activated macrophages appear earlier than

95 Alternatively activated macrophages are a key effector c

96 en or IL-4 demonstrated that marker genes of alternatively activated macrophages are differentially r

97 Alternatively activated macrophages are essential effect

98 Tumor stromal alternatively activated macrophages are important determ

99 Similar metabolic signatures in alternatively-activated macrophages are seen from differ

100 ed expression of other genes associated with alternatively activated macrophages, as well as increase

101 R3-Ig mice, which were further enriched with alternatively activated macrophages based on surface mar

102 Elimination of alternatively activated macrophages blocked smooth muscl

103 -13Ralpha1 contributes to the development of alternatively activated macrophages, but the type 1 IL-4

104 changes were associated with an increase in alternatively activated macrophages concomitant with enh

105 During development of pancreatic cancer, alternatively activated macrophages contribute to fibrog

106 sion, TGF-beta production, and activation of alternatively activated macrophages, contributed by dere

107 tinase-like molecule that is associated with alternatively activated macrophages, could partially res

108 MLC(CD206Hi) alternatively activated macrophages displayed the greate

109 s from wild-type c57BL/6NcR mice accumulated alternatively-activated macrophages, displayed elevated

110 Thus, we conclude that alternatively activated macrophages do not synthesize re

111 ied as classically activated macrophages and alternatively activated macrophages due to different sti

112 etory protein that is transiently induced in alternatively activated macrophages during T-helper (Th)

113 Alternatively activated macrophages express the pattern

114 pe cytokine production, and the induction of alternatively activated macrophages expressing arginase-

115 t and demonstrated a transient population of alternatively activated macrophages expressing stabilin-

116 r, the requirement for either classically or alternatively activated macrophages for Pneumocystis cle

117 o, MR deficiency synergized with inducers of alternatively activated macrophages (for example, IL-4 a

118 Alternatively activated macrophages from the skin of pat

119 Together, our findings suggest that resident alternatively activated macrophages have a beneficial ro

120 -deficient mice is marked by accumulation of alternatively activated macrophages, higher collagen dep

121 om GM(+/+) mice showed numerous hallmarks of alternatively activated macrophages: higher numbers of i

122 d non-classical monocytes as contributors to alternatively activated macrophages, highlighting them a

123 Absence of alternatively activated macrophages impaired metabolic a

124 otype of Ati-CB1-KO mice and the increase in alternatively activated macrophages in adipose tissue we

125 e findings reveal a role for type I IFNs and alternatively activated macrophages in aggressive prolif

126 s our understanding of the potential role of alternatively activated macrophages in atherogenesis and

127 Emerging evidence indicates that alternatively activated macrophages in central nervous s

128 set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.

129 pacity to repair tissue, the precise role of alternatively activated macrophages in obesity-induced i

130 We speculate that accumulation of alternatively activated macrophages in organized cluster

131 g innate inflammation and differentiation of alternatively activated macrophages in response to injur

132 ate lymphoid cells (ILC2s), eosinophils, and alternatively activated macrophages in the adipose tissu

133 , increased Th2 cytokine milieu, and induced alternatively activated macrophages in the gut.

134 Clodronate treatment affected the number of alternatively activated macrophages in the lung, with up

135 f type 2 pulmonary innate lymphoid cells and alternatively activated macrophages in the lungs as well

136 Thus, we have discovered a role for alternatively activated macrophages in the orchestration

137 cryptococci and YM1 crystals, indicative of alternatively activated macrophages in these mice.

138 ced rapid recruitment and differentiation of alternatively activated macrophages in vivo, through IL-

139 sed arginase1 and Ym1 expression, typical of alternatively activated macrophages, in the draining (ce

140 ntrahepatic expression of genes expressed by alternatively activated macrophages, including CD206, Re

141 xpressed many genes characteristic of M2 or "alternatively activated" macrophages, including Ym1, arg

142 es or M1, induced by IFN-gamma plus LPS, and alternatively activated macrophages, induced by IL-4.

143 pe I and type II NKT cells, eosinophils, and alternatively activated macrophages into the VAT.

144 of regenerative wound-healing macrophages as alternatively activated macrophages is currently questio

145 Pomalidomide-induced absence of alternatively activated macrophages led to a decrease in

146 two for their polarization (classically and alternatively activated macrophages: M1 and M2, respecti

147 two for their polarization (classically and alternatively activated macrophages: M1 and M2, respecti

148 ty and classically activated macrophage (M1)-alternatively activated macrophage (M2) polarization.

149 t classically activated macrophage (M1)- and alternatively activated macrophage (M2)-derived proteogl

150 e activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype,

151 M1 macrophages) are proinflammatory, whereas alternatively activated macrophages (M2 macrophages) are

152 Alternatively activated macrophages (M2) have an importa

153 in response to chitosan than intermediate or alternatively activated macrophages (M2).

154 activated macrophages [M1] and expansion in alternatively activated macrophages [M2]), which could i

155 es including Il13, Il17, Il22, Ccl2, and the alternatively activated macrophage marker Cd206; (2) red

156 trite levels, and reduced apoptosis, whereas alternatively activated macrophage markers are unchanged

157 nfiltration of macrophages and up-regulation alternatively activated macrophage markers by a mechanis

158 els in the organs, reduced the expression of alternatively activated macrophage markers, and increase

159 Inhibition or depletion of Arg did not alter alternatively activated macrophage numbers but instead w

160 ces in the accessible chromatin landscape of alternatively activated macrophages on different genetic

161 In thioglycollate-elicited and alternatively activated macrophages, PGE2 selectively im

162 inflammatory, profibrotic, and dysfunctional alternatively activated macrophage phenotype possibly vi

163 ), an established marker of the IL-4-induced alternatively activated macrophage phenotype.

164 nfiltrating blood monocytes toward an M2 or "alternatively" activated macrophage phenotype could prom

165 ned by the local immune environment and that alternatively activated macrophages play a major role in

166 monstrate that pink-staining eosinophils and alternatively activated macrophages play key roles in an

167 , classically activated macrophages; PMN-II, alternatively activated macrophages; PMN-N, no effect on

168 higher expression of Plg-R(KT) compared with alternatively activated macrophages, polarized with inte

169 lidomide depletes pancreatic lesion areas of alternatively activated macrophage populations.

170 Alternatively activated macrophages prevent lethal intes

171 , a major product of IL-4- and IL-13-induced alternatively activated macrophages, prevents cachexia,

172 ifically lacking in Retnla, a characteristic alternatively activated macrophage product associated wi

173 The mechanism by which these alternatively activated macrophages promote repair is un

174 Mice treated with FHES had enhanced alternatively activated macrophages, reduced Th1 and Th1

175 Similarly, alternatively activated macrophages require alpha-ketogl

176 erized hallmark molecules of classically and alternatively activated macrophages, respectively.

177 ral cytokines, chemokines, and markers of an alternatively activated macrophage response.

178 egulate adaptive immunity and eosinophil and alternatively activated macrophage responses, and were r

179 Therefore, alternatively activated macrophages restrain NK cell act

180 Here, we show that an alternatively activated macrophage secreted enzyme, inte

181 ant correlation between TGFBI expression and alternatively activated macrophage signatures.

182 h PKD1 and PKD2, abnormally large numbers of alternatively activated macrophages surrounded the cysts

183 , to aid in the phenotypic transition toward alternatively activated macrophages, synonymous with res

184 Alternatively activated macrophages, TAMs, are an abunda

185 tissue (AT) contains ST2+ Tregs, ILC2s, and alternatively activated macrophages that are lost in mic

186 iased immune response and the development of alternatively activated macrophages that mediate a profi

187 t the increased levels of glucose present in alternatively activated macrophages to sustain chronic i

188 n T-cell and macrophage polarization from T2/alternatively activated macrophages toward T1/classicall

189 GL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively exp

190 h2-type cytokine production and induction of alternatively activated macrophages were also observed i

191 These alternatively activated macrophages were also shown to h

192 addition, alpha-MSH promotes survival of the alternatively activated macrophages where without alpha-

193 duced intestinal pathology or development of alternatively activated macrophages, which are required

194 neoformans, including enhanced generation of alternatively activated macrophages, which is accompanie

195 P2Y agonists in thioglycollate-elicited and alternatively activated macrophages, which provide new c

196 chemokine receptor-2-positive monocytes and alternatively activated macrophages with a prolymphangio

197 d CD163 consistent with differentiation into alternatively activated macrophages with potential regul

198 Cs via LOs to promote the differentiation of alternatively activated macrophage, with potential relev

199 Alveolar macrophages are prototypical alternatively activated macrophages, with up-regulated i

200 WAT) type 2 T helper cells, eosinophils, and alternatively activated macrophages, without affecting t