ライフサイエンスコーパス: amblyopia

1 entricity and both are similarly affected in amblyopia.

2 normalities could prevent the development of amblyopia.

3 llary density in the macula of patients with amblyopia.

4 ome, epiretinal membrane, cornea guttata, or amblyopia.

5 improvement in BCVA when not compromised by amblyopia.

6 ures using OCTA in children (<18 years) with amblyopia.

7 ional recovery of visual acuity defects from amblyopia.

8 he retinal capillary layers in children with amblyopia.

9 active error, and 43000 (25%) from bilateral amblyopia.

10 of perceptual tasks in subjects with treated amblyopia.

11 sary to fully recover deficient functions in amblyopia.

12 d binocular suppression that is unaltered in amblyopia.

13 rch into visual development and the disorder amblyopia.

14 e everyday-life impact of childhood residual amblyopia.

15 eriods may provide clues how to better treat amblyopia.

16 ed a great deal about the pathophysiology of amblyopia.

17 e a promising additional option for treating amblyopia.

18 atment is comparable to patching in treating amblyopia.

19 -year-old persons with unilateral persistent amblyopia.

20 eatment of uncorrected refractive errors and amblyopia.

21 utcomes for children with moderate to severe amblyopia.

22 may cause physicians to overlook associated amblyopia.

23 ignificant tilt after-effects in adults with amblyopia.

24 tral field in humans with moderate-to-severe amblyopia.

25 ontinuous ophthalmic care, most commonly for amblyopia.

26 o follow-up, managed surgically, deprivation amblyopia.

27 of which all had myopic maculopathy or deep amblyopia.

28 ndently with an increased risk of unilateral amblyopia.

29 only, or both, and 112 had no strabismus or amblyopia.

30 al hyperopia were risk factors for bilateral amblyopia.

31 dependently with increased risk of bilateral amblyopia.

32 yopia, and 144 children (3.7%) had bilateral amblyopia.

33 re present in 76% of children with bilateral amblyopia.

34 e present in 91% of children with unilateral amblyopia.

35 ikely to develop oblique astigmatism-related amblyopia.

36 tive errors were risk factors for unilateral amblyopia.

37 pared with related findings in attention and amblyopia.

38 volumes were associated with development of amblyopia.

39 ke certain they do not develop anisometropic amblyopia.

40 ith a congenital form of ptosis demonstrated amblyopia.

41 to 6 hours in children with stable residual amblyopia.

42 obstruction is associated with anisometropic amblyopia.

43 in identifying preschoolers with unilateral amblyopia.

44 ision and may have critical implications for amblyopia.

45 contributes to the pathological etiology of amblyopia.

46 d the development of forms of strabismus and amblyopia.

47 mine-mediated functional recovery from adult amblyopia.

48 (V1), which allows subsequent recovery from amblyopia.

49 ions in macaques with experimentally induced amblyopia.

50 on of treatment in adults with anisometropic amblyopia.

51 a key component of the perceptual losses in amblyopia.

52 rtex can cause impaired binocular vision and amblyopia.

53 Specificity of the PVS for strabismus and amblyopia (0.87; 95% CI, 0.80-0.95) was significantly hi

54 ence of strabismus (1.73%-2.24%, P = .91) or amblyopia (0.9%-2.08%, P = .13) among first grade studen

55 sitivity of the PVS to detect strabismus and amblyopia (0.97; 95% CI, 0.94-1.00) was significantly hi

56 ar vision (strabismus, 2.3%; diplopia, 2.2%; amblyopia, 0.9%; and nystagmus, 0.2%).

57 corneal scars (15.7%), refractive error and amblyopia (12.1%), optic atrophy (6.4%), phthisis bulbi

58 rs (47.1%), keratitis/corneal opacity (16%), amblyopia (14.3%), ocular trauma (11.8%), cataract (6.3%

59 ntified ten main outcome measure domains for amblyopia, 14 for strabismus, and ten common "visual or

60 n aged 5 years to younger than 13 years with amblyopia (20/40 to 20/200, mean 20/63) resulting from s

61 aged 13 to <17 years (mean 14.3 years) with amblyopia (20/40 to 20/200, mean approximately 20/63) re

62 esenting visual acuity were nystagmus (14%), amblyopia (24%) and uncorrected refractive error (62%).

63 ejection (1), recurrence of disease (1), and amblyopia (3).

64 cular features of vision and refraction were amblyopia (32%), myopia (40%), and astigmatism (52%).

65 A total of 142 studies were included; 42 in amblyopia, 33 in strabismus, and 68 in ocular motility d

66 perceived by 11 of the 24 participants with amblyopia (45.8%) and all 9 controls (100%) (adjusted od

67 ildren had a higher percentage of unilateral amblyopia (8% vs. 2%), larger mean IAD (0.07 vs. 0.05 lo

68 viewed, 167 (7.6%) had asymmetric, bilateral amblyopia; 98 met inclusion and exclusion criteria.

69 ence during the sensitive period can lead to amblyopia, a developmental disorder of vision affecting

70 r vision and reduced acuity are hallmarks of amblyopia, a disorder that affects 2%-5% of the populati

71 this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for which avail

72 The neural basis of amblyopia, a visual deficit affecting 3% of the human po

73 In amblyopia, a visual disorder caused by abnormal visual e

74 In amblyopia, abnormal visual experience leads to an extrem

75 sual potential such as macular degeneration, amblyopia, advanced glaucoma, and other optic neuropathi

76 Residual amblyopia affects functional vision and ER-QOL in childr

77 ual acuity and disrupted binocular function, amblyopia affects many low- and high-level perceptual ab

78 Current models assume that amblyopia affects similarly ON and OFF visual pathways,

79 We conclude that amblyopia affects the ON cortical pathway more than the

80 his current belief, here we demonstrate that amblyopia affects the ON visual pathway more than the OF

81 children 7 to 12 years of age with residual amblyopia after patching therapy, oral levodopa while co

82 auses of vision abnormalities in children is amblyopia (also known as "lazy eye").

83 ited strabismus, 1.8% were suspected to have amblyopia and 0.5% had reduced acuity of likely organic

84 woman with Marfan's syndrome presented with amblyopia and a history of gradual bilateral vision loss

85 BVI) were recruited, with either persistent amblyopia and age-related macular degeneration (AMB + AM

86 erly patients with BVI, caused by persistent amblyopia and age-related macular degeneration (AMD) or

87 cular imbalance may be useful for diagnosing amblyopia and as an outcome measure for recovery of bino

88 onance imaging analysis in participants with amblyopia and compared the projections from the amblyopi

89 Due to concerns of possible amblyopia and cosmetics, lamellar keratectomy, sclerotom

90 agnosed with anisometropic and/or strabismic amblyopia and had not undergone previous treatment.

91 rce (USPSTF) recommendation on screening for amblyopia and its risk factors in children.

92 pport the utility of personalized therapy in amblyopia and may have broader relevance for improving t

93 Amblyopia and nystagmus limited visual outcome, indicati

94 have important therapeutic applications for amblyopia and other visual brain disorders.

95 er understand the patterns of strabismus and amblyopia and potentially inform planning for preschool

96 Two strabismus-specific questionnaires, the Amblyopia and Strabismus Questionnaire and the Adult Str

97 During the study period, the rates of amblyopia and strabismus remained stable, indicating the

98 Start preschool children, the prevalence of amblyopia and strabismus was similar among 5 racial/ethn

99 otility disorders (one study overlap between amblyopia and strabismus).

100 Pad game was effective in treating childhood amblyopia and was more efficacious than patching at the

101 ipants included 59 children (<18 years) with amblyopia and without amblyopia examined at a pediatric

102 e mean CISS score for the population without amblyopia and/or strabismus (96.0% of all students) was

103 10 participants (90 neurotypical and 20 with amblyopia) and compared them to psychophysical stereoacu

104 55 (8.39%) received glasses, 873 (1.37%) had amblyopia, and 1125 (1.76%) had strabismus.

105 = 3869), 296 children (7.7%) had unilateral amblyopia, and 144 children (3.7%) had bilateral amblyop

106 fect of age, sex, refractive errors, type of amblyopia, and adherence to glasses wearing on improveme

107 ds on the extent of involvement, the risk of amblyopia, and cosmetic concerns.

108 oportion of children with refractive errors, amblyopia, and/or strabismus.

109 The gold standard treatments in amblyopia are penalizing therapies, such as patching or

110 ing to the younger age group and the role of amblyopia as a cause of visual loss.

111 This is consistent with an explanation of amblyopia as an immature system with a normal complement

112 efficacy in reducing induced astigmatism and amblyopia associated with periocular hemangiomas while m

113 The functional importance of amblyopia at an individual level is unclear as data are

114 PatientPopulation: Patients diagnosed with amblyopia at Boston Children's Hospital between 2010 and

115 ditional 3 participants with ocular disease (amblyopia, autosomal recessive bestrophinopathy, prematu

116 d level of anisometropia at which unilateral amblyopia became significant was lower than current guid

117 attentional blink in each eye of adults with amblyopia before and after 40 hours of active video game

118 thought that the neural deficits underlying amblyopia begin in the circuits of primary visual cortex

119 that age (beta = -0.535; P = .001), type of amblyopia (beta = -0.347; P = .02), and adherence to gla

120 ing has long been the standard treatment for amblyopia, but it does not always restore 20/20 vision o

121 trials have reduced the treatment burden of amblyopia by reducing hours of patching and frequency of

122 Amblyopia can be treated with binocular games that rebal

123 While it is widely believed that amblyopia cannot be treated successfully after the age o

124 brate our portable acuity screening tools so amblyopia could be detected quickly and effectively at s

125 as unknown if a visual system compromised by amblyopia could engage this pathway.

126 e and by 100% of participants whose onset at amblyopia developed at or after 5 years of age.

127 t disorders of binocular vision (strabismus, amblyopia, diplopia, and nystagmus) may have on musculos

128 Despite the extensive animal studies on how amblyopia emerges, we know surprisingly little about the

129 Children with a history of amblyopia, even if resolved, exhibit impaired visual-aud

130 ldren (<18 years) with amblyopia and without amblyopia examined at a pediatric ophthalmology clinic o

131 gistry identified 1,760,066 individuals with amblyopia for a prevalence of 2.47%.

132 ract corneal opacities, refractive error and amblyopia, globe damage due to trauma, infection and nut

133 nal capillary plexus was 54.4% (4.7%) in the amblyopia group and 60.1% (3.3%) in the control group, w

134 with oblique astigmatism-related refractive amblyopia (Group 1) and 82 children with orthogonal asti

135 Participants with amblyopia had more difficulty using non-stereoscopic cue

136 ach to treating anisometropic and strabismic amblyopia has recently been advocated.

137 udy suggests that children with a history of amblyopia have impaired visual-auditory speech perceptio

138 of animal models of the most common forms of amblyopia have provided indispensable insight into the d

139 gery was not associated with the presence of amblyopia, high hyperopia, or the total amount of millim

140 Patients with amblyopia, high myopia or hyperopia, coexisting retinal

141 52 (0.16) logMAR (P = .01), a slower rate of amblyopia improvement, and higher prevalence of parental

142 [SD] age, 7.0 [1.5] years) had a history of amblyopia in 1 eye, with a visual acuity of at least 20/

143 in 31 (43.6%), strabismus in 25 (35.2%), and amblyopia in 10 (14.1%).

144 ience-dependent plasticity and recovery from amblyopia in adulthood.

145 rdable tools provide sensitive screening for amblyopia in children from public, private and home scho

146 cylinder power of astigmatism (in D) causing amblyopia in Group 1 of 2.48 (0.82) was lower than that

147 urprisingly little about the neural basis of amblyopia in humans and nonhuman primates.

148 The causes of amblyopia in the remaining 5 patients were significant r

149 ivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice.

150 ting the targeted conditions, strabismus and amblyopia, in children aged 2 to 6 years.

151 nt as a substitute for current therapies for amblyopia (including patching and optical treatment).

152 The percentage of unilateral amblyopia increased significantly with SE anisometropia

153 Together, we show that amblyopia increases visual dark dominance by 3-10 times

154 plasticity in adults, allowing recovery from amblyopia induced by chronic monocular deprivation.

155 itical period adults, allowing recovery from amblyopia induced by chronic monocular deprivation.

156 While amblyopia involves both binocular imbalance and deficits

157 SIGNIFICANCE STATEMENT: Amblyopia is a common developmental vision disorder in h

158 s vision in amblyopes.SIGNIFICANCE STATEMENT Amblyopia is a developmental visual disorder that alters

159 amblyopia treatments.SIGNIFICANCE STATEMENT Amblyopia is a loss of vision that affects 2-5% of child

160 The neural basis of amblyopia is a matter of debate.

161 Amblyopia is a neurodevelopmental disorder that affects

162 Amblyopia is a sensory developmental disorder affecting

163 Amblyopia is an alteration in the visual neural pathway

164 Treatment of amblyopia is associated with moderate improvements in vi

165 e good visual acuity, although mild residual amblyopia is common.

166 With abnormal visual cortical development, amblyopia is generally associated with high spatial freq

167 Utility of visual impairment caused by amblyopia is important for the cost-effectiveness of scr

168 h animal and human work has established that amblyopia is not simply a monocular deficit, and therefo

169 Amblyopia is the most common cause of visual impairment

170 avior, both during visual development and in amblyopia, is discussed, and several potential resolutio

171 h needed insight into the natural history of amblyopia, its origins and sensitive periods, and the br

172 e evidence on screening for and treatment of amblyopia, its risk factors, and refractive error in chi

173 for the cost-effectiveness of screening for amblyopia (lazy eye, prevalence 3-3.5 %).

174 sual deprivation early in life can result in amblyopia (lazy-eye), a prevalent childhood disorder com

175 refraction power of the two eyes differs, an amblyopia-like state develops in which the foveal region

176 By treating children early, amblyopia may be prevented, quality of life improved, an

177 Interventions to resolve amblyopia may not only influence visual acuity but may a

178 and 9 girls) and 20 with strabismic or mixed amblyopia (mean [SD] age, 4.90 [1.36] years; 10 boys and

179 Group 1 achieved a noninferior resolution of amblyopia (mean final VA 0.18 vs 0.16 logMAR) after long

180 The percentage with unilateral amblyopia, mean IAD, and mean stereoacuity.

181 The exclusion criteria included amblyopia, mental retardation, and concomitant ocular di

182 essful visual-auditory fusion, by which time amblyopia must have either resolved or begun.

183 ocular abnormalities in childhood, including amblyopia, myopia, astigmatism, strabismus, limited ocul

184 Seventeen children with residual amblyopia (no current treatment except glasses), 48 visu

185 Visuomotor comorbidities (eg, amblyopia, nystagmus, foveopathy, optic neuropathy) acco

186 Amblyopia occurred in 1 in 7 children diagnosed with pto

187 In our series, amblyopia occurs in more than half of NF1 children with

188 ateral ocular disease process, and eyes with amblyopia, ocular disease, or spherical equivalent refra

189 Initial treatment for amblyopia of the fellow eye with patching and atropine s

190 49 children had amblyopia of whom 33 were newly diagnosed.

191 sses, PedEyeQ scores were lower for residual amblyopia on the Child Frustration/worry domain (P = .03

192 n in order to understand the broad impact of amblyopia on visual and visual-motor function.

193 Moreover, monocular deprivation elicited amblyopia only during a discrete period of development i

194 f the 300 patients, 188 had strabismus only, amblyopia only, or both, and 112 had no strabismus or am

195 hen of the underlying cellular mechanisms of amblyopia or 'lazy eye', the commonest childhood disorde

196 children younger than 6 years, 1% to 6% have amblyopia or its risk factors (strabismus, anisometropia

197 in all children aged 3 to 5 years to detect amblyopia or its risk factors.

198 Of the 804 without strabismus, amblyopia or organic conditions, 6.0% were myopic </= -

199 devices assess refractive risk factors, not amblyopia or strabismus, underreferring affected childre

200 sual acuity (VA) and cover testing ruled out amblyopia or strabismus.

201 ng functional risks (eg, visual obstruction, amblyopia, or feeding difficulties), ulceration, and sev

202 l dichoptic letter chart in individuals with amblyopia, or normal vision.

203 ars who have received previous treatment for amblyopia other than spectacles, there was no benefit to

204 group had a higher proportion of strabismic amblyopia (P = .007).

205 Many bilateral amblyopia patients have asymmetric visual acuity (VA).

206 going research into the neural correlates of amblyopia provides guidance for novel therapeutic approa

207 rror--either uncorrected refractive error or amblyopia resulting from refractive error.

208 Amblyopia results from abnormal binocular visual experie

209 the benefits are moderate because untreated amblyopia results in permanent, uncorrectable vision los

210 Among children with amblyopia risk factors (eg, strabismus or anisometropia)

211 ross sectional study was conducted to detect amblyopia risk factors and myopia in a rural district of

212 teles Falls, New York, USA) for detection of amblyopia risk factors in children aged 6 months to 3 ye

213 sensitivity and specificity for detection of amblyopia risk factors in this young cohort, particularl

214 likelihood ratios were between 5 and 10 for amblyopia risk factors or nonamblyogenic refractive erro

215 93 children with amblyopia risk factors were identified.

216 n for Pediatric Ophthalmology and Strabismus amblyopia risk factors with 68% (965/96) sensitivity and

217 almology and Strabismus (AAPOS) criteria for amblyopia risk factors.

218 ocular alignment is critical for identifying amblyopia risk factors.

219 Visual acuity, amblyopia, school performance, functioning, quality of l

220 plications are identifiable through existing amblyopia screening methods.

221 Amblyopia secondary to the orbitotemporal plexiform neur

222 capillary hemangiomas at risk of developing amblyopia seen between January 2009 and January 2012 at

223 n dark dominance is strongly correlated with amblyopia severity.

224 uggest that the real-life adverse effects of amblyopia should be characterised and screening and diag

225 A trial of occlusion therapy to treat amblyopia should be initiated in these patients to ensur

226 re reporting within published literature for amblyopia, strabismus and ocular motility and it generat

227 natives indicating the different subtypes of amblyopia, strabismus and ocular motility disorders in r

228 d outcome measures from published studies in amblyopia, strabismus and ocular motility disorders to i

229 tify articles reporting outcome measures for amblyopia, strabismus and ocular motility disorders.

230 Amblyopia, strabismus, and refractive errors are common

231 : prevalence of an ophthalmologic diagnosis (amblyopia, strabismus, optic neuropathy, nystagmus, or r

232 used to classify vision disorders, including amblyopia, strabismus, significant refractive errors, an

233 ly between groups, even after stratifying by amblyopia subtype (P >= .48).

234 Behavioral observations in humans with amblyopia suggest that much of their visual loss is due

235 degree of initial oblique astigmatism caused amblyopia than did orthogonal astigmatism.

236 tly lower (worse) for children with residual amblyopia than for controls without glasses across all d

237 way for new strategies for the treatment of amblyopia that attempt to remove molecular brakes on pla

238 Refractive Error is one of the leading cause amblyopia that exposes children to poor school performan

239 t was perceived by 100% of participants with amblyopia that was resolved by 5 years of age and by 100

240 However, only 18.8% of participants with amblyopia that was unresolved by 5 years of age (n = 16)

241 ntrast in the other eye, but in monkeys with amblyopia the balance of gain modulation is altered so t

242 For severe amblyopia, the cohort (n = 52) was prescribed a mean of

243 For moderate amblyopia, the cohort (n = 71) was prescribed a mean of

244 In patients with strabismus, even without amblyopia, the deviated eye is more variable in position

245 superior to cataract surgery ($2,262/QALY), amblyopia therapy ($2,710/QALY), and retinal detachment

246 reviews the visual outcomes and benefits of amblyopia therapy in children with foveal toxoplasmosis

247 be recommended as a replacement for standard amblyopia therapy.

248 he pediatric population, already at risk for amblyopia, this can be especially damaging.

249 al acuity (VA) improvement in teenagers with amblyopia treated with a binocular iPad game vs part-tim

250 ual acuity (VA) improvement in children with amblyopia treated with a binocular iPad game vs part-tim

251 binocular iPad (Apple Inc) adventure game as amblyopia treatment and compare this binocular treatment

252 The gold standard of a successful amblyopia treatment is full recovery of visual acuity (V

253 lts indicate that improvement occurring with amblyopia treatment is maintained until at least 15 year

254 aseline VA of 59.6 letters, history of prior amblyopia treatment other than spectacles in 96%) were r

255 ds application was compared with that of the Amblyopia Treatment Study (ATS) and the authors' clinic

256 orrelation of visual acuity compared to HOTV-Amblyopia Treatment Study protocol, although most were w

257 acuity using the computerized version of the Amblyopia Treatment Study VA testing protocol that limit

258 ticipants (aged 5 to <7 years) without prior amblyopia treatment, amblyopic-eye VA improved by a mean

259 Charts were reviewed for amblyopia treatment, fundus photographs, optical coheren

260 roved visual outcomes in patients undergoing amblyopia treatment.

261 r children (age 5 to <7 years) without prior amblyopia treatment.

262 or the development of training protocols for amblyopia treatment.

263 med foveal toxoplasmosis scars who underwent amblyopia treatment.

264 finding that could have implications for new amblyopia treatments targeted at strengthening a weak ON

265 nterventions: Binocular game and patching as amblyopia treatments.

266 ding that could have implications for future amblyopia treatments.SIGNIFICANCE STATEMENT Amblyopia is

267 alance as a function of spatial frequency in amblyopia using a novel computer-based method.

268 In patients with asymmetric, bilateral amblyopia, VA improved by 4 lines in the weaker eye and

269 s the dominant eye.SIGNIFICANCE STATEMENT In amblyopia, vision in one eye is impaired as a result of

270 ulticenter clinical trial, 419 children with amblyopia (visual acuity, 20/40 to 20/100) were randomly

271 patients, the mean (SD) age of patients with amblyopia was 8.0 (4.0) years and 10.3 (3.3) years for t

272 Unilateral amblyopia was defined as an interocular difference in be

273 Bilateral amblyopia was defined as best-corrected VA in each eye w

274 Amblyopia was defined as unilateral if there was >/=2 li

275 al acuity between 20/40 and 20/80 and severe amblyopia was defined as visual acuity between 20/100 an

276 Using PEDIG criteria, moderate amblyopia was defined as visual acuity between 20/40 and

277 Amblyopia was detected in 1.81% (95% CI, 1.06-2.89) of A

278 Amblyopia was diagnosed in 16 (14.9%) of the 107 patient

279 Refractive amblyopia was found in 780 children (1.0% of the screene

280 Refractive amblyopia was found in 9% of those examined, or 0.8% of

281 n-Hispanic white children; the prevalence of amblyopia was higher for each subsequent older age categ

282 Amblyopia was identified as the main cause of visual los

283 0.8 lines for 7-12 years, but mean residual amblyopia was more than 2 lines.

284 The effect of beta-blockers on amblyopia was not adequately documented.

285 Prevalence of amblyopia was similar among all groups (P=0.07), ranging

286 Risk of amblyopia was summarized by the odds ratios and their 95

287 Amblyopia was the most common cause of vision loss in th

288 The prevalence of amblyopia was the same in Asian and non-Hispanic white c

289 Developmental delay, strabismus, and amblyopia were common in this cohort.

290 years (range, 17-69 year) and anisometropic amblyopia were enrolled.

291 dominance in binocular rivalry in "treated" amblyopia were largely comparable to those of normal sub

292 s of age, most children treated for moderate amblyopia when younger than 7 years have good visual acu

293 e that can be predicted from the severity of amblyopia, whereas suppression from both eyes is prevale

294 this hypothesis in humans with anisometropic amblyopia who suffered sustained optical blur early afte

295 an 19 years for the prevalence and causes of amblyopia who were diagnosed with childhood ptosis and w

296 ously in 35-year-old persons with unilateral amblyopia with good vision in the other eye.

297 S identified children with strabismus and/or amblyopia with high sensitivity, outperforming the SureS

298 to measure loss of utility in patients with amblyopia with recent decrease of vision in their better

299 norganic visual loss and bilateral ametropic amblyopia with strabismus.

300 ing work aimed at understanding and treating amblyopia, yet its physiological basis remains unknown.