ライフサイエンスコーパス: ameliorate disease

1 cal step in which to intervene to prevent or ameliorate disease.

2 helper cells should lower AChR Ab levels and ameliorate disease.

3 ion of the IL-12 and IL-23 pathways does not ameliorate disease.

4 gets of ceramide-lowering interventions that ameliorate disease.

5 There is a demand for noninvasive methods to ameliorate disease.

6 istant starch restrict L. reuteri growth and ameliorate disease.

7 modulating V. cholerae biofilm dispersal to ameliorate disease.

8 herefore, immune modulation has potential to ameliorate disease.

9 herefore, altering a person's microbiota may ameliorate disease.

10 iled to restore normal levels of Tregs or to ameliorate disease.

11 The net effect of DC deletion was to ameliorate disease.

12 s may rebalance Treg/T effector activity and ameliorate disease.

13 ctive CRAC channel inhibitor after EAE onset ameliorated disease.

14 thality, whereas targeted depletion of MDSCs ameliorated disease.

15 ice to neonates before aeroallergen exposure ameliorated disease.

16 d nephritis, whereas ablating IFN-I activity ameliorated disease.

17 treatment of SLE mice with BAFF antagonists ameliorates disease.

18 s restores the cerebral microvasculature and ameliorates disease.

19 s, and IRF5 deficiency in lupus mouse models ameliorates disease.

20 D1 mice restores dysfunctional microglia and ameliorates disease.

21 ore, administration of exogenous adiponectin ameliorates disease.

22 nisms that benefit the host by preventing or ameliorating disease.

23 , and minerals, in reducing inflammation and ameliorating disease.

24 ation of acetate is remarkably beneficial in ameliorating disease.

25 ent of MS, correcting BBB function and hence ameliorating disease.

26 nding disease pathogenesis and as a means of ameliorating disease?

27 ponsible for such accumulations is likely to ameliorate disease, a therapeutic strategy has been deve

28 prevent and treat nutrient deficiencies and ameliorate disease activity in individuals with inflamma

29 ) T cells beneficially in EAE have failed to ameliorate disease activity in multiple sclerosis, and s

30 own that the pregnancy hormone, estriol, can ameliorate disease and can cause an immune shift.

31 tifying them at the onset of symptoms should ameliorate disease and improve outcomes.

32 d infection with a high dose (50 mug) of CpG ameliorated disease and lowered parasite burden.

33 cologic activation of PGC1alpha successfully ameliorated disease and restored mitochondrial integrity

34 Hematopoietic stem cell transplant (HSCT) ameliorates disease and is associated with central nervo

35 suppresses each distinct phase of pathology, ameliorate disease, and prevent disease progression.

36 F suppress each distinct phase of pathology, ameliorate disease, and prevent disease progression.

37 ss-switched and hypermutated autoantibodies, ameliorated disease, and extended survival in lupus MRL/

38 In both instances, they served to ameliorate disease associated signs and symptoms.

39 igates mHTT accumulation and neuronal death, ameliorating disease-associated phenotypes and lifespan.

40 ies such as anti-TNF or anti-CD20 antibodies ameliorate disease, but at the cost of some increase in

41 iency, suggesting that therapies designed to ameliorate disease by inhibition of apoptosis are more l

42 y specific for the TNF family member, CD154, ameliorates disease by reducing levels of self-reactive

43 utic induction of fetal hemoglobin (HbF) can ameliorate disease complications and has been intently p

44 lycoprotein peptide (MOG(35-55)) revealed an ameliorated disease course in cortactin gene-deficient f

45 Those patients had an ameliorated disease course with longer survival but stil

46 yelitis, which correlated with substantially ameliorated disease course.

47 In contrast, TLR7-deficient mice had ameliorated disease, decreased lymphocyte activation, an

48 Treatment with RANK-Fc significantly ameliorated disease development and attenuated bone dest

49 ase of EAE in mice resulted in significantly ameliorated disease development and progression.

50 mulation depletes pathogenic lymphocytes and ameliorates disease even after disease onset, highlighti

51 Factors in young blood have the potential to ameliorate disease in a model of AD.

52 in a Th2-dominated susceptible mouse and can ameliorate disease in a Th1-dominated resistant strain,

53 selectively inhibit endosomal TLR signaling, ameliorate disease in CIA, and suppress inflammatory cyt

54 ocal inhibition of perforin is sufficient to ameliorate disease in established cutaneous leishmaniasi

55 he adhesion molecule VLA-4 has been shown to ameliorate disease in human multiple sclerosis patients

56 tion, we investigated whether CEP-1347 could ameliorate disease in laboratory models of HAND.

57 ding pathology early enough to intervene and ameliorate disease in later pregnancy remains a complex

58 ry effects such that GABA administration can ameliorate disease in models of type 1 diabetes, rheumat

59 olecules that inhibit MLKL and substantially ameliorate disease in murine models of necroptosis-drive

60 hat affect DNA methylation can exacerbate or ameliorate disease in this transgenic murine lupus model

61 itro and/or to passively protect against, or ameliorate, disease in vivo.

62 gene Rictor in Foxp3-deficient T(reg) cells ameliorated disease in a Foxo1 transcription factor-depe

63 global and B cell-specific Myd88 deficiency ameliorated disease in lupus-prone mice when constitutiv

64 ansion of GM-CSF-producing Th17 cells led to ameliorated disease in mice deficient for IL-1R1 specifi

65 The ameliorated disease in the absence of ADAP was not due t

66 Importantly, the absence of MyD88 in T cells ameliorated disease in the experimental autoimmune encep

67 optosis through TNFalpha or RIPK1 inhibition ameliorated disease in the virally triggered IBD model.

68 ass inhibitor of the SUMO-activating enzyme, ameliorated disease in three murine models of IBD and re

69 by the helminth parasite Fasciola hepatica, ameliorated disease in two different murine models of au

70 Oral dosing of these compounds ameliorates disease in a murine colitis model.

71 asal administration of CD3-specific antibody ameliorates disease in a progressive animal model of mul

72 Treatment with melatonin ameliorates disease in an experimental model of multiple

73 Previous work has shown that Bz-423 ameliorates disease in animal models of systemic lupus e

74 phagy substrates, and autophagy upregulation ameliorates disease in many animal models of neurodegene

75 Anti-TNF therapy ameliorates disease in many patients with rheumatoid art

76 toimmune encephalomyelitis (EAE) model of MS ameliorates disease in recipients in a miRNA-dependent m

77 vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small anim

78 iciency or antibody blockade of TLR9 or TLR7 ameliorates disease less effectively, suggesting that bo

79 type T cells into RAG-1(-/-) mice results in ameliorated disease levels.

80 pletion of an affected calmodulin gene would ameliorate disease manifestations, whereas the other 2 c

81 7b(-/-) mice with the LXR agonist, T0901317, ameliorated disease manifestations despite significant c

82 Treatment with an anti-B7RP-1 Ab ameliorates disease manifestations and leads to a decrea

83 on and was no more effective than placebo in ameliorating disease manifestations.

84 Our results show that Seldegs can ameliorate disease mediated by MOG-specific antibodies a

85 de of the OX40 (CD134) costimulatory pathway ameliorated disease mediated by both memory and effector

86 immune responses, and may hold potential for ameliorating diseases mediated by pathogenic T cells.

87 Ameliorated disease of Tlr9(K51E) mice compared to Tlr9(

88 therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are ha

89 y as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatali

90 s (EAE), we have shown that UV-B irradiation ameliorates disease outcome by regulatory T cells (Treg)

91 identifies cellular and molecular targets to ameliorate disease outcomes.

92 de of cPLA(2)alpha was highly efficacious in ameliorating disease pathogenesis during the effector ph

93 emann-Pick disease type C1 and significantly ameliorates disease pathologies in Niemann-Pick disease

94 d forms of agrin (mAgrin) have been shown to ameliorate disease pathology in a laminin-alpha2 knockou

95 l use for the treatment of AD, cytokines can ameliorate disease pathology in certain experimental mod

96 macological strategies with the potential to ameliorate disease pathology to a clinically significant

97 stromal cells), attenuating inflammation and ameliorating disease pathology.

98 y, but neither approach alone can completely ameliorate disease phenotype in high-fat diet-fed mice.

99 Conversely, normal glia can ameliorate disease phenotype in transgenic HD mice, as s

100 ic potential of reducing rhodopsin levels in ameliorating disease phenotype in knockin models for p.L

101 igand (FASL)-dependent FAS pathway and could ameliorate disease phenotypes in fibrillin-1 mutated sys

102 To determine whether an FTI would ameliorate disease phenotypes in vivo, we created gene-t

103 letion of PTEN boosted protein synthesis and ameliorated disease phenotypes in mutant neurons.

104 Farnesyltransferase inhibitors have ameliorated disease phenotypes in preclinical studies.

105 NAD(+) repletion via nicotinamide riboside ameliorated disease phenotypes in SCA7 mice and patient

106 ends longevity in Caenorhabditis elegans and ameliorates disease phenotypes in humans.

107 uclear shape abnormalities in HGPS cells and ameliorates disease phenotypes in mice harboring a knock

108 vement of SHED-mediated T-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfat

109 nd downstream targets as a specific venue to ameliorate disease progression in 22q11.2 Deletion Syndr

110 odifiable environmental risk factor that may ameliorate disease progression in patients with NAFLD.

111 l autoimmune encephalomyelitis (R-EAE) would ameliorate disease progression.

112 to influence biological processes thought to ameliorate disease progression.

113 treatment of adults was not curative but did ameliorate disease progression.

114 ating other drugs to control hypertension or ameliorate disease progression.

115 whether these pathways can be manipulated to ameliorate disease progression.

116 Probiotics and omega-3 fatty acids may ameliorate disease progression.

117 ection and targeted intervention to delay or ameliorate disease progression.

118 matory stimuli, the conjugate may be able to ameliorate disease progression.

119 myelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced imm

120 idney disease (PKD) and this correlates with ameliorated disease progression in multiple PKD mouse mo

121 harmacologic targeting of GLS1 in this model ameliorated disease progression.

122 t of SLE mice with a BLyS protein antagonist ameliorates disease progression and enhances survival.

123 murine model, infusion of regulatory T cells ameliorates disease progression.

124 n to develop effective therapeutics that can ameliorate disease-related complications and lead to bet

125 nalysis, we discover that nicotinamide (NAM) ameliorated disease-related phenotypes by inhibiting dru

126 eurotoxic metabolites, and has been found to ameliorate disease-relevant phenotypes in several HD mod

127 cking antibody to CLEC12A that significantly ameliorated disease scores in MOG35-55-induced progressi

128 ime of uveitogenic immunization reproducibly ameliorated disease scores.

129 ry amine 12 and the triazole 14 were able to ameliorate disease severity and to delay disease onset b

130 eagents that neutralize IL-17A significantly ameliorate disease severity in several mouse models of h

131 host responses to arenavirus infection could ameliorate disease severity.

132 l, Smad2 deficiency in T cells significantly ameliorated disease severity and reduced generation of T

133 ular administration of sCD59-APT542 markedly ameliorated disease severity in CD59a(-/-) mice, knee sw

134 Depletion of CD8 + T cells ameliorated disease severity in Mdr2-/- mice.

135 hibitor pevonedistat (MLN4924) significantly ameliorated disease severity in murine experimental auto

136 Both compounds ameliorated disease severity, increased mature OLs, and

137 In addition to ameliorated disease severity, MDSC-treated EAMG mice sho

138 clerosis), we show that SerBut substantially ameliorated disease severity, modulated key immune cell

139 ase-coupled fixed spleen cells significantly ameliorated disease severity, suggesting that this prote

140 The 3 highest doses (20, 80, and 320 microg) ameliorated disease severity, whereas the lowest dose (5

141 ted arthritis, anti-VISTA antibody treatment ameliorated disease severity, which was associated with

142 Candida abundance post-FMT was indicative of ameliorated disease severity.

143 f TGF-beta2 during the effector phase of EAE ameliorated disease severity.

144 that therapeutic administration of activin-A ameliorates disease severity and alleviates CNS immunopa

145 derate reduction of a-globin chain synthesis ameliorates disease severity in B-thalassemia.

146 specific ferroptosis inhibitor significantly ameliorates disease severity in lupus-prone mice reveal

147 different nutrient environments and robustly ameliorates disease severity in mice.

148 3C-like protease), decreases viral load and ameliorates disease severity in SARS-CoV-2-infected hams

149 ROS blockade during established EAE markedly ameliorates disease severity, dampening autoimmune infla

150 t in an imiquimod-induced mouse model of PsO ameliorates disease severity, epidermal hyperplasia and

151 ing in EAE elevates IL-10(+) Breg levels and ameliorates disease severity.

152 gest the importance of Treg-derived IL-10 in ameliorating disease severity and in modulating both the

153 tion may not be therapeutically effective at ameliorating disease severity.

154 n for anti-CD44 activity, although anti-CD44 ameliorates disease similarly to IVIg.

155 may represent a novel therapeutic concept to ameliorate disease state in PH.

156 nduce antigen-specific immune responses that ameliorate disease states as diverse as malignancy, infe

157 are expected to extend brain healthspan and ameliorate disease states.

158 vely reduces poly-GA steady-state levels and ameliorates disease, suggesting poly-GA is pathogenic.

159 Interneuron progenitor transplantation can ameliorate disease symptoms in a variety of neurological

160 30,000, but considering such treatments only ameliorate disease symptoms they seem relatively expensi

161 This treatment can reduce virus load and ameliorate disease symptoms.

162 gene expression or function are predicted to ameliorate disease symptoms.

163 they attenuate the inflammatory response and ameliorate disease symptoms.

164 phalomyelitis is sufficient to significantly ameliorate disease symptoms.

165 andemic A/California/04/2009 (CA04) H1N1 IAV ameliorated disease symptoms and resulted in the restora

166 Vaccination also ameliorated disease symptoms when infection was not prev

167 y interallelic trans suppression is known to ameliorate disease, there is reason to be optimistic tha

168 Yet, although Tlr7 deficiency ameliorated disease, Tlr9 deficiency exacerbated it.

169 Efforts to enhance wellness and ameliorate disease via nutritional, chronobiological, an

170 tion represents a long-held strategy towards ameliorating disease via intestinal microbial community

171 lockade of complement cascade at the C5 step ameliorates disease, we evaluated the effect of administ

172 th rabbit anti-TNF-alpha serum significantly ameliorated disease when given during the afferent stage

173 that, in recombinant form, has been shown to ameliorate disease, whereas laminin alpha1, another dise

174 therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired